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1. 发明申请

WO2005121126A1 POLYCYCLIC PYRAZINES AS POTASSIUM ION CHANNEL MODULATORS 审中-公开
标题翻译：聚氯乙烯作为钾离子通道调节剂
公开(公告)号：WO2005121126A1
公开(公告)日：2005-12-22
申请号：PCT/US2005/012525
申请日：2005-04-13
申请人： ICAGEN, INC. , ASTELLAS PHARMA INC. , WANG, Xiaodong , SPEAR, Kerry, Leigh , FULP, Alan, Bradley , SECONI, Darrick , SUZUKI, Takeshi , ISHII, Takahiro , MORITOMO, Ayako
发明人： WANG, Xiaodong , SPEAR, Kerry, Leigh , FULP, Alan, Bradley , SECONI, Darrick , SUZUKI, Takeshi , ISHII, Takahiro , MORITOMO, Ayako
IPC分类号： C07D401/12
CPC分类号： C07D401/14 , C07D213/73 , C07D401/04 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/14 , C07D417/14
摘要： The present invention provides a genus of polycyclic pyrazines of formula I (I) that are useful as modulators of potassium ion channels. The modulators of the invention are of use in both therapeutic and diagnostic methods; wherein A and B are independently substituted or unsubstituted 5- or 6-membered heterocycloalkyl, or substituted or unsubstituted 5- or 6- membered heteroaryl, W 1 is formula II (II); W 2 is -CH=, -NH-, -N=, -S-, or -O-; Z 1 is formula III (III) or formula IV (IV); Z 2 is -CH=, -NH-, -N=, -S-, or -O-; Y is a bond, -CH=N-NH-, -NH-CH 2 -, or -NR 5 -; s and t are independently integers from 1 to 4; R 1 , R 2A , R 2B and R 3 are independently or unsubstituted alkyle, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted 3- to 7- membered cycloalkyl,, substituted or unsubstituted 5- to 7-membered heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; and R 5 is H, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted 3- to 7- membered cycloalkyl,, substituted or unsubstituted 5- to 7-membered heterocycloalkyl, substituted or unsubstituted aryl or substituted or unsubstituted heteroaryl; wherein if s is greater than one, then each R 1 is optionally different; wherein if t is greater than on, then each R 3 is optionally different; wherein two R 1 groups are optionally joined together with the atoms to which they are attached to form a substituted or unsubstituted ring; and wherein two R 3 groups are optionally joined together with the atoms to which they are attached to form a susbtituted or unsubstituted ring.
摘要翻译：本发明提供了可用作钾离子通道调节剂的式I（I）的多环吡嗪属。本发明的调节剂可用于治疗和诊断方法; 其中A和B独立地为取代或未取代的5-或6-元杂环烷基，或取代或未取代的5-或6-元杂芳基，W 1为式II（II）; W 2是-CH =，-NH-，-N =，-S-或-O-; Z 1是式III（III）或式IV（IV）; Z 2是-CH =，-NH-，-N =，-S-或-O-; Y是键，-CH = N-NH-，-NH-CH 2 - 或-NR 5 - ; s和t独立地为1至4的整数; R 1，R 2A，R 2B和R 3独立地是未取代的烷基，取代或未取代的烷基，取代或未取代的杂烷基，取代或未取代的3-至7-元环烷基，取代或未取代的 5-至7-元杂环烷基，取代或未取代的芳基或取代或未取代的杂芳基; 并且R 5是H，取代或未取代的烷基，取代或未取代的杂烷基，取代或未取代的3-至7-元环烷基，取代或未取代的5-至7-元杂环烷基，取代或未取代的芳基或取代或未取代的杂芳基 ; 其中如果s大于1，则每个R 1任选地不同; 其中如果t大于on，则每个R 3任选地不同; 其中两个R 1基团任选地与它们所连接的原子连接在一起形成取代或未取代的环; 并且其中两个R 3基团任选地与它们所连接的原子连接在一起以形成未取代或未取代的环。

2. 发明申请

WO2005099711A1 POLYCYCLIC PYRIMIDINES AS POTASSIUM ION CHANNEL MODULATORS 审中-公开
标题翻译：多环吡啶作为离子通道调节剂
公开(公告)号：WO2005099711A1
公开(公告)日：2005-10-27
申请号：PCT/US2005/012696
申请日：2005-04-13
申请人： ICAGEN, INC. , ASTELLAS PHARMA INC. , WANG, Xiadong , SPEAR, Kerry, Leigh , FULP, Alan, Bradley , SECONI, Darrick , SUZUKI, Takeshi , ISHII, Takahiro , MORITOMO, Ayako , KUBOTA, Hideki , KAZAMI, Jun-ichi
发明人： WANG, Xiadong , SPEAR, Kerry, Leigh , FULP, Alan, Bradley , SECONI, Darrick , SUZUKI, Takeshi , ISHII, Takahiro , MORITOMO, Ayako , KUBOTA, Hideki , KAZAMI, Jun-ichi
IPC分类号： A61K31/506
CPC分类号： C07D401/14 , C07D405/14 , C07D409/14
摘要： The present invention provides a genus of polycyclic pyrimidines that are useful as modulators of potassium ion channels. The modulators of the invention are of use in both therapeutic and diagnostic methods.
摘要翻译：本发明提供了可用作钾离子通道调节剂的多环嘧啶属。本发明的调节剂在治疗和诊断方法中都有用。

3. 发明申请

WO2005100349A3 POLYCYCLIC PYRIDINES AS POTASSIUM ION CHANNEL MODULATORS 审中-公开
标题翻译：多环吡啶作为钾离子通道调节剂
公开(公告)号：WO2005100349A3
公开(公告)日：2006-03-16
申请号：PCT/US2005012837
申请日：2005-04-13
申请人： ICAGEN INC , ASTELLAS PHARMA INC , WANG XIAODONG , SPEAR KERRY LEIGH , FULP ALAN BRADLEY , SECONI DARRICK , SUZUKI TAKESHI , ISHII TAKAHIRO , MORITOMO AYAKO , KUBOTA HIDEKI , KAZAMI JUN-ICHI
发明人： WANG XIAODONG , SPEAR KERRY LEIGH , FULP ALAN BRADLEY , SECONI DARRICK , SUZUKI TAKESHI , ISHII TAKAHIRO , MORITOMO AYAKO , KUBOTA HIDEKI , KAZAMI JUN-ICHI
IPC分类号： A61K31/4427 , A61P9/10 , C07D213/61 , C07D213/65 , C07D213/73 , C07D213/74 , C07D213/75 , C07D213/80 , C07D213/82 , C07D401/04 , C07D401/14 , C07D405/04 , C07D409/04 , C07D417/04 , C07D417/14 , C07D453/02 , C07D471/04 , C07D419/14 , A61K31/4439 , A61P25/00
CPC分类号： C07D401/04 , C07D213/61 , C07D213/65 , C07D213/73 , C07D213/74 , C07D213/75 , C07D213/80 , C07D213/82 , C07D401/14 , C07D405/04 , C07D409/04 , C07D417/04 , C07D417/14 , C07D453/02 , C07D471/04 , C09B57/10
摘要： The present invention provides a genus of polycyclic pyridines that are useful as modulators of potassium ion channels. The modulators of the invention are of use in both therapeutic and diagnostic methods.
摘要翻译：本发明提供了可用作钾离子通道调节剂的多环吡啶属。本发明的调节剂在治疗和诊断方法中都有用。

4. 发明申请

WO2005100349A2 POLYCYCLIC PYRIDINES AS POTASSIUM ION CHANNEL MODULATORS 审中-公开
标题翻译：作为钾离子通道调节剂的多环吡啶
公开(公告)号：WO2005100349A2
公开(公告)日：2005-10-27
申请号：PCT/US2005/012837
申请日：2005-04-13
申请人： ICAGEN, INC. , ASTELLAS PHARMA INC. , WANG, Xiaodong , SPEAR, Kerry, Leigh , FULP, Alan, Bradley , SECONI, Darrick , SUZUKI, Takeshi , ISHII, Takahiro , MORITOMO, Ayako , KUBOTA, Hideki , KAZAMI, Jun-ichi
发明人： WANG, Xiaodong , SPEAR, Kerry, Leigh , FULP, Alan, Bradley , SECONI, Darrick , SUZUKI, Takeshi , ISHII, Takahiro , MORITOMO, Ayako , KUBOTA, Hideki , KAZAMI, Jun-ichi
IPC分类号： C07D417/14
CPC分类号： C07D401/04 , C07D213/61 , C07D213/65 , C07D213/73 , C07D213/74 , C07D213/75 , C07D213/80 , C07D213/82 , C07D401/14 , C07D405/04 , C07D409/04 , C07D417/04 , C07D417/14 , C07D453/02 , C07D471/04 , C09B57/10
摘要： The present invention provides a genus of polycyclic pyridines that are useful as modulators of potassium ion channels. The modulators of the invention are of use in both therapeutic and diagnostic methods.
摘要翻译：本发明提供了可用作钾离子通道调节剂的多环吡啶类。本发明的调节剂可用于治疗和诊断方法。

5. 发明申请

WO2005099673A1 POLYCYLIC THIAZOLES AS POTASSIUM ION CHANNEL MODULATORS 审中-公开
标题翻译：多氯联苯作为离子通道调节剂
公开(公告)号：WO2005099673A1
公开(公告)日：2005-10-27
申请号：PCT/US2005/012911
申请日：2005-04-13
申请人： ICAGEN, INC. , ASTELLAS PHARMA INC. , WANG, Xiaodong , SPEAR, Kerry, Leigh , PULP, Alan, Bradley , SECONI, Darrick , SUZUKI, Takeshi , ISHII, Takahiro , MORITOMO, Ayako , KUBOTA, Hideki
发明人： WANG, Xiaodong , SPEAR, Kerry, Leigh , PULP, Alan, Bradley , SECONI, Darrick , SUZUKI, Takeshi , ISHII, Takahiro , MORITOMO, Ayako , KUBOTA, Hideki
IPC分类号： A61K9/20
CPC分类号： C07D417/14
摘要： The present invention provides a genus of polycyclic thiazoles that are useful as modulators of potassium ion channels. The modulators of the invention are of use in both therapeutic and diagnostic methods.
摘要翻译：本发明提供了可用作钾离子通道调节剂的多环噻唑属。本发明的调节剂在治疗和诊断方法中都有用。

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