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1. 发明申请

WO2014040084A1 FOOTWEAR INSERT WITH FOOT STOP 审中-公开
标题翻译：鞋脚插脚
公开(公告)号：WO2014040084A1
公开(公告)日：2014-03-13
申请号：PCT/US2013/059097
申请日：2013-09-10
申请人： JONES, Todd
发明人： JONES, Todd
IPC分类号： A43B7/14 , A43B5/00 , A43B13/38
CPC分类号： A43B17/00 , A43B7/145 , A43B7/149
摘要： A shoe or footwear insert pad is configured to fit over at least part of the forward portion of the sole of a shoe, boot, or sandal, extending under the toes and ball of a wearer's foot. The pad has an upper face, a lower face, a forward edge, a rear edge, an inner edge, and an outer edge, with the inner and outer edges conforming to the shape of corresponding inner and outer edges of the sole of the footwear. A foot stop bar or rib on the inner face of the pad extends in a selected, at least partially curved path from the inner edge to the outer edge configured to match the curve of the space at the base of a wearer's toes where the toes meet the remainder of the foot. In one example, the position of the foot stop bar on the pad is adjustable.
摘要翻译：鞋或鞋类插入垫被配置成装配在穿着者的脚的脚趾和球下延伸的鞋，靴子或凉鞋的鞋底的前部的至少一部分上。垫具有上表面，下表面，前边缘，后边缘，内边缘和外边缘，其中内边缘和外边缘均符合鞋类鞋底相应的内边缘和外边缘的形状。在垫的内表面上的脚踏棒或肋条从内边缘到外边缘的选定的至少部分弯曲的路径中延伸，所述路径被配置成与脚趾相遇的佩戴者脚趾底部的空间的曲线相匹配余下的脚。在一个示例中，脚踏板在垫上的位置是可调节的。

2. 发明申请

WO2012021442A9 COATED DENTAL CROWNS AND METHOD OF MAKING THE SAME 审中-公开
标题翻译：包皮牙科及其制造方法
公开(公告)号：WO2012021442A9
公开(公告)日：2013-02-28
申请号：PCT/US2011046920
申请日：2011-08-08
申请人： 3M INNOVATIVE PROPERTIES CO , VELAMAKANNI BHASKAR V , JONES TODD D , PATEL ANUPA N
发明人： VELAMAKANNI BHASKAR V , JONES TODD D , PATEL ANUPA N
IPC分类号： A61C5/10 , A61C13/083 , A61C13/09
CPC分类号： A61C5/10 , A61C5/70 , A61C5/73 , A61C5/77 , A61C13/0835 , A61C13/09
摘要： Provided are methods of improving the wear resistance and aesthetic properties of dental articles, as well as dental articles having an abrasion resistant ceramic/polymer hybrid coating thereon. The method for coating a dental article (20) comprises: providing a body comprising a mental substrate (30); priming at least a portion of a surface of the body; depositing a ceramic material on at least a portion of a surface of the body, wherein said depositing forms a ceramic layer (34) bonded directly to the surface: and depositing at least one hardenable composition comprising a polymerizable component on at least a portion of the ceramic layer, wherein depositing at least one hardenable composition forms a polymeric layer (36).
摘要翻译：提供了改善牙科制品的耐磨性和美观性以及其上具有耐磨陶瓷/聚合物混合涂层的牙科用品的方法。用于涂覆牙科用品（20）的方法包括：提供包括精神基底（30）的主体; 起动身体表面的至少一部分; 在所述主体的表面的至少一部分上沉积陶瓷材料，其中所述沉积形成直接结合到所述表面的陶瓷层（34）;以及在至少一部分所述表面上沉积包含可聚合组分的至少一种可硬化组合物陶瓷层，其中沉积至少一种可硬化组合物形成聚合物层（36）。

3. 发明申请

WO2012125730A2 REACTOR SYSTEMS 审中-公开
标题翻译：反应器系统
公开(公告)号：WO2012125730A2
公开(公告)日：2012-09-20
申请号：PCT/US2012029083
申请日：2012-03-14
申请人： ABEC INC , KNIGHT CAMERON , JONES TODD , COLE BRADY , KUBERA PAUL , DONOVAN CINDY L
发明人： KNIGHT CAMERON , JONES TODD , COLE BRADY , KUBERA PAUL , DONOVAN CINDY L
IPC分类号： B01J19/00 , B01J19/18 , C07H1/00 , C07H21/00 , C07K1/00 , C07K1/107 , C07K2/00 , C07K14/00 , C12M1/00 , C12M3/00 , C12N1/00 , C12N5/04 , C12N5/071
CPC分类号： C12M23/52 , B01F7/00133 , B01F7/00141 , B01F7/1605 , B01F7/186 , B01F13/0032 , B01F15/00006 , B01F15/00785 , B01F15/0085 , B01F15/00896 , B01F15/065 , B01J19/0066 , B01J19/18 , B01J19/1812 , B01J19/24 , B01J2219/00094 , B01J2219/00768 , B01J2219/1943 , B01J2219/24 , C12M23/28 , C12M23/46 , C12M23/48 , C12M27/02
摘要： This disclosure relates to equipment utilized to manufacture chemical agents, particularly biopharmaceuticals. In some embodiments, reactor systems comprising a mobile carriage assembly; a disposable reaction container removably attached to the carriage assembly; and, a carriage holder into which the mobile carriage assembly may be removably inserted are provided.
摘要翻译：本公开涉及用于制造化学试剂，特别是生物药物的设备。在一些实施例中，包括移动支架组件的反应器系统; 可移除地附接到托架组件的一次性反应容器; 并且设置有可拆卸地插入移动托架组件的托架保持器。

4. 发明申请

WO2010048067A3 DENTAL COMPOSITION COMPRISING BIPHENYL DI(METH)ACRYLATE MONOMER COMPRISING URETHANE MOIETIES 审中-公开
标题翻译：含有包含尿素活性的联苯二（甲基）丙烯酸酯单体的牙齿组合物
公开(公告)号：WO2010048067A3
公开(公告)日：2011-05-19
申请号：PCT/US2009061124
申请日：2009-10-19
申请人： 3M INNOVATIVE PROPERTIES CO , YANG JIE , KARIM NAIMUL , OLSON DAVID B , JONES TODD D , JACOBS DWIGHT W
发明人： YANG JIE , KARIM NAIMUL , OLSON DAVID B , JONES TODD D , JACOBS DWIGHT W
IPC分类号： C07C271/16 , A61K6/083
CPC分类号： A61K6/083 , A61K6/0017 , A61K6/0023 , C07C271/16 , C07C271/48 , C08F122/105 , C08F2222/1033 , C08G18/3215 , C08G18/8116 , C08L33/00
摘要： Dental compositions and biphenyl di(meth)acrylate monomers are described. The dental compositions comprise at least one biphenyl di(meth)acrylate monomer comprising two aromatic rings connected with a C-C bond wherein the rings each comprise a substituent comprising a urethane moiety and a (meth)acrylate end group.
摘要翻译：描述了牙科组合物和联苯二（甲基）丙烯酸酯单体。牙科用组合物包含至少一种包含与C-C键连接的两个芳环的二（二）甲基丙烯酸联苯单体，其中各环各自包含氨基甲酸酯部分和（甲基）丙烯酸酯端基的取代基。

5. 发明申请

WO2010146046A1 HYDROPONIC SYSTEMS FOR GENERATING TRANSGENIC PLANTS 审中-公开
标题翻译：用于产生转基因植物的水文系统
公开(公告)号：WO2010146046A1
公开(公告)日：2010-12-23
申请号：PCT/EP2010/058377
申请日：2010-06-15
申请人： BASF PLANT SCIENCE COMPANY GMBH , JONES, Todd , OLHOFT, Paula , VANGURI, Aparna Sri , LAI, Fang-Ming , KUIJPERS, Anne-Marie , GEIGER, Michael
发明人： JONES, Todd , OLHOFT, Paula , VANGURI, Aparna Sri , LAI, Fang-Ming , KUIJPERS, Anne-Marie , GEIGER, Michael
IPC分类号： A01H1/04 , C12N15/82 , A01G31/00
CPC分类号： C12N15/8201 , A01G31/00 , A01H1/04
摘要： The present invention is concerned with a method for generating transgenic plants, said method comprising a) providing a population of transgenic and non-transgenic rootless plant shoots grown under in vitro conditions, transferring said plant shoots to a hydroponic medium, and simultaneously allowing said shoots to root on said hydroponic medium and selecting for transgenic shoots.
摘要翻译：本发明涉及用于产生转基因植物的方法，所述方法包括：a）提供在体外条件下生长的转基因和非转基因无根植物芽的群体，将所述植物芽转移到水培培养基中，同时允许所述芽根据所述水培培养基并选择转基因芽。

6. 发明申请

WO2007103752A3 SAFETY GAFF 审中-公开
标题翻译：安全GAFF
公开(公告)号：WO2007103752A3
公开(公告)日：2008-08-28
申请号：PCT/US2007063108
申请日：2007-03-01
申请人： JR JONES COMPANY , JONES TODD A , ALBERT CASCIA
发明人： JONES TODD A , ALBERT CASCIA
IPC分类号： A01K97/14
CPC分类号： A01K97/14
摘要： An elongated handle has a pointed fish hook rotatably affixed to one end of the handle, the hook having two operating dispositions, a first disposition wherein the hook is open for gaffing purposes and a second disposition wherein the hook folded back against the handle to block the hook point for safety. A mechanism releasably secures the hook at either disposition. A button actuated mechanism releases the hook from either disposition so that the hook can be moved from one operating disposition to the other. Preferably the gaff further includes a bias for urging the hook toward its open, gaffing disposition.
摘要翻译：细长的手柄具有可旋转地固定在手柄的一端的尖的鱼钩，钩具有两个操作配置，第一配置，其中钩为打开目的打开，第二配置为第二配置，其中钩向后折靠在手柄上以阻挡钩点安全。一种机构可释放地将挂钩固定在任一配置上。按钮致动机构将挂钩从任一配置中释放，使得钩可以从一个操作配置移动到另一个。优选地，盖子进一步包括用于将钩推向其开放的位置的偏压。

7. 发明申请

WO2005005393A2 CCK-1 RECEPTOR MODULATORS 审中-公开
标题翻译： CCK-1受体调节剂
公开(公告)号：WO2005005393A2
公开(公告)日：2005-01-20
申请号：PCT/US2004/021020
申请日：2004-06-30
申请人： JANSSEN PHARMACEUTICA N.V. , CHOUDHURY, Anusuya , GRIMM, Jeffrey, S. , JONES, Todd, K. , LIANG, Jimmy, T. , MANI, Neelakandha , SORGI, Kirk, L.
发明人： CHOUDHURY, Anusuya , GRIMM, Jeffrey, S. , JONES, Todd, K. , LIANG, Jimmy, T. , MANI, Neelakandha , SORGI, Kirk, L.
IPC分类号： C07D231/00
CPC分类号： C07D231/12 , C07D401/04 , C07D401/06 , C07D403/06 , C07D403/12 , C07D405/04 , C07D405/06 , C07D405/10 , C07D405/14 , C07D409/06
摘要： There are provided by the present invention certain pyrazole based CCK-1 receptor modulators which have the general formula: (I) wherein Ar is an aromatic or heteroaromatic group, X is a hydrocarbon linker, Y is a bond or hydrocarbon linker and R 1 , R 2 , R 3 , R 4 and R 5 are certain organic substituents, and methods of making the same.
摘要翻译：本发明提供了具有以下通式的某些基于吡唑的CCK-1受体调节剂：（I）其中Ar是芳族或杂芳基，X是烃连接基，Y是键或烃连接基，R 1 R 2，R 3，R 4和R 5是某些有机取代基及其制备方法。

8. 发明申请

WO03002751A3 ALTERATION OF OIL TRAITS IN PLANTS 审中-公开
标题翻译：植物油性状的改变
公开(公告)号：WO03002751A3
公开(公告)日：2003-08-21
申请号：PCT/US0220152
申请日：2002-06-27
申请人： DU PONT , PIONEER HI BRED INT , ALLEN STEPHEN M , ALLEN WILLIAM B , CAHOON REBECCA E , EPELBAUM SABINE , FAMODU OMOLAYO O , HARVELL LESLIE T , JONES TODD J , KINNEY ANTHONY J , KLEIN THEODORE M , LI CHANGJIANG , OLIVEIRA IGOR CUNHA , SAKAI HAJIME , SHEN BO , TARCZYNSKI MITCHELL C
发明人： ALLEN STEPHEN M , ALLEN WILLIAM B , CAHOON REBECCA E , EPELBAUM SABINE , FAMODU OMOLAYO O , HARVELL LESLIE T , JONES TODD J , KINNEY ANTHONY J , KLEIN THEODORE M , LI CHANGJIANG , OLIVEIRA IGOR CUNHA , SAKAI HAJIME , SHEN BO , TARCZYNSKI MITCHELL C
IPC分类号： C07K14/415 , C12N15/82 , C07H21/04
CPC分类号： C12N15/8247 , C07K14/415
摘要： The preparation and use of nucleic acid fragments useful in altering the oil phenotype in plants are disclosed. Chimeric construct incorporating such nucleic acid fragments and suitable regulatory sequences can be used to create transgenic plants having altered lipid profiles. Methods for altering the oil phenotype in plants using such nucleic acid fragments also are disclosed.
摘要翻译：公开了用于改变植物中油表型的核酸片段的制备和用途。掺入这种核酸片段和合适的调节序列的嵌合构建体可用于产生具有改变的脂质谱的转基因植物。也公开了用这种核酸片段改变植物中油表型的方法。

9. 发明申请

WO0066581A8 CYANOPYRROLES AS PROGESTERONE RECEPTOR AGONISTS 审中-公开
标题翻译： CYANOPRROLES作为孕激素受体激动剂
公开(公告)号：WO0066581A8
公开(公告)日：2002-05-30
申请号：PCT/US0011844
申请日：2000-05-01
申请人： AMERICAN HOME PROD , LIGAND PHARM INC , COLLINS MARK A , MACKNER VALERIE A , ZHI LIN , JONES TODD K , TEGLEY CHRISTOPHER M , WROBEL JAY E , EDWARDS JAMES P
发明人： COLLINS MARK A , MACKNER VALERIE A , ZHI LIN , JONES TODD K , TEGLEY CHRISTOPHER M , WROBEL JAY E , EDWARDS JAMES P
IPC分类号： C07D403/04 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/405 , A61K31/536 , A61K31/5415 , A61P5/34 , A61P13/08 , A61P15/00 , A61P15/14 , A61P15/16 , A61P15/18 , A61P35/00 , A61P43/00 , C07D413/04
CPC分类号： C07D403/04 , A61K31/405 , A61K31/5415 , C07D413/04
摘要： This invention provides a progesterone receptor antagonist of formula (1) having the structure wherein T is O, S, or absent; R1, and R2 are each, independently, hydrogen, alkyl, substituted alkyl; or R1 and R2 are taken together to form a ring and together contain -CH2(CH2)nCH2-, -CH2CH2CMe2CH2CH2-, -O(CH2)pCH2-, -O(CH2)qO-, -CH2CH2OCH2CH2-, or -CH2CH2NR7CH2CH2-; n=1-5; p=1-4; q=1-4; R3 is hydrogen, OH, NH2, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, or COR ; R is hydrogen, alkyl, substituted alkyl, alkoxy, substituted alkoxy, aminoalkyl, or substituted aminoalkyl; R4 is hydrogen, halogen, CN, NH2, alkyl, substituted alkyl, alkoxy, substituted alkoxy, aminoalkyl, or substituted aminoalkyl; R5 is hydrogen, alkyl, or substituted alkyl; R6 is hydrogen, alkyl, substituted alkyl, or COR ; R is hydrogen, alkyl, substituted alkyl, alkoxy, substituted alkoxy, aminoalkyl, or substituted aminoalkyl; R7 is hydrogen or alkyl; or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明提供式（1）的孕酮受体拮抗剂，其具有其中T为O，S或不存在的结构; R 1和R 2各自独立地为氢，烷基，取代的烷基; 或者R 1和R 2一起形成环，并且一起含有-CH 2（CH 2）n CH 2 - ， - CH 2 CH 2 C 0 H 2 CH 2 CH 2 - ， - O（CH 2）p CH 2 - ， - O（CH 2）q O - ， - CH 2 CH 2 OCH 2 CH 2 - 或-CH 2 CH 2 NR 7 CH 2 CH 2 - ; N = 1-5; P = 1-4; Q = 1-4; R3是氢，OH，NH2，烷基，取代的烷基，烯基，取代的烯基，炔基，取代的炔基或CORA。 R AA是氢，烷基，取代的烷基，烷氧基，取代的烷氧基，氨基烷基或取代的氨基烷基; R4是氢，卤素，CN，NH2，烷基，取代的烷基，烷氧基，取代的烷氧基，氨基烷基或取代的氨基烷基; R5是氢，烷基或取代的烷基; R 6是氢，烷基，取代的烷基或COR B; R B是氢，烷基，取代的烷基，烷氧基，取代的烷氧基，氨基烷基或取代的氨基烷基; R7是氢或烷基; 或其药学上可接受的盐。

10. 发明申请

WO0066164A8 CONTRACEPTIVE COMPOSITIONS CONTAINING ANTIPROGESTINIC AND PROGESTINIC 审中-公开
标题翻译：含有抗菌素和抗生素的合成组合物
公开(公告)号：WO0066164A8
公开(公告)日：2001-05-03
申请号：PCT/US0011643
申请日：2000-05-01
申请人： AMERICAN HOME PROD , LIGAND PHARM INC , GRUBB GARY S , ZHI LIN , JONES TODD K , MARSCHKE KEITH B , TEGLEY CHRISTOPHER M , ZHANG PUWEN , TEREFENKO EUGENE A , FENSOME ANDREW , WROBEL JAY E , EDWARDS JAMES P , FLETCHER HORACE A
发明人： GRUBB GARY S , ZHI LIN , JONES TODD K , MARSCHKE KEITH B , TEGLEY CHRISTOPHER M , ZHANG PUWEN , TEREFENKO EUGENE A , FENSOME ANDREW , WROBEL JAY E , EDWARDS JAMES P , FLETCHER HORACE A
IPC分类号： A61K31/567 , A61K20060101 , A61K31/535 , A61K31/5355 , A61K31/536 , A61K31/537 , A61K31/565 , A61K31/57 , A61K45/06 , A61P20060101 , A61P15/18
CPC分类号： A61K45/06 , A61K31/565 , A61K31/57 , A61K31/535 , A61K2300/00
摘要： This invention relates to cyclic combination therapies and regimens utilizing substituted indoline derivative compounds which are antagonists of the progesterone receptor having general structure (I): wherein R and R may be single substituents or fused to form spirocyclic or hetero-spirocyclic rings; R is H, OH, NH2, C1 to C6 alkyl, substituted C1 to C6 alkyl, C3 to C6 alkenyl, substituted C1 to C6 alkenyl, alkynyl, or substituted alkynyl, COR ; R is H, C1 to C3 alkyl, substituted C1 to C3 alkyl, aryl, substituted aryl, C1 to C3 alkoxy, substituted C1 to C3 alkoxy, C1 to C3 aminoalkyl, or substituted C1 to C3 aminoalkyl; R is H, halogen, CN, NO2, C1 to C6 alkyl, substituted C1 to C6 alkyl, alkynyl, or substituted alkynyl, C1 to C6 alkoxy, substituted C1 to C6 alkoxy, amino, C1 to C6 aminoalkyl, or substituted C1 to C6 aminoalkyl; and R is selected from a trisubstituted benzene ring of a five or six membered ring with 1, 2, or 3 heteroatoms from the group including O, S, SO, SO2 or NR and containing one or two independent substituents from the group including H, halogen, CN, NO2 , amino, and C1 to C3 alkyl, C1 to C3 alkoxy, C1 to C3 aminoalkyl, COR , or NR COR ; or pharmaceutically acceptable salt thereof. These methods of treatment may be used for contraception or for the treatment and/or prevention of secondary amenorrhea, dysfunctional bleeding, uterine leiomyomata, endometriosis; polycystic ovary syndrome, carcinomas and adenocarcinomas of the endormetrium, ovary, breast, colon, prostate, or minimization of side effects or cyclic menstrual bleeding. Additional uses of the invention inlcude stimulation of food intake.
摘要翻译：本发明涉及使用具有通式结构（I）的孕酮受体的拮抗剂的取代的二氢吲哚衍生物化合物的环状组合疗法和方案：其中R 1和R 2可以是单个取代基或稠合形成螺环或异 - 螺环; R 3是H，OH，NH 2，C 1至C 6烷基，取代的C 1 -C 6烷基，C 3至C 6烯基，取代的C 1至C 6烯基，炔基或取代的炔基。 R C是H，C 1至C 3烷基，取代的C 1至C 3烷基，芳基，取代的芳基，C 1至C 3的烷氧基，取代的C 1至C 3的烷氧基，C 1至C 3的氨基烷基或取代的C 1至C 3氨基烷基; R 4是H，卤素，CN，NO 2，C 1至C 6烷基，取代的C 1 -C 6烷基，炔基或取代的炔基，C 1至C 6烷氧基，取代的C 1至C 6烷氧基，氨基，C 1至C 6氨基烷基或取代 C1至C6氨基烷基; R 5选自具有1,2或3个杂原子的五元或六元环的三取代苯环，所述杂原子包括O，S，SO，SO 2或NR 6，并含有一个或两个独立的取代基包括H，卤素，CN，NO 2，氨基和C 1至C 3烷基，C 1至C 3烷氧基，C 1至C 3氨基烷基，COR F或NR G COR F; 或其药学上可接受的盐。这些治疗方法可用于避孕或治疗和/或预防继发性闭经，功能障碍性出血，子宫平滑肌瘤，子宫内膜异位症; 多囊卵巢综合征，宫内膜，卵巢，乳腺，结肠，前列腺的癌和腺癌，或副作用或周期性月经出血的最小化。本发明的另外用途包括刺激食物摄取。

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