专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2007093642A3 MICROPARTICULATE PHARMACEUTICAL FORMS RESISTANT TO IMMEDIATE RELEASE OF THE ACTIVE PRINCIPLE IN THE PRESENCE OF ALCOHOL 审中-公开
标题翻译：微丸药物形式抗酒精存在时活性成分的立即释放
公开(公告)号：WO2007093642A3
公开(公告)日：2007-10-04
申请号：PCT/EP2007051528
申请日：2007-02-16
申请人： FLAMEL TECH SA , GIMBERTEAU FLORENCE , DARGELAS FREDERIC
发明人： GIMBERTEAU FLORENCE , DARGELAS FREDERIC
IPC分类号： A61K9/48 , A61K9/16 , A61K9/26 , A61K9/32 , A61K9/50 , A61K9/52
CPC分类号： A61K9/1676 , A61K9/0095 , A61K9/1652 , A61K9/2077 , A61K9/2866 , A61K9/4816 , A61K9/4891 , A61K9/5047 , A61K9/5073 , A61K9/5078 , A61K9/5084
摘要： The invention aims at minimizing the risks of release of the dose associated with the concurrent consumption of alcohol and certain pharmaceutical or dietary forms with modified release. The invention concerns an oral form comprising reservoir-type microparticles, with modified release of at least one active principle. The invention is characterized in that it is resistant to the immediate release of the dose of active principle in the presence of alcohol. In particular, the inventive oral form is characterized in that the releasing time of 50% of the active principle, in an alcohol-containing solution is not reduced by more than 3 times compared to the releasing time of 50% of the active principle in an alcohol-free aqueous medium. The form comprises an agent D which is a pharmaceutically acceptable compound of which the hydrating or solvating speed and capacity is higher in an alcohol-free aqueous medium than in an alcohol-containing solution.
摘要翻译：本发明旨在最大限度地减少与同时食用酒精和某些具有调节释放的药物或饮食形式相关的剂量释放的风险。本发明涉及包含储库型微粒的口服形式，其具有至少一种活性成分的调节释放。本发明的特征在于它能抵抗有效成分在酒精存在下的立即释放。特别地，本发明的口服形式的特征在于，在含酒精溶液中50％活性成分的释放时间与50％活性成分释放时间相比不减少超过3倍不含酒精的水性介质。该形式包括药剂D，药剂D是无醇水介质中的水合或溶解速度和容量高于含醇溶液中的水合或溶解速度和容量的药学上可接受的化合物。

2. 发明申请

WO2007036671A3 MICROPARTICLES WITH MODIFIED RELEASE OF AT LEAST ONE ACTIVE PRINCIPLE AND ORAL GALENIC FORM COMPRISING SAME 审中-公开
标题翻译：具有至少一个有效原则的修改释放的微生物和包含其中的口服糖尿病形式
公开(公告)号：WO2007036671A3
公开(公告)日：2007-05-24
申请号：PCT/FR2006050944
申请日：2006-09-27
申请人： FLAMEL TECH SA , DARGELAS FREDERIC , GUIMBERTEAU FLORENCE , CASTAN CATHERINE , MEYRUEIX REMI , SOULA GERARD
发明人： DARGELAS FREDERIC , GUIMBERTEAU FLORENCE , CASTAN CATHERINE , MEYRUEIX REMI , SOULA GERARD
IPC分类号： A61K9/50 , A23L33/00 , A61K9/20 , A61K9/48 , A61K31/155 , A61K31/522
CPC分类号： A61K9/5073 , A61K9/2077
摘要： The invention concerns microparticulate systems with modified release of oral active principle(s). The invention aims at providing a novel multimicroparticulate galenic system operating in accordance with a dual time-dependent and pH-dependent release mechanism, which enables the following three parameters to be adjusted independently of one another: a) the latent period preceding the release of the active principle in the stomach; b) the pH triggering the release of the active principle in the intestine; c) the release speed of the active principle. This is achieved through the use of coated microparticles made from particles of active principle each coated with two coating films A and B. A comprises: film-forming (co)polymer (A1) insoluble in fluids of the gastrointestinal tract; ethylcellulose (co)polymer (A2) soluble in fluids of the gastrointestinal tract; plasticizing polyvinylpyrrolidone (A3); castor oil/optionally a surfactant and/or magnesium stearate lubricant (A4). B comprises a hydrophilic polymer (B1) bearing ionized groups with neutral pH (EUDRAGIT® L100-55) and a hydrophobic compound (B2) (LUBRITAB®).The invention also concerns medicines based on said microparticules.
摘要翻译：本发明涉及具有口腔活性成分释放的微粒体系。本发明的目的在于提供一种新颖的多分子盖仑系统，该系统根据双重时间依赖性和pH依赖性释放机制进行操作，这使得以下三个参数可以彼此独立地进行调整：a）释放之前的潜伏期胃中的活跃原则; b）pH触发在肠中释放活性成分; c）有效原理的释放速度。这通过使用由各自涂覆有两个涂膜A和B的活性成分的颗粒制成的涂覆微粒来实现.A包括：不溶于胃肠道流体的成膜（共）聚合物（A1）可溶于胃肠道液体的乙基纤维素（共）聚合物（A2）; 增塑聚乙烯吡咯烷酮（A3）; 蓖麻油/任选的表面活性剂和/或硬脂酸镁润滑剂（A4）。 B包含带有中性pH离子化的亲水性聚合物（B1）（EUDRAGIT L100-55）和疏水性化合物（B2）。本发明还涉及基于所述微粒的药物。

3. 发明申请

WO2007135193A2 SUSTAINED-RELEASE MULTIMICROPARTICULATE ORAL PHARMACEUTICAL FORM 审中-公开
标题翻译：持续释放多重药物口服药物形式
公开(公告)号：WO2007135193A2
公开(公告)日：2007-11-29
申请号：PCT/EP2007055069
申请日：2007-05-24
申请人： FLAMEL TECH SA , GUIMBERTEAU FLORENCE , DARGELAS FREDERIC
发明人： GUIMBERTEAU FLORENCE , DARGELAS FREDERIC
IPC分类号： A61K9/48 , A61K9/16 , A61K9/20 , A61K9/50 , A61K9/52 , A61K31/343 , A61K31/745 , A61K31/785 , A61P25/04
CPC分类号： A61K9/5078 , A61K9/0095 , A61K9/1652 , A61K9/1676 , A61K9/2081 , A61K9/4891 , A61K9/5042 , A61K9/5047 , A61K9/5084 , A61K31/343 , A61K31/745 , A61K31/785
摘要： Modified-release multimicroparticulate pharmaceutical form capable of maintaining the modified release of the active ingredient in an alcoholic solution and of withstanding attempts at misuse.
摘要翻译：能够维持活性成分在酒精溶液中的释放和耐受试图滥用的改性释放多微粒药物形式。

4. 发明申请

WO2006134018A3 ORAL DOSAGE FORM COMPRISING AN ANTIMISUSE SYSTEM 审中-公开
标题翻译：口服剂型包含抗体系统
公开(公告)号：WO2006134018A3
公开(公告)日：2007-03-08
申请号：PCT/EP2006062625
申请日：2006-05-24
申请人： FLAMEL TECH SA , GUIMBERTEAU FLORENCE , DARGELAS FREDERIC , SOULA GERARD , SOULA REMI
发明人： GUIMBERTEAU FLORENCE , DARGELAS FREDERIC , SOULA GERARD , SOULA REMI
IPC分类号： A61K9/51 , A61K9/62
CPC分类号： A61K9/5047 , A61K9/4825 , A61K9/5078 , A61K9/5084 , A61K33/06 , A61K33/26 , A61K33/30 , A61K45/06 , A61K2300/00
摘要： An oral solid dosage form containing one or several active principle(s) having analgesic properties, the composition of said dosage form being such that it prevents the misuse of said dosage form through the liquid extraction of the active principle(s) contained therein, using commonly available solvents. Said oral so lid dosage form containing at least one salt of at least one analgesic active principle, and an anti-misuse system comprising at least one quenching agent, said quenching agent being suitable for inducing complexation of said analgesic active principle salt when the analgesic active principle salt is improperly extracted, notably by a drug abuser, in vitro in solution from said oral solid dosage form.
摘要翻译：含有一种或多种具有镇痛特性的活性成分的口服固体剂型，所述剂型的组成使得其通过液体提取其中包含的活性成分来防止所述剂型的滥用，其使用常用的溶剂。所述含有至少一种至少一种止痛活性成分的盐的口服所述盖剂型和包含至少一种猝灭剂的防误用系统，所述猝灭剂适合于当所述止痛活性成分主要盐在体外在所述口服固体剂型的溶液中被不正确地提取，特别是由药物滥用者提取。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式