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1. 发明申请

WO2022240657A1 FLAT SELF-CURLING SHEET MEMBRANES AND METHODS FOR PRODUCING SAME 审中-公开
公开(公告)号：WO2022240657A1
公开(公告)日：2022-11-17
申请号：PCT/US2022/027933
申请日：2022-05-05
申请人： COLLAGEN MATRIX INC.
发明人： CHEN, Hui-Chen , LEE, Natsuyo Shishido , AMMON, Daniel
IPC分类号： A61L27/24 , A61L27/54 , A61L27/30 , A61L27/32 , A61L2430/10 , A61L2430/12 , A61L27/46
摘要： A flat self-curling rollable composite sheet membrane, and methods for preparing such membranes. The sheet membrane includes a flat layer of collagen and a bioactive agent, such as a calcium phosphate-based mineral. The flat layer self-curls into a predetermined shape upon absorption of an aqueous fluid. The methods for preparing the membranes include the steps of adding mineral to a collagen dispersion, forming a composite collagen matrix having mineral particles dispersed therein, compressing the composite matrix between two plates to form a flat sheet, and drying the flat sheet to yield a rollable composite sheet membrane.

2. 发明申请

WO2013049306A1 METHOD OF PREPARING POROUS CARBONATE APATITE FROM NATURAL BONE 审中-公开
标题翻译：从天然骨制备多孔碳酸钙的方法
公开(公告)号：WO2013049306A1
公开(公告)日：2013-04-04
申请号：PCT/US2012/057492
申请日：2012-09-27
申请人： COLLAGEN MATRIX, INC. , LI, Shu-Tung , CHEN, Hui-Chen , YUEN, Debbie
发明人： LI, Shu-Tung , CHEN, Hui-Chen , YUEN, Debbie
IPC分类号： A61L27/04 , A61L27/56 , A61F2/28
CPC分类号： C01B25/16
摘要： A method for preparing carbonate apatite from natural bones. The method includes obtaining cancellous bone particles; treating the bone particles with hot water and an organic solvent; repeating the treating step at least once; drying the bone particles; and heating the bone particles at 500°C to 620°C for 10 to 50 hours.
摘要翻译：从天然骨制备碳酸盐磷灰石的方法。该方法包括获得松质骨颗粒; 用热水和有机溶剂处理骨颗粒; 重复处理步骤至少一次; 干燥骨颗粒; 并将骨粒子在500℃〜620℃加热10〜50小时。

3. 发明申请

WO2010077434A1 BIOPOLYMERIC MEMBRANE FOR WOUND PROTECTION AND REPAIR 审中-公开
标题翻译：用于保护和修复的生物聚合物膜
公开(公告)号：WO2010077434A1
公开(公告)日：2010-07-08
申请号：PCT/US2009/063549
申请日：2009-11-06
申请人： COLLAGEN MATRIX, INC. , LI, Shu-Tung , LEE, Natsuyo Shishido , YUEN, Debbie
发明人： LI, Shu-Tung , LEE, Natsuyo Shishido , YUEN, Debbie
IPC分类号： A61L15/32 , A61L15/28 , A61K9/70
CPC分类号： A61K9/0014 , A61F13/00012 , A61F13/00034 , A61K47/42 , A61L15/14 , A61L15/28 , A61L15/32 , A61L15/325
摘要： The present invention relates to a conformable and semi-permeable biopolymeric membrane suitable for tissue repair and protection. This membrane contains a first layer made from randomly oriented, reconstituted biopolymer fibers and, on top of the first layer, a coating layer made from biopolymer fibers.
摘要翻译：本发明涉及适用于组织修复和保护的适形和半渗透性生物聚合物膜。该膜包含由随机取向的重组生物聚合物纤维制成的第一层，并且在第一层的顶部上由生物聚合物纤维制成的涂层。

4. 发明申请

WO2006047496A3 BIOPOLYMERIC MEMBRANES 审中-公开
标题翻译：生物聚合膜
公开(公告)号：WO2006047496A3
公开(公告)日：2006-10-12
申请号：PCT/US2005038331
申请日：2005-10-21
申请人： COLLAGEN MATRIX INC , LI SHU-TUNG , YUEN DEBBIE , HANSEN PEGGY
发明人： LI SHU-TUNG , YUEN DEBBIE , HANSEN PEGGY
IPC分类号： A61F2/02 , A61L15/16
CPC分类号： A61L31/044 , A61L31/14
摘要： This invention relates to a sheet membrane for repairing a damaged tissue. The membrane includes an isotropic layer of cross-linked biopolymeric fibers in which the fibers are 10 to 1,000 cm in length. This invention also relates to a method of making an isotropic layer of cross-linked biopolymeric fibers. The method includes: (1) coacervating biopolymeric fibers (e.g., collagen-based fibers) having lengths of less than 1 cm dispersed in an aqueous solution to obtain coacervated biopolymeric fibers having lengths of 10 to 1,000 cm; (2) flattening the coacervated biopolymeric fibers into a layer; (3) drying the layer; and (4) cross-linking the biopolymeric.
摘要翻译：本发明涉及一种用于修复受损组织的片状膜。该膜包括交联生物聚合物纤维的各向同性层，其中纤维的长度为10至1000厘米。本发明还涉及制造交联生物聚合物纤维的各向同性层的方法。该方法包括：（1）将长度小于1cm的生物聚合物纤维（例如胶原基纤维）分散在水溶液中以获得长度为10-1000cm的凝聚生物聚合物纤维; （2）将凝聚的生物聚合物纤维压平成一层; （3）干燥该层; 和（4）交联生物聚合物。

5. 发明申请

WO2013192481A1 COMPRESSION AND KINK RESISTANT IMPLANTS 审中-公开
标题翻译：压缩和抗皱植入
公开(公告)号：WO2013192481A1
公开(公告)日：2013-12-27
申请号：PCT/US2013/046950
申请日：2013-06-21
申请人： COLLAGEN MATRIX, INC.
发明人： LI, Shu-Tung , YUEN, Debbie
IPC分类号： A61F2/02 , A61L27/24 , A61L27/14
CPC分类号： A61L27/24 , A61C8/0006 , A61L27/3878 , A61L2430/32
摘要： A compression and kink resistant tubular implant for nerve repair. The implant includes a tubular biopolymeric membrane and a polymeric supporting filament. Also provided is a shaped compression resistant implant for ridge augmentation in dental surgery. Methods for producing the implants are also provided.
摘要翻译：用于神经修复的压缩和扭结的管状植入物。植入物包括管状生物聚合物膜和聚合物支撑丝。还提供了一种用于牙科手术中的脊突起的成形抗压植入物。还提供了用于生产植入物的方法。

6. 发明申请

WO2013002892A1 FLAT SELF-CURLING PERMEABLE SHEET MEMBRANE 审中-公开
标题翻译：平面自愈透明薄膜
公开(公告)号：WO2013002892A1
公开(公告)日：2013-01-03
申请号：PCT/US2012/036921
申请日：2012-05-08
申请人： COLLAGEN MATRIX, INC. , LI, Shu-Tung , LEE, Natsuyo Shishido , YUEN, Debbie
发明人： LI, Shu-Tung , LEE, Natsuyo Shishido , YUEN, Debbie
IPC分类号： A61L15/22 , A61F13/15 , A61K9/70
CPC分类号： A61K31/715 , A61L27/24 , A61L27/50 , A61L27/54 , A61L2430/02 , A61L2430/12 , A61L2430/20 , A61L2430/32 , A61L2430/38 , B29C61/06
摘要： A flat self-curling permeable sheet membrane containing a matrix formed of crosslinked biopolymeric fibers. The matrix self-curls into a predetermined shape upon absorption of an aqueous fluid and is permeable to molecules having molecular weights not greater than 1x10 6 daltons. Also disclosed is a method of preparing such a flat self-curling permeable membrane.
摘要翻译：包含由交联的生物聚合纤维形成的基体的平坦的自卷曲透过性薄膜。当吸收水性液体时，基体自身卷曲成预定的形状，并且对分子量不大于1×10 6道尔顿的分子是可渗透的。还公开了制备这种平坦的自卷曲渗透膜的方法。

7. 发明申请

WO2003011149A3 IMPLANT DEVICES FOR NERVE REPAIR 审中-公开
公开(公告)号：WO2003011149A3
公开(公告)日：2003-02-13
申请号：PCT/US2002/024412
申请日：2002-08-01
申请人： COLLAGEN MATRIX, INC. , LI, Shu-Tung , YUEN, Debbie
发明人： LI, Shu-Tung , YUEN, Debbie
IPC分类号： A61B17/08
摘要： An implant device (40) including a tubular matrix (42) made of a biocompatible and bioresorbable biopolymeric material. The matrix (42) has a first end and a second end, a wall of a homogeneous thickness; a plurality of ridges (44) on the wall; and a channel which is defined by the wall and extends from the first end to the second end of the tubular matrix (42).

8. 发明申请

WO2022060622A1 COLLAGEN WITH SELECTIVE CHARACTERISTICS, COLLAGEN PRODUCTS CONTAINING SAME AND METHODS FOR PRODUCING SAME 审中-公开
公开(公告)号：WO2022060622A1
公开(公告)日：2022-03-24
申请号：PCT/US2021/049646
申请日：2021-09-09
申请人： COLLAGEN MATRIX, INC.
发明人： LEE, Natsuyo Shishido , AMMON, Daniel , CHEN, Hui-Chen
IPC分类号： A61K38/01 , A61K38/39 , A61K8/65
摘要： Disclosed are methods for forming targeted collagen products having an amplified desired characteristic, including the step of adding peptides exhibiting a desired characteristic to collagen to form the targeted collagen product. Further disclosed are methods for forming a targeted collagen product lacking an undesired characteristic, including the step of subtracting peptides exhibiting the undesired characteristic from collagen to form the targeted collagen product. Also disclosed are targeted collagen products formed by the disclosed methods.

9. 发明申请

WO2019036268A1 COLLAGEN-BASED MENISCUS IMPLANTS 审中-公开
公开(公告)号：WO2019036268A1
公开(公告)日：2019-02-21
申请号：PCT/US2018/045938
申请日：2018-08-09
申请人： COLLAGEN MATRIX, INC.
发明人： LI, Shu-Tung , SHISHIDO LEE, Natsuyo
IPC分类号： A61F2/00 , A61F2/30 , A61F2/38 , A61L27/00 , A61L27/36
摘要： A method for producing a collagen meniscus implant by obtaining a freshly excised non-human meniscus, rinsing it in an aqueous solution, drying the rinsed meniscus, shaping it to approximate in dimension an average-sized human meniscus, extracting non-collagenous material from the shaped meniscus, and sterilizing it, yielding a collagen meniscus implant containing at least 90% by weight of type I collagen, less than 0.5% by weight of glycosaminoglycan, and less than 600 ppm DNA. Also disclosed is a collagen meniscus implant prepared by the above method. Further provided is a biocompatible and bioresorbable porous implant for meniscus repair. The implant includes a three-dimensional network of collagen fibers oriented in a direction approximating the collagen fiber orientation of a human meniscus. The implant has a size and a contour substantially equivalent to a human meniscus, and has a chemical composition similar to the above-described collagen meniscus implant.

10. 发明申请

WO2018009660A1 DENSITY GRADIENT BIOPOLYMERIC MATRIX IMPLANTS 审中-公开
标题翻译：密度梯度生物多元矩阵植入物
公开(公告)号：WO2018009660A1
公开(公告)日：2018-01-11
申请号：PCT/US2017/040894
申请日：2017-07-06
申请人： COLLAGEN MATRIX, INC.
发明人： LI, Shu-Tung , SHISHIDO LEE, Natsuyo , YUEN, Debbie
IPC分类号： A61F2/02 , A61F2/28 , A61F2/30
摘要： A density gradient biopolymeric matrix implant is disclosed. The implant includes a first homogeneous matrix layer and a second homogeneous matrix layer having a density different from that of the first homogeneous matrix layer. Biopolymeric fibers at the surface of the first homogeneous matrix layer are physically in contact with and cross-linked to the biopolymeric fibers at the surface of the second homogeneous matrix layer. Also disclosed is a three-dimensional density gradient biopolymeric matrix implant that includes a first homogeneous matrix surrounding a second homogeneous matrix having a different density. Biopolymeric fibers at an inner surface of the first homogeneous matrix are physically in contact with and cross-linked to biopolymeric fibers at an outer surface of the second homogeneous matrix. Furthermore, methods for preparing the density gradient biopolymeric matrix implant and the three-dimensional density gradient biopolymeric matrix implant are provided.
摘要翻译：公开了一种密度梯度生物聚合物基质植入物。植入物包括第一均质基质层和具有不同于第一均质基质层的密度的第二均质基质层。第一均质基质层表面上的生物聚合物纤维与第二均质基质层表面上的生物聚合物纤维物理接触并交联。还公开了一种三维密度梯度生物聚合物基质植入物，其包括围绕具有不同密度的第二均质基质的第一均质基质。第一均质基体的内表面处的生物聚合物纤维与第二均质基质的外表面处的生物聚合物纤维物理接触并交联。此外，提供了用于制备密度梯度生物聚合物基质植入物和三维密度梯度生物聚合物基质植入物的方法。

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