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1. 发明申请

WO2004081535A2 THE ESTABLISHMENT OF PROTEOME STRUCTURE PROFILE DATABASES AND THEIR USES 审中-公开
标题翻译：建立保健结构简档数据库及其用途
公开(公告)号：WO2004081535A2
公开(公告)日：2004-09-23
申请号：PCT/US2004/007628
申请日：2004-03-12
申请人： BIONOVA CORPORATION , TSAY, Yeou-Guang , WANG, Cheng-Nan
发明人： TSAY, Yeou-Guang , WANG, Cheng-Nan
IPC分类号： G01N
CPC分类号： G01N33/6842 , G01N33/6803 , G01N2800/52
摘要： The present invention provides methods for the determination of the proteome, including primary profile and quaternary profile of a proteome. The present invention also provides methods for determining a proteome status in a biological sample. The methods of the invention may be used to analyze the structure of protein drugs or to analyze the status of gene expression.
摘要翻译：本发明提供了用于测定蛋白质组的方法，包括蛋白质组的主要轮廓和四分体轮廓。本发明还提供了用于确定生物样品中蛋白质组状态的方法。本发明的方法可用于分析蛋白质药物的结构或分析基因表达的状态。

2. 发明申请

WO1996037606A1 COMPOSITIONS AND METHODS FOR THE DIAGNOSIS OF, AND VACCINATION AGAINST, HEPATITIS C VIRUS (HCV) 审中-公开
标题翻译： HEPATITIS C病毒（HCV）诊断和疫苗接种的组合物和方法
公开(公告)号：WO1996037606A1
公开(公告)日：1996-11-28
申请号：PCT/US1996007378
申请日：1996-05-22
申请人： BIONOVA CORPORATION , LIAO, Jaw-Ching , WANG, Cheng-nan
发明人： BIONOVA CORPORATION
IPC分类号： C12N15/11
CPC分类号： C07K14/005 , A61K39/00 , C07K16/109 , C12N2770/24222
摘要： The unprocessed core protein region initially translated from the genome of HCV contains epitopic configurations that are not retained in the processed proteins. In particular, the core protein loses an epitopic configuration upon processing at the cleavage site between the genomic region (e.g., gene) encoding the core protein and the genomic region encoding the adjacent envelope region. The unprocessed epitopic configuration of the core region provides an improved ability to detect the presence of HCV, or antibodies to HCV, in a sample, including an unpurified sample or a sample of very small volume (which can be particularly helpful when testing a sample from an infant or other person having very little blood (or other suitable material) available for testing). Combining the unprocessed core region with a non-structural protein (such as an NS5 or an NS3-NS4 fusion) results in a synergistic effect that greatly enhances the already improved sensitivity and specificity provided by the unprocessed core region. The unprocessed epitopic configuration of the core region also provides an improved ability to induce an immune response upon administration of the core region into an animal.
摘要翻译：最初从HCV基因组翻译的未处理的核心蛋白区域含有不保留在加工的蛋白质中的表位构型。特别地，当在编码核心蛋白质的基因组区域（例如，基因）和编码相邻包膜区域的基因组区域之间的切割位点处理时，核心蛋白质失去表位构型。核心区域的未加工的表位构型提供了检测样品中HCV或HCV抗体的存在的改进能力，包括未纯化的样品或非常小体积的样品（其可以特别有用，当从婴儿或其他可用于测试血液（或其他合适的材料）的人）。将未加工的核心区域与非结构蛋白质（例如NS5或NS3-NS4融合体）结合可产生协同效应，从而大大增强已经提高的未加工核心区域的灵敏度和特异性。核心区域的未加工的表位构型还提供了在将核心区域施用到动物中时诱导免疫应答的改进能力。

3. 发明申请

WO1996038474A2 DIAGNOSIS OF, AND VACCINATION AGAINST, A POSITIVE STRANDED RNA VIRUS USING AN ISOLATED, UNPROCESSED POLYPEPTIDE 审中-公开
标题翻译：使用分离的，不受约束的多肽进行诊断和接种疫苗，使用阳性的有条纹RNA病毒
公开(公告)号：WO1996038474A2
公开(公告)日：1996-12-05
申请号：PCT/US1996008112
申请日：1996-05-31
申请人： BIONOVA CORPORATION , LIAO, Jaw-Ching , WANG, Cheng-nan
发明人： BIONOVA CORPORATION
IPC分类号： C07K14/18
CPC分类号： C07K14/005 , A61K39/00 , C07K2319/00 , C12N2770/24222 , C12Q1/707 , G01N33/5767 , Y10S435/81 , Y10S435/948
摘要： The unprocessed polyprotein initially translated from the genome of a positive-stranded RNA virus contains epitopic configurations that are not retained in the processed proteins. The structural protein region, in particular, loses an epitopic configuration upon processing at the cleavage site between the genomic region encoding the core protein and the genomic region encoding the protein adjacent the core protein, such as the envelope protein in HCV. Compositions, methods and assays relating to the diagnosis and detection of the presence of the positive-stranded RNA virus, or antibodies to the positive-stranded RNA virus, in a sample. Compositions and methods for the induction of immune responses in, and vaccination of, an animal. Combination of the unprocessed core region with a non-structural protein (such as an NS5 or an unprocessed NS3-NS4 fusion from HCV).
摘要翻译：最初从正链RNA病毒基因组翻译的未加工的多蛋白含有未保留在加工的蛋白质中的表位构型。特别是，在编码核心蛋白质的基因组区域和编码与核心蛋白质相邻的蛋白质的基因组区域（例如HCV中的包膜蛋白）之间的切割位点处理时，结构蛋白质区域特别失去了表位构型。与样品中正链RNA病毒的存在或正链RNA病毒的抗体的诊断和检测有关的组合物，方法和测定。用于诱导动物免疫应答和免疫接种的组合物和方法。未加工的核心区域与非结构蛋白（例如NS5或来自HCV的未处理的NS3-NS4融合体）的组合。

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