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1. 发明申请

WO2006122274A3 PHARMACEUTICAL FORMULATIONS OF RHODIOLA CRENULATA AND METHODS OF USE THEREOF 审中-公开
标题翻译：罗汉果的药物制剂及其使用方法
公开(公告)号：WO2006122274A3
公开(公告)日：2006-12-28
申请号：PCT/US2006018316
申请日：2006-05-11
申请人： BAYSTATE HEALTH SYSTEMS INC , UNIV MASSACHUSETTS , SCHNEIDER SALLIE SMITH , SHETTY KALIDAS
发明人： SCHNEIDER SALLIE SMITH , SHETTY KALIDAS
IPC分类号： A61P35/00 , A61K36/41
CPC分类号： A61K36/41 , A61K2300/00
摘要： Isolated extracts of Rhodiola crenulata and their constituents sensitize tumor cells to cancer therapies, such as tamoxifen, retinoids, and radiation, and act to potentiate radiation therapy in the treatment of cancer, with or without adjuvant chemotherapy. Methods are provided for inhibiting the P13kinase/AKT pathway in cancer cells, a general survival pathway which leads to resistance of many tumors to typical therapies; decreasing cyclooxygenase (COX) activities in cancer cells, another pathway known to increase resistance to tumors; inhibiting telomerase activity in cancer cells, an activity notable for its ability to increase the life span of the cells; enhancing the ATM (Ataxia-Telangiectasia Mutated) response in cells, which is involved in DNA damage sensing and repair; modulating cellular response to oxidation, which effects the other signaling pathways on numerous levels; and altering usage of metabolic energy pathways.
摘要翻译：红景天及其成分的分离提取物使肿瘤细胞对诸如他莫昔芬，类维生素A和放射线等癌症疗法敏感，并且在加或不加辅助化疗的情况下用于加强癌症治疗中的放射疗法。提供了抑制癌细胞中P13激酶/ AKT途径的方法，该通路是导致许多肿瘤抵抗典型疗法的一般存活途径; 降低癌细胞中的环氧合酶（COX）活性，这是已知增加对肿瘤抗性的另一种途径; 抑制癌细胞中的端粒酶活性，其增强细胞寿命的能力显着的活性; 增强细胞中的ATM（共济失调 - 毛细血管扩张症突变）反应，其涉及DNA损伤感知和修复; 调节细胞对氧化的反应，其在多个水平上影响其他信号传导途径; 并改变代谢能量通路的使用。

2. 发明申请

WO2006122274A2 PHARMACEUTICAL FORMULATIONS OF RHODIOLA CRENULATA AND METHODS OF USE THEREOF 审中-公开
标题翻译：红霉素的药物制剂及其使用方法
公开(公告)号：WO2006122274A2
公开(公告)日：2006-11-16
申请号：PCT/US2006/018316
申请日：2006-05-11
申请人： BAYSTATE HEALTH SYSTEMS, INC. , UNIVERSITY OF MASSACHUSETTS , SCHNEIDER, Sallie, Smith , SHETTY, Kalidas
发明人： SCHNEIDER, Sallie, Smith , SHETTY, Kalidas
IPC分类号： A61P35/00 , A61K36/41
CPC分类号： A61K36/41 , A61K2300/00
摘要： Isolated extracts of Rhodiola crenulata and their constituents sensitize tumor cells to cancer therapies, such as tamoxifen, retinoids, and radiation, and act to potentiate radiation therapy in the treatment of cancer, with or without adjuvant chemotherapy. Methods are provided for inhibiting the P13kinase/AKT pathway in cancer cells, a general survival pathway which leads to resistance of many tumors to typical therapies; decreasing cyclooxygenase (COX) activities in cancer cells, another pathway known to increase resistance to tumors; inhibiting telomerase activity in cancer cells, an activity notable for its ability to increase the life span of the cells; enhancing the ATM (Ataxia-Telangiectasia Mutated) response in cells, which is involved in DNA damage sensing and repair; modulating cellular response to oxidation, which effects the other signaling pathways on numerous levels; and altering usage of metabolic energy pathways.
摘要翻译：红景天及其成分的分离提取物使肿瘤细胞对癌症治疗敏感，如三苯氧胺，类维生素A和放射线，并且在辅助化疗或无辅助化疗的情况下加强放疗治疗癌症。提供了用于抑制癌细胞中P13激酶/ AKT途径的方法，这是通常的存活途径，其导致许多肿瘤对典型疗法的抗性; 降低癌细胞中的环氧合酶（COX）活性，已知增加对肿瘤的抗性的另一途径; 抑制癌细胞中的端粒酶活性，这是其增加细胞寿命的能力显着的活性; 增强涉及DNA损伤感染和修复的细胞中的ATM（共济失调 - 血管扩张变异突变）反应; 调节细胞对氧化的反应，其在许多水平上影响其他信号传导途径; 并改变代谢能量通路的使用。

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