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1. 发明授权

US09188555B2 Automated EDS standards calibration 有权
标题翻译：自动EDS标准校准
公开(公告)号：US09188555B2
公开(公告)日：2015-11-17
申请号：US13561821
申请日：2012-07-30
申请人： Michael James Owen
发明人： Michael James Owen
IPC分类号： G01N23/225 , G01N31/20 , G06F17/10 , G01N33/28
CPC分类号： G01N23/2252 , G01N33/2823 , G01N2223/3037 , G01N2223/616 , G06F17/10
摘要： This invention relates to a method and system for determining the composition of an unknown sample. The present invention is directed to a method of calibrating an x-ray spectrometer that does not require measuring all possible elements under the operating conditions used to measure the unknown sample to be analyzed. According to a preferred embodiment, the local instrument can be calibrated from an x-ray spectrum of a single elemental standard. The instrument will have a stored library containing high quality spectra for all elements being analyzed. The analysis of the single element is compared to the library spectra for that element to define a transformation that is used to create a calibrated spectra library that includes a calibrated spectrum for each spectrum in the original library. The spectra generated by the local instrument can be compared to the calibrated library spectra to determine the elements in an unknown mineral.
摘要翻译：本发明涉及一种用于确定未知样品的组成的方法和系统。本发明涉及一种校准X射线光谱仪的方法，其不需要在用于测量待分析的未知样品的操作条件下测量所有可能的元素。根据优选实施例，可以从单个元素标准的x射线光谱校准本地仪器。仪器将有一个存储的库，包含所有要分析的元素的高质量光谱。将单个元素的分析与该元素的文库光谱进行比较，以定义用于创建校准光谱库的变换，该校准光谱库包括原始库中每个光谱的校准光谱。可将本地仪器产生的光谱与校准的谱图谱进行比较，以确定未知矿物中的元素。

2. 发明申请

US20050037508A1 Microfluidic titration apparatus 审中-公开
标题翻译：微流控滴定仪
公开(公告)号：US20050037508A1
公开(公告)日：2005-02-17
申请号：US10640697
申请日：2003-08-12
申请人： Juan Hernandez , Dennis Tom , Xianggin Chen , Gary Larson , Dustin Blair
发明人： Juan Hernandez , Dennis Tom , Xianggin Chen , Gary Larson , Dustin Blair
IPC分类号： G01N31/16 , B01L3/00 , G01N31/20 , G01N35/00 , G01N37/00 , G01N33/00
CPC分类号： B01L3/5027 , B01L2300/0816 , B01L2300/0864 , B01L2400/0406 , G01N21/79
摘要： The illustrated invention defines an analytical titration chip comprising an optically transparent substrate such as glass or plastic that defines a fluid inlet port, plural microfluidic sample carrying channels communicating with the inlet, and plural titration chambers fluidly communicating with the channels. Each titration chamber contains a different concentration of the same titrant to define a spectrum or range of titrations. An air management chamber is in fluid communication with the titration chambers to facilitate capillary flow of fluid into the titration chambers.
摘要翻译：所示出的发明定义了一种分析滴定芯片，其包括限定流体入口端口的光学透明基板例如玻璃或塑料，承载与入口连通的通道的多个微流体样品以及与通道流体连通的多个滴定室。每个滴定室含有不同浓度的相同滴定剂，以定义一个或多个滴定范围。空气管理室与滴定室流体连通，以促进流体进入滴定室的毛细管流。

3. 发明授权

US6080295A Electropipettor and compensation means for electrophoretic bias 失效
公开(公告)号：US6080295A
公开(公告)日：2000-06-27
申请号：US45339
申请日：1998-03-20
申请人： J. Wallace Parce , Michael R. Knapp
发明人： J. Wallace Parce , Michael R. Knapp
IPC分类号： G01N31/20 , B01F13/00 , B01J19/00 , B01L3/00 , B01L3/02 , F04B17/00 , F04B19/00 , G01N27/26 , G01N27/447 , G01N37/00 , H02N11/00
CPC分类号： B01F13/0071 , B01J19/0093 , B01L3/502715 , B01L3/50273 , B01L3/502784 , F04B17/00 , F04B19/006 , G01N27/44704 , G01N27/44743 , G01N27/44791 , H02N11/006 , B01F13/0084 , B01F13/0086 , B01J2219/00891 , B01L2200/027 , B01L2400/0415 , B01L2400/0418 , B01L2400/0421 , B01L3/021 , Y10S366/02 , Y10T436/113332 , Y10T436/2575
摘要： The present invention provides for techniques for transporting materials using electrokinetic forces through the channels of a microfluidic system. The subject materials are transported in regions of high ionic concentration, next to spacer material regions of high ionic concentration, which are separated by spacer material regions of low ionic concentration. Such arrangements allow the materials to remain localized for the transport transit time to avoid mixing of the materials. Using these techniques, an electropipettor which is compatible with the microfluidic system is created so that materials can be easily introduced into the microfluidic system. The present invention also compensates for electrophoretic bias as materials are transported through the channels of the microfluidic system by splitting a channel into portions with positive and negative surface charges and a third electrode between the two portions, or by diffusion of the electrophoresing materials after transport along a channel.

4. 发明授权

US6051190A Method and apparatus for transferring and dispensing small volumes of liquid and method for making the apparatus 失效
标题翻译：用于转移和分配少量液体的方法和装置以及用于制造该装置的方法
公开(公告)号：US6051190A
公开(公告)日：2000-04-18
申请号：US59667
申请日：1998-04-13
申请人： William Birch , Alain Carre , Eric Francois
发明人： William Birch , Alain Carre , Eric Francois
IPC分类号： G01N31/20 , B01J4/00 , B01L3/02 , B29C33/00 , B29C39/00 , B29C59/14 , C40B60/14 , G01N1/00 , G01N35/02 , G01N35/10 , G01N1/12
CPC分类号： B01L3/0244 , B29C33/0027 , B29C59/14 , B82Y30/00 , B01J2219/00315 , B01J2219/00387 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00617 , B01J2219/00619 , B01J2219/00621 , B01J2219/00659 , B01J2219/00677 , B29C39/00 , C40B60/14 , G01N2035/1037 , Y10T436/2575
摘要： The invention relates to the transfer and distribution, notably in a biological or chemical analysis, of a small amount of liquid. The invention relates notably to a method which consists of providing a transfer tool (18) having at least one rod (10) whose lower surface (12) of pre-determined cross section is wettable and of which at least one side surface (14) is non-wettable; immersing the rod (10) into a reservoir containing a liquid, for a pre-determined period of time and at a pre-determined depth; removing the rod (10) from the reservoir so that a liquid drop is retained on the lower surface (12) of the rod (10); positioning the rod (10) over a receptor medium; and placing the drop in contact with a surface of a receptor medium. The invention also relates to the transfer tool (18) which has in its structure at least one rod (10) and to a method for making the transfer tool (18).
摘要翻译：本发明涉及少量液体的转移和分布，特别是生物或化学分析。本发明特别涉及一种方法，该方法包括提供具有至少一个杆（10）的转移工具（18），其中预定横截面的下表面（12）是可润湿的，并且其中至少一个侧表面（14）是不可湿润的将棒（10）浸入含有液体的储存器中，预定时间段和预定深度; 从所述储存器移除所述杆（10），使得液滴保持在所述杆（10）的下表面（12）上; 将杆（10）定位在受体介质上; 并且将该滴放置在与受体介质的表面接触的位置。本发明还涉及在其结构中具有至少一个杆（10）的转移工具（18）和用于制造转移工具（18）的方法。

5. 发明授权

US5919711A Analytical cartridge 失效
标题翻译：分析盒
公开(公告)号：US5919711A
公开(公告)日：1999-07-06
申请号：US907426
申请日：1997-08-07
申请人： Douglas E. Boyd , Jan B. Yates
发明人： Douglas E. Boyd , Jan B. Yates
IPC分类号： G01N31/20 , B01L3/00 , G01N1/36 , G01N1/38 , G01N21/07 , G01N33/48 , G01N35/00 , G01N37/00 , G01N35/10
CPC分类号： B01L3/502 , G01N21/07 , B01L3/5027 , G01N1/38 , Y10T436/111666 , Y10T436/25 , Y10T436/25375 , Y10T436/255 , Y10T436/25625 , Y10T436/2575
摘要： An analytical cartridge adapted for use in analyzing fluids which contain liquid and solid components. The cartridge includes a plumbing system composed of various wells or chambers which are interconnected by passageways. After introduction into the cartridge, liquid samples are separated and transported to a test well utilizing a sequential application of centrifugal force followed by pressurization of the system. The cartridge may be used to measure the concentration of a wide variety of chemical constituents in bodily fluids and is useful in measuring other properties of these fluids which contain liquid and solid components.
摘要翻译：适用于分析含有液体和固体组分的流体的分析盒。墨盒包括由通过通道互连的各种井或室组成的管道系统。引入墨盒后，液体样品被分离并运送到测试孔，利用离心力的顺序施加，然后加压该系统。药筒可用于测量体液中各种化学成分的浓度，并且可用于测量含有液体和固体组分的这些流体的其它性质。

6. 发明授权

US5891740A Detection of low level hydrophobic analytes in environmental samples using agglutination reaction capillary slide test and apparatus therefor 失效
标题翻译：使用凝集反应毛细管滑动试验检测环境样品中的低水平疏水性分析物及其设备
公开(公告)号：US5891740A
公开(公告)日：1999-04-06
申请号：US832168
申请日：1997-04-02
申请人： Joseph L. Di Cesare , Steven M. Rosen
发明人： Joseph L. Di Cesare , Steven M. Rosen
IPC分类号： G01N31/20 , B01D61/00 , G01N1/10 , G01N33/53 , G01N33/543
CPC分类号： G01N33/5302 , B01D61/00
摘要： Apparatus and method for detection of low levels of about 1 ppb of hydrophobic analyte in environmental samples using an enclosed permeable membrane enrichment device and agglutination reaction slide test apparatus.
摘要翻译：使用封闭的透过膜富集装置和凝集反应试验装置在环境样品中检测约1ppb的疏水性分析物的低含量的装置和方法。

7. 发明授权

US5716852A Microfabricated diffusion-based chemical sensor 失效
公开(公告)号：US5716852A
公开(公告)日：1998-02-10
申请号：US625808
申请日：1996-03-29
申请人： Paul Yager , Bernhard H. Weigl , James P Brody , Mark R. Holl
发明人： Paul Yager , Bernhard H. Weigl , James P Brody , Mark R. Holl
IPC分类号： G01N37/00 , B01F5/04 , B01F13/00 , B01J19/00 , B01L3/00 , G01N15/06 , G01N15/14 , G01N30/00 , G01N30/38 , G01N30/60 , G01N30/74 , G01N31/20 , G01N35/08 , G01N21/64
CPC分类号： B01F5/0403 , B01F13/0059 , B01F13/0093 , B01J19/0093 , B01L3/502776 , G01N30/0005 , B01J2219/00828 , B01J2219/00831 , B01J2219/00952 , B01L2200/0636 , B01L2300/0654 , B01L2300/0816 , B01L2300/0861 , B01L2300/0867 , B01L2300/087 , B01L2400/0487 , G01N15/14 , G01N30/38 , G01N30/6095 , G01N30/74 , G01N35/085 , Y10S366/01 , Y10T436/25375 , Y10T436/2575
摘要： A channel-cell system is provided for detecting the presence and/or measuring the presence of analyte particles in a sample stream comprising: a) a laminar flow channel; b) two inlet means in fluid connection with said laminar flow channel for respectively conducting into said laminar flow channel (1) an indicator stream which may comprise an indicator substance which indicates the presence of said analyte particles by a detectable change in property when contacted with said analyte particles, and (2) said sample stream; c) wherein said laminar flow channel has a depth sufficiently small to allow laminar flow of said streams and a length sufficient to allow particles of said analyte to diffuse into said indicator stream to the substantial exclusion of said larger particles in said sample stream to form a detection area; and d) outlet means for conducting said streams out of said laminar flow channel to form a single mixed stream.

8. 发明授权

US5200321A Microassay on a card 失效
标题翻译：一张卡上的Microassay
公开(公告)号：US5200321A
公开(公告)日：1993-04-06
申请号：US578390
申请日：1990-09-07
申请人： David A. Kidwell
发明人： David A. Kidwell
IPC分类号： G01N33/53 , B01L3/00 , G01N21/03 , G01N21/29 , G01N21/76 , G01N21/78 , G01N31/20 , G01N33/52 , G01N33/543 , G01N33/545 , G01N33/552 , G01N33/94
CPC分类号： G01N33/54386 , B01L3/5023 , G01N21/78 , G01N33/525 , B01L2200/0621 , B01L2300/0681 , B01L2300/069 , B01L2300/0819 , B01L2300/0822 , B01L2300/087 , B01L2300/0887 , B01L2400/0406 , G01N21/29 , G01N21/76 , G01N2201/04 , Y10S435/805 , Y10S435/81 , Y10S435/967 , Y10S435/969 , Y10S435/97 , Y10S436/805 , Y10S436/808 , Y10S436/81
摘要： A microassay card for a includes an upper layer containing wells for receiving a liquid sample. A second layer of the card, beneath the first layer, includes a supporting surface bound to a reactive species. A third layer includes a superabsorbent support impregnated with an indicator. Typically, the indicator is a substrate for an enzyme, such as a reduced dye precursor and a source of hydrogen peroxide necessary for the action of the enzyme upon the substrate to cause a spectral change in the absorbent layer. By selecting the structure of the first and second layers, the card can be formatted for a displacement assay or a competitive assay. The microassay card of the present invention is particularly useful for drug testing.
摘要翻译：用于a的微型卡片包括含有用于接收液体样品的孔的上层。在第一层下方的卡的第二层包括与活性物质结合的支撑表面。第三层包括浸渍有指示剂的超吸收剂载体。通常，指示剂是用于酶的底物，例如还原的染料前体和过氧化氢源，用于酶在底物上起作用以引起吸收层中的光谱变化。通过选择第一层和第二层的结构，可以将卡格式化为位移测定或竞争性测定。本发明的微量测定卡对于药物测试特别有用。

9. 发明授权

US4062652A Reagent unit intended for microanalyses of standard type and device and method for its production 失效
标题翻译：用于标准型微量分析的试剂单元及其生产方法
公开(公告)号：US4062652A
公开(公告)日：1977-12-13
申请号：US483652
申请日：1974-06-27
申请人： Gudrun Birgitta Margareta Rolfo-Fontana
发明人： Gudrun Birgitta Margareta Rolfo-Fontana
IPC分类号： A61B19/00 , G01N1/00 , G01N31/20 , G01N31/22 , G01N33/48 , G01N33/96 , G01N35/02 , B01L11/00 , B65D23/04 , B65H1/08 , G01N33/00
CPC分类号： G01N33/48 , G01N31/20 , G01N33/96 , G01N35/02 , Y10S206/818
摘要： A prefabricated micro-quantity reagent dosage unit for an analytical procedure, is provided involving reaction of a chemical reagent with a reaction mixture to be analyzed. The unit comprises a composite structure which incorporates the chemical reagent and includes carrier means for carrying the chemical reagent and magnetizable material to facilitate handling of the carrier means and for effecting movement of the latter, under action of a magnetic field acting on the magnetizable material, when the carrier means is subjected to the reaction mixture. The carrier means is provided with precise micro-quantities of reagent preparatory to a single analysis and by virtue of the magnetizable material the composite structure may readily be handled for storage under conditions favorable for the durability of the reagent, simultaneously enabling transfer of the composite structure to the reaction mixture without risk of contamination of the latter.
摘要翻译：提供了用于分析程序的预制微量试剂剂量单元，其涉及化学试剂与待分析的反应混合物的反应。该单元包括复合结构，其包含化学试剂并且包括用于携带化学试剂和可磁化材料的载体装置，以便于处理载体装置并且在作用在可磁化材料上的磁场的作用下使其运动，当载体装置经受反应混合物时。载体装置具有精确的微量试剂，用于单次分析，并且借助于可磁化材料，复合结构可以容易地在有利于试剂耐久性的条件下进行处理，同时能够转移复合结构对反应混合物没有污染后者的风险。

10. 发明授权

US3535918A Microadsorption detector for liquid chromatography 失效
标题翻译：用于液相色谱的微型检测器
公开(公告)号：US3535918A
公开(公告)日：1970-10-27
申请号：US3535918D
申请日：1969-01-31
申请人： VARIAN ASSOCIATES
发明人： MUNK MINER NELSON
IPC分类号： G01N30/62 , G01N31/06 , G01N31/20
CPC分类号： G01N30/62

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