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1. 发明授权

US12146151B2 Cross-species compatible adeno-associated virus compositions and methods of use thereof 有权
公开(公告)号：US12146151B2
公开(公告)日：2024-11-19
申请号：US18474506
申请日：2023-09-26
申请人： Duke University
发明人： Aravind Asokan , Trevor Gonzalez , Lawrence Patrick Havlik
IPC分类号： C12N15/864 , C07K14/005 , C12N5/10 , C12N15/34 , C12N15/86
CPC分类号： C12N15/86 , C07K14/005 , C12N2750/14122 , C12N2750/14143
摘要： The present disclosure provides adeno-associated virus (AAV) vectors, comprising coevolved capsid variant proteins, pharmaceutical compositions, methods of making, and methods for delivering such to a subject.

2. 发明授权

US09493745B2 Hexon isolated from simian adenovirus serotype 19, hypervariable region thereof and chimeric adenovirus using the same 有权
标题翻译：从猿猴腺病毒血清型19，其高变区和使用其的嵌合腺病毒分离的己糖
公开(公告)号：US09493745B2
公开(公告)日：2016-11-15
申请号：US14521864
申请日：2014-10-23
申请人： MOGAM BIOTECHNOLOGY RESEARCH INSTITUTE
发明人： Kyuhyun Lee , Seongtae Yun , Daekyung Koh , Hong-Kyu Lee , Eui-Cheol Jo
IPC分类号： A61K35/76 , C12N15/861 , A61P35/00 , C12N15/34 , C12N5/10 , C12N7/00 , C07K14/005 , C12N15/86
CPC分类号： C12N7/00 , A61K39/0011 , A61K2039/5256 , C07K14/005 , C12N15/86 , C12N2710/10321 , C12N2710/10322 , C12N2710/10332 , C12N2710/10342 , C12N2710/10343 , C12N2710/10345 , C12N2810/6018
摘要： Novel hexon isolated from simian adenovirus serotype 19 encoded in the polynucleotide defined as SEQ ID NO: 3, hepervariable region thereof, chimeric adenovirus comprising the same, and therapeutic use thereof provides a solution to the problem of safety and effective systemic treatment for developing gene therapeutic agents using adenovirus.
摘要翻译：由定义为SEQ ID NO：3的多核苷酸编码的猿猴腺病毒血清型19分离的新型六邻体，其全变体区，包含该多核苷酸的嵌合腺病毒及其治疗用途提供了开发基因治疗的安全性和有效全身治疗问题的解决方案使用腺病毒的药剂。

3. 发明授权

US08435732B2 Chimeric construct of mungbean yellow mosaic india virus (MYMIV) and its uses thereof 失效
标题翻译：绿色黄色马赛克印度病毒（MYMIV）的嵌合构建及其用途
公开(公告)号：US08435732B2
公开(公告)日：2013-05-07
申请号：US12746429
申请日：2008-12-08
申请人： Debasis Chattopadhyay , Rajiv Kumar Yadav , Rakesh Kumar Shukla
发明人： Debasis Chattopadhyay , Rajiv Kumar Yadav , Rakesh Kumar Shukla
IPC分类号： C12Q1/70 , C12Q1/02 , C12N15/34 , C12N15/84 , C12N5/14 , C12N1/21 , C07H21/04
CPC分类号： C12N7/00 , A01H1/04 , C12N15/8203 , C12N15/8205 , C12N2750/12011
摘要： A recombinant DNA construct, recombinant vectors and host cells comprising the dimers of DNA A and DNA B of Mungbean Yellow Mosaic India Virus (MYMIV) in a single Ti plasmid are provided herein.
摘要翻译：本文提供了重组DNA构建体，重组载体和宿主细胞，其在单个Ti质粒中包含绿豆黄马赛克印度病毒（MYMIV）的DNA A和DNA B的二聚体。

4. 发明申请

US20130034576A1 NOVEL ADENOVIRUS ISOLATED FROM TITI MONKEYS 有权
标题翻译：从TITI MONKEYS分离出新的腺病毒
公开(公告)号：US20130034576A1
公开(公告)日：2013-02-07
申请号：US13469011
申请日：2012-05-10
申请人： Charles CHIU , Eunice Chen , Karen Lisa Bales , Jacquelyn Dieter
发明人： Charles CHIU , Eunice Chen , Nicholas W. Lerche , Karen Lisa Bales
IPC分类号： C12N15/34 , C12Q1/70 , C07H21/04 , C12N1/21 , A61P31/20 , C12N1/15 , C12N5/10 , C07K14/075 , C07K16/08 , A61K39/235 , C12N15/63 , C12N1/19
CPC分类号： C12N7/00 , C07K14/005 , C12N2710/10321 , C12N2710/10322 , G01N33/56983 , G01N2469/20
摘要： Provided is a Titi Monkey Adenovirus (TMAdV) that can infect both human and non-human primates. Further provided are nucleic acid sequences, proteins, expression vectors and host cells, anti-TMAdV antibodies, vaccines, compositions, methods of detecting TMAdV, methods for assaying for anti-TMAdV compounds, and methods for treating or preventing a TMAdV infection.
摘要翻译：提供可以感染人和非人灵长类的Titi猴腺病毒（TMAdV）。还提供了核酸序列，蛋白质，表达载体和宿主细胞，抗TMAdV抗体，疫苗，组合物，检测TMAdV的方法，用于测定抗TMAdV化合物的方法，以及用于治疗或预防TMAdV感染的方法。

5. 发明授权

US08263067B2 Adenoviral systems and the uses thereof 有权
标题翻译：腺病毒系统及其用途
公开(公告)号：US08263067B2
公开(公告)日：2012-09-11
申请号：US10451210
申请日：2001-12-21
申请人： Per Sonne Holm
发明人： Per Sonne Holm
IPC分类号： C12N15/00 , C12N15/09 , C12N15/12 , C12N15/34
CPC分类号： C12N15/86 , A61K38/00 , A61K48/00 , C07K14/4702 , C12N2710/10343 , C12N2830/008
摘要： The invention is related to a nucleic acid comprising an adenoviral nucleic acid, which also comprises a nucleic acid sequence coding for YB-1.
摘要翻译：本发明涉及包含腺病毒核酸的核酸，其还包含编码YB-1的核酸序列。

6. 发明申请

US20120189582A1 SIMIAN ADENOVIRUS 41 AND USES THEREOF 有权
标题翻译： SIMIAN ADENOVIRUS 41及其使用
公开(公告)号：US20120189582A1
公开(公告)日：2012-07-26
申请号：US13321985
申请日：2010-05-27
申请人： Soumitra Roy , James M. Wilson , Luc H. Vandenberghe
发明人： Soumitra Roy , James M. Wilson , Luc H. Vandenberghe
IPC分类号： A61K35/76 , A61K38/02 , C12N15/34 , C07K14/075 , C12N7/01 , C12N15/63
CPC分类号： C12N15/86 , A61K39/145 , A61K48/00 , A61K2039/5256 , C07K14/005 , C12N7/00 , C12N2710/10043 , C12N2710/10321 , C12N2710/10322 , C12N2710/10343 , C12N2810/6018
摘要： Novel simian adenovirus 41 and two isolates thereof are described. Various uses of these isolates, including construction of a recombinant vector which comprises simian adenovirus 41 sequences and a heterologous gene under the control of regulatory sequences are provided. A cell line which expresses simian adenovirus 41 gene(s) is also disclosed. Methods of using the vectors and cell lines are provided.
摘要翻译：描述了新型猿猴腺病毒41及其两个分离物。提供这些分离物的各种用途，包括构建包含猿猴腺病毒41序列和在调控序列控制下的异源基因的重组载体。还公开了表达猿腺病毒41基因的细胞系。提供了使用载体和细胞系的方法。

7. 发明申请

US20120027788A1 SIMIAN ADENOVIRUS NUCLEIC ACID- AND AMINO ACID-SEQUENCES, VECTORS CONTAINING SAME, AND USES THEREOF 有权
标题翻译： SIMIAN ADENOVIRUS核酸和氨基酸序列，含有它们的载体及其用途
公开(公告)号：US20120027788A1
公开(公告)日：2012-02-02
申请号：US13147193
申请日：2010-02-06
申请人： Stefano Colloca , Alfredo Nicosia , Riccardo Cortese , Virginia Ammendola , Maria Ambrosio
发明人： Stefano Colloca , Alfredo Nicosia , Riccardo Cortese , Virginia Ammendola , Maria Ambrosio
IPC分类号： A61K39/235 , C12N15/57 , C07K14/075 , C12N15/63 , A61P37/04 , A61K48/00 , C12N1/21 , C12N1/19 , C12N5/10 , A61P31/20 , C12N15/34 , C12N7/01
CPC分类号： C07K14/005 , A61K39/0011 , A61K39/12 , A61K39/235 , A61K48/00 , A61K2039/525 , A61K2039/5256 , A61K2039/545 , C12N7/00 , C12N15/86 , C12N2710/10321 , C12N2710/10322 , C12N2710/10334 , C12N2710/10343 , C12N2710/16634 , C12N2740/16134 , C12N2770/24234
摘要： The present invention relates to novel adenovirus strains with an improved sero-prevalence. In one aspect, the present invention relates to isolated polypeptides of adenoviral capsid proteins such as hexon, penton and fiber protein and fragments thereof and polynucleotides encoding the same. Also provided is a vector comprising the isolated polynucleotide according to the invention and adenoviruses comprising the isolated polynucleotides or polypeptides according to the invention and a pharmaceutical composition comprising said vector, adenovirus, polypeptide and/or polynucleotide. The invention also relates to the use of the isolated polynucleotides, the isolated polypeptides, the vector, the adenoviruses and/or the pharmaceutical composition for the therapy or prophylaxis of a disease.
摘要翻译：本发明涉及具有改善的血清流行性的新型腺病毒株。一方面，本发明涉及腺病毒衣壳蛋白如六邻体，五邻体和纤维蛋白及其片段的分离多肽和编码该多肽的多核苷酸。还提供了包含根据本发明的分离的多核苷酸和包含根据本发明的分离的多核苷酸或多肽的腺病毒的载体和包含所述载体，腺病毒，多肽和/或多核苷酸的药物组合物。本发明还涉及分离的多核苷酸，分离的多肽，载体，腺病毒和/或药物组合物用于治疗或预防疾病的用途。

8. 发明申请

US20110150913A1 TORQUE TENO VIRUS (TTV) ISOLATES AND COMPOSITIONS 有权
标题翻译： TORQUE TENO VIRUS（TTV）隔离物和组合物
公开(公告)号：US20110150913A1
公开(公告)日：2011-06-23
申请号：US12733355
申请日：2009-10-16
申请人： Gregory P. Nitzel , Mira I Stoeva , James R. Thompson , Nancee L. Oien , Jay G. Calvert , Donna Steuerwald Dunyak , Jacqueline Gayle Mark , Robert Gerard Ankenbauer , Douglas Steven Pearce
发明人： Gregory P. Nitzel , Mira I Stoeva , James R. Thompson , Nancee L. Oien , Jay G. Calvert , Donna Steuerwald Dunyak , Jacqueline Gayle Mark , Robert Gerard Ankenbauer , Douglas Steven Pearce
IPC分类号： A61K39/12 , C12N15/34 , C12N15/63 , C12N5/10 , C12N7/01 , C07K14/01 , C07K16/08 , A61P31/20
CPC分类号： C12N7/00 , A61K39/00 , A61K2039/53 , C07K14/005 , C07K16/081 , C12N2750/10021 , C12N2750/10022
摘要： The present invention is directed to novel nucleotide and amino acid sequences of Torque teno virus (“TTV”), including novel genotypes thereof, all of which are useful in the preparation of vaccines for treating and preventing diseases in swine and other animals. Vaccines provided according to the practice of the invention are effective against multiple swine TTV genotypes and isolates. Diagnostic and therapeutic polyclonal and monoclonal antibodies are also a feature of the present invention, as are infectious clones useful in the propagation of the virus and in the preparation of vaccines. Particularly important aspects of the invention include vaccines that provide TTV ORF1 protein, or peptide fragments thereof, as antigen.
摘要翻译：本发明涉及扭矩腱病毒（“TTV”）的新型核苷酸和氨基酸序列，其包括其新型基因型，所有这些都可用于制备用于治疗和预防猪和其他动物疾病的疫苗。根据本发明的实践提供的疫苗对多种猪TTV基因型和分离株有效。诊断和治疗性多克隆和单克隆抗体也是本发明的特征，以及用于病毒繁殖和疫苗制备中的感染性克隆也是如此。本发明的特别重要的方面包括提供TTV ORF1蛋白或其肽片段作为抗原的疫苗。

9. 发明申请

US20100095402A1 Materials and methods for engineering resistance to tomato yellow leaf curl virus (tylcv) in plants, 审中-公开
标题翻译：植物对番茄黄叶卷曲病毒（tylcv）的抗植物材料和方法，
公开(公告)号：US20100095402A1
公开(公告)日：2010-04-15
申请号：US11919106
申请日：2006-04-24
申请人： Jane E. Polston , Ernest Hiebert
发明人： Jane E. Polston , Ernest Hiebert
IPC分类号： C12N15/34 , C12N15/82 , C12N5/10 , A01H5/00
CPC分类号： C07K14/005 , C12N15/8283 , C12N2750/12022
摘要： The subject invention concerns materials and methods for providing genetically-engineered resistance in plants to geminivirus, such as, using polynucleotides containing all or a portion of a replication associated protein (Rep) gene of TYLCV and all or a portion of a Rep intergenic region (IR). Virus-resistant plants produced according to the present invention have horticulturally acceptable phenotypic traits. Methods of the invention comprise transforming a plant with a polynucleotide wherein when the polynucleotide is expressed in the plant, the transformed plant exhibits resistance to plant viral infections. An exemplified embodiment utilizes a polynucleotide comprising a Rep gene derived from a Florida isolate of TYLCV. The methods of the invention can be used to provide resistance to TYLCV infection in plants such as tomato and tobacco. The present invention also concerns transformed and transgenic plants and plant tissue that comprise a polynucleotide of the invention.
摘要翻译：本发明涉及用于在植物中提供遗传工程抗性的双重病毒的材料和方法，例如使用含有TYLCV的全部或部分复制相关蛋白（Rep）基因的全基因组和全部或部分Rep基因间区域 IR）。根据本发明产生的抗病毒植物具有园艺可接受的表型性状。本发明的方法包括用多核苷酸转化植物，其中当多核苷酸在植物中表达时，转化的植物表现出对植物病毒感染的抗性。示例性实施方案使用包含衍生自TYLCV的佛罗里达分离株的Rep基因的多核苷酸。本发明的方法可用于提供植物如番茄和烟草中对TYLCV感染的抗性。本发明还涉及包含本发明的多核苷酸的转化和转基因植物和植物组织。

10. 发明授权

US07608752B2 Gene targeting using replicating DNA molecules 有权
标题翻译：基因靶向使用复制DNA分子
公开(公告)号：US07608752B2
公开(公告)日：2009-10-27
申请号：US11533381
申请日：2006-09-20
申请人： L. Alexander Lyznik , Xiaoxia Zhao , Isabelle S. Coats , William J. Gordon-Kamm
发明人： L. Alexander Lyznik , Xiaoxia Zhao , Isabelle S. Coats , William J. Gordon-Kamm
IPC分类号： C12N15/83 , C12N15/82 , C12N15/34
CPC分类号： C12N15/8213 , C12N9/00
摘要： The invention provides novel methods of gene targeting using replication in order to increase the efficiency of targeted genetic modification in an eukaryotic organism. Included are vectors, expression cassettes, and modified cells, plants and seeds.
摘要翻译：本发明提供使用复制的基因靶向的新方法，以提高真核生物体中靶向遗传修饰的效率。包括载体，表达盒和修饰的细胞，植物和种子。

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