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1. 发明申请

US20220306707A1 PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING INFLAMMATORY DISEASES INCLUDING TOXOPLASMA GONDII GRA9 PROTEIN OR GENE ENCODING THE PROTEIN AS ACTIVE INGREDIENT 有权
公开(公告)号：US20220306707A1
公开(公告)日：2022-09-29
申请号：US17682544
申请日：2022-02-28
申请人： INDUSTRY-UNIVERSITY COOPERATION FOUNDATION HANYANG UNIVERSITY ERICA CAMPUS
发明人： Chul-Su Yang , Jae-Sung Kim
IPC分类号： C07K14/45 , A61P37/06 , A61P31/04 , A23L33/195 , A23L33/00
摘要： The present invention relates to a pharmaceutical composition and a health functional food composition for preventing, alleviating or treating inflammatory diseases, including Toxoplasma gondii GRA9 protein or a gene encoding the protein as an active ingredient. The present inventors have identified the C-terminal region essential for the NLRP3-mediated mechanism of action and function of Toxoplasma gondii GRA9 in macrophages, which are host immune cells and confirmed the substantial anti-inflammatory and antibacterial effects and the antiseptic effect in vivo. Accordingly, Toxoplasma gondii GRA9 protein or a gene encoding the protein is expected to be usefully utilized in the field of prevention or treatment of inflammatory diseases caused by an abnormal NLRP3-mediated inflammatory response, including sepsis.

2. 发明申请

US20120238503A1 HUMAN LAMININ ALPHA2 CHAIN LG3 DOMAIN AND ACTIVE PEPTIDES PROMOTING CELL ADHESION, SPREADING, MIGRATION, AND NEURITE OUTGROWTH 有权
标题翻译：人类LAMININ ALPHA2链LG3域和活性肽促进细胞粘附，扩散，迁移和神经延续
公开(公告)号：US20120238503A1
公开(公告)日：2012-09-20
申请号：US13418137
申请日：2012-03-12
申请人： Byung-Moo MIN
发明人： Byung-Moo MIN
IPC分类号： A61K38/10 , A61K38/08 , A61K38/07 , A61K38/06 , A61P25/00 , A61P17/00 , C07K7/08 , C07K14/45 , C07K7/06 , C07K5/117 , C07K5/097 , A61K38/17 , A61P17/02
CPC分类号： A61K38/39
摘要： The present invention relates to human laminin α2 chain LG3 domain and active peptides promoting cell adhesion, spreading, migration, and neurite outgrowth. More particularly, it was found that when nerve cells are incubated using human laminin α2 chain LG3 domain and active peptides in the LG3 domain, cell adhesion, spreading, migration, and neurite outgrowth of nerve cells promote and the promotion of cell adhesion, spreading, migration, and neurite outgrowth of nerve cells are integrin-mediated and achieved by the activation of PKCδ and FAK phosphorylation. Thus, the present invention can be very useful for researches on cell adhesion, spreading, migration, and neurite outgrowth activities of cells which are focused on nerve cells and mediated by various extracellular matrix proteins including laminin, manufacture of artificial nerve conduits, burns treatment, wounds treatment, and tissue regeneration.
摘要翻译：本发明涉及人层粘连蛋白α2链LG3结构域和促进细胞粘附，扩散，迁移和神经突生长的活性肽。更具体地说，发现当神经细胞在LG3结构域中使用人层粘连蛋白α2链LG3结构域和活性肽进行培养时，神经细胞的细胞粘附，扩散，迁移和神经突生长促进并促进细胞粘附，扩散，神经细胞迁移和神经突增生是整合素介导的，并通过激活PKCδ和FAK磷酸化实现。因此，本发明对于细胞的细胞粘附，扩散，迁移和神经突生长活性的研究非常有用，这些细胞主要集中在神经细胞上并由各种细胞外基质蛋白（包括层粘连蛋白，人造神经导管的制造，烧伤治疗，伤口治疗和组织再生。

3. 发明申请

US20070141076A1 Antigen fragments for the diagnosis of Toxoplasma gondii 审中-公开
公开(公告)号：US20070141076A1
公开(公告)日：2007-06-21
申请号：US11586694
申请日：2006-10-26
申请人： Nicola Gargano , Elisa Beghetto , Manlio Di Cristina , Franco Felici
发明人： Nicola Gargano , Elisa Beghetto , Manlio Di Cristina , Franco Felici
IPC分类号： A61K39/00 , G01N33/569 , C07H21/04 , C12N15/74 , G01N33/53 , A61K39/002 , C07K14/45 , C12N1/10
CPC分类号： C07K14/45 , A61K39/00 , C07K2319/00
摘要： The invention described herein relates to a method for identifying antigen fragments of Toxoplasma gondii proteins, and their use as diagnostic and immunogenic agents. Said method is implemented by means of selection of DNA fragments libraries of the parasite with sera of subjects who have been infected, using the phage display technique, and is characterised in that it uses the expression/exposure vector λKM4. The method allows also to identify antigen fragments related to the time of the infection.

4. 发明申请

US20050112567A1 Serological assay for Neospora caninum 审中-公开
标题翻译：血清学检测新孢子虫
公开(公告)号：US20050112567A1
公开(公告)日：2005-05-26
申请号：US10283540
申请日：2002-10-30
申请人： David Brake , Dianne Ritter
发明人： David Brake , Dianne Ritter
IPC分类号： G01N33/53 , C07K14/45 , C12Q1/68 , G01N33/543 , G01N33/569
CPC分类号： G01N33/56905 , G01N2333/44 , G01N2333/45 , G01N2469/20
摘要： The present invention relates to the serological detection of Neospora caninum-vaccinated animals by means of reaction of a subject serum with a protein reactive with N. caninum. The protein may be a full-length native or recombinant N. caninum or Toxoplasma gondii bradyzoite fusion protein or a truncated fusion protein or fragment thereof. The protein may be used in any of a number of assays including enzyme linked immunosorbant assays (ELISA), a radioimmunoassay (RIA), a Western Blot and other suitable forms of immunoassay.
摘要翻译：本发明涉及血清学检测新孢子虫接种疫苗的动物，通过使受试者血清与与犬尾草反应的蛋白质的反应。该蛋白质可以是全长天然的或重组的N.caninum或弓形体弓形虫融合蛋白或截短的融合蛋白或其片段。蛋白质可以用于许多测定中的任何一种，包括酶联免疫吸附测定（ELISA），放射免疫测定（RIA），Western印迹和其他合适形式的免疫测定。

5. 发明授权

US5633139A Toxoplasma gondii P28 gene and methods for its use 失效
公开(公告)号：US5633139A
公开(公告)日：1997-05-27
申请号：US477357
申请日：1995-06-07
申请人： Jeffrey B. Prince , Fausto G. De Araujo , Somesh D. Sharma , Jack S. Remington
发明人： Jeffrey B. Prince , Fausto G. De Araujo , Somesh D. Sharma , Jack S. Remington
IPC分类号： A61K39/00 , C07K14/45 , C12Q1/68 , C07H21/02 , C07H21/04 , C12P19/34
CPC分类号： C12Q1/6893 , C07K14/45 , A61K39/00 , Y10S530/806 , Y10S530/82
摘要： Genetic material encoding the P28 peptide of Toxoplasma gondii has been isolated and characterized. This genetic material allows the production of peptides for use in diagnosis or immunization or can itself be directly used in hybridization assays.

6. 发明授权

US5629414A Diagnostic genes for toxoplasmosis 失效
标题翻译：弓形体病的诊断基因
公开(公告)号：US5629414A
公开(公告)日：1997-05-13
申请号：US182673
申请日：1994-01-14
申请人： John C. Boothroyd , James L. Burg , Lloyd H. Kasper
发明人： John C. Boothroyd , James L. Burg , Lloyd H. Kasper
IPC分类号： C12N15/09 , A61K39/002 , A61P33/00 , C07K14/45 , C12N1/21 , C12N15/00 , C12N15/30 , C12Q1/68 , C12R1/19 , C12R1/90 , G01N33/569 , C07H21/00 , C12N1/20
CPC分类号： C07K14/45 , G01N33/56905 , C07K2319/00
摘要： Genetic material encoding p30 and B1 peptides of Toxoplasma gondii has been isolated and characterized. This genetic material allows the production of peptides for use in diagnosis or immunization or can itself be directly used in hybridization assays.
摘要翻译：已经分离和表征了编码弓形虫弓形虫的p30和B1肽的遗传物质。这种遗传物质允许产生用于诊断或免疫的肽，或者本身可以直接用于杂交测定。

7. 发明授权

US11945845B2 Compositions and methods for regulation of chronic toxoplasma infection 有权
公开(公告)号：US11945845B2
公开(公告)日：2024-04-02
申请号：US17595894
申请日：2020-05-30
申请人： Whitehead Institute for Biomedical Research
发明人： Ben Waldman , Sebastian Lourido
IPC分类号： A61K39/002 , A61P33/02 , A61P37/04 , C07K14/45 , C12N1/10 , C12N15/74 , A61K39/00
CPC分类号： C07K14/45 , A61K39/002 , A61P33/02 , A61P37/04 , C12N1/10 , C12N15/74 , A61K2039/52 , A61K2039/523 , A61K2039/585
摘要： The present disclosure provides genetically altered protozoan parasites comprising a mutation in a bradyzoite formation deficient 1 (BFD1) gene, wherein the mutation inhibits differentiation of the parasite into a bradyzoite. The genetically altered protozoan parasites can be utilized in vaccine compositions and in methods of treating apicomplexan parasite infection.

8. 发明公开

US20240044911A1 METHODS AND COMPOSITIONS FOR ASSESSING ANTIBODY SPECIFICITIES 审中-公开
公开(公告)号：US20240044911A1
公开(公告)日：2024-02-08
申请号：US18243566
申请日：2023-09-07
申请人： Serimmune Inc.
发明人： Patrick Sean Daugherty , Kathryn Vinaya Louise Kamath , Jack Ryan Reifert
IPC分类号： G01N33/68 , C07K14/285 , G01N33/53 , C07K14/44 , G01N33/569 , G01N33/564 , C07K14/315 , C07K14/195 , C07K14/45 , C07K14/435
CPC分类号： G01N33/6854 , G01N33/6845 , C07K14/285 , G01N33/53 , C07K14/44 , G01N33/56988 , G01N33/564 , G01N33/56944 , C07K14/315 , C07K14/195 , G01N33/56994 , G01N33/6842 , C07K14/45 , G01N33/56905 , G01N33/6878 , G01N33/56966 , C07K14/43554 , G01N33/56911 , G01N33/56983 , G01N33/569 , G01N2333/18 , G01N2333/095 , C12Q1/689
摘要： The present invention provides compositions and methods that can be used to determine a peptide signature for an antibody repertoire in a sample comprising multiple antibodies. The method can be used to characterize a phenotype in a sample, such as providing a diagnosis, prognosis or theranosis of a medical condition.

9. 发明申请

US20230135784A1 USE OF VIRUS-LIKE PARTICLES INCLUDING TOXOPLASMA GONDII APICAL MEMBRANE ANTIGEN 1 FOR SERODIAGNOSING TOXOPLASMOSIS 有权
公开(公告)号：US20230135784A1
公开(公告)日：2023-05-04
申请号：US17969632
申请日：2022-10-19
申请人： University-Industry Cooperation Group of Kyung Hee University
发明人： Fu-Shi Quan , Minju KIM
IPC分类号： G01N33/569 , C07K14/45
摘要： The present disclosure relates to a use of virus-like particles including Toxoplasma gondii apical membrane antigen 1 for serodiagnosing toxoplasmosis, wherein an enzyme-linked immunosorbent assay with an infected serum was conducted using virus-like particles expressing Toxoplasma gondii AMA1, and higher sensitivity than the existing Toxoplasma gondii antigen was observed using virus-like particles, and no false diagnosis such as false negatives and false positives appeared after a reaction with a malaria-infected serum and thus high specificity was identified.

10. 发明申请

US20140004141A1 Methods And Compositions Of Protein Antigens For The Diagnosis And Treatment Of Toxoplasma Gondii Infections And Toxoplasmosis 审中-公开
标题翻译：蛋白质抗原的方法和组成用于弓形虫感染和弓形体病的诊断和治疗
公开(公告)号：US20140004141A1
公开(公告)日：2014-01-02
申请号：US13997603
申请日：2011-12-20
申请人： David Huw Davies , Xiaowu Liang , Philip Felgner
发明人： David Huw Davies , Xiaowu Liang , Philip Felgner
IPC分类号： C07K14/45
CPC分类号： C07K14/45 , A61K39/002 , G01N33/56905
摘要： Contemplated compositions, devices, and methods are drawn to various antigens from the pathogen T. gondii and their use in various diagnostic tests, vaccines, and therapeutic agents. In particularly preferred aspects, the antigens are immunodominant and have quantified and known relative reactivities with respect to sera of a population infected with the pathogen, and/or have a known association with a disease parameter.
摘要翻译：将考虑的组合物，装置和方法绘制到来自病原体弓形虫的各种抗原及其在各种诊断测试，疫苗和治疗剂中的用途。在特别优选的方面，抗原是免疫显性的，并且相对于感染病原体的群体的血清具有定量和已知的相对反应性，和/或具有与疾病参数的已知关联。

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