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1. 发明申请

US20230047729A1 METHOD FOR PREPARING LIRAGLUTIDE USING ENVIRONMENT-FRIENDLY SOLVENT 有权
公开(公告)号：US20230047729A1
公开(公告)日：2023-02-16
申请号：US17963739
申请日：2022-10-11
申请人： DAEBONG LS CO., LTD.
发明人： Eun Ju PARK , Eun Teak KIM , Jin Oh PARK
IPC分类号： C07K1/10 , C07K1/02
摘要： Proposed is a novel method for preparing liraglutide by means of an ionic liquid and a eutectic solvent, which are environment-friendly solvents. More specifically, the method is characterized in that fractionated peptide 1 represented by the following formula (1) and fractionated peptide 2 represented by the following formula (2) are subjected to a coupling reaction in the presence of an ionic liquid or a eutectic solvent. In preparing GLP-1 analogues such as liraglutide, the present method increases reactivity when producing liraglutide, which is an unprocessed reactant, by using an ionic liquid and a eutectic solvent as environment-friendly solvents instead of using organic solvents. Accordingly, through a relatively short and simple purification process, the present method has advantages of reducing the formation of related substances, improving purity, improving yields, shortening reaction times, reducing production cost, and lowering the manufacturing cost.

2. 发明申请

US20220411794A1 RNA OLIGONUCLEOTIDES FOR PREVENTING AGGREGATION OF PROTEINS 有权
公开(公告)号：US20220411794A1
公开(公告)日：2022-12-29
申请号：US17771790
申请日：2020-10-23
申请人： Universitaet Wien
发明人： Bojan ZAGROVIC , Anton POLYANSKY
IPC分类号： C12N15/113 , C07K1/02 , C07K16/32
摘要： A composition comprising a protein and at least one single-stranded linear RNA oligonucleotide with an unfolded tertiary structure, which is characterized by: a) a relative content of each of the nucleotides A, C, U, and G, which is the number of each of the nucleotides per total nucleotide number in the oligonucleotide, which relative content is the same ±10% (number of nucleotides per total nucleotide number) as compared to the relative content of the respective nucleotide in a reference; and/or b) a relative content of at least 50% (number of nucleotides per total nucleotide number) of one type of nucleotide selected from the group consisting of nucleotides A, C, U, and G, which exhibits the highest relative content (number of each of the nucleotides per total nucleotide number) in a reference; wherein the reference consists of a native mRNA or a set of different RNA sequences that covers all RNA sequences allowed by the universal genetic code, each encoding an amino acid sequence of at least three amino acids within a p re-determined aggregation-prone target region of said protein, wherein the oligonucleotide has a length which is the same length as the reference, or longer.

3. 发明授权

US11512108B2 Method for producing amide compound 有权
公开(公告)号：US11512108B2
公开(公告)日：2022-11-29
申请号：US17047464
申请日：2019-04-25
申请人： CHUBU UNIVERSITY EDUCATIONAL FOUNDATION
发明人： Hisashi Yamamoto , Wataru Muramatsu , Tomohiro Hattori
IPC分类号： C07K1/08 , C07K1/00 , C07C231/02 , C07K1/02
摘要： Provided is a novel method whereby an amide compound can be produced by highly stereoselectively and efficiently performing amidation between a plurality of amino acids and/or peptides. A compound of general formula (3) is synthesized by forming an amide bond between the carboxyl group on the right side of general formula (1) in a compound represented thereby and the amino group on the left side of general formula (2) in a compound represented thereby, in the presence of a Lewis acid catalyst and a silylating agent [in formulae (1), (2) and (3), each symbol has the same meaning as defined in claims].

4. 发明申请

US20220332754A1 PEPTIDE SYNTHESIS 有权
公开(公告)号：US20220332754A1
公开(公告)日：2022-10-20
申请号：US17309150
申请日：2019-11-04
申请人： ORIGIN PEPTIDES LIMITED
发明人： Sara TEN HAVE
IPC分类号： C07K1/02 , C07K14/62
摘要： There is provided a method to synthesise peptides, a peptide being synthesised based on the amino acid sequence of a template peptide, peptides provided by the method and use of the peptides.

5. 发明申请

US20220235096A1 An improved process for the preparation of Plecanatide 有权
公开(公告)号：US20220235096A1
公开(公告)日：2022-07-28
申请号：US17617709
申请日：2020-06-08
申请人： Auro Peptides Ltd.
发明人： Abdul Shafee Mohammed , Damodar Reddy Pakal , Bharti Deshmukh , Vivekananda Reddy Goli , Nagana Goud Agasaladinni
IPC分类号： C07K7/64 , C07K1/06 , C07K1/02 , C07K1/16
摘要： The present invention relates to a process for the preparation of Plecanatide, which comprises preparation of three fragments such as Fragment A (7 amino acids), Fragment B (3 amino acids), Fragment D (6 amino acids) and coupling the fragments to provide Plecanatide followed by purification using buffer system comprising Tris hydrochloride (or) Triethylammonium phosphate.

6. 发明申请

US20210340173A1 METHODS FOR PRODUCING A PLURALITY OF POLYPEPTIDE VARIANTS SUITABLE FOR BIOLOGICAL ANALYSIS 有权
公开(公告)号：US20210340173A1
公开(公告)日：2021-11-04
申请号：US17282220
申请日：2019-09-25
申请人： UNIVERSITÉ DE GENÈVE
发明人： Oliver Hartley , Marianne Paolini-Bertrand
IPC分类号： C07K1/02 , G01N33/50
摘要： The present application relates to methods for producing structurally variant polypeptide molecules in parallel using column-free techniques by polypeptide ligation, separation of ligated polypeptides from ligation reactions, folding of polypeptides, and desalting of polypeptides. Further described are methods for determining the effects and properties of structurally variant polypeptide molecules produced in parallel using column-free techniques.

7. 发明申请

US20210300966A1 SOLUTION PHASE SYNTHESIS OF BETA-TURN PEPTIDOMIMETIC CYCLIC SALTS 有权
公开(公告)号：US20210300966A1
公开(公告)日：2021-09-30
申请号：US17337383
申请日：2021-06-02
申请人： MIMETOGEN PHARMACEUTICALS, INC.
发明人： Sébastien Rocchi , Chantal Devin , Wei Tian , Martin Bohlin
IPC分类号： C07K5/113 , C07K1/30 , C07K1/02 , C07K5/10
摘要： The present disclosure relates to methods of preparing and crystallizing β-turn cyclic peptidomimetic salts of formula I: where R1, R2, R3, R4, R5, R6, R7, R8, R10, X, Y and n are as defined in the specification.
The present disclosure provides a more efficient route for preparing a crystalline form of a β-turn cyclic peptidomimetic compounds and salts thereof.

8. 发明申请

US20210261642A1 SOLUBILITY OF GLP-1 PEPTIDE 有权
公开(公告)号：US20210261642A1
公开(公告)日：2021-08-26
申请号：US16771932
申请日：2017-12-19
申请人： Novo Nordisk A/S
发明人： Florian Dismer , Mattias Hansson , Arne Staby
IPC分类号： C07K14/605 , C07K1/02
摘要： The present inventions relates to methods involving incubation of undissolved and/or insoluble GLP-1 peptide in solutions or suspensions comprising one or more organic solvents.

9. 发明授权

US10941190B2 Production of heteromultimeric proteins using mammalian cells 有权
公开(公告)号：US10941190B2
公开(公告)日：2021-03-09
申请号：US15344123
申请日：2016-11-04
申请人： Genentech, Inc.
发明人： Justin Scheer , Whitney Shatz , Domingos Ng
IPC分类号： C07K16/00 , C07K16/46 , C07K1/00 , C07K1/02 , C12P21/02 , C12P21/00 , C12N15/79 , C12N15/90
摘要： Described herein are methods for the efficient production of antibodies and other multimeric protein complexes (collectively referred to herein as heteromultimeric proteins) capable of specifically binding to more than one target. The targets may be, for example, different epitopes located on a single molecule or located on different molecules.

10. 发明授权

US10858389B2 Solution phase method for preparing etelcalcetide 有权
公开(公告)号：US10858389B2
公开(公告)日：2020-12-08
申请号：US15561009
申请日：2016-03-25
申请人： Amgen Inc.
发明人： Sheng Cui , Krishnakumar Ranganathan , Richard Crockett , Ying Chen , Aleksander Swietlow , Kevin Crossley , Yun Shi , Karel Decroos , Etienne Moniotte
IPC分类号： C07K1/02 , C07K7/06 , C07K1/18 , C07K5/083 , C07K5/11
摘要： The instant disclosure is directed to solution phase fragment coupling methods for preparing etelcalcetide and its pharmaceutically acceptable salts.

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