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1. 发明授权

US5380829A Thioglycoside analogs of gangliosides 失效
标题翻译：神经节苷脂的硫糖苷类似物
公开(公告)号：US5380829A
公开(公告)日：1995-01-10
申请号：US842532
申请日：1992-02-27
申请人： Akira Hasegawa , Makoto Kiso
发明人： Akira Hasegawa , Makoto Kiso
IPC分类号： A61K31/70 , A61K31/7028 , A61P31/12 , A61P31/16 , C07H15/10 , C07H15/14 , C12N9/99 , C07H5/08
CPC分类号： C07H15/10 , C07H15/14 , Y02P20/55
摘要： Disclosed are thioglycoside analogs of gangliosides represented by the formula ##STR1## in which Y represents a radical of the following formula ##STR2## and X represents a radical of the formula ##STR3## wherein m is an integer of 15 to 25, l is an integer of 0 to 3 and n is an integer of 11 to 15. The thioglycoside analogs are expected to exert specific enzyme-inhibitory effects.
摘要翻译：公开了由式“IMAGE”表示的神经节苷脂的硫代糖苷类似物，其中Y表示下式的基团，其中X表示下式的基团：其中m是 15〜25的整数，l为0〜3的整数，n为11〜15的整数。预期硫代糖苷类似物具有特异性的酶抑制作用。

2. 发明授权

US4359460A 6'-(1-Adamanta necarboxylate)-6-O-.alpha.-D-galactopyranosyl-.alpha.-D-glucopyranose sulfate salts 失效
标题翻译： 6' - （1-金刚烷羧酸酯）-6-O-α-D-吡喃半乳糖基-α-D-吡喃葡萄糖硫酸盐
公开(公告)号：US4359460A
公开(公告)日：1982-11-16
申请号：US310672
申请日：1981-10-13
申请人： Vijay G. Nair , Seymour Bernstein
发明人： Vijay G. Nair , Seymour Bernstein
IPC分类号： C07H3/04 , A61K31/715 , A61K31/73 , C07H5/08
CPC分类号： C07H3/04
摘要： 6'-(1-Adamantanecarboxylate)-6-O-.alpha.-D-galactopyranosyl-.alpha.-D-glucopyranose sulfate salts, useful as complement inhibitors, and the process for making such compounds.
摘要翻译： 6' - （1-金刚烷羧酸酯）-6-O-α-D-吡喃半乳糖基-α-D-吡喃葡萄糖硫酸盐，可用作补体抑制剂，以及制备此类化合物的方法。

3. 发明授权

US4359458A O-.beta.. -D (and O-.alpha... -D) Multigalactopyranosyl, xylopyranosyl and glucopyranosyl sulfate salts 失效
标题翻译： O-β。 -D（和O-α.. -D）多糖吡喃糖基，木吡喃糖基和吡喃葡萄糖基硫酸盐
公开(公告)号：US4359458A
公开(公告)日：1982-11-16
申请号：US305885
申请日：1981-09-28
申请人： Vijay G. Nair , Joseph P. Joseph , Arthur J. Lewis , Seymour Bernstein
发明人： Vijay G. Nair , Joseph P. Joseph , Arthur J. Lewis , Seymour Bernstein
IPC分类号： C07H3/06 , C07H5/08
CPC分类号： C07H3/06
摘要： O-.beta.-D (and O-.alpha.-D) multi-galactopyranosyl (or xylopyranosyl or glucopyranosyl) 1.alpha.,1.alpha.' galactopyranosyl (or xylopyranosyl or glucopyranosyl) sulfate salts, useful as complement inhibitors, the intermediates thereof and the process for preparation of such compounds.
摘要翻译：可用作补体抑制剂的O-β-D（和O-α-D）多 - 半乳糖吡喃糖基（或木吡喃糖基或吡喃葡萄糖基）1α，1α'半乳糖吡喃糖基（或木吡喃糖基或吡喃葡萄糖基）硫酸盐，其中间体及其制备方法这些化合物的制备。

4. 发明授权

US09611286B2 Ruthenium carbon monoxide releasing molecules and uses thereof 有权
公开(公告)号：US09611286B2
公开(公告)日：2017-04-04
申请号：US14711113
申请日：2015-05-13
申请人： Alfama, Inc.
发明人： Ana Pamplona , Gonçalo J. L. Bernardes , Maria M. Mota , Carlos C. Romão
IPC分类号： A61K31/7135 , C07H5/10 , C07H5/08 , C07F15/00 , A61K45/06 , C07H23/00
CPC分类号： C07H5/10 , A61K31/7135 , A61K45/06 , C07F15/0046 , C07H5/08 , C07H23/00 , Y02A50/411
摘要： The present invention provides novel ruthenium compounds of Formula (I): or salts, isomers, hydrates, or solvates thereof, or combinations thereof; wherein E, R1, R2, R3, R4, R5, X1, and X2 are as defined herein, and pharmaceutical compositions thereof. Also provided are methods of use and treatment. Such compounds have been found useful in the treatment of malaria infection. Such compounds may also be useful in the treatment of inflammatory conditions, such as acute lung injury and acute resipiratory distress syndrome, which optionally may be associated with a malaria infection.

5. 发明授权

US09062089B2 Ruthenium carbon monoxide releasing molecules and uses thereof 有权
标题翻译：钌一氧化碳释放分子及其用途
公开(公告)号：US09062089B2
公开(公告)日：2015-06-23
申请号：US14234024
申请日：2012-07-21
申请人： Ana Pamplona , Gonçalo J. L. Bernardes , Maria M. Mota , Carlos C. Romão
发明人： Ana Pamplona , Gonçalo J. L. Bernardes , Maria M. Mota , Carlos C. Romão
IPC分类号： C07H23/00 , A61K31/7135 , C07H5/08 , C07F15/00 , A61K45/06
CPC分类号： C07H5/10 , A61K31/7135 , A61K45/06 , C07F15/0046 , C07H5/08 , C07H23/00 , Y02A50/411
摘要： The present invention provides novel ruthenium compounds of Formula (I): or salts, isomers, hydrates, or solvates thereof, or combinations thereof; wherein E, R1, R2, R3, R4, R5, X1, and X2 are as defined herein, and pharmaceutical compositions thereof. Also provided are methods of use and treatment. Such compounds have been found useful in the treatment of malaria infection. Such compounds may also be useful in the treatment of inflammatory conditions, such as acute lung injury and acute respiratory distress syndrome, which optionally may be associated with a malaria infection.
摘要翻译：本发明提供式（I）的新型钌化合物：或其盐，异构体，水合物或溶剂合物或其组合; 其中E，R 1，R 2，R 3，R 4，R 5，X 1和X 2如本文所定义，及其药物组合物。还提供了使用和治疗的方法。已经发现这些化合物可用于治疗疟疾感染。此类化合物还可用于治疗炎性病症，例如急性肺损伤和急性呼吸窘迫综合征，其任选地可能与疟疾感染相关。

6. 发明授权

US06114309A Combinatorial library of moenomycin analogs and methods of producing same 失效
标题翻译：霉酚霉素类似物组合库及其生产方法
公开(公告)号：US06114309A
公开(公告)日：2000-09-05
申请号：US975229
申请日：1997-11-21
申请人： Nigel Mark Allanson , Tin Yau Chan , Nicole T. Hatzenbuhler , Rakesh K. Jain , Ramesh Kakarla , Rui Liang , Dashan Liu , Domingos J. Silva , Michael J. Sofia
发明人： Nigel Mark Allanson , Tin Yau Chan , Nicole T. Hatzenbuhler , Rakesh K. Jain , Ramesh Kakarla , Rui Liang , Dashan Liu , Domingos J. Silva , Michael J. Sofia
IPC分类号： C12Q1/02 , A61K31/7016 , A61K31/702 , A61P31/04 , C07B61/00 , C07H1/02 , C07H5/08 , C07H11/04 , C07H15/04 , C07H15/203 , A61K31/70 , C07H13/00
CPC分类号： C07H15/04 , C07H15/203 , C40B40/00
摘要： A combinatorial chemical library of compounds structurally related to the moenomycin class of antibiotics has the formula ##STR1## wherein D is a donor mono- or disaccharide, A is an acceptor monosaccharide, and P-R is a lipophosphoglycerate mimetic group. Members of the library have a glycosidic linkage between the anomeric carbon of D and the C2 carbon of A, and the D-A moiety is in turn covalently linked through the anomeric carbon of A to the P-R group. Members of the library exhibit their greatest structural diversity in terms of substitutions occurring at the C3 position of the A residue, substitutions at the C2 position of the D residue, and different P-R groups used in assembling the compounds. Members of the library are preferably synthesized by solid phase techniques involving stepwise coupling of the respective units to a support, functionalizing the A and/or D saccharides either before or after immobilizing them on the support, and cleaving the assembled compounds from the support. Preferred functionalities attached to the sugar residues are amides, carbamates, ureas, sulfonamides, substituted amines, esters, carbonates, and sulfates. Exemplary P-R groups are derivatives of homoserine, glyceric acid, salicylates and mandelic acid. Members of the library can be screened for anti-microbial activity by contacting them with a culture of microbes and monitoring the growth rate of the microbes.
摘要翻译：结构上与新霉素类抗生素相关的化合物的组合化学文库具有下式：其中D是供体单糖或二糖，A是受体单糖，P-R是脂磷酸甘油酸酯模拟组。文库成员在D的异头碳和A的C2碳之间具有糖苷键，D-A部分又通过A的端基异碳共价连接到P-R基团。关于在A残基的C3位置发生的取代，在D残基的C2位置的取代以及用于组装化合物的不同的P-R基团，图书馆的成员表现出最大的结构多样性。文库的成员优选通过固相技术合成，其包括将各单元逐步偶联到载体上，在将它们固定在载体上之前或之后将A和/或D糖功能化，并将载体化合物从载体上分离。附着于糖残基的优选功能是酰胺，氨基甲酸酯，脲，磺酰胺，取代的胺，酯，碳酸酯和硫酸酯。示例性的P-R基团是高丝氨酸，甘油酸，水杨酸盐和扁桃酸的衍生物。通过与微生物培养物接触并监测微生物的生长速率，可以筛选图书馆成员的抗菌活性。

7. 发明授权

US5424416A Process for preparation of 2-deoxy-2,2-difluoro-D-ribofuranosyl-3,5-hydroxy protected-1-alkyl and aryl sulfonates and their use in preparation of 2',2'-difluoro-2'-deoxy nucleosides 失效
标题翻译：制备2-脱氧-2,2-二氟-D-呋喃核糖基-3,5-羟基保护的1-烷基和芳基磺酸盐的方法及其在制备2'，2'-二氟-2'-脱氧核苷的用途
公开(公告)号：US5424416A
公开(公告)日：1995-06-13
申请号：US111578
申请日：1993-08-25
申请人： Charles D. Jones
发明人： Charles D. Jones
IPC分类号： C07H13/00 , A61K31/70 , A61K31/7024 , A61K31/7042 , A61K31/7052 , A61K31/7076 , A61K31/708 , A61P31/12 , A61P35/00 , C07H11/00 , C07H13/08 , C07H19/16 , C07H19/173 , C07H19/23 , C07H5/08 , C07H1/00 , C07H19/14
CPC分类号： C07H13/08 , C07H11/00 , C07H19/16
摘要： A stereoselective process for preparing a .beta.-anomer enriched 2-deoxy-2,2-difluoro-D-ribofuranosyl-3,5-hydroxy protected-1-alkyl and aryl sulfonate intermediates by contacting an .alpha.-anomer enriched 2-deoxy-2,2-difluoro-D- ribofuranosyl-3,5-hydroxy protected-1-fluoroalkyl and fluoroaryl sulfonate with a conjugate anion of a sulfonic acid containing the desired alkyl or aryl sulfonate.
摘要翻译：通过使富含α-甘油聚合的2-脱氧-2（2-脱氧-2,2-二氟-D-呋喃核糖基-3,5-羟基保护的1-呋喃核糖基-3,5-羟基保护-1-烷基和芳基磺酸酯中间体），2-二氟-D-呋喃核糖基-3,5-羟基保护的1-氟代烷基和氟代芳基磺酸酯，其具有含有所需烷基或芳基磺酸酯的磺酸的共轭阴离子。

8. 发明申请

US20140206658A1 SELENO-COMPOUNDS AND THERAPEUTIC USES THEREOF 审中-公开
标题翻译： SELENO化合物及其治疗方法
公开(公告)号：US20140206658A1
公开(公告)日：2014-07-24
申请号：US13881594
申请日：2011-10-28
申请人： Carl Herbert Schiesser , Corin Storkey , Michael Jonathan Davies
发明人： Carl Herbert Schiesser , Corin Storkey , Michael Jonathan Davies
IPC分类号： C07H5/08 , C07D345/00
CPC分类号： C07H5/08 , A61K31/33 , C07D345/00
摘要： The present invention relates to compounds and compositions useful as antioxidants and in particular to selenium containing compounds of formula (I): wherein n is 1, 2, or 3; m is 2, 3, 4, or 5; and each R] is independently —(optionally substituted C1-C3 alkylene) p-OH, where p is 0 or 1, or a salt thereof. The invention also relates to the use of these seleno-compounds in the treatment of diseases or conditions associated with increased levels of oxidants produced by myeloperoxidase (MPO), such as for instance, atherosclerosis.
摘要翻译：本发明涉及可用作抗氧化剂，特别是含有式（I）的含硒化合物的化合物和组合物：其中n为1,2或3; m为2,3,4或5; 并且每个R'独立地为 - （任选取代的C 1 -C 3亚烷基）p -OH，其中p为0或1，或其盐。本发明还涉及这些硒化合物在治疗与由髓过氧化物酶（MPO）产生的氧化剂水平升高相关的疾病或病症的用途，例如动脉粥样硬化。

9. 发明授权

US5869460A Sulfated and phosphated saccharide derivatives, process for the preparation of the same and use thereof 失效
标题翻译：硫酸化和磷酸化的糖衍生物，其制备方法和用途
公开(公告)号：US5869460A
公开(公告)日：1999-02-09
申请号：US739423
申请日：1996-10-29
申请人： Toshinao Usui , Takao Igami , Takuji Kakigami , Hitoshi Hamashima , Takahito Jomori , Akira Tashita , Yoshiro Ishiwatari , Shoji Yokochi , Takahiko Mitani , Yasuo Suzuki , Akira Hasegawa
发明人： Toshinao Usui , Takao Igami , Takuji Kakigami , Hitoshi Hamashima , Takahito Jomori , Akira Tashita , Yoshiro Ishiwatari , Shoji Yokochi , Takahiko Mitani , Yasuo Suzuki , Akira Hasegawa
IPC分类号： C07H1/00 , A61K31/70 , A61K31/7028 , A61P29/00 , A61P43/00 , C07H1/02 , C07H3/06 , C07H5/08 , C07H11/04 , C07H15/04 , C07H15/00
CPC分类号： A61K31/7024 , C07H11/04 , C07H3/06 , C07H5/08 , Y02P20/55
摘要： There are described sulfated and phosphated saccharide erivatives of the Formula ##STR1## wherein R.sub.1 is hydrogen atom or a residue of sulfate, phosphate or L-fucose; R.sub.2, R.sub.3 and R.sub.4 are hydrogen atom or a residue of sulfate or phosphate, respectively; 1 is an integer of 0 or 1;m is an integer of 0-15; and n is an integer of 0-21, or pharmaceutically acceptable salts thereof, a process for the preparation of the derivatives and salts as well as use thereof, as an anti-inflammatory agent.
摘要翻译：其中R1表示氢原子或硫酸盐，磷酸盐或L-岩藻糖残基;硫酸盐，磷酸盐或L-岩藻糖残基; R2，R3和R4分别是氢原子或硫酸盐或磷酸盐的残基; 1是0或1的整数; m为0-15的整数; n为0-21的整数，或其药学上可接受的盐，作为抗炎剂的衍生物和盐的制备方法及其用途。

10. 发明授权

US4359459A O-.alpha.-D-Multigalactopyranosyl-O-.alpha.-D-multiglucopyranosyl-O-.beta.- D 失效
标题翻译： O-α-D-多糖吡喃糖基-O-α-D-吡喃葡萄糖基-β-D-多葡萄糖基 - 吡喃葡萄糖苷硫酸盐
公开(公告)号：US4359459A
公开(公告)日：1982-11-16
申请号：US305886
申请日：1981-09-28
申请人： Vijay G. Nair , Seymour Bernstein
发明人： Vijay G. Nair , Seymour Bernstein
IPC分类号： C07H3/06 , C07H5/08
CPC分类号： C07H3/06
摘要： O-.alpha.-D-Galactopyranosyl(1.fwdarw.6)-O-.alpha.-D-galactopyranosyl(1.fwdarw.6)-O-.alpha.-D-glucopyranosyl(1.fwdarw.2)-O-.beta.-D-fructofuranosyl(1.fwdarw.6)-O-.alpha.-D-glucopyranosyl(1.fwdarw.4)-O-.alpha.-D-glucopyranosyl-.alpha.-D-glucopyranoside sulfate salts useful as complement inhibitors and the process of making such compounds.
摘要翻译： α-D-吡喃半乳糖基（1-> 6）-O-D-吡喃半乳糖基（1-> 6）-O-α-D-吡喃葡萄糖基（1-> 2）-β-D-呋喃果糖基 1-> 6）-O-α-D-吡喃葡萄糖基（1-> 4）-O-α-D-吡喃葡萄糖-α-D-吡喃葡萄糖苷硫酸盐，可用作补体抑制剂及其制备方法。

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