专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US5559232A Carboxamides 失效
标题翻译：羧甲酰胺
公开(公告)号：US5559232A
公开(公告)日：1996-09-24
申请号：US300821
申请日：1994-09-02
申请人： Jean Ackermann , David Banner , Klaus Gubernator , Kurt Hilpert , G erard Schmid
发明人： Jean Ackermann , David Banner , Klaus Gubernator , Kurt Hilpert , G erard Schmid
IPC分类号： C07D499/12 , A61K31/44 , A61K31/4427 , A61K31/445 , A61K31/452 , A61K31/495 , A61K31/50 , A61K31/505 , A61K31/535 , A61K31/5375 , A61P7/02 , A61P9/08 , A61P9/10 , A61P29/00 , A61P35/00 , A61P43/00 , C07D211/26 , C07D265/30 , C07D277/74 , C07D401/12 , C07D401/14 , C07D405/12 , C07D413/12 , C07D413/14 , C07D501/06 , C07D211/14 , C07D265/28
CPC分类号： C07D265/30 , C07D211/26 , C07D401/12 , C07D401/14 , C07D405/12 , C07D413/12 , C07D413/14
摘要： The novel carboxamides of the formula ##STR1## wherein A, E, G, L, M, R and Q have the significance given in the description, as well as hydrates or solvates thereof inhibit thrombin-induced platelet aggregation and fibrinogen coagulation in plasma. They can be manufactured starting from the corresponding acid and the corresponding amine H.sub.2 NCH.sub.2 Q.
摘要翻译：其中A，E，G，L，M，R和Q具有在描述中给出的含义以及其水合物或溶剂化物的新颖的甲酰胺，其抑制凝血酶诱导的血小板聚集和血浆中的纤维蛋白原凝结。它们可以从相应的酸和相应的胺H 2 NCH 2 Q开始制备。

2. 发明授权

US5206361A Thiazolinoazetidinone derivative 失效
标题翻译：噻唑烷酮衍生物
公开(公告)号：US5206361A
公开(公告)日：1993-04-27
申请号：US665863
申请日：1991-03-07
申请人： Sigeru Torii , Hideo Tanaka , Masatoshi Taniguchi , Michio Sasaoka , Takashi Shiroi , Yutaka Kameyama
发明人： Sigeru Torii , Hideo Tanaka , Masatoshi Taniguchi , Michio Sasaoka , Takashi Shiroi , Yutaka Kameyama
IPC分类号： C07D499/00 , C07D499/04 , C07D499/12 , C07D499/87 , C07D513/04
CPC分类号： C07D513/04 , C07D499/00 , Y02P20/55
摘要： The present invention provides a thiazolinoazetidinone derivative represented by the formula ##STR1## wherein R.sup.1 is phenyl having or not having substituent(s), methyl having or not having substituent(s) or ##STR2## group, R.sup.3 being phenyl having or not having substituent(s), and R.sup.2 is a hydrogen atom or carboxylic acid protective group, and a process for preparing the same.The present invention further provides a process for preparing a 2-exo-methylenepenam derivative characterized by hydrolyzing the thiazoline ring of a thiazolinoazetidinone derivative of the above formula (1) to effect recyclization and obtain a 2-exo-methylenepenam derivative represented by the formula ##STR3## wherein R.sup.1 and R.sup.2 are as defined above.

3. 发明授权

US4996313A Penicillins 失效
标题翻译：青霉素
公开(公告)号：US4996313A
公开(公告)日：1991-02-26
申请号：US438622
申请日：1989-11-17
申请人： Jack E. Baldwin
发明人： Jack E. Baldwin
IPC分类号： C07D499/21 , C07D499/00 , C07D499/10 , C07D499/12 , C07D499/42 , C12P37/00
CPC分类号： C12P37/00 , C07D499/00
摘要： A compound of formula II: ##STR1## wherein R is hydrogen or an alkyl group and R' is an alkoxy group, and salts and esters thereof.
摘要翻译：式II的化合物：其中R是氢或烷基，R'是烷氧基的式（II）化合物及其盐和酯。

4. 发明授权

US4537886A .beta.-lactam antibacterial agents and compositions containing them 失效
标题翻译： β-内酰胺抗菌剂和含有它们的组合物
公开(公告)号：US4537886A
公开(公告)日：1985-08-27
申请号：US479953
申请日：1983-03-29
申请人： Andrew W. Taylor , Richard T. Cook
发明人： Andrew W. Taylor , Richard T. Cook
IPC分类号： C07D499/08 , A61K31/43 , A61P31/04 , C07D231/20 , C07D231/26 , C07D499/00 , C07D499/12 , C07D499/64 , C07D499/68 , C07D499/70 , C07D501/20 , A61K31/545 , C07D499/54 , C07D501/22
CPC分类号： C07D499/00 , C07D231/20 , C07D231/26
摘要： A compound of formula (1) or a pharmaceutically acceptable salt or in vivo hydrolysable ester thereof: ##STR1## wherein R.sup.1 is phenyl, substituted phenyl or a 5- or 6-membered heterocyclic ring containing up to three heteroatoms selected from oxygen, sulphur or nitrogen, optionally substituted with hydroxy, amino, halogen or C.sub.1-6 alkoxy;X represents; ##STR2## wherein R.sup.Y is methyl or acetyl; R.sup.2 and R.sup.3 may be the same or different and each is hydrogen, an aryl group, a heterocyclyl group or a C.sub.1-6 alkyl group optionally substituted by an aryl group or a heterocyclyl group; and R.sup.4 is hydrogen, a C.sub.1-6 alkylcarbonyl group, an aryl group, a heterocyclyl group, a C.sub.1-6 alkyl group optionally substituted by an aryl group or a heterocyclyl group;R.sup.5 represents, hydrogen, methoxy or --NHCHO; and Y is: ##STR3## wherein Y.sup.1 is oxygen, sulphur or --CH.sub.2 -- and Z represents hydrogen, halogen or an organic group such as C.sub.1-4 alkoxy, --CH.sub.2 Q or --CH.dbd.CH--Q wherein Q represents hydrogen, halogen, hydroxy, mercepto, cyano, carboxy, carbamoyloxy carboxylic ester, C.sub.1-4 alkyloxy, acyloxy, aryl, a heterocyclyl group bonded via carbon, a heterocyclylthio group or a nitrogen containing heterocyclic group bonded via nitrogen.
摘要翻译：式（1）化合物或其药学上可接受的盐或体内可水解的酯：其中R 1是苯基，取代的苯基或含有至多三个选自氧的杂原子的5-或6-元杂环，硫或氮，任选被羟基，氨基，卤素或C 1-6烷氧基取代; X表示; 其中RY为甲基或乙酰基; R2和R3可以相同或不同，各自为氢，芳基，杂环基或任选被芳基或杂环基取代的C 1-6烷基; R4是氢，C1-6烷基羰基，芳基，杂环基，任意被芳基或杂环基取代的C1-6烷基; R5表示氢，甲氧基或-NHCHO; Y为：其中Y 1为氧，硫或-CH 2 - ，Z为氢，卤素或有机基团如C 1-4烷氧基，-CH 2 Q或-CH = CH-Q其中Q为氢，卤素，羟基，mercepto，氰基，羧基，氨基甲酰氧基羧酸酯，C 1-4烷氧基，酰氧基，芳基，通过碳键合的杂环基，杂环硫基或通过氮键合的含氮杂环基。

5. 发明授权

US4248780A Process for preparing ampicillin 失效
标题翻译：氨苄青霉素制备方法
公开(公告)号：US4248780A
公开(公告)日：1981-02-03
申请号：US068385
申请日：1979-08-21
申请人： Kekhusroo R. Bharucha , Heinrich M. Schrenk , Clarke E. Slemon
发明人： Kekhusroo R. Bharucha , Heinrich M. Schrenk , Clarke E. Slemon
IPC分类号： C07D499/00 , C07D499/68 , C07D499/12
CPC分类号： C07D499/00
摘要： A process for preparing ampicillin trihydrate is disclosed which comprises acylating silylated 6-aminopenicillanic acid with D(-)-.alpha.-phenylglycylchloride hydrochloride directly in the silylation reaction mixture in the presence of urea as an acid acceptor, hydrolyzing the reaction product and precipitating ampicillin-trihydrate from the resulting aqueous solution. The amounts of reactants, in particular of solvents and water, are adjusted to provide good yields of a product of high purity.
摘要翻译：公开了一种制备氨苄青霉素三水合物的方法，该方法包括在作为酸受体的尿素存在下，在甲硅烷基化反应混合物中直接用D（ - ） - α-苯基甘氨酰氯盐酸盐将甲硅烷基化的6-氨基青霉烷酸酰化，水解反应产物并沉淀氨苄青霉素 - 从得到的水溶液中加入三水合物。调节反应物的量，特别是溶剂和水的量，以提供高纯度产物的良好产率。

6. 发明授权

US4241056A Penicillins and salts thereof 失效
标题翻译：青霉素及其盐
公开(公告)号：US4241056A
公开(公告)日：1980-12-23
申请号：US13006
申请日：1979-02-21
申请人： Bernd Wetzel , Wolfgang Reuter , Eberhard Woitun , Roland Maier , Uwe Lechner , Hanns Goeth , Rolf Werner
发明人： Bernd Wetzel , Wolfgang Reuter , Eberhard Woitun , Roland Maier , Uwe Lechner , Hanns Goeth , Rolf Werner
IPC分类号： C07D499/66 , A61K31/43 , A61P31/04 , C07D239/42 , C07D239/48 , C07D239/52 , C07D239/56 , C07D499/00 , C07D499/12 , C07D499/64 , C07D499/68 , C07D499/70 , A61K31/655
CPC分类号： C07D239/42 , C07D239/48 , C07D239/52 , C07D239/56 , C07D499/00
摘要： Compounds of the formula ##STR1## wherein A is phenyl; 4-hydroxy-phenyl; 2- or 3-thienyl; cyclohexyl; cyclohexen-1-yl; cyclohexa-1, 4-dien-1-yl; or 3,4-disubstituted phenyl, where the substituents may be identical to or different from each other and are selected from the group consisting of chlorine, hydroxyl or methoxy; andR is an aliphatic, cycloaliphatic; aromatic or heterocyclic group of diverse types;and non-toxic, pharmacologically acceptable salts thereof formed with inorganic or organic bases. The compounds as well as their salts are useful as antibiotics.
摘要翻译：其中A是苯基的式“IMAGE”的化合物; 4-羟基 - 苯基; 2-或3-噻吩基; 环己基环己烯-1-基; 环己-1,4-二烯-1-基; 或3,4-二取代的苯基，其中取代基可以彼此相同或不同，并且选自氯，羟基或甲氧基; 和R是脂族，脂环族; 各种类型的芳族或杂环基; 和与无机或有机碱形成的无毒的，药学上可接受的盐。化合物及其盐可用作抗生素。

7. 发明授权

US4202817A Process for the production of penam and cephem derivatives 失效
标题翻译：生产penam和头孢烯衍生物的方法
公开(公告)号：US4202817A
公开(公告)日：1980-05-13
申请号：US943463
申请日：1978-09-18
申请人： Erling Guddal , Poul Borrevang
发明人： Erling Guddal , Poul Borrevang
IPC分类号： C07D499/00 , C07D499/12 , C07D501/06
CPC分类号： C07D499/00
摘要： A process for the preparation of penam and cephem derivatives by reacting a phosphite amide of a 6-aminopenicillanic acid or 7-aminocephalosporanic acid with an acyl halide in an aprotic solvent in the presence of a phosphite halide scavenger.
摘要翻译：在亚磷酸盐清除剂的存在下，通过使非氨质子溶剂中的6-氨基青霉烷酸或7-氨基头孢烷酸的亚磷酸酯酰胺与酰基卤反应来制备penam和头孢烯衍生物的方法。

8. 发明授权

US4024129A Process for the preparation of heterocyclic compounds 失效
标题翻译：制备杂环化合物的方法
公开(公告)号：US4024129A
公开(公告)日：1977-05-17
申请号：US195488
申请日：1971-11-03
申请人： Peter Wolfgang Henniger , Antoon Van Harrewijn
发明人： Peter Wolfgang Henniger , Antoon Van Harrewijn
IPC分类号： C07D499/00 , C07D499/04 , C07D499/10 , C07D499/12 , C07D499/21 , C07D501/04 , C07D501/02
CPC分类号： C07D499/00
摘要： A process for the preparation of acylamido derivatives by reaction of a compound of the formula Z - N = C = O, wherein Z is an optionally substituted alkyl-, aryl- (preferably phenyl or naphthyl) or cycloalkyl or optionally substituted heterocyclic, preferably a penicillanic acid or a cephalosporanic acid nucleus, having carboxyl groups and an optionally present hydroxy group protected, with a carboxylic acid of the formula ##STR1## wherein Z.sup.1 is an optionally substituted hydrocarbon group, in the presence of a catalyst selected from the group consisting of substituted pyridines and their N-oxides, optionally substituted imidazoles or their N-oxides, optionally substituted benzimidazoles or their N-oxides, and optionally substituted imidazo [1,2-.alpha.] pyridines or their N-oxides.
摘要翻译：通过式Z-N = C = O的化合物的反应制备酰氨基衍生物的方法，其中Z是任选取代的烷基 - ，芳基 - （优选苯基或萘基）或环烷基或任选取代的杂环，优选具有羧基和任选存在的羟基的青霉烷酸或头孢菌酸核与式IMA的羧酸反应，其中Z1是任选取代的烃基，在选自以下的催化剂存在下：取代的吡啶及其N-氧化物，任选取代的咪唑或其N-氧化物，任选取代的苯并咪唑或其N-氧化物，以及任选取代的咪唑并[1,2-a]吡啶或其N-氧化物。

9. 发明授权

US3994883A Penicillin and cephalosporin intermediates 失效
标题翻译：青霉素和头孢菌素中间体
公开(公告)号：US3994883A
公开(公告)日：1976-11-30
申请号：US427363
申请日：1973-12-21
申请人： Poul Borrevang , Erling Guddal , Henning Borge Petersen , Peter Faarup , Jorgen Ilum Nielsen
发明人： Poul Borrevang , Erling Guddal , Henning Borge Petersen , Peter Faarup , Jorgen Ilum Nielsen
IPC分类号： C07D499/00 , C07D499/12 , C07D499/42 , C07D501/06 , C07D501/18 , C07F9/6561 , C07D499/02
CPC分类号： C07D499/00 , C07F9/65611 , C07F9/65613
摘要： Novel penicillin and cephalosporin intermediates for the synthesis of 6-APA or 7-aminocephem compounds involving formation of a 6 or 7 phosphite amido compound and the conversion of such compound to a desired 6-APA or 7-aminocephem compound.
摘要翻译：用于合成涉及形成6或7亚磷酸酰胺化合物的6-APA或7-氨基头孢烯化合物的新型青霉素和头孢菌素中间体以及将该化合物转化为所需的6-APA或7-氨基头孢烯化合物。

10. 发明授权

US3939180A Penicillin esters 失效
标题翻译：青霉素酯
公开(公告)号：US3939180A
公开(公告)日：1976-02-17
申请号：US530833
申请日：1974-12-09
申请人： Harry Ferres , John Peter Clayton
发明人： Harry Ferres , John Peter Clayton
IPC分类号： C07D499/08 , A61K31/43 , A61K31/431 , A61P31/04 , C07C51/31 , C07D307/88 , C07D317/58 , C07D333/72 , C07D499/00 , C07D499/04 , C07D499/12 , C07D499/32 , C07D499/42 , C07D499/44 , C07D499/62 , C07D499/64 , C07D499/68 , C07D501/04 , C07D501/20 , C07D499/28
CPC分类号： C07D499/00 , C07C51/31 , C07D307/88 , C07D317/58 , C07D333/72 , Y02P20/55
摘要： 3-CROTONOLACTONE 3-BISCROTONO-LACTANE PENICILLINS WHICH POSSESS ANTIBACTERIAL ACTIVITY ARE DISCLOSED.
摘要翻译： 3-CROTONOLACTONE 3-BISCROTONO-LACTANE PENICILLINS，其具有抗菌活性的功能被披露。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式