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1. 发明授权

US10344008B2 Process for the preparation of terpinolene epoxide 有权
公开(公告)号：US10344008B2
公开(公告)日：2019-07-09
申请号：US15571627
申请日：2016-04-28
申请人： BASF AGRO B.V.
发明人： Bernd Wolf , Michael Rack , Stefan Benson , Helmut Kraus , Roland Goetz , Sukunath Narayanan , Chidambaram Rishinaradamangalam
IPC分类号： C07D301/12 , C07C29/17 , C07C29/56 , C07C35/18 , C07D303/04 , C07D493/08
摘要： The present invention relates to a process for the preparation of terpinolene epoxide by epoxidation of terpinolene.

2. 发明授权

US10266468B2 Process for preparing a mixture of terpene alcohols 有权
公开(公告)号：US10266468B2
公开(公告)日：2019-04-23
申请号：US16079152
申请日：2017-02-16
申请人： BASF Agro B.V.
发明人： Bernd Wolf , Michael Rack , Stefan Benson , Roland Goetz , Helmut Kraus
IPC分类号： C07C35/18 , C07C29/17 , C07C303/04 , C07C29/132 , C07C29/56 , B01J25/02
摘要： The present invention relates to a process for preparing a mixture of terpene alcohols comprising limonene-4-ol and terpinene-4-ol from terpinolene epoxide via an isomerization and/or hydrogenation reaction in the presence of a copper catalyst.

3. 发明授权

US09512059B2 Killing of bed bugs 有权
标题翻译：杀死臭虫
公开(公告)号：US09512059B2
公开(公告)日：2016-12-06
申请号：US14391305
申请日：2013-04-30
申请人： BEDOUKIAN RESEARCH, INC.
发明人： Robert H. Bedoukian
IPC分类号： C07C69/00 , C07C69/533 , A01N35/06 , A01N31/06 , A01N37/02 , A01N35/02 , C07C35/18 , C07C49/543
CPC分类号： C07C69/533 , A01N31/06 , A01N35/02 , A01N35/06 , A01N37/02 , C07C35/18 , C07C49/543
摘要： Killing of bed bugs is accomplished by bringing the bed bugs into contact with a toxic amount of at least one of the compounds of the structure (I) wherein X is —OH, ═O, or —O(O)CR, wherein R is selected from H and a branched or straight chain, saturated or unsaturated hydrocarbyl group with zero to three double bonds and from 1 to 11 carbon atoms; R1 is H or CH3; R2 is H or CH3; R3 is H or a branched or straight chain, saturated or unsaturated hydrocarbyl group with zero to three double bonds and from 1 to 11 carbon atoms; and wherein the compounds of structure (I) contain from 6 to 20 total carbon atoms in the compounds.

4. 发明授权

US08686052B2 Targeting agent for cancer cell or cancer-associated fibroblast 有权
标题翻译：癌细胞或癌相关成纤维细胞的靶向剂
公开(公告)号：US08686052B2
公开(公告)日：2014-04-01
申请号：US12450571
申请日：2008-03-28
申请人： Yoshiro Niitsu , Rishu Takimoto
发明人： Yoshiro Niitsu , Rishu Takimoto
IPC分类号： A01N31/04 , A61K31/07 , C12N15/11 , C07C35/18 , A61K9/127 , A61K48/00 , C12N15/113
CPC分类号： A61K47/10 , A61K9/0019 , A61K9/127 , A61K31/07 , A61K31/704 , A61K31/713 , A61K47/6911 , A61K48/00 , A61K48/005 , A61K2300/00 , C12N15/113 , C12N15/88 , C12N2310/14 , C12N2320/32 , C12N2799/04 , C12N2810/10
摘要： Disclosed are a novel therapeutic agent and a novel treatment method for cancer. Specifically disclosed are: a targeting agent for a cell selected from the group consisting of a cancer cell and a cancer-associated fibroblast, which comprises a retinoid; a substance delivery carrier for the cell, which comprises the targeting agent; an anti-cancer composition utilizing the targeting agent or the carrier; an anti cancer-associated fibroblast composition; and a method for treatment of cancer.
摘要翻译：公开了一种新型治疗剂和一种新型的癌症治疗方法。具体公开的是：选自癌细胞和癌相关成纤维细胞的细胞的靶向剂，其包含类视色素; 用于细胞的物质递送载体，其包含靶向剂; 使用靶向剂或载体的抗癌组合物; 抗癌相关成纤维细胞组合物; 和癌症治疗方法。

5. 发明申请

US20110124924A1 Cyclopropanation Process 有权
标题翻译：环丙烷化方法
公开(公告)号：US20110124924A1
公开(公告)日：2011-05-26
申请号：US12673901
申请日：2008-08-19
申请人： Fridtjof Schroder
发明人： Fridtjof Schroder
IPC分类号： C07C35/18 , C07C35/20 , C07C29/36 , C07C35/04 , C07C35/23 , C07C35/44
CPC分类号： C07C27/00 , A23L27/203 , C07C29/44 , C07C31/1333 , C07C31/137 , C07C35/27 , C07C35/37 , C07C2601/02 , C07C2601/08 , C07C2601/10 , C07C2602/18 , C07C2602/20 , C07C2602/50 , C07C2603/64 , C07C2603/94 , C07C2603/96 , C11B9/003 , C11B9/0042 , C11B9/0049 , C11B9/0057 , C11B9/0061 , C07C33/12 , C07C33/05 , C07C31/13 , C07C35/28 , C07C33/34 , C07C35/23
摘要： A method for the preparation of cyclopropyl carbinols by cyclopropanation of unsaturated alcoholates, utilising a reagent system selected from (A) magnesium metal and dibromomethane, and (B) dibromomethane and a tertiary Grignard reagent, the reaction being carried out in the presence of an ether solvent.The process is useful, for example, for the preparation of ingredients for the flavour and fragrance industry.
摘要翻译：通过使用选自（A）镁金属和二溴甲烷的试剂系统和（B）二溴甲烷和叔格氏试剂，通过不饱和醇的环丙烷化制备环丙基甲醇的方法，该反应在醚的存在下进行溶剂。该方法例如用于制备风味和香料工业的成分是有用的。

6. 发明授权

US07902393B2 Process for the preparation of β-santalol and derivatives thereof 有权
标题翻译： - 制备檀香醇及其衍生物的方法
公开(公告)号：US07902393B2
公开(公告)日：2011-03-08
申请号：US12936325
申请日：2009-05-18
申请人： Charles Fehr , Magali Vuagnoux
发明人： Charles Fehr , Magali Vuagnoux
IPC分类号： C07F7/08 , C07F7/04 , C07C47/00 , C07C45/00 , C07C35/18
CPC分类号： C07C33/14 , C07B2200/07 , C07C29/147 , C07C29/38 , C07C45/30 , C07C45/512 , C07C45/62 , C07C45/68 , C07C45/74 , C07C45/75 , C07C67/00 , C07C67/283 , C07C67/343 , C07C2602/42 , C07C47/225 , C07C49/433 , C07C49/653 , C07C69/007 , C07C69/608 , C07C69/145
摘要： The present invention concerns a process for the preparation of a compound of formula (I) wherein R represents a Me or Et group, as well said compound in the form of any one of its stereoisomers or mixture thereof. The invention concerns also the use of compound (I) for the synthesis of β-santalol or of derivatives thereof.
摘要翻译：本发明涉及一种制备式（I）化合物的方法，其中R代表Me或Et基团，以及所述其立体异构体或其混合物形式的所述化合物。本发明还涉及化合物（I）用于合成檀香醇或其衍生物的用途。

7. 发明授权

US07884252B1 Process for making trans-isocarveol 有权
标题翻译：制备反异构体的方法
公开(公告)号：US07884252B1
公开(公告)日：2011-02-08
申请号：US12799119
申请日：2010-04-19
申请人： Gennadiy G. Kolomeyer , Douglas A. Ferone
发明人： Gennadiy G. Kolomeyer , Douglas A. Ferone
IPC分类号： C07C35/18
CPC分类号： C07C29/56 , C07B2200/07 , C07C2601/14 , C07C35/17
摘要： A process for making trans-isocarveol, an intermediate useful in the manufacture of perillyl alcohol, is disclosed. The process comprises isomerizing a mixture comprising cis-limonene oxide (cis-LMO) and trans-limonene oxide (trans-LMO) in the presence of a phenolic modifier and a chromium catalyst. The process is performed at a temperature less than 220° C. to convert more than 50% of the cis-LMO to trans-isocarveol and less than 50% of the trans-LMO to cis-isocarveol. We surprisingly found that a mixture of cis- and trans-LMO can be selectively isomerized to produce mostly trans-isocarveol, which we discovered is the preferred isomer for making perillyl alcohol by direct isomerization.
摘要翻译：公开了制备反式 - 异环素的方法，其是可用于制备香叶醇的中间体。该方法包括在酚类改性剂和铬催化剂存在下异构化包含顺式柠檬烯氧化物（顺式 - LMO）和反式柠檬烯氧化物（反式 - LMO）的混合物。该方法在低于220℃的温度下进行，以将超过50％的顺式 - 改性活生物体转化成反式异环素和小于50％的反式LMO转化成顺式 - 异环素。我们惊奇地发现，可以选择性地将顺反异构体和反式LMO的混合物异构化以产生大多数反式异环素，我们发现它是通过直接异构化制备紫苏醇的优选异构体。

8. 发明申请

US20090324570A1 Photostabilization of Retinoids with Alkoxycrylene Compounds 有权
标题翻译：类视黄醇与烷氧基化合物的光稳定化
公开(公告)号：US20090324570A1
公开(公告)日：2009-12-31
申请号：US12533598
申请日：2009-07-31
申请人： Craig A. Bonda , Anna Pavlovic , Jean Zhang
发明人： Craig A. Bonda , Anna Pavlovic , Jean Zhang
IPC分类号： A61K31/07 , C07C35/18 , C07C47/225 , C07C57/02 , C07C69/73 , C07C59/64 , C07C63/36 , C07D409/06 , A61K31/192 , A61K31/4365 , A61K31/216 , A61K31/11 , A61P17/00 , A61K31/122
CPC分类号： A61Q19/08 , A61K8/361 , A61K8/368 , A61K8/37 , A61K8/40 , A61K8/49 , A61K8/671 , A61K2800/52 , A61Q17/04 , A61Q19/00
摘要： The photostabilizing electronic excited state energy—particularly singlet state energy from retinoid compounds—has been found to be readily transferred to (accepted by) α-cyanodiphenylacrylate compounds having an alkoxy radical in the four (para) position (hereinafter “alkoxycrylenes”) on one of the phenyl rings having the formula (I): wherein one of R1 and R2 is a straight or branched chain C1-C30 alkoxy radical, preferably C1-C8, more preferably methoxy, and the non-alkoxy radical R1 or R2 is hydrogen; and R3 is a straight or branched chain C1-C30 alkyl radical, preferably C2-C20. The alkoxycrylene compounds of formula (I) significantly increase the photostability of retinoid compounds in a composition by at least 3-fold and as much as 10-fold or greater. The ability of the alkoxycrylene compounds to stabilize the retinoid compound is concentration dependent, with the amount of retinoid photostabilization increasing with the concentration of the alkoxycrylene compound.
摘要翻译：已经发现光稳定化的电子激发态能量 - 特别是来自类视黄醇化合物的单态能量 - 已经被发现容易地转移到（接受）在四（对）位置具有烷氧基的α-氰基二苯基丙烯酸酯化合物（以下称为“烷氧基烯”）的具有式（I）的苯环：其中R 1和R 2中的一个是直链或支链C 1 -C 30烷氧基，优选C 1 -C 8，更优选甲氧基，并且非烷氧基R 1或R 2是氢; 并且R 3是直链或支链C 1 -C 30烷基，优选C 2 -C 20。式（I）的烷氧基化亚烷基化合物显着地将组合物中类视色素化合物的光稳定性提高至少3倍和10倍或更高。氧化烯化合物稳定类视黄醇化合物的能力是浓度依赖性的，随着烷氧基化合物浓度的增加，类视黄醇光稳定化的量增加。

9. 发明申请

US20090076285A1 PROCESS FOR THE TREATMENT OF AN AQUEOUS MIXTURE COMPRISING A DIPOLAR APROTIC COMPOUND 有权
标题翻译：用于处理包含DIPOLAR APROTE COMPOUND的水性混合物的方法
公开(公告)号：US20090076285A1
公开(公告)日：2009-03-19
申请号：US12097653
申请日：2006-12-20
申请人： Jochen Stangl
发明人： Jochen Stangl
IPC分类号： C07D207/267 , C07C35/18 , C07C273/16 , C07F9/28 , C07C317/04
CPC分类号： C07C273/189 , B01D15/00 , B01J20/261 , B01J20/267 , B01J20/34 , C07C315/06 , C07F9/22 , C07C275/06 , C07C317/04
摘要： The invention relates to a process for the treatment of an aqueous mixture comprising a dipolar aprotic compound, comprising: a) an adsorption step, in which the aqueous mixture is brought into contact with a porous adsorbent, whereby the porous adsorbent is chosen such that the dipolar aprotic compound adsorbs to it more readily than water; b) a desorption step, in which the porous adsorbent is brought into contact with a desorbing agent, whereby a recovery solution is formed comprising the desorbing agent and the dipolar aprotic compound.
摘要翻译：本发明涉及一种用于处理包含偶极非质子化合物的含水混合物的方法，包括：a）吸附步骤，其中使含水混合物与多孔吸附剂接触，由此选择多孔吸附剂，使得偶极非质子化合物比水更容易吸附; b）解吸步骤，其中使多孔吸附剂与解吸剂接触，由此形成包含解吸剂和偶极非质子性化合物的回收溶液。

10. 发明授权

US07323607B2 Process for preparation of (+)-p-mentha-2,8-diene-1-ol 有权
标题翻译：制备（+） - 对 - 薄荷-2,8-二烯-1-醇的方法
公开(公告)号：US07323607B2
公开(公告)日：2008-01-29
申请号：US10549976
申请日：2004-04-14
申请人： Hong Gu , J. Kendall Killgore , John R. Duchek
发明人： Hong Gu , J. Kendall Killgore , John R. Duchek
IPC分类号： C07C35/18
CPC分类号： C07D295/096 , C07C29/00 , C07C213/04 , C07C291/04 , C07C2601/14 , C07C2601/16 , C07C215/44 , C07C35/18
摘要： A process for preparing (+)-p-mentha-2,8-diene-1-ol comprising reacting (+)-limonene oxide with at least one amine in the presence of at least one Lewis acid to form amine adduct intermediates. The amine adduct is then oxidized to form an N-oxide that is pyrolized to form (+)-p-mentha-2,8-diene-1-ol.
摘要翻译：制备（+） - 对 - 薄荷-2,8-二烯-1-醇的方法包括在至少一种路易斯酸存在下使（+） - 柠檬烯氧化物与至少一种胺反应形成胺加合物中间体。然后将胺加合物氧化形成N-氧化物，其被热解形成（+） - 对 - 薄荷-2,8-二烯-1-醇。

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