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1. 发明授权

US07951608B2 Detecting succinylacetone 有权
标题翻译：检测琥珀酰丙酮
公开(公告)号：US07951608B2
公开(公告)日：2011-05-31
申请号：US11744789
申请日：2007-05-04
申请人： Blas Cerda , Alex Cherkasskiy , Yijun Li
发明人： Blas Cerda , Alex Cherkasskiy , Yijun Li
IPC分类号： G01N1/00 , G01N24/00 , B01L11/00
CPC分类号： G01N33/64 , G01N33/6848 , G01N2800/04 , G01N2800/50 , Y10T436/147777 , Y10T436/200833 , Y10T436/201666 , Y10T436/24 , Y10T436/2525 , Y10T436/25375 , Y10T436/255
摘要： This invention relates, inter alia, to detecting and/or measuring succinylacetone and one or more additional biological analytes using mass spectrometry.
摘要翻译：本发明特别涉及使用质谱法检测和/或测量琥珀酰丙酮和一种或多种另外的生物分析物。

2. 发明授权

US07867452B2 Multi-well filtration device 有权
标题翻译：多孔过滤装置
公开(公告)号：US07867452B2
公开(公告)日：2011-01-11
申请号：US11801661
申请日：2007-05-09
申请人： Remo Anton Hochstrasser , Dieter Voegelin , Urs Schwitter , Pirmin Hidber
发明人： Remo Anton Hochstrasser , Dieter Voegelin , Urs Schwitter , Pirmin Hidber
IPC分类号： B01L11/00
CPC分类号： B01L3/50255 , B01L2300/0681 , B01L2300/0829 , B01L2300/0851 , Y10T436/255
摘要： A multi-well filtration device for filtering a suspension comprises a filtration plate with a filtration chamber and a collecting plate with a collecting well. The filtration chamber is connected to the collecting well and a filter element is arranged between the filtration chamber and the collecting well. A separation layer is arranged between the filtration plate and the collecting plate adjacent to the filter element. The use such of a separation layer allows an easy detachment of the filtration plate from the collecting plate. The detached filtration plate can comfortably be transferred into an analysis device, in which the solid phase of the filtration chamber can separately be analyzed through the separation layer, without any replacement of the solid phase.
摘要翻译：用于过滤悬浮液的多孔过滤装置包括具有过滤室的过滤板和具有收集井的收集板。过滤室连接到收集井，过滤室和收集井之间布置过滤元件。在过滤板和与过滤元件相邻的收集板之间布置有分离层。使用这样的分离层允许过滤板从收集板容易地分离。分离的过滤板可以舒适地转移到分析装置中，其中可以通过分离层分离过滤室的固相，而不需要更换固相。

3. 发明授权

US07842245B2 Fluid handling unit and fluid handling apparatus using same 失效
标题翻译：流体处理单元和使用其的流体处理装置
公开(公告)号：US07842245B2
公开(公告)日：2010-11-30
申请号：US12416425
申请日：2009-04-01
申请人： Satoshi Ikeya , Kyouhei Yamada , Noriyuki Kawahara
发明人： Satoshi Ikeya , Kyouhei Yamada , Noriyuki Kawahara
IPC分类号： B01L11/00 , B01L3/00 , G01N33/00 , C12M1/34 , C12M1/00
CPC分类号： B01L3/50855 , B01L2200/0642 , B01L2200/141 , B01L2300/0854
摘要： A fluid handling unit 16 has an inside cylindrical portion 16c which is arranged in an outside small-diameter cylindrical portion 16b so as to be eccentric with respect to the outside small-diameter cylindrical portion 16b, and a plurality of slits 16d for establishing a communication between an inside fluid housing chamber 30 and an outside fluid housing chamber 28. The most part of liquid in the inside fluid housing chamber 30 enters the outside fluid housing chamber 28, in which the height of the liquid level varies in circumferential directions, when the quantity of the fed liquid is not larger than a predetermined quantity. The liquid in the outside fluid housing chamber 28 enters the inside fluid housing chamber 30 when the quantity of the fed liquid exceeds the predetermined quantity.
摘要翻译：流体处理单元16具有内圆筒部16c，该内圆筒部16c布置在外小径圆筒部16b中，以相对于外小径圆筒部16b偏心;多个狭缝16d，用于建立连通在内部流体容纳室30和外部流体容纳室28之间。内部流体容纳室30中的大部分液体进入外部流体容纳室28，其中液面高度在圆周方向上变化，进料液体的量不大于预定量。当进料液体的量超过预定量时，外部流体容纳室28中的液体进入内部流体容纳室30。

4. 发明授权

US07686907B1 Phase-changing sacrificial materials for manufacture of high-performance polymeric capillary microchips 失效
标题翻译：用于制造高性能聚合物毛细管微芯片的相变牺牲材料
公开(公告)号：US07686907B1
公开(公告)日：2010-03-30
申请号：US11346398
申请日：2006-02-01
申请人： Adam T. Woolley , Ryan T. Kelly , Melissa Draper Fisk
发明人： Adam T. Woolley , Ryan T. Kelly , Melissa Draper Fisk
IPC分类号： B32B17/00 , B32B17/10 , B32B37/00 , G02C7/00 , B29C65/00 , B29C53/82 , G01N21/00 , G01N31/22 , G01N33/00 , G01N15/06 , B01L11/00 , C03C15/00 , C03C25/68 , C03C27/00 , B32B38/04 , C02F1/40 , C02F11/00 , C25B9/00 , C25B11/00 , C25B13/00 , G01N27/00
CPC分类号： B32B38/06 , B01L3/502707 , B01L2200/0689 , B01L2300/0816 , B01L2300/0887 , B29C65/4895 , B29C65/76 , B29C66/0224 , B29C66/0246 , B29C66/026 , B29C66/032 , B29C66/1122 , B29C66/3242 , B29C66/53461 , B29C66/71 , B29C66/73117 , B29K2021/00 , B29K2033/12 , B29K2067/00 , B29K2067/043 , B29K2069/00 , B29K2083/00 , B29L2031/756 , B32B37/0023 , B32B2309/027 , B32B2323/16 , B32B2333/12 , B32B2367/00 , B32B2369/00 , B81B2201/058 , B81C1/00071 , B81C2201/0108 , B81C2203/038 , G01N21/05 , G01N27/44791 , G01N2021/0346 , G01N2021/6439 , B29K2067/003
摘要： A microchip with capillaries and method for making same is described. A sacrificial material fills microchannels formed in a polymeric substrate, the filled microchannels are covered by a top cover to form filed capillaries, and the sacrificial material is removed to form the microcapillaries. The sacrificial material fills the microchannels as a liquid whereupon it becomes solid in the microchannels, and is liquefied after the top cover is applied and affixed to remove the sacrificial material. The top cover may be solvent sealed on the substrate and of the same or different material as the substrate. The top cover may also be an in situ applied semipermeable membrane.
摘要翻译：描述了具有毛细管的微芯片及其制造方法。牺牲材料填充形成在聚合物基材中的微通道，填充的微通道被顶盖覆盖以形成毛细管毛细管，并且去除牺牲材料以形成微毛细管。牺牲材料作为液体填充微通道，随后在微通道中变成固体，并且在施加顶盖并固定以去除牺牲材料之后液化。顶盖可以在基材上和与基材相同或不同的材料上进行溶剂密封。顶盖也可以是原位应用的半透膜。

5. 发明授权

US07678577B2 Blood analysis apparatus and blood analysis method 失效
标题翻译：血液分析仪器及血液分析方法
公开(公告)号：US07678577B2
公开(公告)日：2010-03-16
申请号：US11659599
申请日：2005-08-09
申请人： Yasuhiro Horiike , Akio Oki
发明人： Yasuhiro Horiike , Akio Oki
IPC分类号： G01N9/30 , B01D21/00 , B01D21/26 , B01L3/02 , B01L11/00 , B01L3/00 , B01L9/00 , G01N21/00
CPC分类号： B01L3/502753 , A61B5/150022 , A61B5/150213 , A61B5/150221 , A61B5/150389 , A61B5/150503 , A61B5/15142 , A61B5/15186 , B01L2200/14 , B01L2200/148 , B01L2300/0645 , B01L2300/0816 , B01L2300/0864 , B01L2400/0409 , G01N27/4163 , G01N35/00693 , G01N2035/00495 , Y10T436/111666
摘要： A corpuscle/plasma separating part is disposed at the lower end of the substrate, and a sensor part connected to the corpuscle/plasma separating part is disposed at the upper end of the substrate, with a calibration solution reservoir being disposed on the lower side of the sensor part, and a calibration solution waste reservoir being disposed on the upper side of the sensor part. A first centrifugal axis is located upper to the corpuscle fraction storing part and lower to the plasma fraction storing part of the corpuscle/plasma separating part, while a second centrifugal axis is located within or close to the sensor part. Conveyance and discharge of the calibration solution can be carried out by performing centrifugation around the first centrifugal axis which is distant from the sensor part at a low speed of rotation, so that the centrifugal force exerted on the sensors would be small. During the centrifuge operation at a high speed of rotation for the separation of blood corpuscles, centrifugation can be performed around the second centrifugal axis so that the centrifugal force exerted on the sensors is small. Centrifuge operation allows separation of the blood corpuscles and blood plasma, and conveyance of the blood plasma and the calibration solution, as well as certain discharge of the calibration solution from the sensors, thereby allowing precise analysis. Any damage in the sensors due to strong centrifugal force during the separation of blood corpuscles and blood plasma can be prevented.
摘要翻译：微粒/等离子体分离部设置在基板的下端，并且连接到微粒/等离子体分离部的传感器部分设置在基板的上端，校准溶液储存器设置在基板的下侧传感器部分和校准溶液废液储存器设置在传感器部分的上侧。第一离心轴位于微粒分数存储部的上方，并且位于小体/等离子体分离部的等离子体部分存储部的上方，而第二离心轴位于传感器部内或靠近传感器部。校准溶液的输送和排出可以通过围绕离开传感器部分的低速旋转的第一离心轴进行离心而进行，使得施加在传感器上的离心力将变小。在用于分离血球的高速旋转离心机操作期间，可以围绕第二离心轴进行离心，使得施加在传感器上的离心力小。离心机操作允许血细胞和血浆分离，血浆和校正溶液的输送，以及校准溶液从传感器中的一定排放，从而允许精确的分析。可以防止在分离血液和血浆期间强力离心力导致的传感器损伤。

6. 发明授权

US07678336B2 Channel apparatus for focusing a fluid flow 失效
标题翻译：用于聚焦流体流的通道装置
公开(公告)号：US07678336B2
公开(公告)日：2010-03-16
申请号：US10583724
申请日：2004-12-17
申请人： Jun Keun Chang , Jun Ha Park , Chanil Chung , Jung Kyung Kim
发明人： Jun Keun Chang , Jun Ha Park , Chanil Chung , Jung Kyung Kim
IPC分类号： B01L11/00 , G01N33/48 , G01N33/00 , C12Q1/02
CPC分类号： B01L3/502746 , B01L2200/0636 , B01L2200/0647 , G01N15/1404 , G01N15/1463 , G01N2015/0073 , G01N2015/1413
摘要： Disclosed is a focusing channel device which focuses fluid containing micro particles so that the micro particles flow in a line. The channel device comprises a nozzle formed by left and right walls each of which comprises an inclination surface. The cross sectional area in vertical direction decreases from the entrance of the nozzle toward the exit of the nozzle. The shape of cross sectional view in horizontal direction is asymmetric for the central line in the length direction. Using the focus channel device of the invention, the micro particles in the fluid are not combined with each other and passed through the channel one by one. Thus, blockage of the channel or combination and movement of two particles together does not occur.
摘要翻译：公开了一种聚焦通道装置，其聚焦含有微粒子的流体，使得微粒子流动成一行。通道装置包括由左右壁形成的喷嘴，每个壁包括倾斜表面。垂直方向的横截面积从喷嘴的入口朝向喷嘴的出口减小。水平方向的横截面形状对于长度方向的中心线是不对称的。使用本发明的聚焦通道装置，流体中的微粒子不会彼此结合并逐个通过通道。因此，不会发生通道或组合的堵塞和两个颗粒的移动。

7. 发明申请

US20100055766A1 MICROFLUIDIC CARTRIDGE FOR SEPARATING TARGET MOLECULES, AND SEPARATOR AND METHOD OF SEPARATING TARGET MOLECULES USING SAME 有权
标题翻译：用于分离目标分子的微流控盒，以及分离器和使用相同方法分离目标分子的方法
公开(公告)号：US20100055766A1
公开(公告)日：2010-03-04
申请号：US12389408
申请日：2009-02-20
申请人： Kyuyoun Hwang , Joonho Kim , Byungsoo Kim , Sungyoung Jeong , Christopher Hansung Ko
发明人： Kyuyoun Hwang , Joonho Kim , Byungsoo Kim , Sungyoung Jeong , Christopher Hansung Ko
IPC分类号： C12N1/06 , B01L11/00 , C12M1/00 , G01N1/34 , C12M1/12
CPC分类号： G01N35/00029 , B01L3/502738 , B01L3/502753 , B01L9/527 , B01L2200/027 , B01L2200/0689 , B01L2300/0681 , B01L2300/0816 , B01L2300/0867 , B01L2400/0409 , B01L2400/0677 , G01N2035/00504 , Y10T436/10
摘要： A microfluidic cartridge includes a capture portion capturing target material on surfaces of nonmagnetic particles; and a separating portion separating target molecules from the target material captured on the surfaces of the particles. The microfluidic cartridge is mounted on an adaptor that is rotated by a rotating unit in order to separate a fluid including the target molecules from the particles through centrifugal force.
摘要翻译：微流体盒包括捕获部分，其捕获非磁性颗粒表面上的目标材料; 以及分离部分，其从所述颗粒表面上捕获的靶材分离目标分子。微流体盒安装在由旋转单元旋转的适配器上，以通过离心力将包含目标分子的流体与颗粒分离。

8. 发明授权

US07655187B2 Systems for isolating toxins and collecting eluates for testing for toxins and methods using the same 失效
标题翻译：用于分离毒素和收集洗脱液以测试毒素的系统及使用其的方法
公开(公告)号：US07655187B2
公开(公告)日：2010-02-02
申请号：US11117801
申请日：2005-04-29
申请人： Dennis E. Jackson , Nancy Zabe
发明人： Dennis E. Jackson , Nancy Zabe
IPC分类号： B01L3/02 , B01L11/00 , G01N1/14 , G01N1/00 , G01N30/02
CPC分类号： G01N1/405 , C07K16/14 , G01N33/02 , Y10T436/25
摘要： The present invention provides systems for isolating toxins and collecting an eluate from a sampling column for subsequent testing and to methods of extracting and collecting an eluate using the same systems. Preferably, the systems comprise a sample holder such as an immuno-affinity column for holding the sample and a self-contained fluid delivery system that can deliver liquid, e.g., reagents, and gaseous fluids, e.g., compressed air. More preferably, the fluid control system of the fluid delivery system provides some amount of pressurized gas continuously to the headspace of the column even when a fluid is not being forced through the resin gel in the column.
摘要翻译：本发明提供了用于分离毒素并从采样塔收集洗脱液用于随后测试的系统以及使用相同系统提取和收集洗脱液的方法。优选地，系统包括样品保持器，例如用于保持样品的免疫亲和柱和可以输送液体例如试剂的自给自体的流体输送系统以及例如压缩空气的气态流体。更优选地，流体输送系统的流体控制系统即使当流体不被迫通过塔中的树脂凝胶时，也会连续地向柱的顶部空间提供一定量的加压气体。

9. 发明申请

US20100009459A1 METHOD AND MICROFLUIDIC DEVICE FOR COMBINING REACTION COMPONENTS CONTAINED IN LIQUIDS 审中-公开
标题翻译：用于组合包含在液体中的反应组分的方法和微流体装置
公开(公告)号：US20100009459A1
公开(公告)日：2010-01-14
申请号：US12499960
申请日：2009-07-09
申请人： Stephan HERMINGHAUS
发明人： Stephan HERMINGHAUS
IPC分类号： B01L11/00 , G01N1/10
CPC分类号： B01L3/502715 , B01J19/0046 , B01J2219/00315 , B01J2219/0052 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00599 , B01J2219/00657 , B01J2219/00659 , B01L3/0293 , B01L3/5025 , B01L3/563 , B01L2200/027 , B01L2200/0642 , B01L2300/0819 , B01L2300/089 , B01L2400/022 , B01L2400/0406 , B01L2400/0415 , Y10T436/2575
摘要： The invention relates to a method and a microfluidic device for combining reaction components contained in liquids. The method comprises the steps: application of at least one first liquid filament containing a first reaction component on a first carrier substrate; application of at least one second liquid filament containing a second reaction component on a second carrier substrate; positioning of the two carrier substrates relative to each other at a predetermined distance such that the liquid filaments face each other; and bringing at least one of the at least one first liquid filament into contact with at least one of the at least one second liquid filament by creating at least one connecting point of the respective first and second liquid filaments. A microfluidic device for combining reaction components contained in liquids comprises two carrier substrates each being adapted for accommodating at least one first and at least one second liquid filament, wherein the liquid filaments are preferably each accommodated in a receiving means which is comprised in the carrier substrate.
摘要翻译：本发明涉及用于组合包含在液体中的反应组分的方法和微流体装置。该方法包括以下步骤：在第一载体衬底上施加含有第一反应组分的至少一个第一液体细丝; 在第二载体基底上施加含有第二反应组分的至少一个第二液体丝; 两个载体基板相对于彼此以预定距离定位，使得液体细丝彼此面对; 以及通过产生相应的第一和第二液体长丝的至少一个连接点，使所述至少一个第一液体细丝中的至少一个与所述至少一个第二液体长丝中的至少一个接触。用于组合包含在液体中的反应组分的微流体装置包括两个载体基底，每个载体基底适于容纳至少一个第一和至少一个第二液体细丝，其中液体丝优选地容纳在包含在载体基底中的接收装置。

10. 发明授权

US07618591B2 Specimen sample collection device and test system 有权
标题翻译：样品采集装置和试验系统
公开(公告)号：US07618591B2
公开(公告)日：2009-11-17
申请号：US11045180
申请日：2005-01-27
申请人： Paul D. Slowey , Richard Herrig , James Wickstead , John Ennis , Paul Smith , Keith Seritella
发明人： Paul D. Slowey , Richard Herrig , James Wickstead , John Ennis , Paul Smith , Keith Seritella
IPC分类号： B01L3/00 , B01L11/00 , B01L3/02 , G01N33/53
CPC分类号： A61B10/02 , A61B10/0051 , A61B2010/0003 , B01L3/5029 , B01L2300/027
摘要： A specimen sample collection device includes a handle having a sufficiency indicator and an absorbent pad partially contained within said handle. A specimen sample collection device and test system includes a handle having a sufficiency indicator, an absorbent pad partially contained within said handle, a pad compression tube insertable over said absorbent pad within said handle and around an end of said handle, and a collection tube having one or more sample chambers, attachable to said pad compression tube, and wherein said compression tube defines one or more chambers, and wherein when said collection tube is attached to said pad compression tube, the chambers are in fluid communication with said pad compression tube. A specimen sample collection device including a sufficiency indicator made up of a light pipe indicator window. A specimen sample collection device including an absorbent pad split and divided into two lengths connected at a base. A specimen sample collection device including a bar code identification. A specimen sample collection device and test system including a lock and key securing mechanism. A specimen sample collection device including a handle one or more analyte test strips. A specimen sample collection device and test system including a reader.
摘要翻译：样本采集装置包括具有足够指示器的手柄和部分地包含在所述手柄内的吸收垫。样本采集装置和测试系统包括具有足够指示器的手柄，部分地包含在所述手柄内的吸收垫，可插入所述手柄内的所述吸收垫上并围绕所述手柄的端部的垫压缩管，以及收集管，一个或多个样品室，可附接到所述垫压缩管，并且其中所述压缩管限定一个或多个室，并且其中当所述收集管附接到所述垫压缩管时，所述室与所述垫压缩管流体连通。一种样本采集装置，包括由光管指示器窗口组成的足够指示器。一种标本样品收集装置，包括分开并分成在基部连接的两个长度的吸收垫。包括条形码识别的样本采集装置。标本采集装置和测试系统，包括锁和钥匙固定机构。包括手柄的一个或多个分析物测试条的样本采集装置。标本样本收集装置和包括阅读器的测试系统。

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