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1. 发明授权

US10391104B2 Application of antidepressant compound in preparation of antidepressant drugs and antidepressant health-care foods 有权
公开(公告)号：US10391104B2
公开(公告)日：2019-08-27
申请号：US15579608
申请日：2016-06-08
申请人： ZHEJIANG ACADEMY OF MEDICAL SCIENCES
发明人： Yiping Ye , Xiaoyu Li , Yewei Yang , Zhengrong Zhao , Fengyang Chen , Shifang Xu , Wenhai Huang
IPC分类号： A61K31/569 , A61P25/24 , A61K9/00 , A61K9/20 , A61K9/48 , A61K9/08 , A61K9/14 , A61K31/58 , A61K45/06 , A61K36/24 , A61K36/27
摘要： The present invention discloses an application of an antidepressant compound in preparation of antidepressant drugs and antidepressant health-care foods, where the antidepressant compound has a structure represented by formula I. The antidepressant compound serves as the only active ingredient or one of active ingredients of antidepressant health-care foods. The antidepressant drug is a liquid preparation, a solid preparation, a spray, an aerosol, or the like. The antidepressant compound according to the present invention is applied in preparation of antidepressant drugs and antidepressant health-care foods, and has a chemical structure different from those of existing antidepressant drugs. The anti-depressant compound has significant antidepressant activities without obvious toxic and side effects, contributes to large-scale promotion and use on the market, and has broad application prospects.

2. 发明授权

US10278966B2 Method of isolating quaternary phenanthroindolizidine alkaloids with G-quaduplex DNA binding activity from Tylophra atrofolliculata, compositions comprising them and their medical use 有权
公开(公告)号：US10278966B2
公开(公告)日：2019-05-07
申请号：US15142407
申请日：2016-04-29
申请人： Macau University of Science and Technology
发明人： Zhi-Hong Jiang , Jing-Rong Wang , Cheng-Yu Chen , Guo-Yuan Zhu
IPC分类号： A61K31/4745 , A61K36/27
摘要： A method of isolating at least one phenanthroindolizidine alkaloid, in particular with telomerase inhibitory activity, from Tylophora atrofolliculata is used to isolate and obtain for example about six to eight phenanthroindolizidine alkaloids, including at least four new phenanthroindolizidine alkaloids which have not been previously isolated. Experimental tests confirmed an exceptional telomerase inhibitory activity of the phenanthroindolizidine alkaloids isolated. A pharmaceutical composition includes at least one phenanthroindolizidine alkaloid and at least one pharmaceutical tolerable excipient. Still further, a method of treating a subject suffering from cancer includes administering at least one phenanthroindolizidine alkaloid isolated from Tylophora atrofolliculata. Also, a method of treating a subject suffering from cancer includes administering to the subject at least one phenanthroindolizidine alkaloid having certain formula.

3. 发明授权

US09931365B2 Methods for treating neurological disorders using nutrient compositions 有权
公开(公告)号：US09931365B2
公开(公告)日：2018-04-03
申请号：US14598632
申请日：2015-01-16
申请人： Lisa Geng
发明人： Lisa Geng
IPC分类号： A61K36/00 , A61K36/185 , A61K36/27 , A61K36/328 , A61K36/9066 , A61K36/82 , A61K36/54 , A61K36/81 , A23L27/10 , A23L27/12 , A23L33/105 , A23L33/00 , A23L33/12
CPC分类号： A61K36/185 , A23L27/10 , A23L27/12 , A23L33/105 , A23L33/12 , A23L33/30 , A23V2002/00 , A61K36/27 , A61K36/328 , A61K36/54 , A61K36/81 , A61K36/82 , A61K36/9066 , A61K2300/00 , A23V2200/322 , A23V2250/21
摘要： Nutrient compositions comprising botanical extracts and an omega 3 fatty acid as well as methods of their use for treating, inter alia, autism or apraxia and/or ameliorating one or more symptoms thereof are disclosed. The use of such compositions for enhancing cognitive function and/or one or more aspects thereof, or for treating stroke or seizures and/or ameliorating one or more symptoms thereof are also disclosed.

4. 发明授权

US09283253B2 Metallo-lactoferrin-coenzyme compositions for detoxification support 有权
标题翻译：金属 - 乳铁蛋白 - 辅酶组合物用于解毒支持
公开(公告)号：US09283253B2
公开(公告)日：2016-03-15
申请号：US13932520
申请日：2013-07-01
申请人： Naidu LP
发明人： A. Satyanarayan Naidu , A.G. Tezus Naidu , A.G. Sreus Naidu
IPC分类号： A61K38/40 , A61K38/43 , A61K35/744 , A61K35/745 , A23L1/03 , A23L1/29 , A23L1/30 , A23L1/302 , A23L1/304 , A23L1/305 , A23L1/308 , A61K9/00 , A61K9/16 , A61K31/715 , A61K31/718 , A61K31/737 , A61K36/185 , A61K36/27 , A61K36/48 , A61K36/54 , A61K36/55 , A61K36/68 , A61K38/44 , A61K38/47 , A61K45/06 , A61K35/747
CPC分类号： A61K35/745 , A23L29/06 , A23L33/105 , A23L33/115 , A23L33/135 , A23L33/15 , A23L33/16 , A23L33/17 , A23L33/175 , A23L33/19 , A23L33/21 , A23L33/30 , A23V2002/00 , A61K9/0095 , A61K9/1617 , A61K31/715 , A61K31/718 , A61K31/737 , A61K35/747 , A61K36/185 , A61K36/27 , A61K36/48 , A61K36/54 , A61K36/55 , A61K36/68 , A61K38/40 , A61K38/44 , A61K38/446 , A61K38/47 , A61K45/06 , A61K2300/00 , A23V2200/30 , A23V2200/332 , A23V2250/54248
摘要： Formulations are provided for detoxification support. The formulations generally include a trigger complex, an elemental complex and a coenzyme-vitamin B complex. The trigger complex is high in fiber such as glucomannan and includes Metallo-Lactoferrin protein in an alkaline buffer system. The elemental complex includes one or more trace element as a suitable salt. The coenzyme-vitamin B complex includes one or more coenzyme, coenzyme precursor and/or B-vitamin. The compositions may optionally include additional components such as Lactic Acid bacteria, L-theanine, cranberry root extract, tumeric root extract, inulin and blond psyllium. The compositions can be administered orally in a variety of forms.
摘要翻译：为排毒支持提供配方。制剂通常包括触发复合物，元素复合物和辅酶维生素B复合物。触发复合物在纤维如葡甘露聚糖中是高的，并且在碱性缓冲系统中包括金属 - 乳铁蛋白。元素络合物包括一种或多种作为合适盐的微量元素。辅酶维生素B复合物包括一种或多种辅酶，辅酶前体和/或β-维生素。组合物可以任选地包括另外的组分，例如乳酸菌，L-茶氨酸，蔓越莓根提取物，肿瘤根提取物，菊粉和金发车前草。组合物可以各种形式口服给药。

5. 发明申请

US20150017268A1 METHODS FOR IMPROVING MILK LETTING DOWN IN MILCH ANIMALS 审中-公开
标题翻译：用于改善哺乳动物下降的方法
公开(公告)号：US20150017268A1
公开(公告)日：2015-01-15
申请号：US14498842
申请日：2014-09-26
申请人： Prashant Neminath Patil
发明人： Prashant Neminath Patil
IPC分类号： A61K36/81 , A61K36/185 , A61K36/27 , A61K36/31 , A61K36/39 , A61K36/88 , A61K36/235
CPC分类号： A61K36/81 , A23K10/30 , A23K20/10 , A23K20/20 , A23K20/30 , A23K50/10 , A61K36/185 , A61K36/235 , A61K36/24 , A61K36/27 , A61K36/31 , A61K36/39 , A61K36/88
摘要： The invention concerns herbal compositions which improve lactation of farmed livestock comprising an effective amount of an extract and/or at least one bioactive fraction or powder from herbs such as Asparagus, Gossypium, Foeniculum, Lepidium, Chlorophytum, Ipomoea, Withania, Leptadenia and optionally dicalcium phosphate, chelated minerals and/or mineral mixture.
摘要翻译：本发明涉及改善养殖牲畜哺乳的草药组合物，其包括有效量的提取物和/或至少一种生物活性成分或来自草药如芦笋，棉花，茯苓，韭菜，Chlorophytum，薯ea汁，无毒，嗜酸芽孢杆菌和任选的二钙磷酸盐，螯合矿物质和/或矿物质混合物。

6. 发明申请

US20130330428A1 METHODS FOR TREATING NEUROLOGICAL DISORDERS USING NUTRIENT COMPOSITIONS 有权
标题翻译：使用营养组合物治疗神经病的方法
公开(公告)号：US20130330428A1
公开(公告)日：2013-12-12
申请号：US13876108
申请日：2011-09-28
申请人： Lisa Geng
发明人： Lisa Geng
IPC分类号： A61K36/9066 , A61K36/185 , A61K36/82 , A61K36/27 , A61K36/328
CPC分类号： A61K36/9066 , A23L33/105 , A23L33/115 , A23L33/15 , A23L33/16 , A23L33/175 , A23L33/185 , A23L33/19 , A23V2002/00 , A61K36/185 , A61K36/27 , A61K36/328 , A61K36/47 , A61K36/82 , A61K45/06 , A61K2300/00 , A23V2200/322 , A23V2250/21
摘要： Nutrient compositions comprising botanical extracts and methods of their use for treating, inter alia, autism or apraxia and/or ameliorating one or more symptoms thereof are disclosed. The use of such compositions for enhancing cognitive function and/or one or more aspects thereof, or for treating stroke or seizures and/or ameliorating one or more symptoms thereof are also disclosed.
摘要翻译：公开了包含植物提取物的营养组合物及其用于治疗特别是自闭症或失神经和/或改善其一种或多种症状的方法。还公开了这样的组合物用于增强认知功能和/或其一个或多个方面，或用于治疗中风或癫痫发作和/或改善其一种或多种症状的用途。

7. 发明申请

US20080038389A1 Appetite-Suppressing Compositions And Methods 审中-公开
标题翻译：食欲抑制组合和方法
公开(公告)号：US20080038389A1
公开(公告)日：2008-02-14
申请号：US11848064
申请日：2007-08-30
申请人： Ilya Raskin , Joseph O'Neal
发明人： Ilya Raskin , Joseph O'Neal
IPC分类号： A61K36/27 , A61K31/56 , A61P1/00 , A61K31/7004
CPC分类号： A61K31/56 , A61K36/27
摘要： The invention relates to appetite-suppressing compositions obtained from botanical sources. More specifically, the invention relates to appetite-suppressing compositions comprising an extract product of an Asclepias plant, methods of making an appetite-suppressing composition, and methods of suppressing an appetite.
摘要翻译：本发明涉及从植物来源获得的食欲抑制组合物。更具体地，本发明涉及包含Asclepias植物提取物的食欲抑制组合物，制备食欲抑制组合物的方法和抑制食欲的方法。

8. 发明申请

US20050013887A1 Compositions incorporating (-)-hydroxycitric acid, chromium, and gymnemic acid, and related methods for promoting healthy body weight and improving related health factors 审中-公开
公开(公告)号：US20050013887A1
公开(公告)日：2005-01-20
申请号：US10911791
申请日：2004-08-03
申请人： Debasis Bagchi , Harry Preuss
发明人： Debasis Bagchi , Harry Preuss
IPC分类号： A23L1/30 , A23L1/304 , A61K31/19 , A61K31/194 , A61K31/555 , A61K31/704 , A61K33/24 , A61K36/18 , A61K36/27 , A61K36/38 , A61P3/04 , A61P3/06 , A61K35/78
CPC分类号： A61K31/19 , A23L33/105 , A23L33/165 , A23V2002/00 , A61K31/194 , A61K31/555 , A61K31/704 , A61K33/24 , A61K36/27 , A61K36/38 , A61K2300/00 , A23V2250/21 , A23V2250/1586
摘要： Methods for promoting healthy body weight and improving a variety of related physiological factors, including serum serotonin levels, serum leptin levels, fat oxidation, cholesterol levels, and body mass index, in persons or other mammals, include administering to those persons or other mammals effective amounts of hydroxycitric acid or a combination of hydroxycitric acid, chromium and gymnemic acid, which work synergistically to further to promote healthy body weight and improve these physiological factors.

9. 发明申请

US20050008724A1 Compositions incorporating (-)-hydroxycitric acid, chromium, and gymnemic acid, and related methods for promoting healthy body weight and improving related health factors 审中-公开
标题翻译：包含（ - ） - 羟基柠檬酸，铬和肌氨酸的组合物，以及促进健康体重和改善相关健康因素的相关方法
公开(公告)号：US20050008724A1
公开(公告)日：2005-01-13
申请号：US10911173
申请日：2004-08-03
申请人： Debasis Bagchi , Harry Preuss
发明人： Debasis Bagchi , Harry Preuss
IPC分类号： A23L1/30 , A23L1/304 , A61K31/19 , A61K31/194 , A61K31/555 , A61K31/704 , A61K33/24 , A61K36/18 , A61K36/27 , A61K36/38 , A61P3/04 , A61P3/06 , A61K35/78
CPC分类号： A61K31/19 , A23L33/105 , A23L33/165 , A23V2002/00 , A61K31/194 , A61K31/555 , A61K31/704 , A61K33/24 , A61K36/27 , A61K36/38 , A61K2300/00 , A23V2250/21 , A23V2250/1586
摘要： Methods for promoting healthy body weight and improving a variety of related physiological factors, including serum serotonin levels, serum leptin levels, fat oxidation, cholesterol levels, and body mass index, in persons or other mammals, include administering to those persons or other mammals effective amounts of hydroxycitric acid or a combination of hydroxycitric acid, chromium and gymnemic acid, which work synergistically to further to promote healthy body weight and improve these physiological factors.
摘要翻译：在人或其他哺乳动物中促进健康体重和改善各种相关生理因素（包括血清5-羟色胺水平，血清瘦素水平，脂肪氧化，胆固醇水平和体重指数）的方法包括对这些人或其他哺乳动物施用有效羟基柠檬酸或羟基柠檬酸，铬和肉桂酸的组合，其协同作用进一步促进健康体重并改善这些生理因素。

10. 发明授权

US06841174B2 Herbal compositions and treatment methods 失效
标题翻译：草药成分及治疗方法
公开(公告)号：US06841174B2
公开(公告)日：2005-01-11
申请号：US09955877
申请日：2001-09-19
申请人： Said I. A. Shalaby , Essam M. A. Hob Allah
发明人： Said I. A. Shalaby , Essam M. A. Hob Allah
IPC分类号： A61K36/23 , A61K36/27 , A61K36/28 , A61K36/51 , A61K36/708 , A61K36/71 , A61K36/899 , A61K35/78
CPC分类号： A61K36/28 , A61K36/23 , A61K36/27 , A61K36/51 , A61K36/708 , A61K36/71 , A61K36/899 , A61K2300/00
摘要： The invention provides herbal compositions with antiviral properties comprising extracts of Foeniculum vulgare, Nigella sativa, Centaurium erythrae (spicatum or pulchellum), Cynara cardunculus var scolymus, Inula helenium (viscosa), Solenostema argel, Sesbania aegyptiaca (sesban), Cichorium intybus (pumilum), Cymbopogon proximus, Hemidesmus indicus, Rheum officinale, Cuminum cyminum, and combinations thereof. The invention further provides herbal compositions with antiviral properties comprising an extract from the leaves or seed of Sesbania aegyptiaca (sesban) and at least one additional herbal extract selected from the group consisting of seed of Nigella sativa, shoot of Cichorium intybus (pumilum), whole plant of Cymbopogon proximus, rhizome of Hemidesmus indicus, leaves of Solenostema argel, rhizome of Rheum officinale, and fruit of Ecballium elaterium. The present invention also provides methods for treating a subject with a viral infection, particularly infections with hepatitis B virus or hepatitis C virus. The methods comprise administering to a subject an effective amount of a herbal composition selected from among the herbal compositions of the invention.
摘要翻译：本发明提供了具有抗病毒性质的草药组合物，其包含茯苓，黑头翁，蜈蚣（Spicatum或pulchellum），Cynara cardunculus var scolymus，Inula helenium（viscosa），Solenostema argel，Sesbania aegyptiaca（sesbania aegyptiaca（sesban）），Cichorium intybus（pumilum），Cymbopogon近端，Hemidesmus indicus，Rheum officinale，Cuminum cyumum及其组合。本发明进一步提供具有抗病毒性质的草药组合物，其包含来自伊斯巴尼亚（Sesbania）的叶子或种子的提取物和至少一种额外的草本提取物，其选自以下的一种草本提取物，所述草药提取物选自Nigella sativa种子，Cichorium intybus（pumilum）仙人掌近缘植物，黑茅根茎，Solenostema argel叶，Rheum officinale根，Ecballium elaterium果实。本发明还提供了用病毒感染，特别是乙型肝炎病毒或丙型肝炎病毒感染治疗受试者的方法。所述方法包括向受试者施用有效量的选自本发明的草药组合物的草药组合物。

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