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1. 发明授权

US12016956B2 Annelid haemoglobin lyophilisation process 有权
公开(公告)号：US12016956B2
公开(公告)日：2024-06-25
申请号：US17014445
申请日：2020-09-08
申请人： Hemarina
发明人： Franck Zal , Morgane Rousselot
IPC分类号： A61K9/19 , A61K35/62 , A61K38/17 , A61K38/42 , A61K47/22 , A61K47/26
CPC分类号： A61K9/19 , A61K35/62 , A61K38/1709 , A61K38/1767 , A61K38/42 , A61K47/22 , A61K47/26
摘要： The present invention relates to a lyophilizate comprising at least one globin, one globin protomer or one extracellular hemoglobin of annelids, and a stabilizer chosen from disaccharides, polyols and antioxidants. The present invention also relates to a composition comprising: a solution comprising at least one globin, one globin protomer or one extracellular hemoglobin of annelids, and a stabilizer chosen from disaccharides, polyols and antioxidants.
Finally, the present invention relates to a process for preparing the lyophilizate.

2. 发明公开

US20240139258A1 METHOD FOR PRODUCING THERAPEUTIC AGENT FOR SKIN LESIONS, AND THERAPEUTIC AGENT FOR SKIN LESIONS 审中-公开
公开(公告)号：US20240139258A1
公开(公告)日：2024-05-02
申请号：US18406509
申请日：2024-01-08
申请人： WELL STONE CO.
发明人： Yoichi ISHII , Takeshi OKAMOTO , Sayaka MAKINO
IPC分类号： A61K35/62 , A61K9/12 , A61K35/02 , A61K36/13 , A61P17/02
CPC分类号： A61K35/62 , A61K9/12 , A61K35/02 , A61K36/13 , A61P17/02
摘要： Provided are: a method of producing a therapeutic agent for skin lesions suitable for treatment or prevention of a skin lesion such as a bedsore; and a therapeutic agent for skin lesions produced by the production method. The method of producing a therapeutic agent for skin lesions characterized by including a mixing step of mixing earthworm castings with water and a collecting step of collecting vaporized water generated from a mixture obtained in the mixing step to obtain a liquid; and the therapeutic agent for skin lesions produced by the production method. It is preferred to further mix an organic substance together with the earthworm castings and the water in the mixing step.

3. 发明申请

US20220362307A1 Stenting-Free Pharmaceutical Composition for Treatment of Cardiovascular and Cerebrovascular Disease 有权
公开(公告)号：US20220362307A1
公开(公告)日：2022-11-17
申请号：US17320194
申请日：2021-05-13
申请人： Yueyang Traditional Chinese Medicine Hospital
发明人： Jinchang AI , Wu TANG
IPC分类号： A61K35/62 , A61K36/258 , A61K36/537 , A61K36/236 , A61K36/8988 , A61K36/734 , A61K36/88 , A61K36/28 , A61K36/16 , A61K36/484 , A61P9/10
摘要： The present disclosure provides a traditional Chinese medicine (TCM) composition for the treatment of cardiovascular and cerebrovascular diseases and use thereof, and belongs to the technical field of TCM. The composition for the treatment of cardiovascular and cerebrovascular diseases provided by the present disclosure includes the following raw materials: Radix Panacis Quinquefolii, Pheretima, Radix et Rhizoma Salviae Miltiorrhizae, Hirudo, Rhizoma Ligustici Chuanxiong, Rhizoma Gastrodiae, Fructus Crataegi, Stigma Croci, Herba Erigerontis, Semen Ginkgo, and Radix et Rhizoma Glycyrrhizae. The present disclosure treats the cardiovascular and cerebrovascular diseases through treatment based on syndrome differentiation and overall regulation in TCM; with less side effects, excellent efficacy, and fast acting, the present disclosure can achieve a stenting-free effect on the cardiovascular and cerebrovascular diseases.

4. 发明授权

US11357608B2 Leech therapy device 有权
公开(公告)号：US11357608B2
公开(公告)日：2022-06-14
申请号：US16278095
申请日：2019-02-16
申请人： Eyal Israely
发明人： Eyal Israely
IPC分类号： A61D3/00 , A01K1/06 , A61M1/00 , A61K35/62 , A61M39/02
摘要： A leech therapy device adapted to latch a medicinal leech to a predetermined wound site is provided. The leech therapy device includes a conduit extending between a first end to a second end; an inner diameter of the conduit dimensioned to receive a medicinal leech, the inner diameter being less than twice a girth of the medicinal leech; and a cutout provided in the conduit closer to the first end than the second end; the cutout extending over a surface area between 100 and 150 squared millimeters. Wherein a user places a medicinal leech into the inner diameter, wherein a head of the medicinal leech is adjacent to the cutout, and then the user selectively positions said leech therapy device so that the cutout substantially circumscribed the wound site so that the medicinal leech can engage the wound site.

5. 发明申请

US20220000937A1 METHOD FOR PRODUCING THERAPEUTIC AGENT FOR SKIN LESIONS, AND THERAPEUTIC AGENT FOR SKIN LESIONS 有权
公开(公告)号：US20220000937A1
公开(公告)日：2022-01-06
申请号：US17480327
申请日：2021-09-21
申请人： WELL STONE CO.
发明人： Yoichi ISHII , Takeshi OKAMOTO , Sayaka MAKINO
IPC分类号： A61K35/62 , A61K35/02 , A61P17/02 , A61K9/12 , A61K36/13
摘要： Provided are: a method of producing a therapeutic agent for skin lesions suitable for treatment or prevention of a skin lesion such as a bedsore; and a therapeutic agent for skin lesions produced by the production method. The method of producing a therapeutic agent for skin lesions characterized by including a mixing step of mixing earthworm castings with water and a collecting step of collecting vaporized water generated from a mixture obtained in the mixing step to obtain a liquid; and the therapeutic agent for skin lesions produced by the production method. It is preferred to further mix an organic substance together with the earthworm castings and the water in the mixing step.

6. 发明申请

US20210113471A1 ANNELID HAEMOGLOBIN LYOPHILISATION PROCESS 有权
公开(公告)号：US20210113471A1
公开(公告)日：2021-04-22
申请号：US17014445
申请日：2020-09-08
申请人： Hemarina
发明人： Franck Zal , Morgane Rousselot
IPC分类号： A61K9/19 , A61K38/17 , A61K38/42 , A61K35/62 , A61K47/22 , A61K47/26
摘要： The present invention relates to a lyophilizate comprising at least one globin, one globin protomer or one extracellular hemoglobin of annelids, and a stabilizer chosen from disaccharides, polyols and antioxidants. The present invention also relates to a composition comprising: a solution comprising at least one globin, one globin protomer or one extracellular hemoglobin of annelids, and a stabilizer chosen from disaccharides, polyols and antioxidants.
Finally, the present invention relates to a process for preparing the lyophilizate.

7. 发明申请

US20190365826A1 TAU PROTEIN PRODUCTION ACCELERATOR, AND THERAPEUTIC OR PREVENTIVE AGENT AND THERAPEUTIC OR PREVENTIVE FOOD COMPOSITION FOR DISEASES CAUSED BY TAU PROTEIN DEFICIENCY 审中-公开
公开(公告)号：US20190365826A1
公开(公告)日：2019-12-05
申请号：US16513927
申请日：2019-07-17
申请人： WELL STONE CO.
发明人： Yoichi ISHII , Takayuki NEMOTO , Takeshi OKAMOTO
IPC分类号： A61K35/62 , A23L33/17 , A61K9/19
摘要： An object of the present invention is to provide: a Tau protein production accelerator containing a natural product as an active ingredient; a therapeutic or preventive agent for a disease caused by Tau protein deficiency; and a therapeutic or preventive food composition for a disease caused by Tau protein deficiency. Provided are: a Tau protein production accelerator containing a dry powder ground product and/or extract of an earthworm as an active ingredient; a therapeutic or preventive agent for a disease caused by Tau protein deficiency; and a therapeutic or preventive food composition for a disease caused by Tau protein deficiency. The disease caused by Tau protein deficiency is preferably Alzheimer's disease.

8. 发明申请

US20170348357A1 TAU PROTEIN PRODUCTION ACCELERATOR, AND THERAPEUTIC OR PREVENTIVE AGENT AND THERAPEUTIC OR PREVENTIVE FOOD COMPOSITION FOR DISEASES CAUSED BY TAU PROTEIN DEFICIENCY 审中-公开
公开(公告)号：US20170348357A1
公开(公告)日：2017-12-07
申请号：US15523767
申请日：2015-11-02
申请人： WELL STONE CO.
发明人： Yoichi ISHII , Takayuki NEMOTO , Takeshi OKAMOTO
IPC分类号： A61K35/62 , A23L33/17 , A61K9/19
CPC分类号： A61K35/62 , A23L33/17 , A23V2002/00 , A61K9/19 , A61K2236/15
摘要： An object of the present invention is to provide: a Tau protein production accelerator containing a natural product as an active ingredient; a therapeutic or preventive agent for a disease caused by Tau protein deficiency; and a therapeutic or preventive food composition for a disease caused by Tau protein deficiency. Provided are: a Tau protein production accelerator containing a dry powder, ground product and/or extract of an earthworm as an active ingredient; a therapeutic or preventive agent for a disease caused by Tau protein deficiency; and a therapeutic or preventive food composition for a disease caused by Tau protein deficiency. The disease caused by Tau protein deficiency is preferably Alzheimer's disease.

9. 发明申请

US20170072000A1 Pharmaceutical Compositions for Treating Thermal Injuries and Wounds Combined with Bone Injuries 审中-公开
标题翻译：用于治疗热损伤和伤口结合骨伤的药物组合物
公开(公告)号：US20170072000A1
公开(公告)日：2017-03-16
申请号：US15362674
申请日：2016-11-28
申请人： Kevin Peng Xu
发明人： Rongxiang Xu
IPC分类号： A61K36/756 , A61K36/185 , A61K35/62 , A61K36/718 , A61K36/66 , A61K35/644 , A61K36/539
CPC分类号： A61K36/756 , A61K35/62 , A61K35/644 , A61K36/14 , A61K36/185 , A61K36/53 , A61K36/539 , A61K36/66 , A61K36/718 , A61K2300/00
摘要： The present invention relates to a pharmaceutical composition for treating thermal injuries and wounds combined with bone injuries. More specifically, the present invention relates to a pharmaceutical composition for treating thermal injuries and wounds combined with bone injuries characterized in consisting of 4%-12% beeswax and 88%-96% sesame oil extract containing such raw materials as Radix Scutellariae, Coptis Chinensis, Cortex Phellodendri, Pericarpium Papaveris and Lumbricus by weight based on the total weight of the said composition, wherein the content of Radix Scutellariae, Coptis Chinensis, Cortex Phellodendri, Pericarpium Papaveris or Lumbricus based on their dry weight is respectively 1%-6% of the total weight of the sesame oil. The pharmaceutical composition of the present invention can treat thermal injuries involving human skin, subcutaneous tissues and bones, as well as involving bone wounds, especially open fractures, deep thermal injuries combined with bone injuries, and deep thermal injuries combined with bone necrosis caused by trauma, such as deep burns combined with bone injuries or bone necrosis.
摘要翻译：本发明涉及一种用于治疗热损伤和与骨损伤相结合的伤口的药物组合物。更具体地说，本发明涉及一种用于治疗热损伤和与骨损伤相结合的伤口的药物组合物，其特征在于包含4％-12％的蜂蜡和88％-96％的芝麻油提取物，其含有黄芩，黄连，皮质黄柏，皮皮罂粟，罂粟皮和重量百分比为基础，其中根据其干重，黄芩，黄连，皮质黄柏，罂粟皮，罂粟或含量分别为1％〜6％芝麻油的总重量。本发明的药物组合物可以治疗涉及人皮肤，皮下组织和骨骼的热损伤，以及涉及骨创伤，特别是开放性骨折，结合骨损伤的深部热损伤，以及与创伤引起的骨坏死相结合的深部热损伤，如深部烧伤与骨损伤或骨坏死相结合。

10. 发明授权

US09511098B2 Method for producing dry earthworm powder 有权
标题翻译：干蚯蚓粉生产方法
公开(公告)号：US09511098B2
公开(公告)日：2016-12-06
申请号：US13519346
申请日：2011-10-05
申请人： Kazuyuki Ishii
发明人： Kazuyuki Ishii
IPC分类号： A61K35/24 , A61K35/37 , A61K35/12 , A61K35/62
CPC分类号： A61K35/62
摘要： A method for producing dry earthworm powder, by which dry earthworm powder having high-titer enzymes can be produced while removing toxic substances contained in the bodies of earthworms, is provided. The method comprises: contacting a live earthworm with a chloride(s) of at least one metal selected from the group consisting of potassium, sodium, magnesium and calcium; and subsequently contacting the live earthworm with powder of a hydroxycarboxylic acid(s) and diluting the resulting mixture with water to adjust pH to 2 to 5, followed by leaving the live earthworm to stand for 3 to 180 minutes, washing the live earthworm with water, grinding the washed live earthworm and freeze-drying the obtained ground product.

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