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1. 发明申请

US20200297384A1 APPARATUS AND METHOD FOR EVERTING CATHETER FOR EMBRYO TRANSFER USING TRANSVAGINAL ULTRASOUND 审中-公开
公开(公告)号：US20200297384A1
公开(公告)日：2020-09-24
申请号：US16898090
申请日：2020-06-10
申请人： CrossBay Medical, Inc.
发明人： Steven R. BACICH , Matthew Thomas YUREK , Cristiano Danilo Maria FONTANA , Piush VIDYARTHI
IPC分类号： A61B17/425 , A61B17/43 , A61B17/435 , A61M25/01
摘要： Everting balloon systems and methods for using the same with an alignment element for stability and anti-rotation of the everting balloon are disclosed herein. The systems can be configured to access and deliver instruments, media, or other catheters into bodily lumens and cavities. The alignment element can eliminate the potential for the everting membrane to become twisted or rotated which could impact access or the ability of the system to deliver materials. A compliance member can facilitate internal pressurization of the everting catheter system. An everting catheter system can be configured for use with transvaginal ultrasound and a lower profile speculum is described.

2. 发明授权

US10438686B2 Methods and systems for assessment of clinical infertility 有权
公开(公告)号：US10438686B2
公开(公告)日：2019-10-08
申请号：US15242215
申请日：2016-08-19
申请人： The Board of Trustees of the Leland Stanford Junior University
发明人： Mylene W. M. Yao , Wing H. Wong
IPC分类号： G16B5/00 , A61B17/425 , G16B25/00 , G16B40/00 , C12Q1/6809 , C12Q1/6883 , G06F19/00 , G16H10/60 , G16B20/00
摘要： Methods and computer-based systems for facilitating assessment of clinical infertility are provided. The methods and systems can be implemented to, for example, facilitate assessment of a subject for an in vitro fertilization treatment cycle, including determining probability of a live birth event. The methods and systems can be implemented to, for example, facilitate a determination of success implantation of embryos, selection of an optimal number of embryos to transfer, and determination of success in subsequent in vitro fertilization treatment cycles following an unsuccessful treatment cycle.

3. 发明授权

US10159510B2 Intravaginal fertility device 有权
公开(公告)号：US10159510B2
公开(公告)日：2018-12-25
申请号：US15210252
申请日：2016-07-14
申请人： Truth in Design, Inc.
发明人： Sherman Souther , Hamilton Souther
IPC分类号： A61B17/425 , A61B17/43
摘要： A device and method for improving fertility among couples after intercourse is disclosed. The device and method uses an intravaginal device that collects ejaculate from the vaginal canal after intercourse and presents it to the os of the cervix. The device also serves to contain ejaculate near the cervical os to increase the chances of successful fertilization.

4. 发明申请

US20170166882A1 METHOD FOR MOBILIZING IMMOBILIZED CELLS 审中-公开
公开(公告)号：US20170166882A1
公开(公告)日：2017-06-15
申请号：US15115380
申请日：2015-01-28
申请人： LEIBNIZ-INSTITUT FUER FESTKOERPER-UND WERKSTOFFFORSCHUNG DRESDEN E.V.
发明人： Oliver G. SCHMIDT
IPC分类号： C12N11/14 , A61K41/00 , A61B17/425 , C12N5/076
CPC分类号： C12N11/14 , A61B17/425 , A61K41/00 , C12N5/061 , C12N5/0612
摘要： The invention concerns the fields of microtechnologies, biology and medicine and relates to a method for producing mobility in immobile cells as can be used, for example, for in vivo or in vitro fertilization.The object of the present invention is to specify a method for producing mobility in individual immobile cells, with which method activity and guided mobility in previously immobile cells can be achieved.The object is attained with a method for producing mobility in immobile cells in which an immobile cell is connected to a microstructure, .wherein the microstructure is composed at least partially of magnetic materials and a non-reciprocal movement of the microstructure with the immobile cell is executed by means of a time-varying, three-dimensional external magnetic field.

5. 发明授权

US09348972B2 Method of assessing risk of multiple births in infertility treatments 有权
标题翻译：不孕症治疗多发胎儿风险的方法
公开(公告)号：US09348972B2
公开(公告)日：2016-05-24
申请号：US13182360
申请日：2011-07-13
申请人： Mylene Yao
发明人： Mylene Yao
IPC分类号： A61B17/425 , A61B17/435 , A61D19/04 , G06F19/00
CPC分类号： G06F19/3431 , A61B17/425 , A61B17/435 , A61D19/04 , G06F19/00 , G16H50/30 , G16H50/50
摘要： Provided is a multiple birth prognostic tool that is used to analyze data in order to predict a multiple birth event in a female human patient undergoing an infertility treatment. The MBP prognostic tool may also be used to enhance the accuracy of diagnostic or prognostic tests that predict embryo viability. The MBP prognostic tool of the present invention may be clinic specific or it may be modified to be used in a multi-clinic approach.
摘要翻译：提供了一种多发生预后工具，用于分析数据，以预测在不孕不育治疗的女性人类患者中的多发性事件。 MBP预后工具还可用于增强预测胚胎存活力的诊断或预后测试的准确性。本发明的MBP预后工具可以是临床特异性的，或者可以修改以用于多临床方法。

6. 发明授权

US09157550B2 Microfluidic systems and methods 有权
标题翻译：微流体系统和方法
公开(公告)号：US09157550B2
公开(公告)日：2015-10-13
申请号：US12652735
申请日：2010-01-05
申请人： Matthew B. Wheeler , Dongshin Kim , David J. Beebe
发明人： Matthew B. Wheeler , Dongshin Kim , David J. Beebe
IPC分类号： C12M1/34 , F16K99/00 , C12M3/06 , C12M3/00 , A61B17/425 , B01L3/00
CPC分类号： F16K99/0001 , A61B17/425 , B01L3/5085 , B01L2300/0829 , C12M21/06 , C12M23/16 , F16K99/0017 , F16K99/0028 , Y10T137/0318 , Y10T137/87249
摘要： Microfluidic systems and methods. A microfluidic device for in vitro fertilization comprises a substrate and a plurality of microchannels disposed in the substrate, including an inlet of at least two of the plurality of microchannels arranged on the substrate to align with a fluid-handling device. Another microfluidic system for assaying a plurality of cells comprises a substrate and a plurality of microfluidic channels comprising a source channel, a sink channel, and a cell chamber. An insert for a microfluidic system comprises a substrate configured to be inserted into a dish and a plurality of microscale wells disposed in the substrate. A microfluidic channel comprises a substrate and at least one microchannel having an open inlet, an open outlet, a channel, and an opening in the substrate disposed over a portion of the channel. A device for providing an amount of fluid for a fluidic system comprises a main reservoir, an aspiration well, tubing coupling the reservoirs, and a seal closing the main reservoir. Air tubing having a hydrophobic end extends into the at least one aspiration well.
摘要翻译：微流体系统和方法。用于体外受精的微流体装置包括衬底和设置在衬底中的多个微通道，包括布置在衬底上的多个微通道中的至少两个的入口，以与流体处理装置对准。用于测定多个细胞的另一个微流体系统包括底物和多个包含源通道，宿通道和细胞室的微流体通道。用于微流体系统的插入件包括构造成插入盘中的衬底和设置在衬底中的多个微孔。微流体通道包括基底和至少一个具有开放入口，开口的出口，通道和布置在通道的一部分上的基底中的开口的微通道。用于为流体系统提供一定量的流体的装置包括主储存器，抽吸井，联接储存器的管道和封闭主储存器的密封件。具有疏水端的空气管延伸到至少一个抽吸井中。

7. 发明申请

US20120271100A1 COMPOSITIONS AND METHODS FOR THE DETECTION OF ZINC 审中-公开
标题翻译：用于检测ZINC的组合物和方法
公开(公告)号：US20120271100A1
公开(公告)日：2012-10-25
申请号：US13442453
申请日：2012-04-09
申请人： Teresa K. Woodruff , Thomas V. O'Halloran , Alison M. Kim , Emily Que , Betty Kong , Miranda Bernhardt
发明人： Teresa K. Woodruff , Thomas V. O'Halloran , Alison M. Kim , Emily Que , Betty Kong , Miranda Bernhardt
IPC分类号： C07F5/02 , A61B17/425 , G01N21/64
CPC分类号： G01N33/5091 , A61B17/435 , A61D19/04 , G01N21/6428 , G01N21/643
摘要： The invention relates generally to compositions and methods for the detection of zinc. In particular, compositions and methods are provided to detect changes in cellular zinc concentration and to correlate them to cellular phenomena.
摘要翻译：本发明一般涉及用于检测锌的组合物和方法。特别地，提供组合物和方法以检测细胞锌浓度的变化并将其与细胞现象相关联。

8. 发明申请

US20120046260A1 Methods and Devices for Delivery of Compositions to Conduits 有权
标题翻译：将组合物输送到管道的方法和装置
公开(公告)号：US20120046260A1
公开(公告)日：2012-02-23
申请号：US13286127
申请日：2011-10-31
申请人： Kathy Lee-Sepsick , Jeffrey A. Marcus , Max S. Azevedo , Daniel S. Currie
发明人： Kathy Lee-Sepsick , Jeffrey A. Marcus , Max S. Azevedo , Daniel S. Currie
IPC分类号： A61K31/57 , A61P15/00 , A61B17/435 , A61K31/519 , A61B17/425 , A61B17/43
CPC分类号： A61M31/00 , A61B17/12022 , A61B17/12099 , A61B17/12159 , A61B17/12186 , A61B17/1219 , A61B17/12195 , A61B17/22012 , A61B17/320758 , A61B17/42 , A61B17/43 , A61B17/435 , A61B2017/22051 , A61B2017/22084 , A61B2017/4225 , A61B2017/4233 , A61F6/005 , A61F6/225 , A61M31/005
摘要： The present invention comprises systems, methods and devices for the delivery of visualizable or treatment compositions or therapeutic agents comprising device elements for diagnosis and/or treatment of conduits. A delivery system comprising an introducer shaft having at least one exit port and at least one delivery catheter for placement of compositions into the conduit, such as a fallopian tube.
摘要翻译：本发明包括用于递送可视化或治疗组合物或治疗剂的系统，方法和装置，其包括用于诊断和/或治疗导管的装置元件。一种输送系统，包括具有至少一个出口的导引器轴和用于将组合物放置在诸如输卵管的导管中的至少一个输送导管。

9. 发明申请

US20120029270A1 CERVICAL CONCEPTION CONDOM 审中-公开
标题翻译：国际概念
公开(公告)号：US20120029270A1
公开(公告)日：2012-02-02
申请号：US12848154
申请日：2010-07-31
申请人： CHRISTINE STUART
发明人： CHRISTINE STUART
IPC分类号： A61B17/425
CPC分类号： A61B17/425 , A61F6/065 , A61F6/08
摘要： The present invention relates to a cervical condom for aiding in conception comprising: a dome shape flexible device, where said device is made of a flexible material; and a rim surrounding the outer perimeter of the device. The device is capable of containing a sperm sample for application upon a user's cervix. In one exemplary embodiment, the flexible material is silicone and the condom measures in a range of about two to five centimeters in length.
摘要翻译：本发明涉及一种用于辅助受孕的子宫颈避孕套，包括：圆顶形柔性装置，其中所述装置由柔性材料制成; 以及围绕设备的外周边的边缘。该装置能够容纳用于应用于用户子宫颈的精子样品。在一个示例性实施例中，柔性材料是硅树脂，并且避孕套的长度在约2至5厘米的范围内。

10. 发明申请

US20100179377A1 SAMPLING NEEDLE 有权
标题翻译：取样针
公开(公告)号：US20100179377A1
公开(公告)日：2010-07-15
申请号：US12532362
申请日：2008-01-24
申请人： Urban Hagby
发明人： Urban Hagby
IPC分类号： A61B17/425 , A61D19/00
CPC分类号： A61B17/435 , A61B10/0283 , A61B17/425 , A61B2010/045
摘要： The invention relates to a sampling needle, in particular to a needle suitable for oocyte retrieval from a human or animal subject, said needle comprising a first tubular region in fluid communication with a second tubular region, the first tubular region comprising a leading end for insertion into a subject and the second tubular region comprising a trailing end for fluid communication with a means for receiving a fluid, in which the first tubular region has an outer diameter which is less than the outer diameter of the second tubular region and the first tubular region has an inner diameter which is less than the inner diameter of the second tubular region. The invention also relates to a method of retrieving a sample, in particular an oocyte, from a human or animal subject.
摘要翻译：本发明涉及一种采样针，特别涉及一种适用于从人或动物受试者进行卵母细胞回收的针，所述针包括与第二管状区域流体连通的第一管状区域，第一管状区域包括用于插入的前端并且第二管状区域包括用于与用于接收流体的装置流体连通的后端，其中第一管状区域的外径小于第二管状区域的外径，第一管状区域具有小于第二管状区域的内径的内径。本发明还涉及从人或动物受试者检索样品，特别是卵母细胞的方法。

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