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1. 发明授权

US5290695A Heparitinase, process for producing the same and bacteria producing the same 失效
标题翻译：肝素酶，生产过程和细菌生产相同
公开(公告)号：US5290695A
公开(公告)日：1994-03-01
申请号：US843812
申请日：1992-02-28
申请人： Kiyoshi Morikawa , Hirofumi Miyazono , Hiroshi Maruyama , Keiichi Yoshida
发明人： Kiyoshi Morikawa , Hirofumi Miyazono , Hiroshi Maruyama , Keiichi Yoshida
IPC分类号： C12N1/20 , C12N9/88 , C12P21/04 , C12R1/09 , C12N1/00 , C12Q1/56
CPC分类号： C12R1/09 , C12N9/88 , Y10S435/835
摘要： Disclosed are novel enzymes, heparitinase T-I, heparitinase T-II, heparitinase T-III and heparitinase T-IV, which degrade heparan sulfate and/or heparin, a process for producing thereof by cultivating a novel Bacillus circulans HpT 298 having an ability of producing these enzymes and a novel Bacillus circulans HpT 298.
摘要翻译：公开了通过培养具有生产能力的新型环状芽孢杆菌HpT 298的新型酶，肝素酶，TI，肝素酶T-II，肝素三磷酸酶T-III和肝素三磷酸酶T-IV，其降解硫酸肝素和/或肝素这些酶和新型环状芽孢杆菌HpT 298。

2. 发明申请

US20190048426A1 COMMAND OF ACTIVE MATTER BY TOPOLOGICAL DEFECTS AND PATTERNS 审中-公开
公开(公告)号：US20190048426A1
公开(公告)日：2019-02-14
申请号：US16100394
申请日：2018-08-10
申请人： Kent State University
发明人： Oleg D. Lavrentovich , Chenhui Peng , Taras Turiv , Yubing Guo , Qi-Huo Wei
IPC分类号： C12R1/125 , C09K19/54 , C12R1/07 , C12R1/08 , C12R1/085 , C12R1/09 , C12R1/10 , C12R1/11 , C12R1/12
摘要： A method for controlling self-propelled particles includes providing the particles to a liquid crystalline medium having predesigned local ordering. The method may control at least one of: a local concentration, trajectory, and net flow of self-propelled particles.

3. 发明授权

US5405759A Heparitinase, process for producing the same and bacteria producing the same 失效
标题翻译：肝素酶，生产过程和细菌生产相同
公开(公告)号：US5405759A
公开(公告)日：1995-04-11
申请号：US154740
申请日：1993-11-18
申请人： Kiyoshi Morikawa , Hirofumi Miyazono , Hiroshi Maruyama , Keiichi Yoshida
发明人： Kiyoshi Morikawa , Hirofumi Miyazono , Hiroshi Maruyama , Keiichi Yoshida
IPC分类号： C12N1/20 , C12N9/88 , C12P21/04 , C12R1/09 , C12N1/00 , C12N9/00 , C12N9/52 , C12N9/54
CPC分类号： C12R1/09 , C12N9/88 , Y10S435/835
摘要： Disclosed are novel enzymes, heparitinase T-I, heparitinase T-II, heparitinase T-III and heparitinase T-IV, which degrade heparan sulfate and/or heparin, a process for producing thereof by cultivating a novel Bacillus circulans HpT 298 having an ability of producing these enzymes and a novel Bacillus circulans HpT 298.
摘要翻译：公开了通过培养具有生产能力的新型环状芽孢杆菌HpT 298的新型酶，肝素酶，TI，肝素酶T-II，肝素三磷酸酶T-III和肝素三磷酸酶T-IV，其降解硫酸肝素和/或肝素这些酶和新型环状芽孢杆菌HpT 298。

4. 发明授权

US4769329A Preparation of optically pure D- and L- lactic acid 失效
标题翻译：制备光学纯的D-和L-乳酸
公开(公告)号：US4769329A
公开(公告)日：1988-09-06
申请号：US393630
申请日：1982-06-30
申请人： Bryan Cooper , Werner Kuesters , Christoph Martin , Hardo Siegel
发明人： Bryan Cooper , Werner Kuesters , Christoph Martin , Hardo Siegel
IPC分类号： C12N1/38 , C12P7/56 , C12R1/865 , C12P29/00 , C12R1/09 , C12R1/85
CPC分类号： C12P7/56 , C12N1/38 , Y10S435/835 , Y10S435/853 , Y10S435/856 , Y10S435/94
摘要： A process for the preparation of optically pure D- or L-lactic acid by fermentation of an aqueous nutrient medium, which contains nitrogen, vitamins, aminoacids, sugars and trace elements, by means of a microorganism, at pH 4-6, wherein the nutrient medium contains brewers' yeast as the source of nitrogen, vitamins, aminoacids and trace elements.
摘要翻译：一种通过在pH 4-6下通过微生物发酵包含氮，维生素，氨基酸，糖和微量元素的含水营养培养基来制备光学纯的D-或L-乳酸的方法，其中营养培养基含有酿造酵母作为氮源，维生素，氨基酸和微量元素的来源。

5. 发明授权

US4477568A Process for the manufacture of cyclodextrin 失效
标题翻译：制备环糊精的方法
公开(公告)号：US4477568A
公开(公告)日：1984-10-16
申请号：US419800
申请日：1982-09-20
申请人： Hendrik Hokse , Frederik S. Kaper , Jacob T. Wijpkema
发明人： Hendrik Hokse , Frederik S. Kaper , Jacob T. Wijpkema
IPC分类号： C08B37/16 , C12N9/10 , C12P19/18 , C12R1/09 , C12N9/18
CPC分类号： C12N9/1074 , C08B37/0012 , C12P19/18 , Y10S435/803 , Y10S435/813
摘要： A process for producing cyclodextrin from starch in which an aqueous solun of starch is subjected to the action of an active cyclodextrin glycosyltransferase and the reaction mixture containing cyclodextrin, starch degradation products and active enzyme is continuously subjected to an ultrafiltration process to effect passage of the formed cyclodextrin through the membrane, while retaining substantially all of the other starch degradation products and active enzyme, thus permitting more cyclodextrin to be formed in the retentate, which will then pass the membrane, collecting the aqueous solution of cyclodextrin and recovering the cyclodextrin.
摘要翻译：从淀粉生产环糊精的方法，其中淀粉水溶液经受活性环糊精糖基转移酶的作用，并且含有环糊精，淀粉降解产物和活性酶的反应混合物连续进行超滤过程，以使形成的环糊精通过膜，同时保留基本上所有其他淀粉降解产物和活性酶，从而允许在滞留物中形成更多的环糊精，然后通过膜，收集环糊精的水溶液并回收环糊精。

6. 发明授权

US09528134B2 Branched α-glucan, α-glucosyltransferase which forms the glucan, their preparation and uses 有权
标题翻译：形成葡聚糖的分支α-葡聚糖，α-葡萄糖基转移酶，其制备和应用
公开(公告)号：US09528134B2
公开(公告)日：2016-12-27
申请号：US14734607
申请日：2015-06-09
申请人： Hayashibara Co., Ltd
发明人： Hikaru Watanabe , Takuo Yamamoto , Tomoyuki Nishimoto , Keiji Tsusaki , Kazuyuki Oku , Hiroto Chaen , Shigeharu Fukuda
IPC分类号： C12P19/04 , C12P19/18 , A21D2/18 , A23C9/13 , A23C9/154 , A23L1/09 , A23L1/19 , A23L1/20 , A23L1/305 , A23L2/39 , A61K8/73 , A61K31/716 , A61Q19/00 , C08B37/00 , C12N9/10 , C12R1/06 , C12R1/09
CPC分类号： A23L33/21 , A21D2/18 , A23C9/1307 , A23C9/1544 , A23L2/39 , A23L9/20 , A23L11/05 , A23L29/35 , A23L33/10 , A23L33/18 , A23V2002/00 , A61K8/73 , A61K8/732 , A61K9/06 , A61K9/20 , A61K31/716 , A61K31/718 , A61Q11/00 , A61Q17/04 , A61Q19/00 , A61Q19/02 , C08B37/0009 , C12N9/1051 , C12P19/04 , C12P19/18 , C12R1/06 , C12R1/09 , Y02P20/52 , A23V2250/5118 , A23V2200/3262 , A23V2200/328
摘要： The present invention has objects to provide a glucan useful as water-soluble dietary fiber, its preparation and uses. The present invention solves the above objects by providing a branched α-glucan, which is constructed by glucose molecules and characterized by methylation analysis as follows: (1) Ratio of 2,3,6-trimethyl-1,4,5-triacetyl-glucitol to 2,3,4-trimethyl-1,5,6-triacetyl-glucitol is in the range of 1:0.6 to 1:4; (2) Total content of 2,3,6-trimethyl-1,4,5-triacetyl-glucitol and 2,3,4-trimethyl-1,5,6-triacetyl-glucitol is 60% or higher in the partially methylated glucitol acetates; (3) Content of 2,4,6-trimethyl-1,3,5-triacetyl-glucitol is 0.5% or higher but less than 10% in the partially methylated glucitol acetates; and (4) Content of 2,4-dimethyl-1,3,5,6-tetraacetyl-glucitol is 0.5% or higher in the partially methylated glucitol acetates; a novel α-glucosyltransferase which forms the branched α-glucan, processes for producing them, and their uses.
摘要翻译：本发明的目的是提供可用作水溶性膳食纤维的葡聚糖及其制备和用途。本发明通过提供由葡萄糖分子构建的特征在于甲基化分析的支链葡聚糖来解决上述目的：（1）2,3,6-三甲基-1,4,5-三乙酰基 - 葡萄糖醇至2,3,4-三甲基-1,5,6-三乙酰基 - 葡萄糖醇的比例范围为1:0.6至1:4; （2）部分甲基化的2,3,6-三甲基-1,4,5-三乙酰 - 葡萄糖醇和2,3,4-三甲基-1,5,6-三乙酰 - 葡糖醇的总含量为60％以上葡萄糖醇乙酸酯; （3）部分甲基化葡萄糖醇乙酸酯中2,4,6-三甲基-1,3,5-三乙酰 - 葡萄糖醇的含量为0.5％以上且小于10％和（4）部分甲基化葡萄糖醇乙酸酯中2,4-二甲基-1,3,5,6-四乙酰 - 葡萄糖醇的含量为0.5％以上; 形成支链葡聚糖的新型± - 葡萄糖基转移酶，其制备方法及其用途。

7. 发明授权

US09090923B2 Branched alpha-glucan, alpha-glucosyltransferase which forms the glucan, their preparation and uses 有权
标题翻译：分支的α-葡聚糖，形成葡聚糖的α-葡萄糖基转移酶，其制备和用途
公开(公告)号：US09090923B2
公开(公告)日：2015-07-28
申请号：US14160749
申请日：2014-01-22
申请人： Hayashibara Co., Ltd
发明人： Hikaru Watanabe , Takuo Yamamoto , Tomoyuki Nishimoto , Keji Tsusaki , Kazuyuki Oku , Hiroto Chaen , Shigeharu Fukuda
IPC分类号： C12P19/18 , A21D2/18 , A23C9/13 , A23C9/154 , A23L1/09 , A23L1/19 , A23L1/20 , A23L1/305 , A23L2/39 , A61K8/73 , A61K31/716 , A61Q19/00 , C08B37/00 , C12N9/10 , C12P19/04 , C12R1/06 , C12R1/09
CPC分类号： A23L33/21 , A21D2/18 , A23C9/1307 , A23C9/1544 , A23L2/39 , A23L9/20 , A23L11/05 , A23L29/35 , A23L33/10 , A23L33/18 , A23V2002/00 , A61K8/73 , A61K8/732 , A61K9/06 , A61K9/20 , A61K31/716 , A61K31/718 , A61Q11/00 , A61Q17/04 , A61Q19/00 , A61Q19/02 , C08B37/0009 , C12N9/1051 , C12P19/04 , C12P19/18 , C12R1/06 , C12R1/09 , Y02P20/52 , A23V2250/5118 , A23V2200/3262 , A23V2200/328
摘要： The present invention has objects to provide a glucan useful as water-soluble dietary fiber, its preparation and uses. The present invention solves the above objects by providing a branched α-glucan, which is constructed by glucose molecules and characterized by methylation analysis as follows: (1) Ratio of 2,3,6-trimethyl-1,4,5-triacetyl-glucitol to 2,3,4-trimethyl-1,5,6-triacetyl-glucitol is in the range of 1:0.6 to 1:4; (2) Total content of 2,3,6-trimethyl-1,4,5-triacetyl-glucitol and 2,3,4-trimethyl-1,5,6-triacetyl-glucitolis 60% or higher in the partially methylated glucitol acetates; (3) Content of 2,4,6-trimethyl-1,3,5-triacetyl-glucitol is 0.5% or higher but less than 10% in the partially methylated glucitol acetates; and (4) Content of 2,4-dimethyl-1,3,5,6-tetraacetyl-glucitol is 0.5% or higher in the partially methylated glucitol acetates; a novel α-glucosyltransferase which forms the branched α-glucan, processes for producing them, and their uses.
摘要翻译：本发明的目的是提供可用作水溶性膳食纤维的葡聚糖及其制备和用途。本发明通过提供由葡萄糖分子构成的特征在于甲基化分析的支链α-葡聚糖来解决上述目的：（1）2,3,6-三甲基-1,4,5-三乙酰基 - 葡萄糖醇至2,3,4-三甲基-1,5,6-三乙酰基 - 葡萄糖醇的比例范围为1:0.6至1:4; （2）在部分甲基化的葡萄糖醇中的2,3,6-三甲基-1,4,5-三乙酰基 - 葡萄糖醇和2,3,4-三甲基-1,5,6-三乙酰基 - 葡萄糖醇的总含量为60％以上醋酸盐（3）部分甲基化葡萄糖醇乙酸酯中2,4,6-三甲基-1,3,5-三乙酰 - 葡萄糖醇的含量为0.5％以上且小于10％和（4）部分甲基化葡萄糖醇乙酸酯中2,4-二甲基-1,3,5,6-四乙酰 - 葡萄糖醇的含量为0.5％以上; 形成支链α-葡聚糖的新型α-葡糖基转移酶，其制备方法及其用途。

8. 发明授权

US06137007A Enantiomer compositions of (1R,4S)-1-butyrylamino-4-(hydroxymethyl)-2-cyclopentene 失效
标题翻译：（1R，4S）-1-丁酰氨基-4-（羟甲基）-2-环戊烯的对映体组成
公开(公告)号：US06137007A
公开(公告)日：2000-10-24
申请号：US373862
申请日：1999-08-13
申请人： Christine Bernegger , Eva Maria Urban , Olwen Mary Birch , Knut Burgdorf , Frank Brux , Kay-Sara Etter , Pierre Bossard , Walter Brieden , Laurent Duc , John Gordon , Colm O'Murchu , Yves Guggisberg
发明人： Christine Bernegger , Eva Maria Urban , Olwen Mary Birch , Knut Burgdorf , Frank Brux , Kay-Sara Etter , Pierre Bossard , Walter Brieden , Laurent Duc , John Gordon , Colm O'Murchu , Yves Guggisberg
IPC分类号： C12P41/00 , C07C231/18 , C07C231/20 , C07C233/23 , C07C271/24 , C07D209/94 , C07D233/04 , C07D233/74 , C07D235/02 , C07D237/06 , C07D239/70 , C07D473/40 , C12P13/00 , C12P13/02 , C12P17/18 , C12R1/01 , C12R1/05 , C12R1/06 , C12R1/09 , C12R1/19 , C12R1/38 , C07C215/42
CPC分类号： C07C231/18 , C07C233/23 , C07C271/24 , C07D209/94 , C12P13/001 , C12P13/02 , C12P17/182 , C07B2200/07 , C07C2101/10
摘要： A novel process for the preparation of (1S,4R)- or (1R,4S)-4-(2-amino-6-chloro-9H-purin-9-yl)-2-cyclopentene-1-methanol of the formulae ##STR1## is described. This entails in the first stage (.+-.)-2-azabicyclo[2.2.1]hept-5-en-3-one of the formula ##STR2## being acylated to give a (.+-.)-2-azabicyclo[2.2.1]hept-5-en-3-one derivative of the general formula ##STR3## in which R.sup.1 denotes C.sub.1-4 -alkyl, C.sub.1-4 -alkoxy, aryl or aryloxy, the latter being reduced in the second stage to give a cyclopentene derivative of the general formula ##STR4## in which R.sup.1 has the stated meaning, the latter then being converted in the third stage biotechnologically into the (1R,4S)- or (1S,4R)-1-amino-4-(hydroxymethyl)-2-cyclopentene of the formula ##STR5## the latter being converted in the fourth stage with N-(2-amino-4,6-dichloro-5-pyrimidinyl)formamide of the formula ##STR6## into the (1S,4R)- or (1R,4S)-4-[(2-amino-6-chloro-5-formamido-4-pyrimidinyl)amino]-2-cyclopentene-1-methanol of the formulae ##STR7## and the latter being cyclized in the fifth stage in a known manner to the final product of the formula I or II.
摘要翻译：制备式（1S，4R） - 或（1R，4S）-4-（2-氨基-6-氯-9H-嘌呤-9-基）-2-环戊烯-1-甲醇的新方法，被描述。这需要在被酰化的式（+/-）-2-氮杂双环[2.2.1]庚-5-烯-3-酮的第一阶段中得到（+/-）-2-氮杂双环[2.2.1 ]庚-5-烯-3-酮衍生物，其中R 1表示C 1-4 - 烷基，C 1-4 - 烷氧基，芳基或芳氧基，后者在第二阶段中还原，得到其中R 1具有所述含义的通式，后者在第三阶段中生物技术转化为（1R，4S） - 或（1S，4R）-1-氨基-4-（羟甲基）-2-环戊烯式（1R，4S）-4 - （（1S，4R） - 或（1R，4S）-4 - 2-氨基-6-氯-5-甲酰氨基-4-嘧啶基）氨基] -2-环戊烯-1-甲醇，后者在第五阶段以已知方式环化为式I的最终产物或II。

9. 发明授权

US5759840A Modification of xylanase to improve thermophilicity, alkalophilicity and thermostability 失效
标题翻译：改良木聚糖酶以改善嗜热性，嗜碱性和热稳定性
公开(公告)号：US5759840A
公开(公告)日：1998-06-02
申请号：US709912
申请日：1996-09-09
申请人： Wing L. Sung , Makoto Yaguchi , Kazuhiko Ishikawa
发明人： Wing L. Sung , Makoto Yaguchi , Kazuhiko Ishikawa
IPC分类号： C12N15/09 , C12N9/24 , C12N15/00 , C12N15/56 , C12R1/09 , C12R1/885 , D21C5/00 , D21C9/10
CPC分类号： C12Y302/01032 , C12N9/248 , C12Y302/01008 , D21C5/005 , C07K2319/00
摘要： Producing a xylanase enzyme of superior performance in the bleaching of pulp. More specifically, a modified xylanase of Family 11 that shows improved thermophilicity, alkalophilicity, and thermostability as compared to the natural xylanase. The modified xylanases contain any of three types of modifications: (1) changing amino acids 10, 27, and 29 of Trichoderma reesei xylanase II or the corresponding amino acids of another Family 11 xylanase, where these amino acids are changed to histidine, methionine, and leucine, respectively; (2) substitution of amino acids in the N-terminal region with amino acids from another xylanase enzyme. In a preferred embodiment, substitution of the natural Bacillus circulans or Trichoderma reesei xylanase with a short sequence of amino acids from Thermomonospora fusca xylanase yielded chimeric xylanases with higher thermophilicity and alkalophilicity; (3) an extension upstream of the N-terminus of up to 10 amino acids. In a preferred embodiment, extension of the N-terminus of the xylanase with the tripeptide glycine-arginine-arginine improved its performance.
摘要翻译：在木浆漂白中生产出优异的木聚糖酶。更具体地，与天然木聚糖酶相比，家族11的改性木聚糖酶显示出改善的嗜热性，嗜碱性和热稳定性。修饰的木聚糖酶包含三种类型的修饰中的任何一种：（1）改变里氏木霉木聚糖酶II的氨基酸10,27和29或另一种家族11木聚糖酶的相应氨基酸，其中这些氨基酸被改变为组氨酸，甲硫氨酸，和亮氨酸; （2）用来自另一种木聚糖酶的氨基酸取代N-末端区域中的氨基酸。在一个优选的实施方案中，用热单孢菌木聚糖酶短链氨基酸取代天然环状芽孢杆菌或里氏木霉木聚糖酶得到具有较高嗜热性和嗜碱性的嵌合木聚糖酶; （3）N-末端上游至多10个氨基酸的延伸。在优选的实施方案中，木聚糖酶的N-末端与三肽甘氨酸 - 精氨酸 - 精氨酸的延伸改善了其性能。

10. 发明授权

US4958016A Bifunctional oligosaccharides and also active compounds derived therefrom 失效
标题翻译：双功能寡糖以及由其衍生的活性化合物
公开(公告)号：US4958016A
公开(公告)日：1990-09-18
申请号：US202788
申请日：1988-06-03
申请人： Antonius Kerkenaar , Diederik J. M. Schmedding , Ronald T. M. Van Den Dool
发明人： Antonius Kerkenaar , Diederik J. M. Schmedding , Ronald T. M. Van Den Dool
IPC分类号： C07H7/02 , C07H3/06 , C12N1/20 , C12N9/88 , C12P19/00 , C12P19/04 , C12R1/07 , C12R1/09
CPC分类号： C12P19/00 , C07H3/06 , C12N9/88 , C12P19/04 , Y10S435/835
摘要： Bifunctional oligosaccharides, characterized by the formula ##STR1## wherein R.sub.1 represents a hydrogen atom, an alkyl group having 1-4 carbon atoms or an alkali metal, R.sub.2 represents a single bond or a divalent radical compound of monosaccharides and glc represents glucose, are obtained with the help of a specific microbial lyase cleaving the glucose-glucoronic acid bond in polysaccharides; said bifunctional oligosaccharides can be reacted with all kinds of products like proteins and drugs resulting in products having modified properties like solubility etc.

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