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1. 发明授权

US4613691A Preparation of amino acids from unsaturated hydantoins 失效
标题翻译：从不饱和乙内酰脲制备氨基酸
公开(公告)号：US4613691A
公开(公告)日：1986-09-23
申请号：US751581
申请日：1985-07-08
申请人： Stanley B. Mirviss , Mark W. Empie
发明人： Stanley B. Mirviss , Mark W. Empie
IPC分类号： C12P13/04 , C12P13/22 , C12P41/00 , C07C99/08
CPC分类号： C12P13/222 , C12P13/04 , C12P41/00
摘要： Amino acids can be easily prepared by reducing unsaturated hydantoins to the corresponding saturated hydantoins by hydrogenating the unsaturated hydantoin using either Raney Nickel catalyst in the presence of more than a stoichiometric amount of caustic or by using zinc and hydrochloric acid followed by hydrolyzing the resultant composition with at least 3 molar equivalents of an alkali metal hydroxide to produce a racemate of an alpha amino acid. The amino acid in suitable derivative form can then be resolved particularly using a two-phase solvent system. The residual isomer of the amino acid remaining after the resolution process can then be racemized using either pyridoxal-5-phosphate or an aliphatic acid in combination with an aldehyde or a ketone. By these procedures, it is possible to obtain high yields of amino acids.
摘要翻译：氨基酸可以容易地通过将不饱和乙内酰脲还原成相应的饱和乙内酰脲，通过使用阮内镍催化剂在不超过化学计量的苛性碱存在下氢化不饱和乙内酰脲，或者通过使用锌和盐酸，然后水解所得组合物，至少3摩尔当量的碱金属氢氧化物以产生α氨基酸的外消旋体。然后可以使用两相溶剂系统特别地分解合适的衍生物形式的氨基酸。然后可以使用吡哆醛-5-磷酸或与醛或酮的组合的脂族酸，将拆分过程后残留的氨基酸的残余异构体外消旋化。通过这些方法，可以获得高产率的氨基酸。

2. 发明授权

US4647694A Process for the preparation of D1-.beta.-aryl amino acids 失效
标题翻译：制备D1-β-芳基氨基酸的方法
公开(公告)号：US4647694A
公开(公告)日：1987-03-03
申请号：US710838
申请日：1985-03-12
申请人： Sandor Hosztafi , Tibor Timar , Zoltan Salamon , Ilona Fabian nee Orban , Julianna Nagy nee Vajda
发明人： Sandor Hosztafi , Tibor Timar , Zoltan Salamon , Ilona Fabian nee Orban , Julianna Nagy nee Vajda
IPC分类号： C07C9/00 , C07C67/00 , C07C227/00 , C07C227/24 , C07C227/26 , C07C229/08 , C07C229/36 , C07D233/74 , C07D233/78 , C07D233/96 , C07C99/08
CPC分类号： C07D233/78 , C07D233/74
摘要： The invention relates to a process for the preparation of DL-.beta.-aryl-amino acids of the general Formula ##STR1## wherein R, R.sub.1 and R.sub.2 stand for hydrogen, halogen, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, nitro or C.sub.1-4 dialkylamino; wherebyin the case of monosubstituted derivatives R and R.sub.1 are hydrogen and R.sub.2 has the same meaning as stated above and can be attached to position 2, 3 or 4 related to the methylene group;in the case of disubstituted derivatives R is hydrogen and R.sub.1 and R.sub.2 have the same meaning as stated above and are attached to positions 2,3; 2,4; 2,5; 2,6; 3,4 or 3,5 related to the methylene group;in the case of trisubstituted derivatives R, R.sub.1 and R.sub.2 have the same meaning as stated above and are attached to positions 2,3,4; 2,3,5; 2,3,6; 3,4,5 or 3,4,6 related to the methylene group.
摘要翻译：本发明涉及一种制备通式V-V的DL-β-芳基 - 氨基酸的方法，其中R，R 1和R 2代表氢，卤素，C 1-6烷基，C 1-6烷氧基，硝基或 C 1-4二烷基氨基; 在单取代衍生物的情况下，R和R 1是氢，R 2具有与上述相同的含义，并且可以连接到与亚甲基有关的2,3或4位; 在二取代的衍生物的情况下，R为氢，R 1和R 2具有与上述相同的含义并且连接于2,3位; 2,4; 2,5; 2,6 3,4或3,5与亚甲基有关; 在三取代衍生物的情况下，R 1，R 2和R 2具有与上述相同的含义并且连接在2,3,4位上; 2,3,5; 2,3,6; 3,4,5或3,4,6与亚甲基有关。

3. 发明授权

US4082767A Production of alpha-amino acids 失效
标题翻译：生产阿尔法 - 氨基酸
公开(公告)号：US4082767A
公开(公告)日：1978-04-04
申请号：US671984
申请日：1976-03-30
申请人： Takeshi Yamahara , Shun Inokuma
发明人： Takeshi Yamahara , Shun Inokuma
IPC分类号： C07B61/00 , B01J31/00 , B01J31/02 , C07C20060101 , C07C67/00 , C07C227/00 , C07C227/24 , C07C229/02 , C07C313/00 , C07C319/20 , C07C323/58 , C07D209/20 , C07C99/08 , C07C121/43
CPC分类号： C07D209/20
摘要： .alpha.-Amino acids are prepared by catalytically hydrolyzing a hydantoin compound of the formula, ##STR1## wherein R.sub.1 and R.sub.2 are individually hydrogen or an unsubstituted or substituted alkyl, cycloalkyl, alkenyl, aryl or aralkyl group, in the presence of imidazole or a derivative thereof.

4. 发明授权

US3911001A Process for the preparation of lysine involving 1-ureido-4-cyanovaleramide and 1-ureido-5-aminocapronamide intermediaries 失效
标题翻译：涉及1-脲基-4-氰基戊酰胺和1-脲基-5-氨基己酰胺中间体的赖氨酸制备方法
公开(公告)号：US3911001A
公开(公告)日：1975-10-07
申请号：US34851973
申请日：1973-04-06
申请人： STAMICARBON
发明人： SUVERKROPP GEERTRUDES H , REICHRATH WERNER
IPC分类号： C07C275/16 , C07D233/76 , C07C99/08
CPC分类号： C07C275/16 , C07D233/76
摘要： A process is disclosed for the preparation of lysine and lysine compounds wherein a mixture of 5-(3-cyanopropyl)-hydantoin and 1ureido-4-cyanovaleramide is obtained and hydrogenated in the presence of a catalyst to a mixture of 5-(4-aminobutyl)-hydantoin and 1-ureido-5-aminocapronamide, which in turn is hydrolyzed to lysine or a lysine compound.
摘要翻译：公开了制备赖氨酸和赖氨酸化合物的方法，其中得到5-（3-氰基丙基） - 乙内酰脲和1-脲基-4-氰基戊酰胺的混合物，并在催化剂存在下氢化为5-（ 4-氨基丁基） - 乙内酰脲和1-脲基-5-氨基己酰胺，其又被水解成赖氨酸或赖氨酸化合物。

5. 发明授权

US3668221A A process for producing {60 -amino acids 失效
标题翻译：一种生产{60-氨基酸的方法
公开(公告)号：US3668221A
公开(公告)日：1972-06-06
申请号：US3668221D
申请日：1967-07-21
申请人： SUMITOMO CHEMICAL CO
发明人： SHIMA TAKESABURO , YAMAGISHI AKIO , SADA MASAO , YAMAMOTO ZENICHI , SHIOZAKI HASUNAGA
IPC分类号： C07C20060101 , C07D233/72 , C07D27/60 , C07C99/08
摘要： A process for producing Alpha -amino acid by hydrolyzing a hydantoin compound in which the hydrolysis is effected while withdrawing out of the system ammonia and carbon dioxide generated during the hydrolysis and while during the reaction period, adjusting the amount of reaction medium to at least 1.5 l. per mole of the hydantoin compound initially employed. Particularly, a process in which the hydrolysis is effected in such a manner that an aqueous alkaline solution of hydantoin compound is fed to the upper part of a plate column-type reactor or packed column-type reactor and, simultaneously, steam is fed from the lower part of said reactor, while withdrawing ammonia and carbon dioxide out of the system. By thus effecting the hydrolysis without concentrating the reaction liquid, and while withdrawing the generated gases out of the system, Alpha -amino acid can be produced in high yields.
摘要翻译：通过水解产生水解的乙内酰脲化合物生产α-氨基酸的方法，同时在水解过程中产生的氨和二氧化碳排出系统，同时在反应期间将反应介质的量调节至至少1.5 l。每摩尔最初使用的乙内酰脲化合物。特别是，水解是以乙内酰脲化合物的碱性水溶液进料到塔式反应器或填充柱式反应器的上部的方式进行水解的方法，同时从同时将氨和二氧化碳从系统中排出。通过在不浓缩反应液体的情况下进行水解，并且在将所产生的气体从系统中排出的同时，可以高产率生产α-氨基酸。

6. 发明授权

US4716246A Process for L-dopa 失效
标题翻译： L-多巴的方法
公开(公告)号：US4716246A
公开(公告)日：1987-12-29
申请号：US899283
申请日：1986-08-22
申请人： Donald F. Reinhold , Torleif Utne , Newton L. Abramson
发明人： Donald F. Reinhold , Torleif Utne , Newton L. Abramson
IPC分类号： C07C227/24 , C07C227/12 , C07C229/34 , C07C229/36 , C07C99/08
CPC分类号： C07C229/36 , C07C227/24 , C07C227/34
摘要： A process for the preparation of (S)- or L-3-(3,4-dihydroxyphenyl)alanine (L-dopa) is described. The process utilizes water as reaction process solvent and proceeds via formation of an intermediate which can be kinetically resolved in a polar solvent to a precursor of the desired isomer and in which the undesired isomer can be efficiently racemized for reuse.

7. 发明授权

US3917684A Recovery of lysine values by removal of ammonium chloride from lysine containing liquors 失效
标题翻译：通过从含赖氨酸的酒中除去氯化铵来回收赖氨酸值
公开(公告)号：US3917684A
公开(公告)日：1975-11-04
申请号：US38373873
申请日：1973-07-30
申请人： ALLIED CHEM
发明人： SIFNIADES STYLIANOS , TUNICK ALLEN ABRAHAM
IPC分类号： C07C227/18 , C07C20060101 , C07C229/26 , C07C99/08 , C07C101/24
CPC分类号： C07C229/24
摘要： Lysine.2HCl is converted to lysine.HCl by neutralization and crystallization with ammonia in an organic solvent. After removal of the precipitated lysine.HCl, the solvent mixture containing NH4Cl, some lysine.HCl and organic solvent is fractionated to recycle the solvent and then acidified with hydrochloric acid to salt out a major portion of the NH4Cl. The remaining solution is then combined with a lysine precursor to produce lysine.2HCl. This novel method ensures virtually complete recovery of lysine from the processing system.
摘要翻译：将赖氨酸2HCl通过中和转化成赖氨酸，并在有机溶剂中用氨结晶。除去沉淀的赖氨酸HCl后，将含有NH 4 Cl，一些赖氨酸HCl和有机溶剂的溶剂混合物分馏以再循环溶剂，然后用盐酸酸化以将NH4Cl的主要部分盐析。然后将剩余的溶液与赖氨酸前体组合以产生赖氨酸2HCl。这种新颖的方法确保从处理系统中几乎完全恢复赖氨酸。

8. 发明授权

US3886209A Process for preparing alpha, omega-diaminocarboxylic acids 失效
标题翻译：制备α，ω-二氨基羧酸的方法
公开(公告)号：US3886209A
公开(公告)日：1975-05-27
申请号：US30790072
申请日：1972-11-20
申请人： MITSUBISHI CHEM IND
发明人： KIKUMOTO RYOJI , ITO MASAHIRO , NAKAMURA AKIO , NOMURA TATSUO
IPC分类号： C07C227/26 , C07C227/24 , C07C229/26 , C07D233/76 , C07C99/08
CPC分类号： C07D233/76 , C07C227/24
摘要： A process for producing an Alpha , omega -diaminocarboxylic acid which comprises contacting a 2-cyano saturated cyclic amine under reaction conditions with H2O, NH3 and CO2, to obtain a reaction product containing 5-( omega -aminoalkyl)hydantoin, and hydrolyzing the reaction product is disclosed.
摘要翻译：一种制备α，ω-二氨基羧酸的方法，其包括在反应条件下使2-氰基饱和环胺与H 2 O，NH 3和CO 2接触，得到含有5-（ω-氨基烷基）乙内酰脲的反应产物，并水解该反应产品被披露。

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