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1. 发明授权

US06423874B1 Process for obtaining fragrant ketone 失效
标题翻译：获得香酮的方法
公开(公告)号：US06423874B1
公开(公告)日：2002-07-23
申请号：US09506984
申请日：2000-02-18
申请人： Mark B. Erman , Melissa J. Williams , Carlos G. Cárdenas
发明人： Mark B. Erman , Melissa J. Williams , Carlos G. Cárdenas
IPC分类号： C07C4567
CPC分类号： C07C403/02 , B01J27/053 , C07B2200/07 , C07C45/66 , C07C45/67 , C07C45/82 , C07C45/85 , C07C2601/16 , C07C49/553
摘要： A process for obtaining Ketone of formula 1a,b, which includes contacting a Ketone represented by formula 2a,b with a first catalyst under conditions and for a time sufficient to obtain an intermediate mixture, which intermediate mixture contains a Ketone represented by formula 4a,b; and contacting the intermediate mixture, or a fraction thereof, with a second catalyst under conditions effective to provide a product containing a Ketone of formula 1a,b. Moreover, the first catalyst preferably differs from the second catalyst with the first catalyst preferably being an isomerization catalyst and the second catalyst being a cyclization catalyst. The process is capable of providing unexpectedly incresased yields of both Ketone 4 and Ketone 1.
摘要翻译：一种获得式1a，b的酮的方法，其包括使式2a，b表示的酮与第一催化剂在足以获得中间体混合物的条件和时间下接触，该中间体混合物含有由式4a表示的酮， b; 在有效提供含有式1a的酮的产物的条件下，将中间体混合物或其一部分与第二催化剂接触，b。此外，第一催化剂优选不同于第二催化剂，第一催化剂优选为异构化催化剂，第二催化剂为环化催化剂。该方法能够预期提高酮酮4和酮1的收率。

2. 发明授权

US06274772B1 Continuous process for the manufacture of 3,5,5-trimethylcyclohexa-3-en-one(&bgr;-isophorone) 失效
标题翻译：用于制造3,5,5-三甲基环己-3-烯（β-异佛尔酮）的连续方法
公开(公告)号：US06274772B1
公开(公告)日：2001-08-14
申请号：US09598485
申请日：2000-06-22
申请人： Rémy Teissier , Georges Martino-Gauchi
发明人： Rémy Teissier , Georges Martino-Gauchi
IPC分类号： C07C4567
CPC分类号： C07C45/67 , C07C45/82 , C07C49/603
摘要： This invention relates to a continuous process for the manufacture of &bgr;-isophorone by isomerization under homogeneous catalysis of &agr;-isophorone. The process consists of introducing &agr;-isophorone and a solution of an alkaline hydroxide into a reaction region at a temperature ranging from 150° C. to 216° C., simultaneously removing by distillation a fraction comprising an amount by weight of &bgr;-isophorone ranging from 30% to 90%, drawing off the heavy products and then rectifying the fraction removed from the reaction mixture by distillation.
摘要翻译：本发明涉及在α-异佛尔酮的均相催化下通过异构化生产β-异佛尔酮的连续方法。该方法包括在150℃至216℃的温度范围内将α-异佛尔酮和碱性氢氧化物溶液引入反应区域，同时通过蒸馏除去包含重量百分比的β-异佛尔酮的馏分从30％到90％，抽出重产物，然后通过蒸馏精馏从反应混合物中除去的馏分。

3. 发明授权

US06198004B1 Process for hydrogenation of isoalpha acids 有权
标题翻译：异磷酸氢化方法
公开(公告)号：US06198004B1
公开(公告)日：2001-03-06
申请号：US09329299
申请日：1999-06-10
申请人： John Paul Maye , Jianping Xu , George Gauthier , Scott W. Weis
发明人： John Paul Maye , Jianping Xu , George Gauthier , Scott W. Weis
IPC分类号： C07C4567
CPC分类号： C12C5/026 , C12C3/08 , C12C3/12 , C12C9/025
摘要： The invention relates to a process for converting alpha acid and isoalpha acids to tetrahydroisoalpha acid. The process comprises isomerizing an alpha acid to produce isoalpha acid and hydrogenating the isoalpha acid in the presence of a noble metal catalyst wherein, the noble metal catalyst is added incrementally or continuously throughout the hydrogenation step. The invention also relates to tetrahydroisoalpha acids made by the above process.
摘要翻译：本发明涉及将α-酸和异α-酸转化为四氢异α酸的方法。该方法包括异构化α酸以产生异α酸并在贵金属催化剂存在下氢化异α酸，其中贵金属催化剂在整个氢化步骤中逐渐或连续地加入。本发明还涉及通过上述方法制备的四氢异构酸。

4. 发明授权

US06274771B1 Continuous process for the manufacture of 3,5,5-trimethylcyclohexa-3-en-1-one (B-isophorone) 失效
标题翻译：用于制造3,5,5-三甲基环己-3-烯-1-酮（B-异佛尔酮）的连续方法
公开(公告)号：US06274771B1
公开(公告)日：2001-08-14
申请号：US09598484
申请日：2000-06-22
申请人： Francois Mongenet , Rémy Teissier
发明人： Francois Mongenet , Rémy Teissier
IPC分类号： C07C4567
CPC分类号： C07C45/67 , C07C45/82 , C07C49/603
摘要： For the continuous manufacture of &bgr;-isophorone by isomerization under homogeneous catalysis of &agr;-isophorone, the steps of introducing the &agr;-isophorone and a solution of an alkaline hydroxide into a reaction region, bringing the reaction mixture to reflux at a temperature at least equal to 150° C. under a equal P1 of less than or equal to atmospheric pressure, continuously and simultaneously removing from the reaction mixture: &bgr;-isophorone vapor, by distillation under a pressure P2 less than P1 and at a temperature at most equal to 150° C., and heavy products, at a rate, so that their content by weight is at most equal to 7% in the reaction mixture, and continuous returning the distillation to the reaction region.
摘要翻译：对于在α-异佛尔酮的均相催化下通过异构化连续制造β-异佛尔酮的步骤，将α-异佛尔酮和碱性氢氧化物溶液引入反应区域，使反应混合物在至少相等的温度下回流在小于或等于大气压的相等的P1下，连续并同时地从反应混合物中除去β-异佛尔酮蒸气：在小于P1的压力P2和在至多等于150的温度下蒸馏 °C和重质产物，使其在反应混合物中的重量含量至多等于7％，并将蒸馏物连续返回到反应区域。

5. 发明授权

US06218579B1 Process for the preparation of acylated cyclic 1,3-dicarbonyl compounds 有权
标题翻译：酰化环状1,3-二羰基化合物的制备方法
公开(公告)号：US06218579B1
公开(公告)日：2001-04-17
申请号：US09529743
申请日：2000-04-18
申请人： Robert Oliver Jones , Thomas William Bentley , Stephen Martin Brown
发明人： Robert Oliver Jones , Thomas William Bentley , Stephen Martin Brown
IPC分类号： C07C4567
CPC分类号： C07D231/12 , C07C45/46 , C07C45/54 , C07C315/04 , C07C2601/14 , C07D233/56 , C07D249/08 , C07C317/24 , C07C49/792
摘要： A process for preparing a compound of Formula (I); where Q completes an optionally substituted 5-or 6-member saturated carbocyclic ring and R is optionally substituted phenyl or optionally substituted C3-C6 cycloalkyl which comprises the rearrangement of a compound of Formula (II); where Q and R are as defined in relation to Formula (I) in a polar aprotic, dipolar aprotic or aromatic hydrocarbon solvent in the presence of a moderate base and an azole.
摘要翻译：制备式（I）化合物的方法; 其中Q完成任选取代的5或6元饱和碳环，R是任选取代的苯基或任选取代的C 3 -C 6环烷基，其包括式（II）化合物的重排; 其中Q和R在极性非质子偶极非质子或芳族烃溶剂中在中等碱和唑的存在下如关于式（I）所定义。

6. 发明授权

US06822121B2 Production process of cyclohexenyl ketones 失效
标题翻译：环己烯酮的生产工艺
公开(公告)号：US06822121B2
公开(公告)日：2004-11-23
申请号：US09875158
申请日：2001-06-07
申请人： Shinya Watanabe , Hideo Ujihara , Takeshi Yamamoto , Toshimitsu Hagiwara
发明人： Shinya Watanabe , Hideo Ujihara , Takeshi Yamamoto , Toshimitsu Hagiwara
IPC分类号： C07C4567
CPC分类号： C07C403/16 , C07C45/67 , C07C45/69 , C07C2601/16 , C07C49/543
摘要： An economical process for producing (2- and/or 1-)cyclohexenyl methyl ketones which are intermediates for the synthesis of &agr;- or &bgr;-damascone. In the presence of a catalyst, a 3-cyclohexenyl methyl ketone represented by the following formula (1a): wherein, R1, R2 and R3 each independently represents a hydrogen atom or a methyl group and at least two of R1, R2 and R3 are methyl groups, is isomerized.
摘要翻译：用于生产（2-和/或1-）环己烯基甲基酮的经济方法，其是用于合成α-大脑皮质或大黄酮的中间体。在催化剂存在下，由下式（1a）表示的3-环己烯基甲基酮：其中，R 1，R 2和R 3各自独立地表示氢原子或甲基，R 1，R 2和R 3中的至少两个为甲基，异构化。

7. 发明授权

US06583322B1 Dihydro and hexahydro isoalpha acids having a high ratio of trans to cis isomers, production thereof, and products containing the same 有权
公开(公告)号：US06583322B1
公开(公告)日：2003-06-24
申请号：US09512944
申请日：2000-02-25
申请人： Khalil Shahlai , Randall H. Mennett , Paul H. Todd , James A. Guzinski
发明人： Khalil Shahlai , Randall H. Mennett , Paul H. Todd , James A. Guzinski
IPC分类号： C07C4567
CPC分类号： C12C3/085 , C12C5/02
摘要： This invention describes heretofore unknown forms of dihydro (DHIA) and hexahydro (HHIA) isoalpha acids having a high ratio of trans to cis isomers and a process for their production. Also, non-precipitating clear 5, 10, 20% and higher aqueous solutions thereof, since they are soluble at room temperature in soft water. This is due to the high ratio of trans to cis isomers. Unlike prior art essentially all cis isomer products, they remain haze free both at a neutral pH in water and at 1% to 2% and higher concentrations. This invention has the advantage over the prior art in that DHIA and HHIA can be provided as stable, non-separating liquids, at practical concentrations in the range of 5% to about 40%, which do not require heating to about 50° to 90° C. and above with stirring to effect dissolution of precipitates. The high trans products described herein can be admixed with isoalpha- and tetrahydro-isoalpha acids.

8. 发明授权

US06521796B2 Dihydro and hexahydro isoalpha acids having a high ratio of trans to cis isomers, production thereof, and products containing the same 有权
公开(公告)号：US06521796B2
公开(公告)日：2003-02-18
申请号：US09911063
申请日：2001-07-23
申请人： Khalil Shahlai , Randall H. Mennett , Paul H. Todd , James A. Guzinski
发明人： Khalil Shahlai , Randall H. Mennett , Paul H. Todd , James A. Guzinski
IPC分类号： C07C4567
CPC分类号： C12C3/085 , C12C5/02
摘要： This invention describes heretofore unknown forms of dihydro (DHIA) and hexahydro (HHIA) isoalpha acids having a high ratio of trans to cis isomers and a process for their production. Also, non-precipitating clear 5, 10, 20% and higher aqueous solutions thereof, since they are soluble at room temperature in soft water. This is due to the high ratio of trans to cis isomers. Unlike prior art essentially all cis isomer products, they remain haze free both at a neutral pH in water and at 1% to 2% and higher concentrations. This invention has the advantage over the prior art in that DHIA and HHIA can be provided as stable, non-separating liquids, at practical concentrations in the range of 5% to about 40%, which do not require heating to about 50° to 90° C. and above with stirring to effect dissolution of precipitates. The high trans products described herein can be admixed with isoalpha- and tetrahydro-isoalpha acids.

9. 发明授权

US06518461B2 Method of continuously producing a cyclododecanone compound 有权
公开(公告)号：US06518461B2
公开(公告)日：2003-02-11
申请号：US09981963
申请日：2001-10-19
申请人： Ryoji Sugise , Shuji Tanaka , Takashi Doi , Masayuki Nishio , Sadao Niida , Tsunao Matsuura
发明人： Ryoji Sugise , Shuji Tanaka , Takashi Doi , Masayuki Nishio , Sadao Niida , Tsunao Matsuura
IPC分类号： C07C4567
CPC分类号： C07C45/58 , C07C49/413 , C07C49/607
摘要： A cyclododecanone compound is continuously produced by an isomerization reaction of a corresponding epoxycyclododecane compound in the presence of a catalyst including lithium bromide and/or lithium iodide, the isomerization reaction being carried out by passing a reaction mixture containing the epoxycyclododecane compound and the catalyst through a continuous reaction apparatus including at least one tubular reactor preferably at a temperature of 100 to 350° C.

10. 发明授权

US06469215B1 Process for the production of an intermediate mixture of &bgr;-isophorone epoxide and its isomer 4-hydroxyisophorone (HIP) 失效
标题翻译：制备β-异佛尔酮环氧化物及其异构体4-羟基异佛尔酮（HIP）的中间体混合物的方法
公开(公告)号：US06469215B1
公开(公告)日：2002-10-22
申请号：US10084157
申请日：2002-02-28
申请人： Steffen Krill , Klaus Huthmacher , Sylvain Perrin
发明人： Steffen Krill , Klaus Huthmacher , Sylvain Perrin
IPC分类号： C07C4567
CPC分类号： C07C45/58 , C07C45/512 , C07C45/64 , C07C49/403 , C07C49/713
摘要： A process for the production of an intermediate mixture of &bgr;-isophorone epoxide and its isomer 4-hydroxyisophorone (HIP), comprising reacting &bgr;-isophorone with an organic percarboxylic acid, in the form of its non-aqueous solution, in an inert solvent.
摘要翻译：制备β-异佛尔酮环氧化物及其异构体4-羟基异佛尔酮（HIP）的中间体混合物的方法，其包括以非水溶液的形式将β-异佛尔酮与有机过羧酸在惰性溶剂中反应。

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