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1. 发明授权

US5945408A Hydroxyanidino derivatives useful as nitric oxide synthase inhibitors 失效
标题翻译：羟基亚氨基衍生物可用作一氧化氮合酶抑制剂
公开(公告)号：US5945408A
公开(公告)日：1999-08-31
申请号：US689463
申请日：1996-08-08
申请人： R. Keith Webber , Foe S. Tjoeng , Robert E. Manning
发明人： R. Keith Webber , Foe S. Tjoeng , Robert E. Manning
IPC分类号： A61K31/00 , A61K31/155 , A61K31/195 , A61K31/197 , A61K31/22 , A61K31/415 , A61K31/4164 , A61K31/4166 , A61K31/42 , A61K31/535 , A61K31/5377 , A61K31/5395 , A61K31/55 , A61P9/00 , A61P25/04 , A61P29/00 , A61P37/00 , C07C257/14 , C07C259/14 , C07C271/22 , C07C275/16 , C07C313/28 , C07C313/34 , C07C323/60 , C07C327/22 , C07C329/02 , C07C329/06 , C07C333/04 , C07C391/00 , C07D223/12 , C07D233/56 , C07D233/76 , C07D261/08 , C07D273/02 , C07F7/08 , C07K5/068 , C07F7/10 , A01N55/00
CPC分类号： C07F7/0818 , C07C257/14 , C07C259/14 , C07C275/16 , C07C313/28 , C07C323/60 , C07C327/22 , C07C329/02 , C07C329/06 , C07C333/04 , C07C391/00 , C07D223/12 , C07D261/08
摘要： The current invention discloses hydroxyamidino derivatives useful as nitric oxide synthase inhibitors.
摘要翻译：本发明公开了可用作一氧化氮合酶抑制剂的羟基脒基衍生物。

2. 发明授权

US4987135A Substituted benzene derivatives, processes for their production and antitumor compositions containing them 失效
标题翻译：取代苯衍生物，其制备方法和含有它们的抗肿瘤组合物
公开(公告)号：US4987135A
公开(公告)日：1991-01-22
申请号：US324559
申请日：1989-03-16
申请人： Takahiro Haga , Nobutoshi Yamada , Hideo Sugi , Toru Koyanagi , Hiroshi Okada
发明人： Takahiro Haga , Nobutoshi Yamada , Hideo Sugi , Toru Koyanagi , Hiroshi Okada
IPC分类号： C07D295/12 , A61K31/50 , A61K31/505 , A61P35/00 , C07C257/08 , C07C275/54 , C07C313/34 , C07C323/44 , C07C327/58 , C07C329/04 , C07C381/04 , C07C381/08 , C07D213/64 , C07D213/81 , C07D237/14 , C07D239/34 , C07D295/155 , C07D401/12 , C07F9/24 , C07F9/6512
CPC分类号： C07D213/64 , C07C257/08 , C07C327/58 , C07D237/14 , C07D239/34 , C07D295/155 , C07D401/12 , C07F9/65127 , C07C2101/08 , C07C2101/14
摘要： A substituted benzene derivative represented by a formula: ##STR1## where A represents: ##STR2## wherein X is a hydrogen atom, a halogen atom or a nitro group, R.sup.1 is --X.sup.1 Z.sup.1 (X.sup.1 is an oxygen atom or a sulfur atom and Z.sup.1 is a substituted or unsubstituted alkyl group, a substituted or unsubstituted alkenyl group, a substituted or unsubstituted alkynyl group, a substituted or unsubstituted aryl group or a substituted or unsubstituted heteroaryl group), --COZ.sup.1 group (Z.sup.1 is as defined above), ##STR3## group (Z.sup.1 is as defined above, Z.sup.2 is --CO.sub.2 Z.sup.3 wherein Z.sup.3 is the same as Z.sup.1, or --SO.sub.2 Z.sup.3 wherein Z.sup.3 is as defined above and n is 0 or 1), ##STR4## (Z.sup.1 and Z.sup.3 are as defined above) or ##STR5## (X.sup.2, X.sup.3 and X.sup.4 are, respectively, an oxygen atom or a sulfur atom and Z.sup.4 and Z.sup.5 are the same as Z.sup.1), and R.sup.3 is a nitro group or ##STR6## (R.sup.4 and R.sup.5 are, respectively, an alkyl group, or they may form a heterocyclic group together with the adjacent nitrogen atom), or ##STR7## wherein X and R.sup.3 are as defined above and R.sup.2 is --X.sup.1 Z.sup.1 (X.sup.1 and Z.sup.1 are as defined above); Y is a halogen atom, a substituted or unsubstituted alkyl group, a substituted or unsubstituted alkoxy group, a substituted or unsubstituted alkylthio group, a nitro group or ##STR8## (R.sup.6 and R.sup.7 are, respectively, a substituted or unsubstituted alkyl group); R is ##STR9## (R.sup.8 is the same as Y and q is an integer of 1 to 4), ##STR10## (R.sup.8 is as defined above, and r is an integer of 1 to 3) or ##STR11## (R.sup.8 and r are defined above); and m is an integer, of 1 to 4, or its salt.

3. 发明授权

US4514417A Combating fungi with new N-sulphenylated allophanates 失效
标题翻译：与新的N-磺基脲基甲酸酯反应真菌
公开(公告)号：US4514417A
公开(公告)日：1985-04-30
申请号：US328318
申请日：1981-12-07
申请人： Engelbert Kuhle , Hermann Hagemann , Volker Paul , Wilhelm Brandes
发明人： Engelbert Kuhle , Hermann Hagemann , Volker Paul , Wilhelm Brandes
IPC分类号： A01N47/34 , C07C17/25 , C07C67/00 , C07C313/00 , C07C313/34 , C07C323/49 , C07C83/10 , A01N37/00
CPC分类号： C07C313/34 , A01N47/34 , C07C17/25
摘要： N-sulphenylated allophanates of the formula ##STR1## in which R.sup.1 represents a trihalogenomethyl radical,R.sup.2 represents an aliphatic, cycloaliphatic, araliphatic or aromatic radical which may in each case be optionally substituted,R.sup.3 represents an aliphatic, cycloaliphatic, araliphatic or aromatic radical which may in each case be optionally substituted andX represents oxygen or sulphur,which possess fungicidal activity.
摘要翻译：式“IMAGE”的N-磺基化脲基甲酸酯，其中R 1表示三卤代甲基，R 2表示脂族，脂环族，芳脂族或芳族基团，其各自可任选被取代，R 3表示脂族，脂环族，芳脂族或芳族基团，在每种情况下可以任选被取代，X代表具有杀真菌活性的氧或硫。

4. 发明授权

US4482737A Preparation of N-substituted N-isocyanatocarbonyl-carbamates 失效
标题翻译： N-取代的N-异氰酸基羰基 - 氨基甲酸酯的制备
公开(公告)号：US4482737A
公开(公告)日：1984-11-13
申请号：US439101
申请日：1982-11-03
申请人： Engelbert Kuhle , Hermann Hagemann
发明人： Engelbert Kuhle , Hermann Hagemann
IPC分类号： A01N47/40 , C07C67/00 , C07C239/00 , C07C271/08 , C07C273/18 , C07C275/60 , C07C275/62 , C07C313/34 , C07D307/83 , C07C125/065 , C07C125/067
CPC分类号： C07C275/60
摘要： N-substituted N-isocyanatocarbonyl-carbamates, some of which are new, of the general formula ##STR1## are prepared by reacting an N-substituted carbamic acid ester of the general formulaR--NH--COOR.sup.1 (II)with chlorocarbonyl isocyanate of the formulaCl--CO--NCO (III)in a diluent, at a temperature between 50.degree. and 200.degree. C. The compounds (I) can be used as intermediate products for the preparation of new pest-combating agents.
摘要翻译： N-取代的N-异氰酸酯基羰基 - 氨基甲酸酯，其中一些是新的通式为（I）的化合物通过使通式为R-NH-COOR1（II）的N-取代氨基甲酸酯与氯羰基稀释剂中的式Cl-CO-NCO（III）的异氰酸酯在50至200℃的温度下进行。化合物（I）可用作制备新的防虫剂的中间产物。

5. 发明授权

US4012436A Carbamoyl chlorides 失效
标题翻译：氨基甲酰氯
公开(公告)号：US4012436A
公开(公告)日：1977-03-15
申请号：US549215
申请日：1975-02-12
申请人： Joseph E. Moore
发明人： Joseph E. Moore
IPC分类号： C07C313/34 , C07C161/00
CPC分类号： C07C313/34 , Y02P20/582
摘要： N-substituted-thio N-alkyl carbamoyl chlorides are prepared by reacting an N-arylthio- or N-aliphaticthio-N-alkylamine with phosgene. The N-arylthio- or N-aliphaticthio-N-alkyl carbamoyl chlorides are useful intermediates for the preparation of pesticides.
摘要翻译： N-取代硫代N-烷基氨基甲酰氯通过N-芳硫基或N-脂族硫代-N-烷基胺与光气反应来制备。 N-芳硫基或N-脂族硫代-N-烷基氨基甲酰氯是制备农药的有用的中间体。

6. 发明授权

US10717704B2 Inhibitors of creatine transport and uses thereof 有权
公开(公告)号：US10717704B2
公开(公告)日：2020-07-21
申请号：US16389008
申请日：2019-04-19
申请人： Rgenix, Inc.
发明人： Eduardo J. Martinez , Sohail F. Tavazoie
IPC分类号： A61K31/7105 , A61K31/704 , A61K31/337 , A61K31/155 , A61K31/53 , A61K31/7068 , A61K45/06 , A61K31/397 , A61K31/40 , A61K31/4168 , A61K31/4402 , A61K31/4427 , A61K31/505 , C07C279/14 , C07C279/16 , C07C313/34 , C07F9/48 , C07F9/09 , C07F9/24 , C07F9/38 , C07F9/40 , A61K31/00 , C07D213/76 , C07C257/14 , C07C259/14 , C07C279/26 , C07C279/36 , C07C281/16 , C07C281/18 , C07D231/12 , C07C309/15 , C07D233/26 , C07D233/46 , C07D233/52 , C07D233/64 , C07D233/88 , C07D401/04 , C07D239/06 , C07D405/04 , C07D239/14 , C07D249/08 , C07D249/14 , C07D253/06 , C07D257/08 , C07D487/04 , C07D205/04 , C07D207/16 , C07D207/22 , C07D295/32 , C07F9/568 , C07F9/572 , C07F9/6506 , C07C275/70 , C07D205/08 , C07D213/74 , C07H19/06
摘要： This invention relates to compounds that inhibit creatine transport and/or creatine kinase, pharmaceutical compositions including such compounds, and methods of utilizing such compounds and compositions for the treatment of cancer.

7. 发明授权

US4623658A Pesticidal benzoylurea compounds 失效
标题翻译：杀虫剂苯甲酰脲化合物
公开(公告)号：US4623658A
公开(公告)日：1986-11-18
申请号：US825172
申请日：1986-02-03
申请人： Martin Anderson
发明人： Martin Anderson
IPC分类号： A01N47/34 , C07C313/34 , C07D207/48 , C07C145/04
CPC分类号： C07C313/34 , A01N47/34 , C07D207/48
摘要： Pesticidal benzoylurea compounds of the formula: ##STR1## wherein R represents a moiety --C(O)OR.sup.1 or --NR.sup.2 R.sup.3, and the meanings of each of the other symbols is described in the specification.
摘要翻译：其中R表示-C（O）OR 1或-NR 2 R 3的部分的下式的农药苯甲酰脲化合物，以及其它各符号的含义在说明书中描述。

8. 发明授权

US4517193A Pesticidal benzoylurea compounds 失效
标题翻译：杀虫剂苯甲酰脲化合物
公开(公告)号：US4517193A
公开(公告)日：1985-05-14
申请号：US529909
申请日：1983-09-07
申请人： Martin Anderson
发明人： Martin Anderson
IPC分类号： A01N47/34 , C07C67/00 , C07C313/00 , C07C313/34 , C07C317/44 , C07C323/64 , C07D213/64 , C07D213/643 , C07D307/12 , C07C145/04
CPC分类号： C07D213/643 , A01N47/34 , C07C313/34 , C07D307/12
摘要： A benzoylurea compound of formula: ##STR1## in which each of P and Q independently represents a halogen atom or an alkyl group; m represents 0, 1 or 2; R represents an optionally-substituted alkyl, alkenyl, alkynyl, cycloalkyl or phenyl group, a hydrogen atom, one equivalent of an alkali metal or alkaline earth metal, or an ammonium or substituted ammonium group; each X independently represents a halogen atom, a cyano, nitro or carboxy group, or an optionally-substituted alkyl, alkoxy, alkylthio, cycloalkyl, cycloalkyloxy, cycloalkylthio, alkenyl, alkenylthio, alkylcarbonyl, alkoxycarbonyl, alkylsulphonyl, alkynyl, phenyl, phenoxy, phenylthio or amino group; q=0, 1, 2, 3 or 4; T represents a halogen atom, an alkyl, haloalkyl, alkoxy, haloalkoxy, alkenyloxy or haloalkenyloxy group, or a phenoxy or pyridyloxy group optionally substituted by one or more substituents selected from halogen atoms and nitro, alkyl, haloalkyl and cyano groups; each Y independently represents a halogen atom or a nitro, cyano, alkyl or haloalkyl group; and p=0, 1, 2, 3 or 4. The compounds have pesticidal activity, and may be prepared from novel sulphenamide starting materials.
摘要翻译：其中P和Q各自独立地表示卤素原子或烷基的式（I）的苯甲酰脲化合物： m表示0,1或2; R表示任选取代的烷基，烯基，炔基，环烷基或苯基，氢原子，一当量的碱金属或碱土金属，或铵或取代的铵基; 每个X独立地表示卤素原子，氰基，硝基或羧基，或任选取代的烷基，烷氧基，烷硫基，环烷基，环烷氧基，环烷硫基，烯基，烯硫基，烷基羰基，烷氧基羰基，烷基磺酰基，炔基，苯基，苯氧基，或氨基; q = 0,1,2,3或4; T表示卤素原子，烷基，卤代烷基，烷氧基，卤代烷氧基，烯氧基或卤代烯氧基，或任选被一个或多个选自卤素原子和硝基，烷基，卤代烷基和氰基的取代基取代的苯氧基或吡啶氧基; 每个Y独立地表示卤素原子或硝基，氰基，烷基或卤代烷基; 并且p = 0,1,2,3或4.这些化合物具有杀虫活性，并且可以由新的磺基苯胺起始原料制备。

9. 发明授权

US4137068A Novel ureas 失效
标题翻译：小牛尿
公开(公告)号：US4137068A
公开(公告)日：1979-01-30
申请号：US667992
申请日：1976-03-18
申请人： Jacques Perronnet , Jean-Pierre Demoute , Pierre Girault , Andre Teche
发明人： Jacques Perronnet , Jean-Pierre Demoute , Pierre Girault , Andre Teche
IPC分类号： A01N47/34 , C07C67/00 , C07C313/00 , C07C313/08 , C07C313/34 , C07D263/04 , A01N9/12 , C07C119/20
CPC分类号： C07C313/34
摘要： Novel ureas of the formula ##STR1## wherein A and B are chlorine or A is chlorine or hydrogen and B is --CF.sub.3, R and R.sub.1 are individually alkyl of 1 to 3 carbon atoms and R.sub.2 is alkyl of 1 to 6 carbon atoms optionally substituted with a halogen having herbicidal properties, particularly useful in cultivated grass crops and their preparation and use.
摘要翻译：其中A和B为氯或A为氯或氢且B为-CF 3，R和R 1分别为1至3个碳原子的烷基和R 2为任选的1至6个碳原子的烷基的新颖的脲被具有除草性的卤素取代，特别适用于栽培草作物及其制备和用途。

10. 发明授权

US3887619A N-hydrocarbylsulfenyl-N-alkyl-N{40 -arylformamidines 失效
标题翻译： N-烃基亚磺酰基-N-烷基-N（40-芳基甲酰胺）
公开(公告)号：US3887619A
公开(公告)日：1975-06-03
申请号：US36699973
申请日：1973-06-01
申请人： UPJOHN CO
发明人： RIZZO VICTOR L
IPC分类号： A01N37/52 , C07C67/00 , C07C239/00 , C07C257/12 , C07C313/00 , C07C313/34 , C07C123/00
CPC分类号： A01N37/52
摘要： Novel pesticidal N-hydrocarbylsulfenyl derivatives of N-alkylN''-aryl formamidines are disclosed with novel compositions thereof and methods of their use in controlling invertebrate pests, particularly insects and acarina. Certain of the novel compounds are particularly effective miticides.
摘要翻译：公开了N-烷基-N'-芳基甲酰胺的新型农药N-烃基亚磺酰基衍生物及其用于控制无脊椎动物害虫，特别是昆虫和螨类的新型组合物及其方法。某些新化合物是特别有效的杀螨剂。

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