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1. 发明授权

US06844464B2 Process for producing alkyl nitrite 有权
公开(公告)号：US06844464B2
公开(公告)日：2005-01-18
申请号：US10388302
申请日：2003-03-13
申请人： Ryoji Sugise , Shuji Tanaka , Hirofumi Ii , Kazuaki Mii
发明人： Ryoji Sugise , Shuji Tanaka , Hirofumi Ii , Kazuaki Mii
IPC分类号： C07C201/04 , C07C203/00 , C07C203/02
CPC分类号： C07C201/04 , C07C203/00
摘要： An alkyl nitrite is produced with high efficiency by bringing a nitrogen monoxide gas into contact with an aqueous solution of an alkyl alcohol and nitric acid in a reactor 2, which aqueous solution may be a liquid fraction generated in an alkyl nitrite-production process in which an alkyl alcohol is reacted with nitrogen monoxide and oxygen in a reaction column 1.

2. 发明授权

US3792077A 2,2-dimethylpropanediol-1,3-dinitrite 失效
标题翻译： 2,2-二甲基丙酰胺-1,3-丁腈
公开(公告)号：US3792077A
公开(公告)日：1974-02-12
申请号：US3792077D
申请日：1971-10-04
申请人： BASF AG
发明人： BERMES R , SCHMEIDL K
IPC分类号： C07C67/00 , C07C201/00 , C07C201/04 , C07C203/00 , C09B41/00 , C09B67/24 , C07C77/02
CPC分类号： C09B41/00 , C07C203/00 , C09B67/0072
摘要： NITRITES OF GLYCOLS AND GLYCOL DERIVATIVES OBTAINABLE BY ESTERIFICATION WITH NITROUS ACID. THE COMPOUNDS ARE EMINENTLY SUITABLE AS DIAZOTIZING AGENTS, PARTICULARLY IN ORGANIC SOLUTION.

3. 发明授权

US3649665A Hydrocarbon oxidation with nitric oxide and oxygen 失效
标题翻译：与氧化氮和氧气的氢氧化
公开(公告)号：US3649665A
公开(公告)日：1972-03-14
申请号：US3649665D
申请日：1969-04-23
申请人： TEXACO INC
发明人： CHAFETZ HARRY , BLACKLEY WILLIAM D , KREUZ KENNETH L
IPC分类号： C07C45/33 , C07C45/36 , C07C51/31 , C07C201/02 , C07C201/04 , C07C203/00 , C07C205/02 , C07C205/06 , C07C77/00 , C07C77/02 , C07C79/02
CPC分类号： C07C201/02 , C07C45/33 , C07C45/36 , C07C51/316 , C07C201/04 , C07C201/06 , C07C2601/14 , C07C203/02 , C07C203/00 , C07C205/06 , C07C205/02
摘要： THIS INVENTION RELATES TO THE RELATIVELY LOW TEMPERATURE TREATMENT OF HYDROCARBONS WITH NITRIC OIDE (NO) AND OXYGEN TO RPODUCE NITRATES, NITRITES AND KETONES AND OTHER OXIDATION PRODUCTS. THROUGH THE USE OF ALKALINE INHIBITORS SUCH AS ALKALI METAL BICARBONATES, THE PRODUCTION OF KETONES AND OTHER NON-NITROGEN CONTAINING OXIDATION PRODUCTS CAN BE MINIMIZED WHILE THE PRODUCTION OF ITRATES AND NITRIES ARE MAXIMIZED.

4. 发明授权

US3607877A Process for converting aromatic thiols to nitroso and nitro compounds 失效
标题翻译：将硝酸和硝基化合物转化为芳香油的方法
公开(公告)号：US3607877A
公开(公告)日：1971-09-21
申请号：US3607877D
申请日：1968-10-31
申请人： DOW CHEMICAL CO
发明人： DOMENICO PENELOPE B
IPC分类号： C07B43/02 , C07C201/04 , C07C201/10 , C07C205/06 , C07C205/10 , C07C205/12 , C07C205/57 , C07D213/61 , C07D213/71 , C07D213/79 , C07D213/84 , C07D31/40
CPC分类号： C07D213/79 , C07B43/02 , C07C201/10 , C07C303/22 , C07C319/20 , C07D213/61 , C07D213/71 , C07D213/84 , C07C205/06 , C07C205/11 , C07C205/12 , C07C205/57 , C07C309/40 , C07C323/09
摘要： A process is disclosed for converting aromatic thiols to the corresponding nitroso- or nitro-substituted compounds by treating the thiol compounds with an excess of nitric acid having a HNO3 concentration of 90 to 100 percent. Representative starting compounds are benzenethiols and pyridinethiols which, in addition to the thiol group, are substituted with one or more electronwith-drawing groups such, for example, as chloro, nitro or cyano, among others. The nitroso and nitro compounds produced during the reaction have utility as pesticides and are variously effective as herbicides and in the control of fungi and nematodes as well as of parasites infecting warmblooded animals.

5. 发明授权

US3520744A Free-running pentaerythritoltetranitrate and process of preparing same 失效
标题翻译：自由运行的精油和其制备方法
公开(公告)号：US3520744A
公开(公告)日：1970-07-14
申请号：US3520744D
申请日：1969-02-27
申请人： ICI LTD
发明人： THOMAS HUGH , TURBET JOHN
IPC分类号： C06B25/00 , C06B25/32 , C07C67/00 , C07C201/00 , C07C201/04 , C07C203/04 , C07C205/04 , C06B3/00
CPC分类号： C07C203/04 , C06B25/32

6. 发明授权

US09844599B2 Nitric oxide releasing produgs of therapeutic agents 有权
公开(公告)号：US09844599B2
公开(公告)日：2017-12-19
申请号：US14761887
申请日：2014-01-17
申请人： Apparao Satyam
发明人： Apparao Satyam
IPC分类号： A61K31/21 , A61K31/60 , C07D201/04 , A61K47/48 , C07C229/42 , C07C201/04 , C07C227/18 , A61K31/216 , A61K31/621 , C07C203/04
CPC分类号： A61K47/542 , A61K31/21 , A61K31/216 , A61K31/60 , A61K47/55 , C07C201/04 , C07C203/04 , C07C227/18 , C07C229/42
摘要： The present invention relates to nitric oxide releasing prodrugs of known drugs or therapeutic agents wherein the drug or therapeutic agents contain at least one carboxylic acid group. The invention also relates to processes for the preparation of these nitric oxide releasing prodrugs, to pharmaceutical compositions containing them and to methods of using these produgs.

7. 发明申请

US20150328323A1 Nitric Oxide Releasing Produgs of Therapeutic Agents 审中-公开
标题翻译：一氧化氮释放治疗药物
公开(公告)号：US20150328323A1
公开(公告)日：2015-11-19
申请号：US14761887
申请日：2014-01-17
申请人： Apparao SATYAM
发明人： Apparao Satyam
IPC分类号： A61K47/48 , C07C229/42 , C07C227/18 , A61K31/621 , A61K31/216 , C07C201/04 , C07C203/04 , A61K45/06
CPC分类号： A61K47/542 , A61K31/21 , A61K31/216 , A61K31/60 , A61K47/55 , C07C201/04 , C07C203/04 , C07C227/18 , C07C229/42
摘要： The present invention relates to nitric oxide releasing prodrugs of known drugs or therapeutic agents wherein the drug or therapeutic agents contain at least one carboxylic acid group. The invention also relates to processes for the preparation of these nitric oxide releasing prodrugs, to pharmaceutical compositions containing them and to methods of using these produgs.
摘要翻译：本发明涉及已知药物或治疗剂的一氧化氮释放前药，其中药物或治疗剂含有至少一个羧酸基团。本发明还涉及制备这些一氧化氮释放前体药物的方法，含有它们的药物组合物以及使用这些产品的方法。

8. 发明授权

US5649322A Process for the preparation of C.sub.1 -C.sub.4 -alkyl nitrites 失效
标题翻译：制备C1-C4烷基亚硝酸盐的方法
公开(公告)号：US5649322A
公开(公告)日：1997-07-15
申请号：US571625
申请日：1995-12-11
申请人： Heinz Landscheidt , Paul Wagner , Zoltan Kricsfalussy , Alexander Klausener
发明人： Heinz Landscheidt , Paul Wagner , Zoltan Kricsfalussy , Alexander Klausener
IPC分类号： C07C201/04 , C07C203/00 , C07C203/02
CPC分类号： C07C201/04
摘要： C.sub.1 -C.sub.4 -Alkyl nitrites can be prepared by reaction of C.sub.1 -C.sub.4 -alkanols with nitrogen oxides with the participation of oxygen in a reactor designed as a scrubber column, nitrogen oxides having a proportion of more than 50% of NO of the total amount of gram atoms of N of the nitrogen oxides, oxygen and optionally inert gas being fed into the lower part of the reactor. 5 to 60% of the total amount of C.sub.1 -C.sub.4 -alkanol used is likewise fed into the lower part of the reactor in vaporous or atomized form, while the remaining C.sub.1 -C.sub.4 -alkanol is delivered to the column head.
摘要翻译： C1-C4烷基亚硝酸盐可以通过在设计为洗涤塔的反应器中将C1-C4-链烷醇与氮氧化物反应而制备，氧化反应设计为总量超过NO的50％的氮原子的氮原子的克原子，氧和任选的惰性气体被供给到反应器的下部。使用的C 1 -C 4烷醇的总量的5-60％同样以蒸气或雾化的形式进料到反应器的下部，而剩余的C1-C4-链烷醇被输送到塔头。

9. 发明授权

US5543548A Process for the preparation of dimethyl carbonate 失效
标题翻译：碳酸二甲酯的制备方法
公开(公告)号：US5543548A
公开(公告)日：1996-08-06
申请号：US273548
申请日：1994-07-11
申请人： Heinz Landscheidt , Erich Wolters , Paul Wagner , Alexander Klausener
发明人： Heinz Landscheidt , Erich Wolters , Paul Wagner , Alexander Klausener
IPC分类号： C07B61/00 , C07C31/04 , C07C68/00 , C07C68/08 , C07C69/96 , C07C201/04 , C07C203/00
CPC分类号： C07C68/00
摘要： Dimethyl carbonate (DMC) is prepared by continuous gas reaction of carbon monoxide and methyl nitrite a heterogeneous catalyst comprising a platinum at 50.degree. to 170.degree. C. under 1 to 5 bar.
摘要翻译：通过一氧化碳和亚硝酸甲酯的连续气相反应制备碳酸二甲酯（DMC），该催化剂在1至5巴下在50至170℃下包含铂。

10. 发明授权

US4879401A Process for removal of impurities in alkyl nitrite formation 失效
标题翻译：去除亚硝酸烷基酯形成中的杂质的方法
公开(公告)号：US4879401A
公开(公告)日：1989-11-07
申请号：US102370
申请日：1987-09-29
申请人： Arthur R. Doumaux, Jr. , James R. Nelson
发明人： Arthur R. Doumaux, Jr. , James R. Nelson
IPC分类号： C07C201/16 , C07C67/00 , C07C201/00 , C07C201/04 , C07C203/00 , C07C203/02 , C07C203/04
CPC分类号： C07C201/04
摘要： A process is provided for removing impurities from the gaseous product of an alkyl nitrite production zone by contacting a portion of it with lower alcohol and oxygen to convert substantially all of the nitric oxide in that portion of the gaseous product stream to alkyl nitrite, the oxygen being present in an amount such that the mole ratio of nitric oxide to oxygen is in the range of about 4:1 to about 2:1 and the lower alcohol being present in the reaction zone such that the mole ratio of nitric oxide to lower alcohol is about 1:1 or less. A recovery stream, comprising alkyl nitrite substantially free of nitric oxide, is withdrawn from the reaction zone and at least a portion of the alkyl produced in the reaction zone is removed. A least a portion of the balance of the recovery stream from which the alkyl nitrite has been removed is purged, thereby removing impurities from the process.
摘要翻译：提供了一种通过使其一部分与低级醇和氧接触而从亚硝酸烷基酯生产区的气态产物中除去杂质的方法，以将该部分气态产物流中的所有一氧化氮转化为亚硝酸烷基酯，氧气存在的量使得一氧化氮与氧的摩尔比在约4:1至约2:1的范围内，低级醇存在于反应区中，使得一氧化氮与低级醇的摩尔比约为1：1或更少。包含基本上不含一氧化氮的亚硝酸烷基酯的回收流从反应区中排出，并且除去反应区中产生的烷基的至少一部分。将亚硝酸烷基酯从其中除去的回收料流的余量的至少一部分被清除，从而从该方法中除去杂质。

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