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1. 发明授权

US4515732A Conversion of acetonitrile to glycolonitrile and/or glycolamide 失效
标题翻译：乙腈转化为乙醇腈和/或乙二醇酰胺
公开(公告)号：US4515732A
公开(公告)日：1985-05-07
申请号：US614609
申请日：1984-05-29
申请人： James F. Brazdil, Jr. , William A. Marritt , Michael D. Ward
发明人： James F. Brazdil, Jr. , William A. Marritt , Michael D. Ward
IPC分类号： C07C121/36 , C07C103/167
CPC分类号： C07C255/00
摘要： The vapor phase oxidation of acetonitrile with molecular oxygen in the presence or absence of water vapor to produce glycolonitrile or glycolamide.
摘要翻译：在存在或不存在水蒸气的情况下，用分子氧进行乙腈气相氧化，生成乙醇腈或乙二醇。

2. 发明授权

US4611067A Process for the preparation of HMG-CoA reductase inhibitors and intermediate compounds employed therein 失效
标题翻译：用于制备HMG-CoA还原酶抑制剂及其中使用的中间体化合物的方法
公开(公告)号：US4611067A
公开(公告)日：1986-09-09
申请号：US696963
申请日：1985-01-31
申请人： Ralph P. Volante , Thomas R. Verhoeven , Meyer Sletzinger , James M. McNamara , Thomas M. H. Liu , Edward G. Corley
发明人： Ralph P. Volante , Thomas R. Verhoeven , Meyer Sletzinger , James M. McNamara , Thomas M. H. Liu , Edward G. Corley
IPC分类号： C07D309/30 , C07C102/00 , C07C102/08 , C07C103/167 , C07C103/173
CPC分类号： C07D309/30
摘要： This invention relates to a novel process for the preparation of 3-hydroxy-3-methylglutarylcoenzyme A (HMG-CoA) reductase inhibitors which contain a 4-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one moiety, such as compactin and mevinolin, by utilizing an alkyl 4-cyano-3(R)-hydroxybutanoate as a chiral synthon for the stereospecific introduction of the 4-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one moiety.
摘要翻译：本发明涉及一种制备含有4-羟基-3,4,5,6-四氢-2H-吡喃-2-酮的3-羟基-3-甲基戊二酰辅酶A（HMG-CoA）还原酶抑制剂的新方法通过利用4-氰基-3（R） - 羟基丁酸烷基酯作为手性合成子，用于立体有择地引入4-羟基-3,4,5,6-四氢-2H-吡喃-2-酮， 2-one部分。

3. 发明授权

US4028397A Hydroxycitric acid derivatives 失效
标题翻译：羟基柠檬酸衍生物
公开(公告)号：US4028397A
公开(公告)日：1977-06-07
申请号：US600995
申请日：1975-08-01
申请人： Robert William Guthrie , Richard Wightman Kierstead
发明人： Robert William Guthrie , Richard Wightman Kierstead
IPC分类号： C07C103/167 , C07C103/37
CPC分类号： C07C235/14 , C07C2103/74
摘要： Ester and amide derivatives of threo-hydroxycitric acid .gamma.-lactone inhibit fatty acid synthesis in biological systems and are useful in the treatment of obesity and in correcting conditions of lipid abnormalities.
摘要翻译：苏氨酸羟基柠檬酸γ-内酯的酯和酰胺衍生物抑制生物系统中的脂肪酸合成，并且可用于治疗肥胖症和纠正脂质异常的情况。

4. 发明授权

US3911002A 3-Carbamoyl-3-hydroxy-4-halobutyric acid and salts thereof 失效
标题翻译： 3-氨基甲酰基-3-羟基-4-卤代丁酸及其盐
公开(公告)号：US3911002A
公开(公告)日：1975-10-07
申请号：US34782273
申请日：1973-04-04
申请人： ETHYL CORP
发明人： WIEGAND KARL E
IPC分类号： C07C51/04 , C07C51/08 , C07C51/41 , C07F1/00 , C07C103/167
CPC分类号： C07F1/005 , C07C51/04 , C07C51/08 , C07C51/41 , C07C51/412 , C07C59/21 , C07C59/265
摘要： It is disclosed that citric acid or its salts are obtained by the hydrolysis of a 3-carbamoyl-3-hydroxy-4-cyanobutyric acid or salt, that a 3-carbamoyl-3-hydroxy-4-cyanobutyric acid or salt is obtained from a 3-carbamoyl-3,4-epoxybutyric acid or salt, that a 3-carbamoyl-3,4-epoxybutyric acid or salt is obtained from a 3carbamoyl-3-hydroxy-4-halobutyric acid or salt, that a 3carbamoyl-3-hydroxy-4-halobutyric acid is obtained from a 3cyano-3-hydroxy-4-halobutyric acid or salt, that a 3-cyano-3hydroxy-4-halobutyric acid or salt is obtained from a 3-oxo-4halobutyric acid or salt, that a 3-oxo-4-halobutyric acid or salt is obtained from a 3-oxo-4-halobutyryl halide, and that a 3-oxo4-halobutyryl halide is obtained from diketene. Preferred halide compounds are compounds of chlorine.
摘要翻译：公开了通过水解3-氨基甲酰基-3-羟基-4-氰基丁酸或其盐得到柠檬酸或其盐，得到3-氨基甲酰基-3-羟基-4-氰基丁酸或其盐由 3-氨基甲酰基-3,4-环氧丁酸或其盐，由3-氨基甲酰基-3-羟基-4-卤代丁酸或其盐得到3-氨基甲酰基-3,4-环氧丁酸或其盐，将3 - 氨基甲酰基-3-羟基-4-卤代丁酸得自3-氰基-3-羟基-4-卤代丁酸或其盐，得到3-氰基-3-羟基-4-卤代丁酸或其盐 3-氧代-4-卤代丁酸或其盐，由3-氧代-4-卤代丁酰卤得到3-氧代-4-卤代丁酸或其盐，得到3-氧代-4-卤代丁酰卤，由双烯酮优选的卤化物是氯的化合物。

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