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1. 发明申请

US20210000738A1 AEROSOL FORMULATION FOR COPD 有权
公开(公告)号：US20210000738A1
公开(公告)日：2021-01-07
申请号：US17019740
申请日：2020-09-14
申请人： CHIESI FARMACEUTICI S.p.A.
发明人： Sauro Bonelli , Francesca Usberti , Enrico Zambelli
IPC分类号： A61K9/00 , A61K31/40 , A61K45/06 , A61K31/167 , A61K31/573 , A61K47/06 , A61K47/10 , B65B31/06 , B65B31/10
摘要： Stable aerosol solution formulations comprising glycopyrronium bromide are useful for administration to patients with COPD and other respiratory conditions.

2. 发明授权

US10766648B2 Propellant filling apparatus 有权
公开(公告)号：US10766648B2
公开(公告)日：2020-09-08
申请号：US16336254
申请日：2017-09-18
申请人： MEXICHEM FLUOR S.A. DE C.V.
发明人： Paul Alan Dowdle , Stuart Corr , Paul Watkinson
IPC分类号： B65B31/10 , B65B55/02 , B65B57/14 , B65B31/00 , A61M15/00 , F24F3/16
摘要： A propellant filling apparatus (10) comprising a filling booth (11) for receiving within it one or more containers for filling with a propellant; a propellant inlet (12) to the filling booth (11) that is capable of supplying propellant into one or more containers within the filling booth (11) from a propellant supply; an inert gas inlet (13) supplying inert gas from an inert gas supply (14) into the filling booth (11), a discharge outlet (16) from the filling booth (11); an extraction fan (17) that is capable of adjusting its fan speed to maintain the pressure of gas in the filling booth (11) to be lower than atmospheric pressure; and an oxygen detector (27) that is capable of detecting levels of oxygen in the filling booth (11) and triggering circulation of inert gas in the filling booth (11) when the level of oxygen in the filling booth (11) falls below an oxygen threshold level.

3. 发明申请

US20140345613A1 Arrangement for a Drug Delivery Device and Method of Assembling the Same 审中-公开
标题翻译：药物输送装置的装置及其组装方法
公开(公告)号：US20140345613A1
公开(公告)日：2014-11-27
申请号：US14367223
申请日：2012-12-14
申请人： Stefan Mayer
发明人： Stefan Mayer
IPC分类号： A61M15/00 , B65B31/10 , B65B31/00
CPC分类号： A61M15/0065 , A61M15/0025 , A61M2202/0468 , B65B31/003 , B65B31/10
摘要： An arrangement for a drug delivery device and a method of assembling the same are provided. The drug delivery device comprises a support, a connection part, and a spring element, wherein the spring element is arranged between the support and the connection part, and wherein the support comprises a support connection element and the connection part comprises a part connection element, wherein these connection elements are configured to establish a releasable connection to releasably connect the support and the connection part.
摘要翻译：提供了用于药物输送装置的装置及其组装方法。药物输送装置包括支撑件，连接部件和弹簧元件，其中弹簧元件布置在支撑件和连接部件之间，并且其中支撑件包括支撑连接元件，并且连接部件包括部件连接元件，其中这些连接元件构造成建立可释放的连接以可释放地连接支撑件和连接部件。

4. 发明申请

US20110135737A1 COMPOSITIONS FOR RESPIRATORY DELIVERY OF ACTIVE AGENTS AND ASSOCIATED METHODS AND SYSTEMS 审中-公开
标题翻译：用于呼吸传递活性药剂和相关方法和系统的组合物
公开(公告)号：US20110135737A1
公开(公告)日：2011-06-09
申请号：US12790671
申请日：2010-05-28
申请人： Reinhard Vehring , Michael Steven Hartman , Adrian Edward Smith , Vidya B. Joshi , Sarvajna Kumar Dwivedi
发明人： Reinhard Vehring , Michael Steven Hartman , Adrian Edward Smith , Vidya B. Joshi , Sarvajna Kumar Dwivedi
IPC分类号： A61K9/12 , A61K9/14 , A61M15/00 , B65B31/10
CPC分类号： A61K9/008 , A61K9/1611 , A61K9/1617 , A61K31/135 , A61K31/137 , A61K31/16 , A61K31/167 , A61K31/192 , A61K31/194 , A61K31/40 , A61K31/46 , A61K31/56 , A61K31/573 , A61K31/58 , A61M15/0065 , A61K2300/00
摘要： Compositions, methods and systems are provided for pulmonary or nasal delivery of active agents via a metered dose inhaler. In one embodiment, the compositions include a suspension medium, active agent particles, and suspending particles, in which the active agent particles and suspending particles form a co-suspension within the suspension medium.
摘要翻译：提供组合物，方法和系统用于通过计量剂量吸入器肺或鼻递送活性剂。在一个实施方案中，组合物包括悬浮介质，活性剂颗粒和悬浮颗粒，其中活性剂颗粒和悬浮颗粒在悬浮介质中形成共悬浮液。

5. 发明授权

US3880207A Device for controlling fluid supply and introduction of drawing tubes carried on aerosol valves within containers 失效
标题翻译：用于控制流体供应和引入在容器内的气溶胶阀上的拉管的装置
公开(公告)号：US3880207A
公开(公告)日：1975-04-29
申请号：US38191873
申请日：1973-07-23
申请人： COSTER TECNOLOGIE SPECIALI SPA
发明人： GIUFFREDI GIANCARLO
IPC分类号： B65D83/16 , B05B9/04 , B65B31/00 , B65B31/10 , B65D83/28 , B65D83/42 , B65D83/58 , B67B1/00 , B65B31/02
CPC分类号： B65B31/003 , Y10T29/53335 , Y10T137/8376
摘要： Device comprising a rigid body having two holes between which a ball is rotably arranged between two positions. At one position the two holes of the rigid body communicate to each other by a large hole passing through the ball, so as to allow for applying a valve onto the mouth of an aerosol container. At the second position of the ball, the top hole of the rigid body is closed, while the bottom hole communicates through a duct formed in the ball with a reservoir, from which, prior to valve application, a liquid or gas material is introduced into the container, material intended to be delivered from the container upon use of the latter.
摘要翻译：装置包括具有两个孔的刚体，在两个孔之间可旋转地布置有球。在一个位置处，刚体的两个孔通过穿过球的大孔彼此连通，以允许将阀施加到气溶胶容器的口上。

6. 发明授权

US3604095A Apparatus for placing tube stock mounted valves on aerosol containers 失效
标题翻译：用于安装气溶胶容器上的管状安装阀的装置
公开(公告)号：US3604095A
公开(公告)日：1971-09-14
申请号：US80357769
申请日：1969-03-03
申请人： COSTER TECNOLOGIE SPECIALI SPA
发明人： GIUFFREDI GIANCARLO
IPC分类号： B65B31/10 , B21D51/42 , B65B7/28 , F17C13/04 , B23P19/04
CPC分类号： B21D51/42 , B65B7/28 , Y10T29/53335 , Y10T29/5383
摘要： Apparatus for automatically applying tube stock mounted valves on aerosol containers. The apparatus comprises a sucking member gripping and lifting one valve at a time off of a valve feeding device, a tubular body lowering on the valve held by said member overlying its tube stock. A funnel-shaped element, on the major section end of which the lower end of the tubular body rests at the end of its downward stroke, and a rigid platform on which the containers rest with the inlet thereof just below the minor section end of the funnel element. After the tubular body has overlain the valve tube stock, also the valve retaining member lowers on said funnel element causing the tube stock to penetrate into the container and placing the valve on the inlet of said container. Then, said member and said tubular body move up again to rest position. Lowering and lifting movement of said member and said tubular body is pneumatically carried out by compressed air.

7. 发明授权

US11980780B2 Carbon dioxide shampoo apparatus and method of use thereof 有权
公开(公告)号：US11980780B2
公开(公告)日：2024-05-14
申请号：US17709099
申请日：2022-03-30
申请人： Nyangenya Maniga
发明人： Nyangenya Maniga
IPC分类号： A61Q5/02 , A61K8/04 , A61K8/22 , A61K8/27 , A61K8/362 , A61K8/49 , B65B31/00 , B65B31/10
CPC分类号： A61Q5/02 , A61K8/046 , A61K8/22 , A61K8/27 , A61K8/362 , A61K8/4913 , B65B31/003 , B65B31/10 , A61K2800/5424
摘要： The invention comprises a shampoo apparatus and method of use thereof, comprising: putting a shampoo and carbon dioxide into a container, at least a portion of the carbon dioxide comprising at least one of a solid form and a liquid form; sealing the container; warming the carbon dioxide by at least fifty degrees Fahrenheit to form a carbon dioxide gas, the carbon dioxide gas at least partially dissolved in the shampoo, the carbon dioxide gas comprising a concentration of one-half to ten percent of the shampoo by mass; and pressurizing the container to a pressure exceeding sixty pounds per square inch, such as where a headspace forms in the container, the headspace comprising the carbon dioxide at a concentration greater than one thousand parts per million, where the pressurized carbon dioxide yields a propulsive force, a foam expansion function, and a cleaning function.

8. 发明授权

US10806701B2 Aerosol formulation for COPD 有权
公开(公告)号：US10806701B2
公开(公告)日：2020-10-20
申请号：US14791553
申请日：2015-07-06
申请人： CHIESI FARMACEUTICI S.p.A.
发明人： Sauro Bonelli , Francesca Usberti , Enrico Zambelli
IPC分类号： A61K9/00 , A61K31/167 , A61K31/40 , A61K45/06 , A61K47/06 , A61K31/573 , A61K47/10 , B65B31/06 , B65B31/10
摘要： Stable aerosol solution formulations comprising glycopyrronium bromide are useful for administration to patients with COPD and other respiratory conditions.

9. 发明申请

US20110061651A1 FORMOTEROL SUPERFINE FORMULATION 有权
标题翻译：福莫司他汀制剂
公开(公告)号：US20110061651A1
公开(公告)日：2011-03-17
申请号：US12873690
申请日：2010-09-01
申请人： Rebecca Jaine DAVIES , David Ganderton , David Andrew Lewis , Brian John Meakin , Tanya Kathleen Church , Gaetano Brambilla , Alessandra Ferraris
发明人： Rebecca Jaine DAVIES , David Ganderton , David Andrew Lewis , Brian John Meakin , Tanya Kathleen Church , Gaetano Brambilla , Alessandra Ferraris
IPC分类号： A61M15/00 , B65B31/10 , A61J1/05
CPC分类号： A61K9/008 , A61K31/4704 , A61K31/485 , A61K45/06 , A61K47/10 , A61K2300/00
摘要： A metal container and a method of preparing a metal container for a pharmaceutical formulation where the active ingredient is formoterol, a stereoisomer of formoterol, and a physiologically acceptable salt of formoterol, in a solution of a liquefied HFA propellant.
摘要翻译：在液化HFA推进剂的溶液中，金属容器和制备用于药物制剂的金属容器的方法，其中活性成分是福莫特罗，福莫特罗的立体异构体和福莫特罗的生理学上可接受的盐。

10. 发明申请

US20090038708A1 AEROSOL CAN FILLING SYSTEM 失效
标题翻译：气溶胶罐灌装系统
公开(公告)号：US20090038708A1
公开(公告)日：2009-02-12
申请号：US11836170
申请日：2007-08-09
申请人： Donald J. Hirz
发明人： Donald J. Hirz
IPC分类号： B65B31/10
CPC分类号： B65B31/003
摘要： A system for filling pre-charged aerosol cans comprising a frame, a power actuator on the frame having an output member that extends forcibly downwardly through a stroke of fixed length and retracts upwardly, a combined reservoir and filling head supported in the frame generally below the output member, the filling head having a cylindrical dispensing bore and an outlet below the bore adapted to be coupled to the valve of the aerosol can, a dispensing piston with a lower face operable in the bore to create hydraulic pressure on liquid received in the bore from the reservoir, a set of cooperating elements for coupling a dispensing piston to the output member selectively at a plurality of predetermined fixed spacings from the output member, whereby the volume of fluid displaced from the dispensing chamber by the dispensing piston is regulated to fill cans of different capacity while the output member of the power actuator traverses its stroke of constant length.
摘要翻译：一种用于填充预充气的气溶胶罐的系统，包括框架，框架上的动力致动器具有输出构件，该输出构件强制向下延伸固定长度的行程并向上缩回，组合的储存器和填充头大致在框架下方输出构件，填充头具有圆柱形分配孔和适于联接到气溶胶罐的阀的孔下方的出口;分配活塞，其具有可在孔中操作的下表面，以在容纳在孔中的液体上产生液压来自储存器的一组协作元件，用于以选择性地与输出构件的多个预定的固定间隔将分配活塞耦合到输出构件，由此通过分配活塞从分配腔排出的流体的体积被调节以填充罐功率致动器的输出部件横穿其长度不同的行程。

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