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1. 发明授权

US08728411B2 Device for and method of isolating a fraction in a biological sample 有权
$Device for and method of isolating a fraction in a biological sample$
标题翻译：分离生物样品中馏分的装置和方法
公开(公告)号：US08728411B2
公开(公告)日：2014-05-20
申请号：US13604192
申请日：2012-09-05
申请人： David J. Beebe , Scott M. Berry , David J. Guckenberger , Ben P. Casavant
发明人： David J. Beebe , Scott M. Berry , David J. Guckenberger , Ben P. Casavant
IPC分类号： B01D21/00 , B01L3/00 , B01D59/48 , B01D17/06 , B03C5/02
CPC分类号： G01N1/34 , B01L3/502761 , B01L3/502792 , B01L2200/0668 , B01L2200/0673 , B01L2300/087 , B01L2400/043 , G01N1/4077 , G01N35/0098
摘要： A device and a method are provided for isolating a fraction in a biological sample. The fraction is bound to solid phase substrate to define a fraction-bound solid phase substrate. The device includes an input zone for receiving the biological sample therein and a second zone for receiving an isolation fluid therein. A force is provided that is generally perpendicular to gravity. The force is movable between a first position adjacent the input zone and a second position adjacent the isolation zone. The force captures the fraction-bound solid phase substrate and the fraction-bound solid phase substrate moves from the input zone to the isolation zone in response to the force moving from the first position to the second position.
摘要翻译：提供了用于分离生物样品中的级分的装置和方法。该馏分与固相底物结合以限定分馏结合的固相底物。该装置包括用于在其中接收生物样品的输入区和用于在其中接收隔离流体的第二区。提供通常垂直于重力的力。该力可在邻近输入区的第一位置与邻近隔离区的第二位置之间移动。该力捕获分馏结合的固相底物，并且部分结合的固相基板响应于从第一位置移动到第二位置的力而从输入区移动到隔离区。

2. 发明授权

US07482583B2 Time of flight mass spectrometer 有权
标题翻译：飞行时间质谱仪
公开(公告)号：US07482583B2
公开(公告)日：2009-01-27
申请号：US11603159
申请日：2006-11-22
申请人： Yoshihiro Ueno
发明人： Yoshihiro Ueno
IPC分类号： B01D59/48
CPC分类号： H01J49/30 , H01J49/408
摘要： In a time of flight mass spectrometer (TOFMS) having a flight space in which ions fly in a loop orbit formed by a plurality of electric sector fields, the present invention provides a simple structure that creates a spiral path by deflecting the ions in the axial direction of the electric fields at every turn of the ions. In a mode of the present invention, the TOFMS has cylindrical electrodes 11 and 12 for creating electric sector fields E1 and E2, between which a parallel pair of planer magnetic poles 15a and 15b are provided. The planer magnetic poles 15a and 15b create a deflecting magnetic field B1 for shifting the ions in the axial direction (Y-direction) of the electric sector fields. The ions experience a Lorenz force once every turn when they pass through the deflecting magnetic field B1. This construction uses only one pair of magnetic poles facing each other across the ion path P to deflect every ion irrespective of its number of turns. There is no need to provide one deflector for each turn of the ions, as in the case of conventional TOFMSs.
摘要翻译：在具有飞行空间的飞行时间质谱仪（TOFMS）中，离子飞行在由多个电扇区形成的环轨道中，本发明提供了一种简单的结构，其通过在轴向上偏转离子而产生螺旋路径方向的电场每转一圈的离子。在本发明的模式中，TOFMS具有用于产生电扇区E1和E2的圆柱形电极11和12，平行的一对平面磁极15a和15b之间形成有电扇区E1和E2。平面磁极15a和15b产生偏转磁场B1，用于使离子在电扇区的轴向（Y方向）上移位。当离子经过偏转磁场B1时，离子经历一次洛伦茨力。这种结构仅使一对磁极彼此跨过离子路径P，以偏转每个离子而不考虑其匝数。对于常规TOFMS的情况，不需要为每一圈的离子提供一个偏转器。

3. 发明授权

US5653854A Method and apparatus for separating isotopes 失效
标题翻译：分离同位素的方法和装置
公开(公告)号：US5653854A
公开(公告)日：1997-08-05
申请号：US607467
申请日：1996-02-27
申请人： Goro Miyamoto , Yoshio Murakami , Seiji Hiroki , Kenji Katsuki
发明人： Goro Miyamoto , Yoshio Murakami , Seiji Hiroki , Kenji Katsuki
IPC分类号： B01D59/34 , B01D59/48 , H01J49/26 , C25B5/00
CPC分类号： B01D59/34 , B01D59/48
摘要： The improved isotope separator comprises a vacuum vessel, a plasma generator located substantially in the center of the vacuum vessel, an electrode bounded by a hyperboloid of one sheet and a pair of electrodes bounded by a hyperboloid of two sheets, said electrodes being located within the vacuum vessel in such a way as to surround the plasma generator, a power source for supplying said electrodes with a fixed voltage and a pulsating voltage, and magnetic field generating means located outside the vacuum vessel. The apparatus is implemented by a method for isotope separation that achieves high separation factor per stage (process), that enables the process throughput to be increased with ease and which yet is applicable to the isotopic separation of many elements.
摘要翻译：改进的同位素分离器包括真空容器，基本上位于真空容器中心的等离子体发生器，由一片双曲面界定的电极和由两片双曲面界定的一对电极，所述电极位于真空容器，以围绕等离子体发生器的方式，用于向固定电压和脉动电压供应所述电极的电源，以及位于真空容器外部的磁场产生装置。该装置通过一种同步分离方法来实现，该方法在每个阶段达到高的分离因子（工艺），这使得能够容易地提高工艺流程并且还适用于许多元素的同位素分离。

4. 发明授权

US5422481A Device for isotope separation by ion cyclotron resonance 失效
标题翻译：离子回旋共振同位素分离装置
公开(公告)号：US5422481A
公开(公告)日：1995-06-06
申请号：US242136
申请日：1994-05-13
申请人： Pierre Louvet
发明人： Pierre Louvet
IPC分类号： B01D59/48 , B01D59/02 , H05H1/46 , H01J49/38
CPC分类号： B01D59/02
摘要： Device for isotope separation by ion cyclotron resonance (ICR). This device comprises a vertical enclosure (2), means (6) for producing a homogeneous, vertical magnetic field in said enclosure, a plasma source (8) for producing in the central part of the enclosure an ion plasma of the isotope to be separated, means (10) for producing in the enclosure an electric field perpendicular to the magnetic field and oscillating at the ion cyclotron frequency of the isotope to be separated, which is adjusted as a function of the mass of said isotope, collection means (12) for recovering a mixture which is enriched and a mixture which is depleted with said isotope. The plasma source comprises a container (14) containing the element (20), whose isotope is to be separated and means (18) for ionizing atoms of the element. Application to the separation of the isotopes of gadolinium.
摘要翻译：离子回旋共振（ICR）同位素分离装置。该装置包括垂直外壳（2），用于在所述外壳中产生均匀的垂直磁场的装置（6），用于在外壳的中心部分中产生待分离的同位素的离子等离子体的等离子体源（8）用于在外壳中产生垂直于磁场并以要分离的同位素的离子回旋加速器振荡的装置（10），其被调节为所述同位素收集装置（12）的质量的函数，用于回收富集的混合物和用所述同位素耗尽的混合物。等离子体源包括容纳包含元素（20）的容器（14），其同位素将被分离，并且用于离子化该元件的原子的装置（18）。应用于分离钆同位素。

5. 发明授权

US4740758A Apparatus for generating a magnetic field in a volume having bodies influencing the field pattern 失效
标题翻译：用于在具有影响场模式的物体的体积中产生磁场的装置
公开(公告)号：US4740758A
公开(公告)日：1988-04-26
申请号：US826105
申请日：1986-02-05
申请人： Gunter Ries
发明人： Gunter Ries
IPC分类号： B01D59/48 , G21K1/093 , H01F6/00 , H01F7/20 , H05H7/04 , H01J1/50 , H01J3/34
CPC分类号： H01F7/20 , G21K1/093 , H05H7/04
摘要： Apparatus for generating a magnetic field having a spatially predetermined field pattern in a useful volume, where bodies of ferro-magnetic material influencing the field pattern are disposed in the useful volume. To assure a spatially predetermined field pattern in the useful volume with only small field errors, outside and on opposite sides of the useful volume at least one thin plate-shaped body of predetermined geometric extent comprising a material having high permeability is provided, of which the surfaces facing the useful volume are shaped and arranged so that the surfaces lie on a magnetic equipotential surface of the magnetic field to be generated in the useful volume.
摘要翻译：用于在有用体积中产生具有空间预定场模式的磁场的装置，其中影响场模式的铁磁材料体被布置在有用体积中。为了确保在有用体积中的空间预定场模式仅具有小的场误差，在有用体积的外侧和相对侧上，提供包括具有高磁导率的材料的至少一个预定几何程度的薄板状体，其中，面对有用体积的表面被成形和布置成使得表面位于要在有用体积中产生的磁场的磁等势面上。

6. 发明授权

US3922543A Ion cyclotron resonance spectrometer and method 失效
标题翻译：离子回旋共振光谱仪及方法
公开(公告)号：US3922543A
公开(公告)日：1975-11-25
申请号：US45552074
申请日：1974-03-28
申请人： BEAUCHAMP JESSE L
发明人： BEAUCHAMP JESSE L
IPC分类号： B01D59/48 , H01J49/32 , H01J49/38 , B01D59/44
CPC分类号： H01J49/38 , B01D59/48
摘要： An ion cyclotron resonance mass spectrometer having a source region and an analyzer region operable in both the standard drift mode and in a pulsed mode which includes ion trapping. Appropriate configurations of applied electrostatic fields permit trapping of ions in the source region of the spectrometer for relatively long periods after which detection is effected by drifting the ions from the source through the analyzer region where their power absorption is measured. The spectrometer may also be operated in the normal mode, thus allowing for the full range of conventional ion cyclotron resonance measurements with the additional capability of examining the variation of ion abundance with time.
摘要翻译：离子回旋共振质谱仪具有可在标准漂移模式和包括离子捕获的脉冲模式中操作的源区和分析区。施加的静电场的适当配置允许在光谱仪的源区域中捕获离子相对较长的时间，之后通过将来自源的离子漂移到其测量功率吸收的分析器区域来进行检测。光谱仪还可以在正常模式下操作，从而允许常规离子回旋共振测量的全范围，并具有随时间检查离子丰度变化的额外能力。

7. 发明授权

US2923822A Electromagnetic separation of isotopes 失效
标题翻译：同位素的电磁分离
公开(公告)号：US2923822A
公开(公告)日：1960-02-02
申请号：US3739648
申请日：1948-07-07
申请人： BARNES SIDNEY W , CANTRELL CLIFFORD M
发明人： BARNES SIDNEY W , CANTRELL CLIFFORD M
IPC分类号： B01D59/48
CPC分类号： B01D59/48

8. 发明授权

US2852687A Isotope separating apparatus 失效
标题翻译：同位素分离装置
公开(公告)号：US2852687A
公开(公告)日：1958-09-16
申请号：US62184645
申请日：1945-10-11
申请人： KUDRAVETZ MICHAEL K , GREENE HAROLD B
发明人： KUDRAVETZ MICHAEL K , GREENE HAROLD B
IPC分类号： B01D59/48
CPC分类号： B01D59/48

9. 发明授权

US2806143A Isotope separating apparatus 失效
标题翻译：同位素分离装置
公开(公告)号：US2806143A
公开(公告)日：1957-09-10
申请号：US70682146
申请日：1946-10-31
申请人： CARTER ROLLA N
发明人： CARTER ROLLA N
IPC分类号： B01D59/48
CPC分类号： B01D59/48

10. 发明申请

US20210343443A1 ENRICHMENT AND RADIOISOTOPE PRODUCTION 有权
公开(公告)号：US20210343443A1
公开(公告)日：2021-11-04
申请号：US17283823
申请日：2019-09-13
申请人： ASML Netherlands B.V.
发明人： Pieter Willem Herman DE JAGER , Antonius Theodorus Anna Maria DERKSEN
IPC分类号： G21G1/12 , B01D59/48
摘要： A combined enrichment and radioisotope production apparatus comprising an electron source arranged to provide an electron beam, the electron source comprising an electron injector and an accelerator, an undulator configured to generate a radiation beam using the electron beam, a molecular stream generator configured to provide a stream of molecules which is intersected by the radiation beam, a receptacle configured to receive molecules or ions selectively received from the stream of molecules, and a target support structure configured to hold a target upon which the electron beam is incident in use.

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