专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20040204481A1 Activation of natural killer cells by adenosine A3 receptor agonists 审中-公开
标题翻译：通过腺苷A3受体激动剂激活天然杀伤细胞
公开(公告)号：US20040204481A1
公开(公告)日：2004-10-14
申请号：US09832818
申请日：2001-04-12
发明人： Pnina Fishman
IPC分类号： A61K031/7076 , A61K031/695 , A61K031/52
CPC分类号： A61K31/52 , A61K31/00 , A61K31/70 , A61K31/7076
摘要： The present invention is based on the surprising finding that adenosine A3 receptor agonists (A3RAg) are capable of activating natural killer (NK) cells. In particular, methods and pharmaceutical compositions for activating NK cells in an individual comprising administering said individual with an effective amount of one or more A3RAg are provided herein. A further method includes treatment of a disease comprising administering to an individual in need of such treatment NK cells a priori activated with an effective amount of at least one A3RAg. The NK cells may be either autologous cells or cells withdrawn from a donor individual. Further provided are pharmaceutical compositions comprising one or more A3RAg in an amount effective to achieve a therapeutic effect, the therapeutic effect comprising activation of NK cells, the pharmaceutical composition optionally comprising physiologically acceptable additives.
摘要翻译：本发明基于令人惊奇的发现，即腺苷A3受体激动剂（A3RAg）能够激活天然杀伤（NK）细胞。特别地，本文提供了用于激活个体中的NK细胞的方法和药物组合物，其包括给予所述个体有效量的一种或多种A3RAg。另一种方法包括治疗疾病，其包括向需要这种治疗的个体施用先天用有效量的至少一种A3RAg活化的NK细胞。 NK细胞可以是自体细胞或从供体个体中取出的细胞。还提供了包含一种或多种有效实现治疗效果的量的一种或多种A3RAg的药物组合物，所述治疗效果包括NK细胞的活化，所述药物组合物任选包含生理上可接受的添加剂。

2. 发明申请

US20040127464A1 Use of triaryl methane compounds for inhibiting unwanted cellular proliferation associated with inflammatory disease 有权
标题翻译：三芳基甲烷化合物用于抑制与炎性疾病相关的不想要的细胞增殖
公开(公告)号：US20040127464A1
公开(公告)日：2004-07-01
申请号：US10454372
申请日：2003-06-03
发明人： Carlo Brugnara , Jose Halperin , Emile M. Bellot JR. , Mark Froimowitz , Richard John Lombardy , John J. Clifford , Ying-Duo Gao , Reem M. Haidar , Eugene W. Kelleher , Falguni M. Kher , Adel M. Moussa , Yesh P. Sachdeva , Minghua Sun , Heather N. Taft
IPC分类号： A61K031/695 , A61K031/675 , A61K031/66 , A61K031/555 , A61K031/27
CPC分类号： A61K31/03 , A61K31/05 , A61K31/075 , A61K31/085 , A61K31/10 , A61K31/15 , A61K31/381 , C07C15/16 , C07C22/04 , C07C25/18 , C07C39/12 , C07C39/15 , C07C39/367 , C07C43/164 , C07C43/225 , C07C43/23 , C07C45/004 , C07C45/41 , C07C45/44 , C07C47/23 , C07C47/24 , C07C47/273 , C07C49/215 , C07C49/233 , C07C211/27 , C07C211/52 , C07C211/54 , C07C215/68 , C07C233/11 , C07C239/22 , C07C255/33 , C07C255/35 , C07C259/06 , C07C2601/14 , C07D207/26 , C07D213/16 , C07D213/20 , C07D213/30 , C07D295/145 , C07D307/33 , C07F7/0805 , C07F7/081 , C07F7/30 , C07F9/5352
摘要： The present invention provides a class of chemical compounds useful as efficacious drugs in the treatment of sickle cell disease and diseases characterized by unwanted or abnormal cell proliferation, and in particular inflammatory diseases associated with unwanted cellular proliferation. The active compounds are substituted triaryl methane compounds or analogues thereof where one or more of the aryl groups is replaced with a heteroaryl, cycloalkyl or heterocycloalkyl group and/or the tertiary carbon atom is replaced with a different atom such as Si, Ge, N or P. the compounds inhibit mammalian cell proliferation, inhibit the Gardos channel of erythrocytes, reduce sickle erythrocyte dehydration and/or delay the occurrence of erythrocyte sickling or deformation.
摘要翻译：本发明提供了一类用于治疗镰状细胞疾病的有效药物的化合物和特征在于不想要的或异常细胞增殖的疾病，特别是与不想要的细胞增殖相关的炎性疾病。活性化合物是取代的三芳基甲烷化合物或其类似物，其中一个或多个芳基被杂芳基，环烷基或杂环烷基代替，和/或叔碳原子被不同的原子代替，例如Si，Ge，N或该化合物抑制哺乳动物细胞增殖，抑制红细胞的Gardos通道，减少镰状红细胞脱水和/或延缓红细胞镰状或变形的发生。

3. 发明申请

US20040127430A1 Chiral monophosphorus compounds and their transition metal complexes 审中-公开
标题翻译：手性单磷化合物及其过渡金属络合物
公开(公告)号：US20040127430A1
公开(公告)日：2004-07-01
申请号：US10660150
申请日：2003-09-11
发明人： Benjamin Meseguer , Hans-Christian Militzer , Sergio Castillon , Carmen Claver , Ester Guiu
IPC分类号： A61K031/70 , A61K031/695 , A61K031/665
CPC分类号： C07D307/20 , C07B2200/07 , C07C231/18 , C07F9/65515 , C07C233/05
摘要： The present invention relates to chiral monophosphorus compounds and their transition metal complexes, to a process for preparing chiral monophosphorus compounds and their transition metal complexes and also to their use in asymmetric syntheses.
摘要翻译：本发明涉及手性单磷化合物及其过渡金属络合物，涉及制备手性单磷化合物及其过渡金属络合物的方法，以及它们在不对称合成中的用途。

4. 发明申请

US20040063665A1 Substituted benzopyranones as telomerase inhibitors 审中-公开
标题翻译：取代的苯并吡喃酮作为端粒酶抑制剂
公开(公告)号：US20040063665A1
公开(公告)日：2004-04-01
申请号：US10471919
申请日：2003-09-16
发明人： Alberto Bargiotti , Luisella Bonomini , Maria Menichincheri , Jurgen Moll , Paolo Polucci , Chiara Soncini , Ermes Vanotti
IPC分类号： A61K031/695 , A61K031/353
CPC分类号： C07D405/04 , A61K31/352 , C07D311/30 , C07D413/04 , C07D417/04
摘要： The present invention relates to benzopyranone derivative, to methods for treating telomerase-modulated diseases, in particular cancers, with said derivatives, to a process for their preparation, to their use as medicaments and to pharmaceutical compositions comprising them.
摘要翻译：本发明涉及苯并吡喃酮衍生物，涉及用于治疗端粒酶调节的疾病，特别是癌症与所述衍生物的方法，其制备方法，用作药物和包含它们的药物组合物。

5. 发明申请

US20040053990A1 Radicicol derivatives 审中-公开
标题翻译：蓝霉素衍生物
公开(公告)号：US20040053990A1
公开(公告)日：2004-03-18
申请号：US10629655
申请日：2003-07-30
申请人： KYOWA HAKKO KOGYO CO., LTD
发明人： Yoji Ino , Nobuyoshi Amishiro , Mayumi Miyata , Chikara Murakata , Harumi Ogawa , Tadakazu Akiyama , Shiro Akinaga , Shiro Soga , Yukimasa Shiotsu
IPC分类号： A61K031/695 , A61K031/365 , A61K031/4433 , A61K031/4025 , C07D313/20 , C07D45/02
CPC分类号： C07D493/04 , C07D313/00
摘要： Radicicol derivatives represented by the following formula (I) having tyrosine kinase inhibition activity or pharmacologically acceptable salts thereof: 1 wherein R1 and R2 are the same or different, and each represents hydrogen, alkanoyl, alkenoyl, tert-butyldiphenylsilyl or tert-butyldimethylsilyl; R3 represents YnullR5 nullwherein Y represents substituted or unsubstituted alkylene; and R5 represents CONR6R7 (wherein R6 represents hydrogen, hydroxyl, substituted or unsubstituted lower alkyl, substituted or unsubstituted higher alkyl, and the like; R7 represents hydroxyl, substituted lower alkyl, and the like), CO2R12 (wherein R12 represents substituted lower alkyl, substituted or unsubstituted higher alkyl, and the like), and the likenull and the like; X represents halogen or is combined together with R4 to represent a single bond; and R4 is combined together with X to represent a single bond, or represents hydrogen, alkanoyl, and the like.
摘要翻译：由下式（I）表示的具有酪氨酸激酶抑制活性的衍生物衍生物或其药理学上可接受的盐：其中R 1和R 2相同或不同，各自表示氢，链烷酰基，烯酰基，叔丁基二苯基甲硅烷基或叔丁基二甲基甲硅烷基; R 3表示Y-R 5 {其中Y表示取代或未取代的亚烷基; 并且R 5表示CONR 6 R 7（其中R 6表示氢，羟基，取代或未取代的低级烷基，取代或未取代的高级烷基等; R 7表示羟基，取代的较低级烷基等），CO 2 R 12（其中R 12表示取代的低级烷基，取代或未取代的高级烷基等）等}等; X表示卤素或与R 4结合以表示单键; 和R 4与X一起表示单键，或表示氢，烷酰基等。

6. 发明申请

US20040029834A1 Object having a microbicide coating, method for the production thereof and use of the same 有权
标题翻译：具有杀微生物剂涂层的物体，其制造方法及其用途
公开(公告)号：US20040029834A1
公开(公告)日：2004-02-12
申请号：US10415396
申请日：2003-04-28
发明人： Thomas Schiestel , Hermann Schirra , Helmut Schmidt , Detmar Buxmann
IPC分类号： A61K031/695 , A61K009/14
CPC分类号： C09D183/08 , C09D4/00 , C09D5/14 , C09D183/02 , C09D183/04 , C08G77/00 , C08L2666/52
摘要： A microbicidally coated article, especially a container, having on at least part of it a coating comprising an organically modified inorganic matrix comprising silver colloids which is obtainable by application of a coating composition comprising a) a hydrolysate or condensate based on at least one hydrolysable silane with at least one non-hydrolysable substituent and b) a silver compound to the surface of the article and treatment with heat and/or radiation to form the silver colloid coating. Articles coated in accordance with the invention are therefore particularly suitable for purposes of disinfection, preservation, cosmetic, pharmaceutical or medical purposes. Articles from the pharmaceutical or medical sector, especially containers for pharmaceuticals or articles or components which come into contact with the human body and are required to be free from germs, are preferred fields of application.
摘要翻译：一种杀微生物涂覆的制品，特别是容器，其至少部分具有包含有机改性的无机基质的涂层，其包含银胶体，其可通过施用涂料组合物获得，所述涂料组合物包含：a）基于至少一种可水解硅烷的水解产物或缩合物与至少一种不可水解的取代基和b）一种银化合物到制品的表面并用热和/或辐射进行处理以形成银胶体涂层。因此，根据本发明涂覆的制品特别适用于消毒，保存，化妆品，医药或医疗目的。优选的药物或医疗领域的药物，尤其是与人体接触并被要求不含细菌的药物或制品或成分的容器。

7. 发明申请

US20040023926A1 Novel organosilicon compounds comprising a multifunctional polyorganosiloxane bearing at least one activated imide-type double ethylene bond and method for preparing same 审中-公开
标题翻译：包含具有至少一个活化的酰亚胺型双乙烯键的多官能聚有机硅氧烷的新型有机硅化合物及其制备方法
公开(公告)号：US20040023926A1
公开(公告)日：2004-02-05
申请号：US10311545
申请日：2003-08-26
发明人： Nathalie Guennouni , Jean-Jacques Lebrun
IPC分类号： A61K031/695 , A61K007/06 , A61K007/11
CPC分类号： C08G77/26 , C08G77/388
摘要： The field of the present invention is that of novel organosilicon compounds comprising a multifunctional polyorganosiloxane (abbreviated as POS) comprising, per molecule, and attached to silicon atoms, firstly at least one hydroxyl radical and/or at least one alkoxy radical, and secondly at least one group containing an activated ethylenic double bond consisting of a maleimide group. The present invention also relates to functionalization processes leading to the POSs targeted above, which consist in particular in reacting an organosilane bearing a maleamic acid function and at least two alkoxy functions with a polysilazane. The compounds comprising a multifunctional POS as targeted above are capable of showing advantageous properties, for example of acting as coupling agents (for white filler-elastomer coupling) in rubber compositions based on isoprene elastomer(s) comprising a white filler as reinforcing filler.
摘要翻译：本发明的领域是包含每分子包含并连接到硅原子的多官能聚有机硅氧烷（缩写为POS）的新型有机硅化合物，首先至少有一个羟基和/或至少一个烷氧基，其次在至少一个含有由马来酰亚胺基团组成的活化烯键双键的基团。本发明还涉及导致上述POS的官能化方法，其特别包括使具有马来酰胺酸官能团和至少两个烷氧基官能团的有机硅烷与聚硅氮烷反应。包含如上所述的多功能POS的化合物能够显示出有利的性质，例如在基于包含白色填料作为增强填料的异戊二烯弹性体的橡胶组合物中作为偶联剂（用于白色填料 - 弹性体偶联）。

8. 发明申请

US20030236225A1 Methods of use and compositions for the diagnosis and treatment of infectious disease 有权
标题翻译：传染病诊断和治疗方法及组合物
公开(公告)号：US20030236225A1
公开(公告)日：2003-12-25
申请号：US10147587
申请日：2002-05-17
发明人： Marina Nikolaevna Protopopova , Richard Edward Lee , Richard Allan Slayden , Clifton E. Barry III
IPC分类号： A61K031/695 , A61K031/46 , A61K031/445 , A61K031/137 , A61K031/13
CPC分类号： C07C323/25 , A61K31/132 , A61K31/133 , A61K31/40 , A61K31/445 , C07C211/29 , C07C211/34 , C07C211/35 , C07C211/42 , C07C215/14 , C07C215/30 , C07C215/60 , C07C217/08 , C07C217/10 , C07C217/58 , C07C217/60 , C07C217/62 , C07C323/47 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07C2602/10 , C07C2602/42 , C07C2603/74 , C07D211/46
摘要： Methods and compositions for treating disease caused by microorganisms, particularly tuberculosis. In particular, methods and compositions comprising substituted ethylene diamines for the treatment of infectious diseases are provided. In one embodiment, these methods and compositions are used for the treatment of mycobacterial infections, including, but not limited to, tuberculosis.
摘要翻译：用于治疗由微生物，特别是结核病引起的疾病的方法和组合物。特别地，提供了包含用于治疗感染性疾病的取代的乙二胺的方法和组合物。在一个实施方案中，这些方法和组合物用于治疗分枝杆菌感染，包括但不限于结核病。

9. 发明申请

US20030232786A1 Tricyclic-bis-enone derivatives and methods of use thereof 失效
标题翻译：三环 - 双烯酮衍生物及其使用方法
公开(公告)号：US20030232786A1
公开(公告)日：2003-12-18
申请号：US10345053
申请日：2003-01-15
发明人： Tadashi Honda , Frank G. Favaloro , Gordon W. Gribble , Michael B. Sporn , Nanjoo Suh
IPC分类号： A61K031/695 , C07D265/30 , C07D211/06 , A61K031/537 , C07D249/08 , A61K031/497
CPC分类号： C07C62/38 , C07C225/12 , C07C255/47 , C07C271/18 , C07C2603/00 , C07C2603/26 , C07F7/1804
摘要： Novel tricyclic-bis-enone derivatives (TBEs) as well as the process for the preparation of such TBEs are provided. Also provided are methods for prevention and/or treatment of cancer, Alzheimer's disease, Parkinson's disease, multiple sclerosis, amyotropic lateral sclerosis, rheumatoid arthritis, inflammatory bowel disease, and all other diseases whose pathogenesis is believed to involve excessive production of either nitric oxide (NO) or prostaglandins or the overexpression of iNOS or COX-2 genes or gene products. Further, methods for the synthesis of the TBE compounds of the invention utilize cheap commercially available reagents and are highly cost effective and amenable to scale-up. Additional high efficiency synthetic methods that utilize novel intermediates as well as the synthesis of these intermediates are also provided. Furthermore, the invention also provides methods for designing novel and water-soluble TBEs.
摘要翻译：提供了新的三环双烯衍生物（TBE）以及制备这种TBE的方法。还提供了用于预防和/或治疗癌症，阿尔茨海默氏病，帕金森病，多发性硬化，肌萎缩性侧索硬化，类风湿性关节炎，炎症性肠病以及其发病机制被认为涉及过量产生一氧化氮的所有其它疾病的方法 NO）或前列腺素或iNOS或COX-2基因或基因产物的过表达。此外，用于合成本发明的TBE化合物的方法使用便宜的市售试剂，并且是高成本有效的并且适于放大。还提供了利用新型中间体以及这些中间体的合成的其它高效合成方法。此外，本发明还提供了设计新型和水溶性TBE的方法。

10. 发明申请

US20030216354A1 Decalactones, method for making, and pharmaceuticals there from 失效
标题翻译：十聚内酯，制造方法和药品
公开(公告)号：US20030216354A1
公开(公告)日：2003-11-20
申请号：US10143596
申请日：2002-05-09
发明人： Gerhard Bringmann , Peter Proksch , Ru Angelie Edrada , Markus Heubes , Sudarsono , Eckhard Gunther
IPC分类号： A61K031/695 , A61K031/4433 , A61K031/365 , C12P017/02
CPC分类号： C07D313/00 , C12P17/08
摘要： A novel class of decalactones with the general formula (I) and their stereoisomers is disclosed. A method for the synthesis of the decalactones of general formula (I) and the use of the decalactones in pharmaceutical compositions is also described. 1
摘要翻译：公开了一类具有通式（I）的十聚内酯及其立体异构体。还描述了用于合成通式（I）的十聚内酯的方法和在药物组合物中使用十聚酮内酯。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式