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1. 发明授权

US6001870A Nasopharynx administration of mupirocin for prophylactic treatment of recurrent otitis media 失效
标题翻译：鼻咽给药莫匹罗星用于预防性治疗复发性中耳炎
公开(公告)号：US6001870A
公开(公告)日：1999-12-14
申请号：US940730
申请日：1997-09-30
申请人： Timothy John Henkel
发明人： Timothy John Henkel
IPC分类号： A61K47/14 , A61K9/00 , A61K31/35 , A61K31/351 , A61P27/16 , A61P31/04 , A61K9/06 , A61K9/10 , A61K9/107
CPC分类号： A61K9/0043 , A61K31/351 , Y10S514/956
摘要： Mupirocin or a salt or ester thereof may be used to treat recurrent sinusitis and recurrent otitis, in particular with novel spray or cream formulations adapted for administration to the nasopharynx.
摘要翻译：莫匹罗星或其盐或酯可用于治疗复发性鼻窦炎和复发性耳炎，特别是适用于向鼻咽给药的新型喷雾剂或霜剂。

2. 发明授权

US5508269A Aminoglycoside formulation for aerosolization 失效
标题翻译：用于雾化的氨基糖苷配方
公开(公告)号：US5508269A
公开(公告)日：1996-04-16
申请号：US325705
申请日：1994-10-19
申请人： Arnold L. Smith , Bonnie W. Ramsey , Alan B. Montgomery
发明人： Arnold L. Smith , Bonnie W. Ramsey , Alan B. Montgomery
IPC分类号： A61K9/12 , A61K9/00 , A61K9/72 , A61K31/702 , A61K31/715 , A61P31/04 , A61K31/73
CPC分类号： A61K9/0078 , A61K31/7036 , Y10S514/956
摘要： An aminoglycoside formulation for delivery by aerosolization. The concentrated aminoglycoside formulation containing an efficacious amount of aminoglycoside able to inhibit 95-100% of susceptible bacteria. Aminoglycoside formulated in 5 ml solution of a quarter normal saline having pH between 5.5 and 6.5. The method for treatment of endobronchial infections by a produced by a formulation delivered as an aerosol having mass medium average diameter predominantly between 1 to 5 .mu., produced by a jet or ultrasonic nebulizer.
摘要翻译：用于通过气雾化传递的氨基糖苷配方。浓缩的氨基糖苷配方含有有效量的能抑制95-100％敏感细菌的氨基糖苷。氨基糖苷配制在pH5.5和6.5之间的四分之一生理盐水溶液的5ml溶液中。通过由喷射或超声雾化器产生的具有主要在1至5μm之间的质量中等平均直径的气溶胶递送的制剂治疗支气管内感染的方法。

3. 发明授权

US5380711A Methods for delipidation of skin and cerumen removal 失效
标题翻译：去皮皮肤脱毛方法
公开(公告)号：US5380711A
公开(公告)日：1995-01-10
申请号：US212856
申请日：1994-03-15
申请人： Robert A. Sanchez , Sheldon S. Hendler
发明人： Robert A. Sanchez , Sheldon S. Hendler
IPC分类号： A61K9/08 , A01N43/04 , A61K8/00 , A61K8/73 , A61K9/50 , A61K31/715 , A61P17/00 , A61P27/16 , A61Q5/02 , A61Q19/10 , C08B37/16 , A61K31/70
CPC分类号： A61K31/715 , Y10S424/13 , Y10S514/844 , Y10S514/846 , Y10S514/859 , Y10S514/887 , Y10S514/956 , Y10S530/833
摘要： The present invention provides delipidating compositions containing essentially oil-free "empty" cyclodextrin compositions. It also provides compositions for use in removal of cerumen from the ear. The compositions containing "empty" cyclodextrin advantageously avoid use of harsh, drying agents or injurious mechanical methods.
摘要翻译：本发明提供含有基本上无油的“空”环糊精组合物的脱脂组合物。它还提供用于从耳朵中除去耳垢的组合物。含有“空”环糊精的组合物有利地避免使用苛刻的干燥剂或有害的机械方法。

4. 发明申请

US20190209467A1 SUSTAINED DRUG DELIVERY IMPLANT 审中-公开
公开(公告)号：US20190209467A1
公开(公告)日：2019-07-11
申请号：US16354692
申请日：2019-03-15
申请人： Allergan, Inc.
发明人： Jane-Guo Shiah , Chetan Pujara
IPC分类号： A61K9/00 , A61K31/498 , A61F9/00 , A61K47/32
CPC分类号： A61K9/0051 , A61F9/0017 , A61F2210/0004 , A61K31/498 , A61K47/32 , Y10S514/912 , Y10S514/913 , Y10S514/953 , Y10S514/954 , Y10S514/956
摘要： Biocompatible intraocular implants may include a brimonidine free base and a biodegradable polymer associated with the brimonidine free base to facilitate the release of the brimonidine free base into an eye with the polymer matrix lasts a period of time of not more than twice the drug release duration, but more than the drug release duration.

5. 发明授权

US09393242B2 Compositions for treatment of ear disorders and methods of use thereof 有权
公开(公告)号：US09393242B2
公开(公告)日：2016-07-19
申请号：US13220350
申请日：2011-08-29
申请人： Eran Eilat
发明人： Eran Eilat
IPC分类号： A61K9/12 , A61F9/02 , A61K31/19 , A61K31/495 , A61K9/00
CPC分类号： A61K31/495 , A61K9/0046 , A61K9/122 , Y10S514/945 , Y10S514/956
摘要： The present invention relates to compositions and methods useful for the treatment of ear disorders, administered to a treated ear in the form of a foam or a mousse. Administering a medicament in such forms will increase the residence time of the medicament in the ear canal, provide relatively uniform distribution of the composition, and can increase the penetration of the active pharmaceutical ingredient in the affected area, may release active substances slowly, enhance treatment effectiveness, increase compliance and is more convenient to use than currently available ear medications. The administration in the form of a foam or a mousse may preferably be provided as a metered dose, of a volume suitable to fill the ear canal.

6. 发明授权

US08030362B2 Compositions for treatment of ear disorders and methods of use thereof 有权
标题翻译：用于治疗耳部疾病的组合物及其使用方法
公开(公告)号：US08030362B2
公开(公告)日：2011-10-04
申请号：US10582712
申请日：2004-12-12
申请人： Eran Eilat
发明人： Eran Eilat
IPC分类号： A61F9/02 , A61K9/12
CPC分类号： A61K31/495 , A61K9/0046 , A61K9/122 , Y10S514/945 , Y10S514/956
摘要： The present invention relates to compositions and methods useful for the treatment of ear disorders, administered to a treated ear in the form of a foam or a mousse. Administering a medicament in such forms will increase the residence time of the medicament in the ear canal, provide relatively uniform distribution of the composition, and can increase the penetration of the active pharmaceutical ingredient in the affected area, may release active substances slowly, enhance treatment effectiveness, increase compliance and is more convenient to use than currently available ear medications. The administration in the form of a foam or a mousse may preferably be provided as a metered dose, of a volume suitable to fill the ear canal.
摘要翻译：本发明涉及用于治疗耳朵疾病的组合物和方法，其以泡沫或摩丝形式施用于治疗的耳朵。以这种形式施用药物将增加药物在耳道中的停留时间，提供组合物的相对均匀的分布，并且可以增加活性药物成分在受影响区域中的渗透性，可缓慢释放活性物质，增强治疗有效性，提高依从性，比目前可用的耳药更方便使用。以泡沫或摩丝形式的施用可以优选地以适于填充耳道的体积计量剂量提供。

7. 发明申请

US20080075670A1 Compositions for Treatment of Ear Disorders and Methods of Use Thereof 有权
标题翻译：治疗耳部疾病的组合物及其使用方法
公开(公告)号：US20080075670A1
公开(公告)日：2008-03-27
申请号：US10582712
申请日：2004-12-12
申请人： Eran Eilat
发明人： Eran Eilat
IPC分类号： A61K9/12 , A61P27/16
CPC分类号： A61K31/495 , A61K9/0046 , A61K9/122 , Y10S514/945 , Y10S514/956
摘要： The present invention relates to compositions and methods useful for the treatment of ear disorders, administered to a treated ear in the form of a foam or a mousse. Administering a medicament in such forms will increase the residence time of the medicament in the ear canal, provide relatively uniform distribution of the composition, and can increase the penetration of the active pharmaceutical ingredient in the affected area, may release active substances slowly, enhance treatment effectiveness, increase compliance and is more convenient to use than currently available ear medications. The administration in the form of a foam or a mousse may preferably be provided as a metered dose, of a volume suitable to fill the ear canal.
摘要翻译：本发明涉及用于治疗耳朵疾病的组合物和方法，其以泡沫或摩丝形式施用于治疗的耳朵。以这种形式施用药物将增加药物在耳道中的停留时间，提供组合物的相对均匀的分布，并且可以增加活性药物成分在受影响区域中的渗透性，可缓慢释放活性物质，增强治疗有效性，提高依从性，比目前可用的耳药更方便使用。以泡沫或摩丝形式的施用可以优选地以适于填充耳道的体积计量剂量提供。

8. 发明授权

US07087249B2 Treatment of mucosal membranes 有权
公开(公告)号：US07087249B2
公开(公告)日：2006-08-08
申请号：US10131509
申请日：2002-04-23
申请人： Robert Edward Burrell , Antony George Naylor , Peter Howard Moxham
发明人： Robert Edward Burrell , Antony George Naylor , Peter Howard Moxham
IPC分类号： A61K9/00 , A61K9/02 , A61K9/14 , A61K9/70 , A61K9/72 , A61K31/28 , A61K31/282 , A61K33/24 , A61K33/38 , A61P11/00
CPC分类号： A61K9/0024 , A01N59/16 , A61K9/0019 , A61K9/0075 , A61K9/0078 , A61K9/14 , A61K9/7007 , A61K33/24 , A61K33/38 , A61K33/40 , A61K47/34 , A61K47/38 , A61L15/46 , A61L17/145 , A61L27/30 , A61L29/10 , A61L31/082 , A61L2300/102 , A61L2300/104 , A61L2300/404 , A61L2300/452 , A61L2300/606 , A61L2300/624 , A61L2300/63 , Y10S424/15 , Y10S514/825 , Y10S514/826 , Y10S514/829 , Y10S514/83 , Y10S514/849 , Y10S514/851 , Y10S514/853 , Y10S514/861 , Y10S514/862 , Y10S514/864 , Y10S514/865 , Y10S514/88 , Y10S514/881 , Y10S514/882 , Y10S514/886 , Y10S514/887 , Y10S514/90 , Y10S514/901 , Y10S514/902 , Y10S514/912 , Y10S514/914 , Y10S514/925 , Y10S514/931 , Y10S514/932 , Y10S514/933 , Y10S514/934 , Y10S514/944 , Y10S514/951 , Y10S514/953 , Y10S514/954 , Y10S514/956 , Y10S514/958 , Y10S514/964 , Y10S514/965 , Y10S514/966 , Y10S514/967 , Y10S514/968 , Y10S514/969 , Y10T428/31855 , A61K2300/00 , A01N25/04 , A01N25/10 , A01N25/12
摘要： The invention relates to the use of one or more antimicrobial metals preferably selected from silver, gold, platinum, and palladium but most preferably silver, formed with atomic disorder, and preferably in a nanocrystalline form, for reducing inflammation or infection of the mucosal membrane. The antimicrobial metal may be formulated as, or used in the form of, a nanocrystalline coating of one or more antimicrobial or noble metals, a nanocrystalline powder of one or more antimicrobial or noble metals, or a liquid or solution containing dissolved species from a nanocrystalline powder or coating of one or more antimicrobial or noble metals.

9. 发明申请

US20060083792A1 Therapeutic treatments using the direct application of antimicrobial metal compositions 审中-公开
公开(公告)号：US20060083792A1
公开(公告)日：2006-04-20
申请号：US11284507
申请日：2005-11-22
申请人： Scott Gillis
发明人： Scott Gillis
IPC分类号： A61K33/38
CPC分类号： A61K9/0024 , A01N59/16 , A61K9/0019 , A61K9/0075 , A61K9/0078 , A61K9/14 , A61K9/7007 , A61K33/24 , A61K33/38 , A61K33/40 , A61K47/34 , A61K47/38 , A61L15/46 , A61L17/145 , A61L27/30 , A61L29/10 , A61L31/082 , A61L2300/102 , A61L2300/104 , A61L2300/404 , A61L2300/452 , A61L2300/606 , A61L2300/624 , A61L2300/63 , Y10S424/15 , Y10S514/825 , Y10S514/826 , Y10S514/829 , Y10S514/83 , Y10S514/849 , Y10S514/851 , Y10S514/853 , Y10S514/861 , Y10S514/862 , Y10S514/864 , Y10S514/865 , Y10S514/88 , Y10S514/881 , Y10S514/882 , Y10S514/886 , Y10S514/887 , Y10S514/90 , Y10S514/901 , Y10S514/902 , Y10S514/912 , Y10S514/914 , Y10S514/925 , Y10S514/931 , Y10S514/932 , Y10S514/933 , Y10S514/934 , Y10S514/944 , Y10S514/951 , Y10S514/953 , Y10S514/954 , Y10S514/956 , Y10S514/958 , Y10S514/964 , Y10S514/965 , Y10S514/966 , Y10S514/967 , Y10S514/968 , Y10S514/969 , Y10T428/31855 , A61K2300/00 , A01N25/04 , A01N25/10 , A01N25/12
摘要： Therapeutic treatments using the direct application of selected structures of antimicrobial metals in free-standing powder form, solution form and/or suspension form in therapeutically effective amounts. The selected structures of antimicrobial metals serve as an antimicrobial agent, an anti-inflammatory agent, an immuno modulator agent, an enzyme modulator agent, and/or an anti-tumor agent, for human and/or animal use.

10. 发明授权

US06723350B2 Lubricious coatings for substrates 有权
标题翻译：底漆润滑涂层
公开(公告)号：US06723350B2
公开(公告)日：2004-04-20
申请号：US10131513
申请日：2002-04-23
申请人： Robert Edward Burrell , Hua Qing Yin , Antony George Naylor , Peter Howard Moxham , Walter Carlton Theodore Cholowski , Leonard Salvin Bowlby , David James Field
发明人： Robert Edward Burrell , Hua Qing Yin , Antony George Naylor , Peter Howard Moxham , Walter Carlton Theodore Cholowski , Leonard Salvin Bowlby , David James Field
IPC分类号： A61K900
CPC分类号： A61K9/0024 , A01N59/16 , A61K9/0019 , A61K9/0075 , A61K9/0078 , A61K9/14 , A61K9/7007 , A61K33/24 , A61K33/38 , A61K33/40 , A61K47/34 , A61K47/38 , A61L15/46 , A61L17/145 , A61L27/30 , A61L29/10 , A61L31/082 , A61L2300/102 , A61L2300/104 , A61L2300/404 , A61L2300/452 , A61L2300/606 , A61L2300/624 , A61L2300/63 , Y10S424/15 , Y10S514/825 , Y10S514/826 , Y10S514/829 , Y10S514/83 , Y10S514/849 , Y10S514/851 , Y10S514/853 , Y10S514/861 , Y10S514/862 , Y10S514/864 , Y10S514/865 , Y10S514/88 , Y10S514/881 , Y10S514/882 , Y10S514/886 , Y10S514/887 , Y10S514/90 , Y10S514/901 , Y10S514/902 , Y10S514/912 , Y10S514/914 , Y10S514/925 , Y10S514/931 , Y10S514/932 , Y10S514/933 , Y10S514/934 , Y10S514/944 , Y10S514/951 , Y10S514/953 , Y10S514/954 , Y10S514/956 , Y10S514/958 , Y10S514/964 , Y10S514/965 , Y10S514/966 , Y10S514/967 , Y10S514/968 , Y10S514/969 , Y10T428/31855 , A61K2300/00 , A01N25/04 , A01N25/10 , A01N25/12
摘要： The invention provides methods and kits to form water swellable gel coatings, preferably lubricious coatings, on substrates, and coated substrates thus formed. The coatings contain one or more antimicrobial metals formed with atomic disorder, together with one or more antimicrobial metals formed with atomic disorder such that the coatings provide an antimicrobial and anti-inflammatory effect when wet. The invention also provides a method to produce metal powders by sputtering a coating onto a moving surface, and then scraping the coating with one or more scrapers to produce the metal powder. The method is particularly useful for producing large amounts of nanocrystalline antimicrobial metal powders formed with atomic disorder, useful in the water swellable gel coatings of this invention.
摘要翻译：本发明提供了在基底上形成水可溶胀凝胶涂层，优选润滑涂层的方法和试剂盒，以及如此形成的涂覆的基底。涂层含有一种或多种由原子紊乱形成的抗微生物金属，以及一种或多种由原子紊乱形成的抗微生物金属，使得涂层在湿润时提供抗微生物和抗炎作用。本发明还提供了通过将涂层溅射到移动表面上然后用一个或多个刮刀刮擦涂层以产生金属粉末来生产金属粉末的方法。该方法特别适用于生产大量由原子紊乱形成的纳米晶体抗微生物金属粉末，可用于本发明的水溶胀性凝胶涂层。

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