专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20100330584A1 LONG WAVELENGTH FLUOROGENIC INTRACELLULAR ION INDICATORS THAT ARE WELL RETAINED IN THE CYTOSOL 有权
标题翻译：长期存在于细胞周期中的长波长荧光细胞离子指示器
公开(公告)号：US20100330584A1
公开(公告)日：2010-12-30
申请号：US12602973
申请日：2008-06-05
申请人： Kyle Gee , Vladimir Martin
发明人： Kyle Gee , Vladimir Martin
IPC分类号： G01N33/53 , C12N5/00 , C07D413/10 , C07D311/82
CPC分类号： G01N33/84 , A61K31/353 , C07D311/90 , C07D413/04 , C07D413/10 , C07D491/04 , C07D491/147 , C09B11/24 , G01N33/582 , G01N33/6872 , G01N2223/406 , G01N2458/00
摘要： Cell permeable metal ion indicator compounds and methods of their use and synthesis are described. The compound comprises a metal chelating moiety (Mc), a reporter molecule and two or more lipophilic groups (GL) covalently bonded through a linker to the reporter molecule, wherein the lipophilic groups, when present in a live cell, are cleaved resulting in two or more negatively charged groups.
摘要翻译：描述了细胞可渗透金属离子指示剂化合物及其使用和合成方法。化合物包括金属螯合部分（Mc），报告分子和通过接头共价键合到报告分子上的两个或多个亲油基团（GL），其中亲和基团当存在于活细胞中时被切割，导致两个或更多带负电的组。

2. 发明申请

US20060233302A1 Angled-beam detection system for container inspection 失效
公开(公告)号：US20060233302A1
公开(公告)日：2006-10-19
申请号：US11258832
申请日：2005-10-24
申请人： Matthew Might , Mark Ferderer , Gary Bowser
发明人： Matthew Might , Mark Ferderer , Gary Bowser
IPC分类号： G01N23/04
CPC分类号： G01N23/06 , G01N23/04 , G01N2223/1016 , G01N2223/406 , G01N2223/639 , G01V5/0041 , G01V5/0058
摘要： A non-intrusive inspection system, including apparatuses and methods, for non-intrusively inspecting containers such as, without limitation, those employed to transport items in international commerce. The non-intrusive inspection system is configured to generate and scan a container with multiple bremsstrahlung, or x-ray, beams having multiple spectra and directed at the container in multiple directions and planes separated by one or more angle(s). Using data collected from such scanning, software of the non-intrusive inspection system generates three-dimensional images of the items present in a container, calculates the volumes and densities of such items, computes effective “Z” numbers, and distinguishes between multiple materials, or elements, of such items. By employing multiple bremsstrahlung beams directed upon a container in multiple planes, the non-intrusive inspection system reduces the number of orientations and geometries of items within a container that might otherwise be employed to avoid the detection of harmful materials being transported within a container.

3. 发明授权

US08989474B2 X-ray image capturing system 有权
标题翻译： X射线摄像系统
公开(公告)号：US08989474B2
公开(公告)日：2015-03-24
申请号：US13635189
申请日：2011-02-23
申请人： Kazuhiro Kido , Chiho Makifuchi , Junko Kiyohara
发明人： Kazuhiro Kido , Chiho Makifuchi , Junko Kiyohara
IPC分类号： G06K9/00 , G01N23/04 , A61B6/00
CPC分类号： G01N23/04 , A61B6/4283 , A61B6/4291 , A61B6/4423 , A61B6/484 , A61B6/50 , A61B6/548 , G01N2223/406 , G01N2223/612 , G21K2207/005
摘要： Disclosed in an x-ray imaging device, which uses a Talbot-Lau interferometer, eliminates the effects on image quality of a reconstructed image that arises in such cases as when the direction of a multi-slit or each lattice slit is altered and imaging is performed, and provides reconstructed images favorable for diagnosis. When a plurality of moire images imaged with an imaging subject loaded onto a imaging subject stand (13) and a plurality of moire images imaged without the imaging subject are input, a control unit (51) of a controller (5) corrects signal value differences arising from variations in x-ray strength during imaging respectively between the plurality of moire images with the imaging subject and between the plurality of moire images without the imaging subject, and respectively creates a reconstructed image with the imaging subject and a reconstructed image without the imaging subject. Then, the control unit (51) creates a reconstructed image of the imaging subject for diagnosis by correcting, on the basis of the reconstructed image without the imaging subject, image unevenness in the reconstructed image with the imaging subject caused by heterogeneity in light distribution caused by the angle of rotation of the multi-slit.
摘要翻译：在使用Talbot-Lau干涉仪的x射线成像装置中公开的消除了在诸如多狭缝或每个格子狭缝的方向被改变并且成像是的情况下产生的重建图像的图像质量的影响并提供有利于诊断的重建图像。当输入加载到成像对象支架（13）上的成像对象成像的多个莫尔条纹图像和没有成像对象成像的多个莫尔图像时，控制器（5）的控制单元（51）将信号值差异由成像对象的多个莫尔图像之间以及在没有成像对象的多个莫尔图像之间的成像期间的X射线强度的变化引起的，并且分别使用成像对象和没有成像的重建图像来创建重建图像学科。然后，控制单元（51）通过基于没有成像对象的重建图像来校正由于分布不均匀引起的成像对象的重建图像中的图像不均匀而创建用于诊断的成像对象的重建图像通过多缝的旋转角度。

4. 发明申请

US20090041185A1 Angled-beam detection system for container inspection 审中-公开
标题翻译：用于集装箱检验的角度束检测系统
公开(公告)号：US20090041185A1
公开(公告)日：2009-02-12
申请号：US12079942
申请日：2008-03-28
申请人： Matthew B. Might , Mark A. Ferderer , Gary F. Bowser
发明人： Matthew B. Might , Mark A. Ferderer , Gary F. Bowser
IPC分类号： G01N23/04
CPC分类号： G01N23/06 , G01N23/04 , G01N2223/1016 , G01N2223/406 , G01N2223/639 , G01V5/0041 , G01V5/0058
摘要： A non-intrusive inspection system, including apparatuses and methods, for non-intrusively inspecting containers such as, without limitation, those employed to transport items in international commerce. The non-intrusive inspection system is configured to generate and scan a container with multiple bremsstrahlung, or x-ray, beams having multiple spectra and directed at the container in multiple directions and planes separated by one or more angle(s). Using data collected from such scanning, software of the non-intrusive inspection system generates three-dimensional images of the items present in a container, calculates the volumes and densities of such items, computes effective “Z” numbers, and distinguishes between multiple materials, or elements, of such items. By employing multiple bremsstrahlung beams directed upon a container in multiple planes, the non-intrusive inspection system reduces the number of orientations and geometries of items within a container that might otherwise be employed to avoid the detection of harmful materials being transported within a container.
摘要翻译：非侵入式检查系统，包括用于非侵入性检查集装箱的装置和方法，例如但不限于用于在国际商业中运输物品的容器。非侵入式检查系统被配置为产生并扫描具有多个光谱的多个bre致辐射或X射线束的容器，并且在多个方向上指向容器并且由一个或多个角度分开的平面。使用从这种扫描收集的数据，非入侵检测系统的软件生成容器中存在的项目的三维图像，计算这些项目的体积和密度，计算有效的“Z”数，并区分多种材料，或元素。通过采用指向多个平面中的容器的多个bre致辐射束，非侵入式检查系统减少了容器内的物品的取向和几何形状，否则可能用于避免检测在容器内运输的有害物质。

5. 发明授权

US09464990B2 Centimeter-scale high resolution metrology of entire CVD grown graphene sheets 有权
标题翻译：整个CVD生长石墨烯片的厘米级高分辨率测量
公开(公告)号：US09464990B2
公开(公告)日：2016-10-11
申请号：US14412948
申请日：2013-07-03
申请人： The Regents of The University of California
发明人： Jennifer Reiber Kyle , Cengiz S. Ozkan , Mihrimah Ozkan
IPC分类号： G01N21/64 , G01N21/65
CPC分类号： G01N21/6458 , G01N21/643 , G01N21/65 , G01N2021/6417 , G01N2021/6432 , G01N2021/646 , G01N2223/406 , G01N2223/633
摘要： A method for quick and easy identification of layer thickness and uniformity of entire large-area graphene samples on arbitrary substrates utilizing fluorescence quenching microscopy in which a polymer mixed with fluorescent dye is applied onto the graphene, then viewing the sample under a fluorescence microscope. A large-scale, high-resolution montage image of the sample is obtained for histogram-based segmentation based on contrast relative to the substrates.
摘要翻译：使用荧光猝灭显微镜，将荧光染料混合的聚合物施加到石墨烯上，然后在荧光显微镜下观察样品，快速方便地识别任意底物上的大面积石墨烯整个样品的层厚度和均匀度。基于基于相对于底物的对比度的基于直方图的分割，获得样本的大规模高分辨率蒙太奇图像。

6. 发明授权

US09341631B2 Long wavelength fluorogenic intracellular ion indicators that are well retained in the cytosol 有权
标题翻译：长波长的荧光细胞内离子指示剂，很好地保留在细胞溶质中
公开(公告)号：US09341631B2
公开(公告)日：2016-05-17
申请号：US14302175
申请日：2014-06-11
申请人： Kyle Gee , Vladimir Martin
发明人： Kyle Gee , Vladimir Martin
IPC分类号： A61K31/353 , C07D311/90 , C07D413/04 , C07D491/04 , G01N33/84 , C07D413/10 , C07D491/147 , C09B11/24 , G01N33/58 , G01N33/68
CPC分类号： G01N33/84 , A61K31/353 , C07D311/90 , C07D413/04 , C07D413/10 , C07D491/04 , C07D491/147 , C09B11/24 , G01N33/582 , G01N33/6872 , G01N2223/406 , G01N2458/00
摘要： Cell permeable metal ion indicator compounds and methods of their use and synthesis are described. The compound comprises a metal chelating moiety (Mc), a reporter molecule and two or more lipophilic groups (GL) covalently bonded through a linker to the reporter molecule, wherein the lipophilic groups, when present in a live cell, are cleaved resulting in two or more negatively charged groups. An exemplary compound for use as a cell permeable metal ion indicator is represented by the structure:
摘要翻译：描述了细胞可渗透金属离子指示剂化合物及其使用和合成方法。化合物包括金属螯合部分（Mc），报告分子和通过接头共价键合到报告分子上的两个或多个亲油基团（GL），其中亲和基团当存在于活细胞中时被切割，导致两个或更多带负电的组。用作细胞可渗透金属离子指示剂的示例性化合物由以下结构表示：

7. 发明申请

US20140363839A1 LONG WAVELENGTH FLUOROGENIC INTRACELLULAR ION INDICATORS THAT ARE WELL RETAINED IN THE CYTOSOL 有权
标题翻译：长期存在于细胞周期中的长波长荧光细胞离子指示器
公开(公告)号：US20140363839A1
公开(公告)日：2014-12-11
申请号：US14302175
申请日：2014-06-11
申请人： Kyle GEE , Vladimir MARTIN
发明人： Kyle GEE , Vladimir MARTIN
IPC分类号： G01N33/58 , C09B11/24
CPC分类号： G01N33/84 , A61K31/353 , C07D311/90 , C07D413/04 , C07D413/10 , C07D491/04 , C07D491/147 , C09B11/24 , G01N33/582 , G01N33/6872 , G01N2223/406 , G01N2458/00
摘要： Cell permeable metal ion indicator compounds and methods of their use and synthesis are described. The compound comprises a metal chelating moiety (Mc), a reporter molecule and two or more lipophilic groups (GL) covalently bonded through a linker to the reporter molecule, wherein the lipophilic groups, when present in a live cell, are cleaved resulting in two or more negatively charged groups.
摘要翻译：描述了细胞可渗透金属离子指示剂化合物及其使用和合成方法。化合物包括金属螯合部分（Mc），报告分子和通过接头共价键合到报告分子上的两个或多个亲油基团（GL），其中亲和基团当存在于活细胞中时被切割，导致两个或更多带负电的组。

8. 发明申请

US20170038398A1 LONG WAVELENGTH FLUOROGENIC INTRACELLULAR ION INDICATORS THAT ARE WELL RETAINED IN THE CYTOSOL 审中-公开
标题翻译：长期存在于细胞周期中的长波长荧光细胞离子指示器
公开(公告)号：US20170038398A1
公开(公告)日：2017-02-09
申请号：US15099388
申请日：2016-04-14
申请人： LIFE TECHNOLOGIES CORPORATION
发明人： Kyle GEE , Vladimir MARTIN
IPC分类号： G01N33/84 , G01N33/58
CPC分类号： G01N33/84 , A61K31/353 , C07D311/90 , C07D413/04 , C07D413/10 , C07D491/04 , C07D491/147 , C09B11/22 , C09B11/24 , G01N33/582 , G01N33/6872 , G01N2223/406 , G01N2458/00
摘要： Cell permeable metal ion indicator compounds and methods of their use and synthesis are described. The compound comprises a metal chelating moiety (Mc), a reporter molecule and two or more lipophilic groups (GL) covalently bonded through a linker to the reporter molecule, wherein the lipophilic groups, when present in a live cell, are cleaved resulting in two or more negatively charged groups.
摘要翻译：描述了细胞可渗透金属离子指示剂化合物及其使用和合成方法。化合物包括金属螯合部分（Mc），报告分子和通过接头共价键合到报告分子上的两个或多个亲油基团（GL），其中亲和基团当存在于活细胞中时被切割，导致两个或更多带负电的组。

9. 发明申请

US20130011040A1 X-RAY IMAGING SYSTEM 有权
标题翻译： X射线成像系统
公开(公告)号：US20130011040A1
公开(公告)日：2013-01-10
申请号：US13635189
申请日：2011-02-23
申请人： Kazuhiro Kido , Chiho Makifuchi , Junko Kiyohara
发明人： Kazuhiro Kido , Chiho Makifuchi , Junko Kiyohara
IPC分类号： G06K9/00
CPC分类号： G01N23/04 , A61B6/4283 , A61B6/4291 , A61B6/4423 , A61B6/484 , A61B6/50 , A61B6/548 , G01N2223/406 , G01N2223/612 , G21K2207/005
摘要： Disclosed in an x-ray imaging device, which uses a Talbot-Lau interferometer, eliminates the effects on image quality of a reconstructed image that arises in such cases as when the direction of a multi-slit or each lattice slit is altered and imaging is performed, and provides reconstructed images favorable for diagnosis. When a plurality of moire images imaged with an imaging subject loaded onto a imaging subject stand (13) and a plurality of moire images imaged without the imaging subject are input, a control unit (51) of a controller (5) corrects signal value differences arising from variations in x-ray strength during imaging respectively between the plurality of moire images with the imaging subject and between the plurality of moire images without the imaging subject, and respectively creates a reconstructed image with the imaging subject and a reconstructed image without the imaging subject. Then, the control unit (51) creates a reconstructed image of the imaging subject for diagnosis by correcting, on the basis of the reconstructed image without the imaging subject, image unevenness in the reconstructed image with the imaging subject caused by heterogeneity in light distribution caused by the angle of rotation of the multi-slit.
摘要翻译：在使用Talbot-Lau干涉仪的x射线成像装置中公开的消除了在诸如多狭缝或每个格子狭缝的方向被改变并且成像是的情况下产生的重建图像的图像质量的影响并提供有利于诊断的重建图像。当输入加载到成像对象支架（13）上的成像对象成像的多个莫尔条纹图像和没有成像对象成像的多个莫尔图像时，控制器（5）的控制单元（51）将信号值差异由成像对象的多个莫尔图像之间以及在没有成像对象的多个莫尔图像之间的成像期间的X射线强度的变化引起的，并且分别使用成像对象和没有成像的重建图像来创建重建图像学科。然后，控制单元（51）通过基于没有成像对象的重建图像来校正由于分布不均匀引起的成像对象的重建图像中的图像不均匀而创建用于诊断的成像对象的重建图像通过多缝的旋转角度。

10. 发明授权

US07356118B2 Angled-beam detection system for container inspection 失效
标题翻译：用于集装箱检验的角度束检测系统
公开(公告)号：US07356118B2
公开(公告)日：2008-04-08
申请号：US11258832
申请日：2005-10-24
申请人： Matthew B. Might , Mark A. Ferderer , Gary F. Bowser
发明人： Matthew B. Might , Mark A. Ferderer , Gary F. Bowser
IPC分类号： G01N23/04
CPC分类号： G01N23/06 , G01N23/04 , G01N2223/1016 , G01N2223/406 , G01N2223/639 , G01V5/0041 , G01V5/0058
摘要： A non-intrusive inspection system, including apparatuses and methods, for non-intrusively inspecting containers such as, without limitation, those employed to transport items in international commerce. The non-intrusive inspection system is configured to generate and scan a container with multiple bremsstrahlung, or x-ray, beams having multiple spectra and directed at the container in multiple directions and planes separated by one or more angle(s). Using data collected from such scanning, software of the non-intrusive inspection system generates three-dimensional images of the items present in a container, calculates the volumes and densities of such items, computes effective “Z” numbers, and distinguishes between multiple materials, or elements, of such items. By employing multiple bremsstrahlung beams directed upon a container in multiple planes, the non-intrusive inspection system reduces the number of orientations and geometries of items within a container that might otherwise be employed to avoid the detection of harmful materials being transported within a container.
摘要翻译：非侵入式检查系统，包括用于非侵入性检查集装箱的装置和方法，例如但不限于用于在国际商业中运输物品的容器。非侵入式检查系统被配置为产生并扫描具有多个光谱的多个bre致辐射或X射线束的容器，并且在多个方向上指向容器并且由一个或多个角度分开的平面。使用从这种扫描收集的数据，非入侵检测系统的软件生成容器中存在的项目的三维图像，计算这些项目的体积和密度，计算有效的“Z”数，并区分多种材料，或元素。通过采用指向多个平面中的容器的多个bre致辐射束，非侵入式检查系统减少了容器内的物品的取向和几何形状，否则可能用于避免检测在容器内运输的有害物质。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式