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1. 发明公开

US20230416677A1 MEDIUM COMPOSITION FOR DERMAL PAPILLA CELL GROWTH, CONTAINING ROTENONE AND ALBUMIN AS ACTIVE INGREDIENTS 审中-公开
公开(公告)号：US20230416677A1
公开(公告)日：2023-12-28
申请号：US18039027
申请日：2021-11-23
申请人： XCELL THERAPEUTICS INC.
发明人： Ui il LEE , Joo Youn LEE , Ji Soo PARK , Ji eun JANG , Yu yeong YANG , Min hee KANG
IPC分类号： C12N5/071
CPC分类号： C12N5/0628 , C12N2500/30 , C12N2500/90
摘要： The present invention relates to a culture medium composition obtained by further adding at least one selected from the group consisting of rotenone and albumin to a serum-free medium prepared through a CAMPs technology. It has been ascertained that the proliferation of dermal papilla cells and maintenance of characteristics thereof during culturing can be improved by regulating the concentration of rotenone and albumin, and since the culture medium composition is a serum-free chemical medium comprising no serum, there is no risk of side effects, which can be caused by using a conventional serum medium, during use on the human body.
The culture medium composition of the present invention obtained by further adding at least one selected from the group consisting of rotenone and albumin to a serum-free medium, or dermal papilla cells cultured through the composition can be effectively used in the development of therapeutic agents for hair loss prevention and hair growth promotion.

2. 发明公开

US20230257702A1 METHOD FOR ISOLATING AND MASS PROLIFERATING DERMAL PAPILLA CELLS DERIVED FROM SCALP TISSUE 审中-公开
公开(公告)号：US20230257702A1
公开(公告)日：2023-08-17
申请号：US18010372
申请日：2021-03-05
申请人： Da Witt KANG , HANMOBIO CO., LTD. , HANBIO CO., LTD.
发明人： Da Witt KANG , Jung In YOON , Jeong Won RHO
IPC分类号： C12N5/071
CPC分类号： C12N5/0628 , C12N2501/115 , C12N2511/00 , C12N2509/10
摘要： Provided is a method for isolation and expansion of dermal papilla cells, and more particularly, to a method of isolating dermal papilla cells from hair bulbs, isolated from scalp tissue, by chopping, and then expanding the isolated dermal papilla cells by passaging. The expanded dermal papilla cells may play an important role in hair growth, and thus the present invention may be used in various industrial fields, including the medical field and the cosmetic field.

3. 发明公开

US20230241121A1 COMPOSITIONS AND METHODS RELATING TO EXOSOMES DERIVED FROM HUMAN DERMAL PAPILLA CELLS 审中-公开
公开(公告)号：US20230241121A1
公开(公告)日：2023-08-03
申请号：US17995066
申请日：2021-03-30
申请人： NORTH CAROLINA STATE UNIVERSITY
发明人： Ke Cheng , Shiqi Hu
IPC分类号： A61K35/36 , C12N5/071 , C12N15/113 , A61P17/14
CPC分类号： A61K35/36 , C12N5/0628 , C12N15/113 , A61P17/14 , C12N2513/00
摘要： The present disclosure provides compositions and methods relating to the use of exosomes derived from human dermal papilla (DP) cells. In particular, the present disclosure provides novel compositions and methods for generating and maintaining exosomes derived from DP spheroids, as well as compositions and methods for delivering exosomes to a subject for various therapeutic purposes, such as the treatment of diseases and conditions related to hair follicle development.

4. 发明授权

US09617311B2 Use of PEDF-derived polypeptides for promoting stem cells proliferation and wound healing 有权
公开(公告)号：US09617311B2
公开(公告)日：2017-04-11
申请号：US14656107
申请日：2015-03-12
申请人： Mackay Memorial Hospital
发明人： Yeou-Ping Tsao , Tsung-Chuan Ho
IPC分类号： C07K14/00 , A61K38/18 , C12N5/079 , C12N5/071 , C07K7/08 , C12N5/0797
CPC分类号： C07K14/00 , A61K38/18 , C07K7/08 , C12N5/0621 , C12N5/0623 , C12N5/0628 , C12N2501/10 , C12N2501/998
摘要： Disclosed herein is a synthetic peptide, which has an amino acid sequence that has 20-39 amino acid residues. The synthetic peptide has at least 80% amino acid sequence identity to SEQ ID NO: 1, and includes at least 20 consecutive residues that has at least 90% amino acid sequence identity to residues 11-30 of SEQ ID NO: 1. Also disclosed herein are compositions containing the synthetic peptide and applications thereof. According to various embodiments of the present disclosure, the synthetic peptide is useful in promoting stem cells proliferation or wound healing.

5. 发明申请

US20170000724A1 COMPOSITION DERIVED FROM STEM CELL RELEASED MOLECULES & METHODS FOR FORMULATION THEREOF 审中-公开
标题翻译：从干细胞释放的分子衍生的组合物及其制备方法
公开(公告)号：US20170000724A1
公开(公告)日：2017-01-05
申请号：US15266951
申请日：2016-09-15
申请人： BioRegenerative Sciences, Inc.
发明人： Greg Maguire
IPC分类号： A61K8/98 , A61K35/33 , A61Q7/00 , A61K35/28
CPC分类号： A61K8/981 , A61K35/12 , A61K35/28 , A61K35/33 , A61K2800/74 , A61Q7/00 , C12N5/0628 , C12N5/0656 , C12N5/0667
摘要： Compositions for use in treatment of a variety of tissue diseases include stem cells and stem cell released molecules (SRM's) suspended in an aqueous solution with a cellulosic material or other thickening agent. The stem cells and SRM's can be derived from one or more distinct cell lines. The SRM's can further include one or more mucins, cytokines, or growth factors. Exemplary formulations include stem cells and SRMs derived from epithelial stem cells, corneal limbal stem cells, and fibroblasts. Other compositions and methods for formulation thereof are described.
摘要翻译：用于治疗各种组织疾病的组合物包括用纤维素材料或其它增稠剂悬浮在水溶液中的干细胞和干细胞释放分子（SRM）。干细胞和SRM可以衍生自一个或多个不同的细胞系。 SRM可以进一步包括一种或多种粘蛋白，细胞因子或生长因子。示例性制剂包括源自上皮干细胞，角膜缘干细胞和成纤维细胞的干细胞和SRM。其他组合物及其配制方法进行了描述。

6. 发明申请

US20150361390A1 COMPOSITION AND METHOD FOR GENERATING A DESIRED CELL TYPE AND/OR TISSUE TYPE FROM HAIR FOLLICULAR STEM CELLS 审中-公开
标题翻译：用于从毛发细胞干细胞产生所需细胞类型和/或组织类型的组合物和方法
公开(公告)号：US20150361390A1
公开(公告)日：2015-12-17
申请号：US14764226
申请日：2014-02-03
申请人： Conradus Ghosal GHO
发明人： Conradus Ghosal Gho
IPC分类号： C12N5/071 , A61K35/12
CPC分类号： C12N5/0602 , A61K35/12 , C12N5/0628 , C12N5/0666 , C12N2500/20 , C12N2500/24 , C12N2500/38 , C12N2500/40 , C12N2500/44 , C12N2501/11 , C12N2501/115 , C12N2501/13 , C12N2501/14 , C12N2501/999 , C12N2502/11 , C12N2502/115 , C12N2506/03 , C12N2509/00
摘要： The present invention is concerned with a composition and in vitro method for generating a desired cell type and/or tissue type from hair follicular stem cells. The composition and in vitro method are particularly suitable for generating an autologous desired cell type and/or tissue type. Furthermore, the composition and method are especially efficient and suitable for use in the context of cosmetic cell and/or tissue transplantation in recipient areas of a subject experiencing cell and/or tissue loss caused by, for example, a wound, scar, burn injury, tissue degeneration, and aging. The composition and in vitro method are also suitable to circumvent complications related to infections and/or immune rejection of a cosmetic cell and/or tissue implant or graft.
摘要翻译：本发明涉及从毛囊干细胞产生所需细胞类型和/或组织类型的组合物和体外方法。组合物和体外方法特别适合于产生自体期望的细胞类型和/或组织类型。此外，组合物和方法特别有效并且适合用于经历由例如伤口，瘢痕，烧伤引起的细胞和/或组织损失的受试者的受体区域中的化妆品细胞和/或组织移植的上下文中，组织变性和衰老。组合物和体外方法也适用于避免与化妆品细胞和/或组织植入物或移植物的感染和/或免疫排斥相关的并发症。

7. 发明授权

US08431400B2 Dermal sheath cup cell population 有权
标题翻译：真皮鞘细胞群体
公开(公告)号：US08431400B2
公开(公告)日：2013-04-30
申请号：US10516031
申请日：2003-06-05
申请人： Rolf Hoffmann , Kevin J. McElwee
发明人： Rolf Hoffmann , Kevin J. McElwee
IPC分类号： C12N15/02 , C12N5/00
CPC分类号： C12N5/0666 , A61K8/985 , A61K35/12 , A61K35/28 , A61K35/36 , A61Q7/00 , C12N5/0628 , C12N2509/10
摘要： The present invention relates to a method for isolating hair follicle mesenchymal stem cells and to the use thereof for therapy and prophylaxis as well as for cosmetic treatments.
摘要翻译：本发明涉及一种分离毛囊间充质干细胞的方法及其用于治疗和预防以及美容治疗的用途。

8. 发明授权

US07666675B2 Nestin-expressing hair follicle stem cells 失效
标题翻译：巢蛋白表达的毛囊干细胞
公开(公告)号：US07666675B2
公开(公告)日：2010-02-23
申请号：US10251657
申请日：2002-09-20
申请人： Lingna Li , Meng Yang
发明人： Lingna Li , Meng Yang
IPC分类号： A01N63/00 , A61K48/00 , A01K67/027 , C12N5/00 , C12N5/02
CPC分类号： C12N5/0661 , A61K35/12 , C12N5/0619 , C12N5/0622 , C12N5/0628 , C12N2501/13 , C12N2501/135 , C12N2506/092
摘要： Hair follicle stem cells are isolated from mammals by isolating nestin-expressing cells. These hair follicle stem cells are a source of adult stem cells for autologous or heterologous stem cell therapy. The stem cells can be systemically implanted into the mammal or directly implanted into the organ. In addition, the stem cells may be further differentiated in vitro and then implanted systemically or directly into the mammal.
摘要翻译：通过分离巢蛋白表达细胞从哺乳动物中分离毛囊干细胞。这些毛囊干细胞是用于自体或异源干细胞治疗的成体干细胞的来源。干细胞可全身植入哺乳动物或直接植入器官。此外，干细胞可以在体外进一步分化，然后系统地或直接植入哺乳动物。

9. 发明授权

US07655465B2 Methods for ex vivo propagation of somatic hair follicle stem cells 有权
标题翻译：体细胞毛囊干细胞体外增殖的方法
公开(公告)号：US07655465B2
公开(公告)日：2010-02-02
申请号：US11147013
申请日：2005-06-07
申请人： James L. Sherley , Johnathan King
发明人： James L. Sherley , Johnathan King
IPC分类号： C12N5/06
CPC分类号： C12N5/0628 , A61K35/12 , C12N2500/40
摘要： The present invention is directed to methods for readily propagating somatic hair follicle stem cells or melanocyte stem cells. The methods comprise enhancing guanine nucleotide (GNP) biosynthesis, thereby expanding guanine nucleotide pools. This in turn conditionally suppresses asymmetric cell kinetics in the explanted cells. The methods of the invention include pharmacological methods and genetic methods. For example, the resulting cultured somatic hair follicle stem cells can be used for a variety of applications including cell replacement therapies such as hair transplants, gene therapies, and tissue engineering applications, such as the generation of artificial skin and skin regeneration strategies including skin grafts.
摘要翻译：本发明涉及容易繁殖体细胞毛囊干细胞或黑素细胞干细胞的方法。该方法包括增强鸟嘌呤核苷酸（GNP）生物合成，从而扩大鸟嘌呤核苷酸库。这又有条件地抑制了移植细胞中的不对称细胞动力学。本发明的方法包括药理学方法和遗传方法。例如，所产生的培养的体细胞毛囊干细胞可用于各种应用，包括细胞替代疗法，例如毛发移植，基因治疗和组织工程应用，例如生成人造皮肤和皮肤再生策略，包括皮肤移植。

10. 发明申请

US20080286243A1 Method For Isolation of a Hair Follicle Stem Cell and a Composition For Hair Reproduction 审中-公开
标题翻译：用于分离毛囊干细胞的方法和用于头发繁殖的组合物
公开(公告)号：US20080286243A1
公开(公告)日：2008-11-20
申请号：US11995910
申请日：2007-07-04
申请人： Kyung Sun Kang , Jeong Chan Ra
发明人： Kyung Sun Kang , Jeong Chan Ra
IPC分类号： A61K35/12 , C12N5/02 , A61P17/14
CPC分类号： C12N5/0628 , A61K35/12 , C12N2500/25 , C12N2500/32 , C12N2500/38 , C12N2500/90 , C12N2501/11 , C12N2501/115 , C12N2501/599 , C12N2501/70
摘要： The present invention relates to a method for isolating hair follicle stem cells and a composition for inducing hair growth. More specifically, relates to a method for isolating hair follicle stem cells showing a positive immunological response to CD34, by chemically degrading hair follicle-containing scalp tissue and then culturing the degraded tissue in a serum-containing medium and a serum-free medium, as well as a composition for inducing hair growth, which contains, as an active ingredient, CD34-positive hair follicle stem cells isolated by the method. The hair follicle-derived stem cells, which are obtained according to the disclosed method, are classified as autologous adult stem cells, have self-renewal capability, the ability to differentiate into adult hair follicle cells and the ability to induce hair growth, and can be used as a novel cell therapeutic agent against hair loss. In addition, the present invention relates to a method for culturing hair follicle cells, which has high yield compared to that of the prior art, as well as a method for identifying hair follicle stem cells.
摘要翻译：本发明涉及一种分离毛囊干细胞的方法和用于诱导毛发生长的组合物。更具体地，涉及通过化学降解含毛囊的头皮组织然后在含血清的培养基和无血清培养基中培养所述降解组织，分离出对CD34具有阳性免疫应答的毛囊干细胞的分离方法，如以及用于诱导毛发生长的组合物，其含有通过该方法分离的CD34阳性毛囊干细胞作为活性成分。根据公开的方法获得的来自毛囊的干细胞被分类为自体成体干细胞，具有自我更新能力，分化成成年毛囊细胞的能力和诱导毛发生长的能力，并且可以用作抗脱发的新型细胞治疗剂。此外，本发明涉及培养与现有技术相比具有高产量的毛囊细胞的方法以及用于鉴定毛囊干细胞的方法。

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