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    • 2. 发明授权
    • Method for preparing and applying a sprayable, light stable polyurethane
    • 制备和应用可喷涂的轻质聚氨酯的方法
    • US5656677A
    • 1997-08-12
    • US485140
    • 1995-06-07
    • Lucien JourquinEddie Du Prez
    • Lucien JourquinEddie Du Prez
    • C08G18/16C08G18/22C08G18/24C08G18/26C08J9/00
    • C08G18/227C08G18/161C08G18/246C08G18/26C08G2150/50C08G2150/60
    • A method for preparing a light stable polyurethane, sprayable by means of a spray pistol, wherein use is made of an active hydrogen containing compound, wherein the functional groups consist for at least 50% of an active CH.sub.2 OH, NH and/or NH.sub.2 group, the functionality of which varies from 2 to 8 and the equivalent weight of which is comprised between 100 and 3500, together with 2 to 300 parts, per 100 parts of said compounds of a chain extender and/or a cross-linker, the functional groups of which are OH groups, at least 50% of which are primary OH groups, the equivalent weight of which is less than 100 and the functionality of which varies from 2 to 6, and with a catalytic system which comprises at least an organic lead, bismuth and/or tin (IV) compound and at least an amine initiator, having a functionality of 2 to 6, an equivalent weight lower than or equal to 200, and at least one aliphatic NH.sub.2 or NH group.
    • 一种制备可通过喷雾手枪喷雾的轻质稳定聚氨酯的方法,其中使用含活性氢的化合物,其中所述官能团由至少50%的活性CH 2 OH,NH和/或NH 2基组成, 其功能从2至8变化,其当量重量在100至3500之间,连同2至300份,每100份所述化合物的扩链剂和/或交联剂,官能团 其中OH基团中的至少50%是伯OH基团,其当量小于100且官能度为2-6,催化体系至少包含有机铅, 铋和/或锡(IV)化合物和至少一种官能度为2-6,当量重量小于等于200的胺引发剂和至少一种脂族NH 2或NH基团。
    • 4. 发明授权
    • Biologically degradable superparamagnetic materials for use in clinical
applications
    • 用于临床应用的生物可降解超顺磁材料
    • US4827945A
    • 1989-05-09
    • US67586
    • 1987-06-26
    • Ernest V. GromanLee JosephsonJerome M. Lewis
    • Ernest V. GromanLee JosephsonJerome M. Lewis
    • A61K33/26A61K31/695A61K31/715A61K33/00A61K38/00A61K39/00A61K39/395A61K49/00A61K49/18A61P7/06C01G49/00C08G18/18C08G18/20C08G18/24C08G18/26C08J9/14G01R33/28
    • B82Y5/00A61K49/18A61K49/1806A61K49/1863A61K49/1869C08G18/1808C08G18/1816C08G18/1825C08G18/2036C08G18/246C08G18/26C08J9/144G01R33/5601C08G2101/00C08J2375/04
    • This invention relates to materials exhibiting certain magnetic and biological properties which make them uniquely suitable for use as magnetic resonance imaging (MRI) agents to enhance MR images of animal organs and tissues. More particularly, the invention relates to the in vivo use of biologically degradable and metabolizable superparamagnetic metal oxides as MR contrast agents. Depending on their preparation, these metal oxides are in the form of superparamagnetic particle dispersoids or superparamagnetic fluids where the suspending medium is a physiologically-acceptable carrier, and may be uncoated or surrounded by a polymeric coating to which biological molecules can be attached. These materials are administered to animals, including humans, by a variety of routes and the metal oxides therein collect in specific target organs to be imaged; in the case of coated particles, the biological molecules can be chosen to target specific organs or tissues. The biodistribution of the metal oxides in target organs or tissues results in a more detailed image of such organs or tissues because the metal oxides, due to their superparamagnetic properties, exert profound effects on the hydrogen nuclei responsible for the MR image. In addition, the dispersoids and fluids are quite stable and, in the case of the fluids, can even be subjected to autoclaving without impairing their utility. Furthermore, the materials are biodegradable and, in the case of iron oxide compounds, can eventually be incorporated into the subject's hemoglobin, making them useful in treating anemia. Thus, the materials are well-suited for in vivo use.
    • 本发明涉及具有某些磁性和生物学特性的材料,使得它们独特地适用于磁共振成像(MRI)试剂以增强动物器官和组织的MR图像。 更具体地,本发明涉及生物可降解和代谢的超顺磁性金属氧化物作为MR造影剂的体内应用。 取决于它们的制备,这些金属氧化物是超顺磁性颗粒分散体或超顺磁性流体的形式,其中悬浮介质是生理上可接受的载体,并且可以是未涂覆的或被可附着生物分子的聚合物涂层包围。 这些材料通过各种途径施用于包括人在内的动物,并且其中的金属氧化物收集在要成像的特定靶器官中; 在涂覆颗粒的情况下,可以选择生物分子来靶向特定的器官或组织。 金属氧化物在靶器官或组织中的生物分布导致这种器官或组织的更详细的图像,因为金属氧化物由于其超顺磁性质对负责MR图像的氢原子发挥深远的作用。 此外,分散体和流体是相当稳定的,并且在流体的情况下,甚至可以进行高压灭菌而不损害它们的效用。 此外,材料是可生物降解的,并且在氧化铁化合物的情况下,最终可以并入受试者的血红蛋白中,使其可用于治疗贫血。 因此,这些材料非常适合于体内使用。