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1. 发明授权

US09962628B2 Use of citrate solution for affinity chromatographic purification of CRP using phosphocholine and derivatives thereof 有权
公开(公告)号：US09962628B2
公开(公告)日：2018-05-08
申请号：US15526263
申请日：2015-11-12
申请人： Pentracor GmbH
发明人： Ahmed Sheriff , Birgit Vogt , Stephan Mattecka
IPC分类号： B01D15/38 , B01D15/12 , B01J20/286 , B01J20/32 , C07K14/47 , B01J20/22 , B01J20/281 , B01J20/285
CPC分类号： B01D15/3804 , B01D15/12 , B01J20/22 , B01J20/285 , B01J20/286 , B01J20/3242 , B01J20/3251 , B01J20/3255 , C07K14/4737 , G01N30/48
摘要： The invention relates to the use of a citrate solution for affinity-chromatographic removal of C-reactive protein (CRP) from biological fluids, wherein the CRP is affinity-chromatographically removed using (Ca2+-dependent) binding of CRP to a column material functionalized with ω-phosphonooxyalkyl ammonium groups and/or with ω-ammoniumalkoxy-hydroxy-phosphoryloxy groups.

2. 发明授权

US09944910B2 TATk-CDKL5 fusion proteins, compositions, formulations, and use thereof 有权
公开(公告)号：US09944910B2
公开(公告)日：2018-04-17
申请号：US15075457
申请日：2016-03-21
申请人： Alma Mater Studiorum—Universitá di Bologna
发明人： Elisabetta Ciani , Franco Laccone
IPC分类号： C07K19/00 , C12N9/12 , C07K14/47 , A61K38/00
CPC分类号： C12N9/12 , A61K38/00 , C07K14/4737 , C07K14/4738 , C07K2319/01 , C07K2319/10 , C07K2319/21 , C07K2319/41 , C07K2319/60 , C12N9/1205 , C12N2501/405 , C12Y207/11022
摘要： Disclosed herein are compositions and formulations containing a TATk-CDKL5 fusion protein. Also disclosed are methods of producing a TATk-CDKL5 fusion protein from vectors containing a TATk-CDKL5 cDNA and methods of transducing cells with the vectors containing a TATk-CDKL5 cDNA and the TATk-CDKL5 fusion protein.

3. 发明申请

US20170319982A1 USE OF A CITRATE SOLUTION FOR AFFINITY CHROMATOGRAPHIC PURIFICATION OF CRP USING PHOSPHOCHOLINE AND DERIVATIVES THEREOF 有权
公开(公告)号：US20170319982A1
公开(公告)日：2017-11-09
申请号：US15526263
申请日：2015-11-12
申请人： Pentracor GmbH
发明人： Ahmed SHERIFF , Birgit VOGT , Stephan MATTECKA
IPC分类号： B01D15/38 , C07K14/47 , B01D15/12
CPC分类号： B01D15/3804 , B01D15/12 , B01J20/22 , B01J20/285 , B01J20/286 , B01J20/3242 , B01J20/3251 , B01J20/3255 , C07K14/4737 , G01N30/48
摘要： The invention relates to the use of a citrate solution for affinity-chromatographic removal of C-reactive protein (CRP) from biological fluids, wherein the CRP is affinity-chromatographically removed using (Ca2+-dependent) binding of CRP to a column material functionalized with ω-phosphonooxyalkyl ammonium groups and/or with ω-ammoniumalkoxy-hydroxy-phosphoryloxy groups.

4. 发明申请

US20160347805A1 BIOMARKER FOR HUMAN EYES AND METHOD THEREOF 审中-公开
标题翻译：人眼生物标志物及其方法
公开(公告)号：US20160347805A1
公开(公告)日：2016-12-01
申请号：US15236746
申请日：2016-08-15
申请人： Po-Kang LIN
发明人： Po-Kang LIN
IPC分类号： C07K14/47 , G01N33/68 , A61B3/135 , C07C323/58
CPC分类号： C07K14/4737 , A61B3/135 , C07C323/58 , G01N33/6815 , G01N33/6893 , G01N2333/4737 , G01N2800/16
摘要： The present invention provides a biomarker for detecting and diagnosing polypoidal choroidal vasculopathy (PCV) of human eyes, including levels of hyperhomocysteinemia that are identified, wherein elevated levels of hyperhomocysteinemia are highly associated with PCV of the human eyes. In addition, the present invention further provides a method for detecting and diagnosing PCV of the human eyes.
摘要翻译：本发明提供用于检测和诊断人眼的多发性脉络膜血管病变（PCV）的生物标志物，包括鉴定的高同型半胱氨酸血症水平，其中升高的高同型半胱氨酸血症水平与人眼的PCV高度相关。此外，本发明还提供了一种用于检测和诊断人眼的PCV的方法。

5. 发明申请

US20150037880A1 DNA ENCODING CANINE MONOMERIC CRP AND EXPRESSION VECTOR CONTAINING THE DNA 审中-公开
标题翻译： DNA编码含有单核细胞CRP和表达载体的DNA
公开(公告)号：US20150037880A1
公开(公告)日：2015-02-05
申请号：US14487513
申请日：2014-09-16
申请人： NITTO BOSEKI CO., LTD. , NATIONAL INSTITUTE OF AGROBIOLOGICAL SCIENCES
发明人： Iwao KIYOKAWA , Yuji Arimatsu , Toshihide Miura , Ryo Kojima , Hideki Sezutsu , Keiro Uchino , Isao Kobayashi , Toshiki Tamura
IPC分类号： C07K14/47
CPC分类号： C07K14/4737 , A01K67/0333 , A01K67/04 , A01K2217/052 , A01K2227/706 , C07K2319/02
摘要： Pentameric CRP is produced at a high efficiency by transferring DNA, which encodes monomeric CRP, into a silkworm to thereby construct a transgenic silkworm and then collecting and purifying pentameric CRP that is produced by the transgenic silkworm constructed above.
摘要翻译：通过将编码单体CRP的DNA转移到蚕中，从而构建转基因蚕，然后收集和纯化由上述构建的转基因蚕产生的五聚体CRP，从而高效生产五聚体CRP。

6. 发明申请

US20090202520A1 Treatment and diagnostic methods for fibrosis related disorders 有权
标题翻译：纤维化相关疾病的治疗和诊断方法
公开(公告)号：US20090202520A1
公开(公告)日：2009-08-13
申请号：US12215700
申请日：2008-06-27
申请人： Mark L. Lupher, JR. , Teresa Surowy , Shawn Li
发明人： Mark L. Lupher, JR. , Teresa Surowy , Shawn Li
IPC分类号： A61K39/395 , C12Q1/00 , A61K38/00 , A61K31/7088
CPC分类号： C07K14/4737 , G01N33/6887 , G01N2333/4709 , G01N2333/4737 , G01N2800/085 , G01N2800/382
摘要： Compositions and methods are provided for the treatment of fibrosis related disorders utilizing the ratio of the concentration of serum amyloid P(SAP) to C-reactive protein (CRP) in a patient. The methods may further comprise determining the R131/H131 polymorphism of FcγRIIA. Diagnostic methods are also provided.
摘要翻译：提供了使用患者血清淀粉样蛋白P（SAP）与C反应蛋白（CRP）浓度之比来治疗纤维化相关疾病的组合物和方法。所述方法还可以包括确定FcγRIIA的R131 / H131多态性。还提供了诊断方法。

7. 发明授权

US5874238A Mutant protein and methods and materials for making and using it 失效
标题翻译：突变蛋白及其制备和使用的方法和材料
公开(公告)号：US5874238A
公开(公告)日：1999-02-23
申请号：US480270
申请日：1995-06-07
申请人： Lawrence A. Potempa , Hans H. Liao , Becky L. Crump
发明人： Lawrence A. Potempa , Hans H. Liao , Becky L. Crump
IPC分类号： A61K38/00 , C07K14/47 , C12P21/00 , C12N15/12 , C12N15/74
CPC分类号： C07K14/4737 , A61K38/00
摘要： The invention provides a mutant protein which has the same amino acid sequence as an unmutated C-reactive protein (CRP) subunit or an unmutated preCRP, except that at least one amino acid of the unmutated CRP subunit or unmutated preCRP has been deleted, at least one amino acid of the unmutated CRP subunit or unmutated preCRP has been replaced by another amino acid, at least one amino acid has been added to the unmutated CRP subunit or preCRP, or a combination of such changes has been made. The amino acid(s) added, deleted and/or replaced are chosen so that the mutant protein is less likely to form covalently cross-linked aggregates than the unmutated CRP subunit or unmutated preCRP. The mutant protein also exhibits at least one of the biological activities of modified-CRP. The invention also provides DNA molecules coding for the mutant proteins of the invention, vectors for expressing the mutant proteins, host cells which have been transformed so that they can express the mutant proteins, and a method of producing the mutant proteins of the invention comprising culturing the transformed host cells. Finally, the invention provides methods and materials for using the mutant proteins.
摘要翻译：本发明提供了与未突变的C-反应蛋白（CRP）亚基或未突变的preCRP具有相同氨基酸序列的突变蛋白，除了未突变的CRP亚基或未突变的preCRP的至少一个氨基酸已被缺失，至少未突变的CRP亚基或未突变的preCRP的一个氨基酸已经被另一个氨基酸替代，至少一个氨基酸已经添加到未突变的CRP亚基或preCRP中，或者已经进行了这些改变的组合。选择加入，缺失和/或替换的氨基酸，使得突变蛋白不比未突变的CRP亚基或未突变的preCRP形成共价交联的聚集体。突变蛋白还表现出修饰CRP的至少一种生物活性。本发明还提供编码本发明的突变型蛋白质的DNA分子，用于表达突变型蛋白质的载体，已被转化的宿主细胞，使得它们能够表达突变型蛋白质，以及产生本发明的突变型蛋白质的方法，包括培养转化的宿主细胞。最后，本发明提供了使用突变蛋白的方法和材料。

8. 发明申请

US20180045724A1 METHODS OF DETECTING INFLAMMATORY MARKERS AND TREATING INFLAMMATORY CONDITIONS IN HUMANS 审中-公开
公开(公告)号：US20180045724A1
公开(公告)日：2018-02-15
申请号：US15674427
申请日：2017-08-10
申请人： VETICA LABS, INC.
发明人： Juan ESTRUCH , Genevieve HANSEN
IPC分类号： G01N33/564 , C07K14/705 , C07K14/47
CPC分类号： G01N33/564 , C07K14/4713 , C07K14/4718 , C07K14/4728 , C07K14/4737 , C07K14/70546 , C07K14/79 , C07K16/00 , C07K2319/21 , G01N2333/4727 , G01N2333/70546 , G01N2800/062 , G01N2800/065 , G01N2800/50 , G01N2800/7095
摘要： The present invention provides methods and systems to accurately detect and measure in a biological sample from a patient, endogenous antibodies, e.g., IgA, to inflammatory proteins, which antibodies are useful as diagnostic markers for inflammatory conditions, including bowel disease (IBD), in patients. Such methods and systems identify whether a sample from the patient is associated with an inflammatory condition, by using non-invasive means, thus conveniently providing information useful for guiding treatment decisions.

9. 发明申请

US20160305951A1 BIOMARKER FOR HUMAN EYES AND METHOD THEREOF 审中-公开
公开(公告)号：US20160305951A1
公开(公告)日：2016-10-20
申请号：US14845746
申请日：2015-09-04
申请人： Po-Kang Lin
发明人： Po-Kang Lin
IPC分类号： G01N33/68 , C07C323/58 , A61B3/135 , C07K14/47
CPC分类号： C07K14/4737 , A61B3/135 , C07C323/58 , G01N33/6815 , G01N33/6893 , G01N2333/4737 , G01N2800/16
摘要： The present invention provides a biomarker for detecting and diagnosing polypoidal choroidal vasculopathy (PCV) of human eyes, including levels of hyperhomocysteinemia that are identified, wherein elevated levels of hyperhomocysteinemia are highly associated with PCV of the human eyes. In addition, the present invention further provides a method for detecting and diagnosing PCV of the human eyes.

10. 发明申请

US20110318846A1 Aptamer and detection method for C-reactive protein 失效
标题翻译： C反应蛋白的适体和检测方法
公开(公告)号：US20110318846A1
公开(公告)日：2011-12-29
申请号：US12924225
申请日：2010-09-22
申请人： Gwo-Bin Lee , Shu-Chu Shiesh , Chao-June Huang , Hsin-I Lin
发明人： Gwo-Bin Lee , Shu-Chu Shiesh , Chao-June Huang , Hsin-I Lin
IPC分类号： G01N33/566 , C12N9/00 , C07H21/00
CPC分类号： G01N33/68 , C07K14/4737 , G01N2333/4737
摘要： An aptamer specifically binding to C-reactive protein (CRP) is provided. The aptamer includes a following nucleotide sequence: 5′-angngggngnntgnnt-3′, wherein n is a nucleotide selected from a, t, c and g.
摘要翻译：提供了特异性结合C反应蛋白（CRP）的适体。适体包括以下核苷酸序列：5'-angngggngnntntntnt-3'，其中n是选自a，t，c和g的核苷酸。

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