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1. 发明申请

US20190247356A1 Aminocarbonylcarbamate Compounds 审中-公开
公开(公告)号：US20190247356A1
公开(公告)日：2019-08-15
申请号：US16395422
申请日：2019-04-26
申请人： SK BIOPHARMACEUTICALS CO., LTD.
发明人： Young-Soon KANG , Jin-Yong CHUNG , Cheol-Young MAENG , Han-Ju YI , Ki-Ho LEE , Joon HEO , Eun-Hee CHAE , Yu-Jin SHIN
IPC分类号： A61K31/325 , A61P25/00 , A61K9/00 , C07C275/60 , A61K45/06 , A61K31/27
CPC分类号： A61K31/325 , A61K9/0053 , A61K31/27 , A61K45/06 , A61P25/00 , C07C275/60
摘要： The present disclosure provides a compound represented by Formula (I) and a pharmaceutically acceptable salt which are effective as a dopamine reuptake inhibitor and a method of using the compound: wherein X is independently halo, alkyl, alkoxy or nitro; m is 0, 1, 2, 3 or 4; n is 1 or 2; R1 and R2 are independently H— or alkyl; R3 is H—, alkyl or aralkyl; and R4 is H— or aryl.

2. 发明申请

US20180085337A1 AMINOCARBONYLCARBAMATE COMPOUNDS 审中-公开
公开(公告)号：US20180085337A1
公开(公告)日：2018-03-29
申请号：US15805293
申请日：2017-11-07
申请人： SK BIOPHARMACEUTICALS CO., LTD.
发明人： Young-Soon KANG , Jin-Yong CHUNG , Cheol-Young MAENG , Han-Ju YI , Ki-Ho LEE , Joon HEO , Eun-Hee CHAE , Yu-Jin SHIN
IPC分类号： A61K31/325 , A61K31/27 , A61K45/06 , C07C275/60 , A61K9/00
CPC分类号： A61K31/325 , A61K9/0053 , A61K31/27 , A61K45/06 , A61P25/00 , C07C275/60
摘要： The present disclosure provides a compound represented by Formula (I) and a pharmaceutically acceptable salt which are effective as a dopamine reuptake inhibitor and a method of using the compound: wherein X is independently halo, alkyl, alkoxy or nitro; m is 0, 1, 2, 3 or 4; n is 1 or 2; R1 and R2 are independently H— or alkyl; R3 is H—, alkyl or aralkyl; and R4 is H— or aryl.

3. 发明申请

US20170291880A1 PROCESS FOR THE PREPARATION OF TOLTRAZURIL AND AN INTERMEDIATE USEFUL FOR ITS PREPARATION 有权
公开(公告)号：US20170291880A1
公开(公告)日：2017-10-12
申请号：US15480565
申请日：2017-04-06
申请人： ERREGIERRE S.p.A.
发明人： Massimo Ferrari , Daniele De Zani , Matteo Bonaldi
IPC分类号： C07D251/30 , C07C271/66
CPC分类号： C07D251/30 , C07C271/66 , C07C275/60 , C07C319/20 , C07C323/20
摘要： Disclosed is a process for the preparation of toltrazuril of formula (I) via the intermediate N-methyl-N′-[3-methyl-4-[4-[(trifluoromethyl)thio]phenoxy]phenyl] imidodicarbonic diamide of formula (III) wherein intermediate (III) is obtained via a novel intermediate without the use of potentially hazardous reagents or potentially unstable intermediates.

4. 发明申请

US20160303067A1 AMINOCARBONYLCARBAMATE COMPOUNDS 有权
标题翻译：氨基羰基化合物
公开(公告)号：US20160303067A1
公开(公告)日：2016-10-20
申请号：US15195326
申请日：2016-06-28
申请人： SK BIOPHARMACEUTICALS CO., LTD.
发明人： Young-Soon KANG , Jin-Yong CHUNG , Cheol-Young MAENG , Han-Ju YI , Ki-Ho LEE , Joon HEO , Eun-Hee CHAE , Yu-Jin SHIN
IPC分类号： A61K31/325 , A61K45/06 , A61K9/00
CPC分类号： A61K31/325 , A61K9/0053 , A61K31/27 , A61K45/06 , C07C275/60
摘要： The present disclosure provides a compound represented by Formula (I) and a pharmaceutically acceptable salt which are effective as a dopamine reuptake inhibitor and a method of using the compound: wherein X is independently halo, alkyl, alkoxy or nitro; m is 0, 1, 2, 3 or 4; n is 1 or 2; R1 and R2 are independently H— or alkyl; R3 is H—, alkyl or aralkyl; and R4 is H— or aryl.

5. 发明授权

US09394244B2 Ethylenically unsaturated oligomers 有权
标题翻译：烯键式不饱和低聚物
公开(公告)号：US09394244B2
公开(公告)日：2016-07-19
申请号：US14430934
申请日：2013-10-22
申请人： BASF SE
发明人： Eugene Valentine Sitzmann , David Trumbo , Mervin Wood
IPC分类号： C08F2/50 , C08F2/46 , C08G61/04 , C07C275/60 , C07D401/14 , C07C273/18 , C07D211/94 , C07D251/24 , C08F222/22 , C09D135/02 , C07D249/20 , C07D307/62
CPC分类号： C07C275/60 , C07C273/1854 , C07D211/94 , C07D249/20 , C07D251/24 , C07D307/62 , C07D401/14 , C08F222/22 , C08G18/282 , C08G18/2825 , C08G18/73 , C08G18/755 , C08G18/7837 , C08G18/8166 , C09D135/02
摘要： Disclosed are functional polyallophanate oligomers comprising ethylenically unsaturated groups and polymer stabilizer groups selected from hindered amine light stabilizers, ultraviolet light absorbers, antioxidants and dihydrocarbylhydroxylamines. The ethylenically unsaturated groups and the polymer stabilizer groups are bound to the polyallophanate oligomers through allophanate and/or carbamate groups. The polyallophanate oligomers are useful in curable coatings, inks and varnishes. The present polyallophanate oligomers are derived from a) organic polyisocyanates, b) compounds containing at least one isocyanate reactive group and at least one ethylenically unsaturated group and c) polymer stabilizers containing at least one isocyanate reactive group.
摘要翻译：公开了包含烯键式不饱和基团和选自受阻胺光稳定剂，紫外光吸收剂，抗氧化剂和二烃基羟胺的聚合物稳定剂基团的官能化聚山梨酸酯低聚物。烯属不饱和基团和聚合物稳定剂基团通过脲基甲酸酯和/或氨基甲酸酯基团结合到多聚叶酸酯低聚物。聚对苯二甲酸乙二醇酯低聚物可用于可固化涂料，油墨和清漆。本发明的聚阴离子低聚物衍生自a）有机多异氰酸酯，b）含有至少一个异氰酸酯反应性基团和至少一个烯键式不饱和基团的化合物，和c）含有至少一个异氰酸酯反应性基团的聚合物稳定剂。

6. 发明申请

US20150246874A1 AMINOCARBONYLCARBAMATE COMPOUNDS 有权
标题翻译：氨基羰基化合物
公开(公告)号：US20150246874A1
公开(公告)日：2015-09-03
申请号：US14633388
申请日：2015-02-27
申请人： SK BIOPHARMACEUTICALS CO., LTD.
发明人： Young-Soon KANG , Jin-Yong CHUNG , Cheol-Young MAENG , Han-Ju YI , Ki-Ho LEE , Joon HEO , Eun-Hee CHAE , Yu-Jin SHIN
IPC分类号： C07C275/60 , A61K31/27 , A61K45/06
CPC分类号： A61K31/325 , A61K9/0053 , A61K31/27 , A61K45/06 , C07C275/60
摘要： The present disclosure provides a compound represented by Formula (I) and a pharmaceutically acceptable salt which are effective as a dopamine reuptake inhibitor and a method of using the compound: wherein X is independently halo, alkyl, alkoxy or nitro; m is 0, 1, 2, 3 or 4; n is 1 or 2; R1 and R2 are independently H— or alkyl; R3 is H—, alkyl or aralkyl; and R4 is H— or aryl.
摘要翻译：本公开内容提供了作为多巴胺再摄取抑制剂有效的由式（I）表示的化合物和药学上可接受的盐以及使用该化合物的方法：其中X独立地为卤素，烷基，烷氧基或硝基; m为0,1,2,3或4; n为1或2; R1和R2独立地为H或烷基; R3是H，烷基或芳烷基; R4是H或芳基。

7. 发明申请

US20090030161A1 Allophanate modified diphenylmethane diisocyanates, prepolymers thereof, and their use in the preparation of polyureas and polyurethanes 审中-公开
标题翻译：脲基甲酸酯改性二苯甲烷二异氰酸酯，其预聚物及其在制备聚脲和聚氨酯中的应用
公开(公告)号：US20090030161A1
公开(公告)日：2009-01-29
申请号：US11881611
申请日：2007-07-27
申请人： Jay A. Johnston , Karl W. Haider , Wendy S. Gustavich
发明人： Jay A. Johnston , Karl W. Haider , Wendy S. Gustavich
IPC分类号： C08G18/28
CPC分类号： C08G18/7657 , C07C275/60 , C08G18/10 , C08G18/283 , C08G18/3243 , C08G18/4825 , C08G18/5024 , C08G18/6685 , C08G18/7837 , C08G2190/00
摘要： This invention relates to novel allophanate-modified diphenylmethane diisocyanates, prepolymers of these allophanate-modified diphenylmethane diisocyanates, and two-component polyureas and one-component polyureaurethanes prepared from these prepolymers. In addition, the invention also relates to processes for the preparation of these various compositions, and to the preparation of sealants from the two-component polyureas and caulking agents from the one-component polyureaurethanes.
摘要翻译：本发明涉及新型脲基甲酸酯改性二苯基甲烷二异氰酸酯，这些脲基甲酸酯改性二苯基甲烷二异氰酸酯的预聚物，以及由这些预聚物制备的双组分聚脲和单组分聚脲聚氨酯。此外，本发明还涉及制备这些各种组合物的方法以及来自双组分聚脲和来自单组分聚脲氨酯的填缝剂的密封剂的制备。

8. 发明授权

US06878841B2 Diethyloctandioldicarbamates and diethyloctandioldiallophanates, method for the production and use thereof 失效
标题翻译：二十二烷基二恶唑烷酸酯和二乙基辛二酸二乙酯，生产和使用方法
公开(公告)号：US06878841B2
公开(公告)日：2005-04-12
申请号：US10182528
申请日：2001-01-24
申请人： Heinz-Peter Rink , Jochem Henkelmann , Werner-Alfons Jung , Paul J. Harris , Swaminathan Ramesh
发明人： Heinz-Peter Rink , Jochem Henkelmann , Werner-Alfons Jung , Paul J. Harris , Swaminathan Ramesh
IPC分类号： C07C269/04 , C07C271/12 , C07C275/60 , C08K5/205 , C08K5/21 , C09D179/00 , C09D201/02 , C09J7/02 , C09J179/00 , C09J201/02 , C07C261/00
CPC分类号： C08K5/21 , C07C271/12 , C07C275/60 , C08K5/205
摘要： Positionally isomeric diethyloctanediol dicarbamates and diethyloctanediol diallophanates, processes for preparing them, and their use as synthesis building blocks and constituents of adhesives, sealing compounds, and coating materials.
摘要翻译：位置异构的二乙基辛二醇二氨基甲酸酯和二乙二醇二环戊二酸酯，它们的制备方法，以及它们作为粘合剂，密封化合物和涂料的合成结构单元和成分的用途。

9. 发明申请

US20030023017A1 Diethyloctandioldicarbamates and diethyloctandioldiallophanates, method for the production and use thereof 失效
标题翻译：二十二烷基二恶唑烷酸酯和二乙基辛二酸二乙酯，生产和使用方法
公开(公告)号：US20030023017A1
公开(公告)日：2003-01-30
申请号：US10182528
申请日：2002-07-22
发明人： Heinz-Peter Rink , Jochem Henkelmann , Werner-Alfons Jung , Paul J Harris , Swaminathan Ramesh
IPC分类号： C07F007/22 , C07F007/24 , C07F007/30 , C07C261/00 , C07C269/00 , C07C271/00 , C08F026/02 , C08F018/16 , C08F022/26
CPC分类号： C08K5/21 , C07C271/12 , C07C275/60 , C08K5/205
摘要： The invention relates to positional isomer diethyloctandioldicarbamates and diethyloctandioldiallophanates, to a method for the production thereof and to the use thereof as synthetic building blocks and constituents of adhesives, luting compounds and coating materials.
摘要翻译：本发明涉及位置异构体二乙基辛二酸二异氰酸酯和二乙基辛二酸二乙酸酯，其制备方法及其作为合成结构单元及其粘合剂，粘合剂和涂料的成分的用途。

10. 发明授权

US5672736A Polyisocyanates containing allophanate groups 失效
标题翻译：含有脲基甲酸酯基的多异氰酸酯
公开(公告)号：US5672736A
公开(公告)日：1997-09-30
申请号：US555200
申请日：1995-11-08
申请人： Martin Brahm , Lutz Schmalstieg , Josef Pedain
发明人： Martin Brahm , Lutz Schmalstieg , Josef Pedain
IPC分类号： C07C273/18 , C07C275/60 , C08G18/78 , C09D175/00 , C07C263/00
CPC分类号： C08G18/7837 , C07C275/60
摘要： The present invention relates to a process for preparing polyisocyanates containing allophanate groups by reacting compounds a), which i) contain urethane groups, but which are substantially free of hydroxyl groups and isocyanate groups, ii) have an average of at least two urethane groups per molecule, iii) are prepared by reacting organic isocyanates a1) with organic hydroxyl compounds a2) and iv) have an average molecular weight of at most 2,500, with excess quantities, based on the urethane groups, of distillable organic polyisocyanates b) to form polyisocyanates containing allophanate groups and subsequently removing by distillation the unreacted excess of component b) to a residual content of less than 0.5 wt. %, provided that polyisocyanates a1) and polyisocyanates b) are different. The present invention also relates to the products obtained from this process and to their use as binders or binder components in coating compositions.
摘要翻译：本发明涉及通过使具有氨基甲酸酯基但不含羟基和异氰酸酯基的化合物a）反应制备含有脲基甲酸酯基团的多异氰酸酯的方法，ii）基本上不含羟基和异氰酸酯基团，ii）平均具有至少两个氨基甲酸酯基团分子，iii）通过使有机异氰酸酯a1）与有机羟基化合物a2）和iv）具有至多2500的平均分子量，基于氨基甲酸酯基团的过量的可蒸馏有机多异氰酸酯b）来制备，以形成多异氰酸酯含有脲基甲酸酯基团，随后通过蒸馏将未反应的组分b）过量除去至少于0.5wt。％，条件是多异氰酸酯a1）和多异氰酸酯b）不同。本发明还涉及从该方法获得的产品及其作为涂料组合物中的粘合剂或粘合剂组分的用途。

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