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1. 发明申请

US20040118688A1 Transparent polymer support for electrophoresis and electrochromatography and related methods 审中-公开
标题翻译：透明聚合物支持电泳和电色谱及相关方法
公开(公告)号：US20040118688A1
公开(公告)日：2004-06-24
申请号：US10630628
申请日：2003-07-29
发明人： David P. Dumas
IPC分类号： G01N027/26 , G01N027/27
CPC分类号： G01N27/44721 , B01L3/5027 , G01N27/44704 , G01N30/02 , G01N30/6082 , G01N2030/645 , B01D15/3842
摘要： The invention provides polyol (allyl carbonate) polymer for electrokinetic devices. The devices can be modified for attachment of a chemical moiety or ligand. The electrokinetic devices can be used for a variety of applications, including chemical analysis, biochemical analysis, cell sorting, purification, analytical devices, diagnostic devices, and tissue culture applications. The invention also provides methods of using the polyol (allyl carbonate) polymer electrokinetic devices. The invention also provides for a sensor that allows for the detection of various chemicals, biochemicals, ions, metals, solvents, and bio-polymers.
摘要翻译：本发明提供用于电动装置的多元醇（碳酸烯丙酯）聚合物。可以修饰这些装置以连接化学部分或配体。电动装置可用于各种应用，包括化学分析，生化分析，细胞分选，纯化，分析装置，诊断装置和组织培养应用。本发明还提供了使用多元醇（碳酸烯丙酯）聚合物电动装置的方法。本发明还提供一种允许检测各种化学物质，生物化学物质，离子，金属，溶剂和生物聚合物的传感器。

2. 发明授权

US06475363B1 Apparatus and method for performing microfluidic manipulations for chemical analysis and synthesis 有权
标题翻译：用于进行化学分析和合成的微流控操作的装置和方法
公开(公告)号：US06475363B1
公开(公告)日：2002-11-05
申请号：US09477585
申请日：2000-01-04
申请人： J. Michael Ramsey
发明人： J. Michael Ramsey
IPC分类号： G01N27447
CPC分类号： B01L3/5027 , B01F13/0059 , B01F13/0062 , B01F13/0076 , B01J19/0093 , B01J2219/00783 , B01J2219/00826 , B01J2219/00828 , B01J2219/00831 , B01J2219/00853 , B01J2219/00889 , B01J2219/00891 , B01J2219/00912 , B01J2219/00916 , B01J2219/00952 , B01J2219/0097 , B01J2219/00995 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L3/502753 , B01L3/502776 , B01L3/502784 , B01L2200/0605 , B01L2300/0816 , B01L2300/0867 , B01L2300/0883 , B01L2400/0415 , B01L2400/0418 , B01L2400/0421 , B29C65/4895 , B29C66/026 , B29C66/034 , B29C66/54 , G01N27/44743 , G01N27/44791 , G01N30/02 , G01N30/16 , G01N30/6095 , G01N2030/027 , G01N2030/162 , G01N2030/285 , G01N2030/383 , G01N2030/8435 , Y10S366/01 , B01D15/3842
摘要： A microchip laboratory system and method provide fluid manipulations for a variety of applications, including sample injection for microchip chemical separations. The microchip is fabricated using standard photolithographic procedures and chemical wet etching, with the substrate and cover plate joined using direct bonding. Capillary electrophoresis and electrochromatography are performed in channels formed in the substrate. Analytes are loaded into a four-way intersection of channels by electrokinetically pumping the analyte through the intersection, followed by switching of the potentials to force an analyte plug into the separation channel.
摘要翻译：微芯片实验室系统和方法为各种应用提供流体操作，包括用于微芯片化学分离的样品注入。使用标准光刻工艺和化学湿法蚀刻制造微芯片，其中基板和盖板通过直接接合连接。毛细管电泳和电色谱在基底中形成的通道中进行。通过电化学地将分析物泵送通过交叉点，将分析物加载到四通道通道中，然后切换电位以迫使分析物插塞进入分离通道。

3. 发明申请

US20020008030A1 Apparatus and method for performing microfluidic manipulations for chemical analysis 审中-公开
标题翻译：用于进行化学分析的微流控操作的装置和方法
公开(公告)号：US20020008030A1
公开(公告)日：2002-01-24
申请号：US09909638
申请日：2001-07-20
发明人： J. Michael Ramsey
IPC分类号： G01N027/26 , G01N027/447
CPC分类号： B01L3/5027 , B01F13/0059 , B01F13/0062 , B01F13/0076 , B01J19/0093 , B01J2219/00783 , B01J2219/00826 , B01J2219/00828 , B01J2219/00831 , B01J2219/00853 , B01J2219/00889 , B01J2219/00891 , B01J2219/00912 , B01J2219/00916 , B01J2219/00952 , B01J2219/0097 , B01J2219/00995 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L3/502753 , B01L3/502776 , B01L3/502784 , B01L2200/0605 , B01L2300/0816 , B01L2300/0867 , B01L2300/0883 , B01L2400/0415 , B01L2400/0418 , B01L2400/0421 , B29C65/4895 , B29C66/026 , B29C66/034 , B29C66/54 , G01N27/44743 , G01N27/44791 , G01N30/02 , G01N30/16 , G01N30/6095 , G01N2030/027 , G01N2030/162 , G01N2030/285 , G01N2030/383 , G01N2030/8435 , Y10S366/01 , B01D15/3842
摘要： A microchip apparatus and method provide fluidic manipulations for a variety of applications, including sample injection for microchip liquid chromatography. The microchip is fabricated using standard photolithographic procedures and chemical wet etching, with the substrate and cover plate joined using direct bonding. Capillary electrophoresis is performed in channels formed in the substrate. Injections are made by electro-osmotically pumping sample through the injection channel that crosses the separation channel, followed by a switching of the potentials to force a plug into the separation channel.
摘要翻译：微芯片装置和方法为各种应用提供流体操作，包括用于微芯片液相色谱的样品注入。使用标准光刻工艺和化学湿法蚀刻制造微芯片，其中基板和盖板通过直接接合连接。在基底中形成的通道中进行毛细管电泳。注射通过电渗透泵送样品通过穿过分离通道的注入通道，然后切换电位以迫使插塞进入分离通道。

4. 发明授权

US4957620A Liquid chromatography using microporous hollow fibers 失效
标题翻译：使用微孔中空纤维的液相色谱法
公开(公告)号：US4957620A
公开(公告)日：1990-09-18
申请号：US271449
申请日：1988-11-15
申请人： Edward L. Cussler
发明人： Edward L. Cussler
IPC分类号： B01J20/281 , B01D15/08 , B01D69/08 , G01N30/60 , G01N30/88
CPC分类号： B01J20/28023 , B01D15/08 , B01D15/22 , B01D15/3804 , B01D15/3842 , B01J20/28014 , G01N30/6043
摘要： Liquid chromatography separations of solutes are achieved using porous hollow fibers. The pores of the hollow fibers immobilize a solute-absorbing phase (preferably organic) which has a greater absorbance affinity towards at least one solute in a mixture of solutes. By passing the solute mixture through the central lumen of the hollow fibers, chromatographic separation are realized due to the greater retention time of that solute with which the immobilized phase has greater absorbance affinity. The immobilized phase may be a liquid organic which may contain a surfactant so as to form reversed micelles or it may be in the form of a polymeric gel. Separations of biological species (e.g., proteins) may thus be accomplished by means of the present invention.

5. 发明申请

US20090045119A1 POROUS POLYMER AND PROCESS FOR PRODUCING THE SAME 失效
标题翻译：多孔聚合物及其制造方法
公开(公告)号：US20090045119A1
公开(公告)日：2009-02-19
申请号：US11915302
申请日：2006-05-09
申请人： Ken Hosoya , Hiroshi Aoki , Norio Ishizuka , Katsuya Yamamoto
发明人： Ken Hosoya , Hiroshi Aoki , Norio Ishizuka , Katsuya Yamamoto
IPC分类号： B01D15/34 , C08J9/26
CPC分类号： B01J20/28092 , B01D15/3842 , B01J20/28054 , B01J20/28083 , B01J20/28085 , B01J20/285 , B01J20/305 , C08J9/26 , C08J2201/046 , C08J2205/048 , Y10T428/249978
摘要： The present invention relates to a polymeric porous material characterized in that: the porous material has a bimodal pore size distribution attributable to macropores having a pore size of at least 50 nm and mesopores having a pore size of from 2 nm to less than 50 nm, the proportion of the specific surface area of the macropores to the specific surface area of all pores of the porous material is at least 10%, and the porous material is produced by (1) polymerizing a monomer in the presence of a polymerization initiator using as a porogen a solution obtained by dissolving a polymer having a weight-average molecular weight of at least 100,000 and a molecular weight distribution Mw/Mn of not more than 1.5 in a good solvent for the monomer, and (2) removing the porogen from the resultant product.
摘要翻译：本发明涉及一种聚合物多孔材料，其特征在于：多孔材料具有归属于孔径至少为50nm的大孔和孔径为2nm至小于50nm的中孔的双峰孔径分布，大孔的比表面积与多孔材料的所有孔的比表面积的比例为至少10％，多孔材料通过（1）在聚合引发剂的存在下使用单体聚合来制备多孔材料，其使用如通过将具有至少100,000的重均分子量和不大于1.5的分子量分布Mw / Mn的聚合物溶解在用于单体的良溶剂中而获得的致孔剂溶液，和（2）从所述单体中除去致孔剂结果产品。

6. 发明申请

US20040007464A1 Apparatus and method for performing microfluidic manipulations for chemical analysis 审中-公开
标题翻译：用于进行化学分析的微流控操作的装置和方法
公开(公告)号：US20040007464A1
公开(公告)日：2004-01-15
申请号：US10434874
申请日：2003-05-09
发明人： J. Michael Ramsey
IPC分类号： G01N027/27
CPC分类号： B01L3/5027 , B01F13/0059 , B01F13/0062 , B01F13/0076 , B01J19/0093 , B01J2219/00783 , B01J2219/00826 , B01J2219/00828 , B01J2219/00831 , B01J2219/00853 , B01J2219/00889 , B01J2219/00891 , B01J2219/00912 , B01J2219/00916 , B01J2219/00952 , B01J2219/0097 , B01J2219/00995 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L3/502753 , B01L3/502776 , B01L3/502784 , B01L2200/0605 , B01L2300/0816 , B01L2300/0867 , B01L2300/0883 , B01L2400/0415 , B01L2400/0418 , B01L2400/0421 , B29C65/4895 , B29C66/026 , B29C66/034 , B29C66/54 , G01N27/44743 , G01N27/44791 , G01N30/02 , G01N30/16 , G01N30/6095 , G01N2030/027 , G01N2030/162 , G01N2030/285 , G01N2030/383 , G01N2030/8435 , Y10S366/01 , B01D15/3842
摘要： A microchip apparatus and method provide fluidic manipulations for a variety of applications, including sample injection for microchip liquid chromatography. The microchip is fabricated using standard photolithographic procedures and chemical wet etching, with the substrate and cover plate joined using direct bonding. Capillary electrophoresis is performed in channels formed in the substrate. Injections are made by electro-osmotically pumping sample through the injection channel that crosses the separation channel, followed by a switching of the potentials to force a plug into the separation channel.
摘要翻译：微芯片装置和方法为各种应用提供流体操作，包括用于微芯片液相色谱的样品注入。使用标准光刻工艺和化学湿法蚀刻制造微芯片，其中基板和盖板通过直接接合连接。在基底中形成的通道中进行毛细管电泳。注射通过电渗透泵送样品通过穿过分离通道的注入通道，然后切换电位以迫使插塞进入分离通道。

7. 发明授权

US06342142B1 Apparatus and method for performing microfluidic manipulations for chemical analysis 有权
标题翻译：用于进行化学分析的微流控操作的装置和方法
公开(公告)号：US06342142B1
公开(公告)日：2002-01-29
申请号：US09300060
申请日：1999-04-27
申请人： J. Michael Ramsey
发明人： J. Michael Ramsey
IPC分类号： G01N2726
CPC分类号： B01L3/5027 , B01F13/0059 , B01F13/0062 , B01F13/0076 , B01J19/0093 , B01J2219/00783 , B01J2219/00826 , B01J2219/00828 , B01J2219/00831 , B01J2219/00853 , B01J2219/00889 , B01J2219/00891 , B01J2219/00912 , B01J2219/00916 , B01J2219/00952 , B01J2219/0097 , B01J2219/00995 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L3/502753 , B01L3/502776 , B01L3/502784 , B01L2200/0605 , B01L2300/0816 , B01L2300/0867 , B01L2300/0883 , B01L2400/0415 , B01L2400/0418 , B01L2400/0421 , B29C65/4895 , B29C66/026 , B29C66/034 , B29C66/54 , G01N27/44743 , G01N27/44791 , G01N30/02 , G01N30/16 , G01N30/6095 , G01N2030/027 , G01N2030/162 , G01N2030/285 , G01N2030/383 , G01N2030/8435 , Y10S366/01 , B01D15/3842
摘要： A microchip apparatus and method provide fluidic manipulations for a variety of applications, including sample injection for microchip liquid chromatography. The microchip is fabricated using standard photolitographic procedures and chemical wet etching, with the substrate and cover plate joined using direct bonding. Capillary electrophoresis is performed in channels formed in the substrate. Injections are made by electro-osmotically pumping sample through the injection channel that crosses the separation channel, followed by a switching of the potentials to force a plug into the separation channel.
摘要翻译：微芯片装置和方法为各种应用提供流体操作，包括用于微芯片液相色谱的样品注入。微芯片采用标准光刻工艺和化学湿法蚀刻制成，基板和盖板通过直接接合连接。在基底中形成的通道中进行毛细管电泳。注射通过电渗透泵送样品通过穿过分离通道的注入通道，然后切换电位以迫使插塞进入分离通道。

8. 发明授权

US4808314A Method for reducing bacterial endotoxin contamination in solutions of macromolecules 失效
标题翻译：降低大分子溶液中细菌内毒素污染的方法
公开(公告)号：US4808314A
公开(公告)日：1989-02-28
申请号：US98299
申请日：1987-09-18
申请人： Thomas E. Karplus , Richard J. Ulevitch , Curtis B. Wilson
发明人： Thomas E. Karplus , Richard J. Ulevitch , Curtis B. Wilson
IPC分类号： A61K9/08 , A61K38/00 , B01D15/00 , C07K1/14 , C07K1/16 , C07K1/34 , C07K14/435 , C07K14/52 , C07K14/555 , C07K14/575 , C07K14/62 , C07K14/745 , C07K16/00 , B01D13/00
CPC分类号： B01D15/00 , B01D15/3842
摘要： The present invention contemplates a method of reducing a bacterial endotoxin contaminant in a biologically useful macromolecule. AN aqueous medium containing an endotoxin-contaminated macromolecule is admixed with a dialyzable surfactant, and the admixture so formed is contacted with an endotoxin sorbant to form a solid-liquid phase admixture. The contacting is maintained until the endotoxin is bound to the sorbant. The surfactant is dialyzed out of the aqueous liquid phase at a time no earlier than the maintenance step. The liquid phase containing the macromolecule is separated and recovered.

9. 发明申请

US20070243622A1 POLYMERIC SULFATED SURFACTANTS FOR CAPILLARY ELECTROPHORESIS (CE) AND CE-MASS SPECTROMETRY (CE-MS) 有权
标题翻译：用于毛细管电泳（CE）和CE-质谱（CE-MS）的聚合硫酸化表面活性剂
公开(公告)号：US20070243622A1
公开(公告)日：2007-10-18
申请号：US11692602
申请日：2007-03-28
申请人： Shahab Shamsi , Syed Rizvi
发明人： Shahab Shamsi , Syed Rizvi
IPC分类号： G01N33/20
CPC分类号： G01N27/44747 , B01D15/3842 , Y10T436/10 , Y10T436/145555 , Y10T436/173845 , Y10T436/24 , Y10T436/25375 , Y10T436/255
摘要： The present invention relates generally to sulfated micelle compositions, methods of manufacture, and applications thereof. In particular, the micelles of the present invention provide an efficient enantiomeric separation and detection techniques for use in capillary electrophoresis and capillary electrophoresis with mass spectrometry.
摘要翻译：本发明一般涉及硫酸化胶束组合物，其制备方法及其应用。特别地，本发明的胶束提供了用于毛细管电泳和用质谱法进行毛细管电泳的有效的对映异构体分离和检测技术。

10. 发明申请

US20040206626A1 Micellar gradient focusing 有权
标题翻译：胶束梯度聚焦
公开(公告)号：US20040206626A1
公开(公告)日：2004-10-21
申请号：US10864485
申请日：2004-06-10
发明人： David J. Ross , Peter B. Howell , Wyatt N. Vreeland
IPC分类号： G01L001/20 , C07K001/26
CPC分类号： C07K1/26 , G01N30/02 , G01N30/34 , B01D15/3842
摘要： A method and device are provided for affinity gradient focusing for directing at least one analyte in a solution containing a pseudostationary phase and located in a channel such as a capillary or a microchannel. The method includes establishing a steady-state spatial gradient in a retention factor of the pseudostationary phase for the at least one analyte. The analyte is caused to be moved within the channel whereby the concentration of the at least one analyte changes at one or more positions along the gradient. The pseudostationary phase is charged and the analyte is either neutral or charged or alternatively, the pseudostationary phase is neutral and the analyte is charged. The device may include a fluid channel, a pseudostationary phase having a retention factor gradient, an electrical current source and a pump system for establishing the bulk flow in the solution in the channel.
摘要翻译：提供了一种用于亲和梯度聚焦的方法和装置，用于将至少一种分析物引导到含有假阶段并且位于诸如毛细管或微通道的通道中的溶液中。该方法包括在至少一种分析物的假定相的保留因子中建立稳态空间梯度。导致分析物在通道内移动，由此至少一种分析物的浓度在沿梯度的一个或多个位置处变化。假定相被充电，分析物是中性的或带电的，或者替代地，假定相是中性的并且分析物被充电。该装置可以包括流体通道，具有保持因子梯度的假定相，电流源和用于在通道中的溶液中建立大量流的泵系统。

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