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1. 发明申请

US20130157883A1 Complex miRNA Sets as Novel Biomarkers for an Acute Coronary Syndrome 有权
标题翻译：复杂miRNA作为急性冠脉综合征的新型生物标志物
公开(公告)号：US20130157883A1
公开(公告)日：2013-06-20
申请号：US13642321
申请日：2011-04-19
申请人： Andreas Keller , Peer F. Stähler , Markus Beier , Benjamin Meder , Hugo A. Katus , Wolfgang Rottbauer
发明人： Andreas Keller , Peer F. Stähler , Markus Beier , Benjamin Meder , Hugo A. Katus , Wolfgang Rottbauer
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6876 , C12Q1/6883 , C12Q2600/158 , C12Q2600/178
摘要： The present invention relates to single polynucleotides or sets of polynucleotides for detecting single miRNAs or sets of miRNAs for diagnosing and/or prognosing of an acute coronary syndrome in a blood sample from a human. Further, the present invention relates to means for diagnosing and/or prognosing of an acute coronary syndrome comprising said polynucleotides or sets of polynucleotides. Furthermore, the present invention relates to a method for diagnosing and/or prognosing of an acute coronary syndrome based on the determination of expression profiles of single miRNAs or sets of miRNAs representative for an acute coronary syndrome compared to a reference. In addition, the present invention relates to a kit for diagnosing and/or prognosing of an acute coronary syndrome comprising means for determining expression profiles of single miRNAs or sets of miRNAs representative for an acute coronary syndrome and at least one reference.
摘要翻译：本发明涉及用于检测来自人的血液样品中用于诊断和/或预测急性冠状动脉综合征的单miRNA或多组miRNA的多核苷酸或多组核苷酸。此外，本发明涉及用于诊断和/或预测包含所述多核苷酸或多组核苷酸的急性冠状动脉综合征的方法。此外，本发明涉及一种用于诊断和/或预测急性冠状动脉综合征的方法，所述方法基于与参考文献相比较来确定代表急性冠状动脉综合征的单个miRNA或miRNA集合的表达谱。此外，本发明涉及一种用于诊断和/或预后的急性冠状动脉综合征的试剂盒，其包括用于确定代表急性冠状动脉综合征的单个miRNA或miRNA集合的表达谱的方法和至少一个参考文献。

2. 发明授权

US08173368B2 Programmable oligonucleotide synthesis 有权
标题翻译：可编程寡核苷酸合成
公开(公告)号：US08173368B2
公开(公告)日：2012-05-08
申请号：US12438425
申请日：2007-08-23
申请人： Peer Staehler , Raphael Carapito
发明人： Peer Staehler , Raphael Carapito
IPC分类号： C12Q1/68
CPC分类号： C12Q1/686 , C07H21/00 , C12P19/34 , C12Q1/6806
摘要： The invention relates to methods and devices for preparing synthetic nucleic acids.
摘要翻译：本发明涉及用于制备合成核酸的方法和装置。

3. 发明申请

US20120108462A1 MIRNA FINGERPRINT IN THE DIAGNOSIS OF LUNG CANCER 有权
标题翻译： MIRNA指纹在肺癌诊断中的应用
公开(公告)号：US20120108462A1
公开(公告)日：2012-05-03
申请号：US13376281
申请日：2010-06-07
申请人： Andreas Keller , Eckart Meese , Anne Borries , Markus Beier
发明人： Andreas Keller , Eckart Meese , Anne Borries , Markus Beier
IPC分类号： C40B30/04 , C40B40/06 , C12Q1/68
CPC分类号： C12Q1/6883 , C12Q1/6809 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/158 , C12Q2600/178 , G06F19/20 , G06F19/24 , C12Q2525/207
摘要： The present invention provides novel methods for diagnosing diseases based on the determination of specific miRNAs that have altered expression levels in disease states compared to healthy controls.
摘要翻译：本发明提供了用于基于与健康对照相比在疾病状态中改变表达水平的特异性miRNA的确定来诊断疾病的新方法。

4. 发明申请

US20130331290A1 COMPLEX MIRNA SETS AS NOVEL BIOMARKERS FOR LUNG DISEASES 审中-公开
标题翻译：复杂的MIRNA集作为肺病的新生物标志物
公开(公告)号：US20130331290A1
公开(公告)日：2013-12-12
申请号：US13981089
申请日：2012-01-26
申请人： Andreas Keller , Markus Beier
发明人： Andreas Keller , Markus Beier
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2525/207 , C12Q2600/158 , C12Q2600/178
摘要： The present invention relates to single polynucleotides or sets of polynucleotides for detecting single miRNAs or sets of miRNAs for diagnosing and/or prognosing of a lung disease in a biological sample from a patient. Further, the present invention relates to means for diagnosing and/or prognosing of a lung disease comprising said polynucleotides or sets of polynucleotides. Furthermore, the present invention relates to a method for diagnosing and/or prognosing of a lung disease based on the determination of expression profiles of single miRNAs or sets of miRNAs representative for a lung disease. In addition, the present invention relates to a kit for diagnosing and/or prognosing of a lung disease comprising means for determining expression profiles of single miRNAs or sets of miRNAs representative for a lung disease and optionally at least one reference and/or algorithm or mathematical function comprised on at least one data carrier.
摘要翻译：本发明涉及用于检测来自患者的生物样品中用于诊断和/或预测肺部疾病的单个miRNA或miRNA集合的单个多核苷酸或多组核苷酸组。此外，本发明涉及用于诊断和/或预测包括所述多核苷酸或多组核苷酸的肺病的手段。此外，本发明涉及一种用于诊断和/或预测肺部疾病的方法，所述方法基于代表肺部疾病的单个miRNA或miRNA集合的表达谱的确定。另外，本发明涉及用于诊断和/或预测肺部疾病的试剂盒，其包括用于确定代表肺部疾病的单个miRNA或miRNA集合的表达谱的方法，以及可选地至少一种参考和/或算法或数学功能包括在至少一个数据载体上。

5. 发明申请

US20130035251A1 miRNA FINGERPRINT IN THE DIAGNOSIS OF WILMS' TUMOUR 审中-公开
公开(公告)号：US20130035251A1
公开(公告)日：2013-02-07
申请号：US13519959
申请日：2010-12-30
申请人： Andreas Keller , Eckart Meese , Anne Borries , Markus Beier
发明人： Andreas Keller , Eckart Meese , Anne Borries , Markus Beier
IPC分类号： C40B30/04 , G01N27/62 , C40B30/10 , C07H21/04 , C12Q1/68 , C40B40/06
CPC分类号： C12Q1/6883 , A61N5/10 , C12Q1/6886 , C12Q2600/112 , C12Q2600/158 , C12Q2600/178
摘要： MicroRNAs (miRNA) are a recently discovered class of small non-coding RNAs (17-14 nucleotides). Due to their function as regulators of gene expression they play a critical role both in physiological and in pathological processes, such as cancer. The present invention provides novel methods for diagnosing a state of health based on the determination of specific miRNAs that have altered expression levels in different conditions, e.g. disease states compared to healthy controls.

6. 发明申请

US20120309645A1 miRNA IN THE DIAGNOSIS OF OVARIAN CANCER 有权
标题翻译： miRNA在OVARIAN癌症诊断中的应用
公开(公告)号：US20120309645A1
公开(公告)日：2012-12-06
申请号：US13577335
申请日：2011-02-07
申请人： Andreas Keller , Matthias Scheffler , Markus Beier
发明人： Andreas Keller , Matthias Scheffler , Markus Beier
IPC分类号： C40B30/04 , C12Q1/68 , C40B40/06
CPC分类号： C12Q1/6886 , C12Q2600/156 , C12Q2600/178
摘要： The present invention provides novel methods for diagnosing a state of health based on the determination of specific miRNAs that have altered expression levels in different conditions, e.g. disease states compared to healthy controls.
摘要翻译：本发明提供了基于在不同条件下具有改变的表达水平的特异性miRNA的测定来诊断健康状况的新方法，例如，疾病状态与健康对照相比。

7. 发明申请

US20120157336A1 miRNA FINGERPRINT IN THE DIAGNOSIS OF DISEASES 有权
标题翻译： miRNA指纹在疾病诊断中的应用
公开(公告)号：US20120157336A1
公开(公告)日：2012-06-21
申请号：US13376225
申请日：2010-06-07
申请人： Andreas Keller , Eckart Meese , Anne Borries , Peer Friedrich Staehler , Markus Beier
发明人： Andreas Keller , Eckart Meese , Anne Borries , Peer Friedrich Staehler , Markus Beier
IPC分类号： C40B30/04 , H01J49/26 , C40B40/06 , G01N33/53 , C12Q1/68
CPC分类号： C12Q1/6883 , C12Q1/6809 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/158 , C12Q2600/178 , G06F19/20 , G06F19/24 , C12Q2525/207
摘要： The present invention provides novel methods for diagnosing a state of health based on the determination of specific miRNAs that have altered expression levels in different conditions, e.g. disease states compared to healthy controls.
摘要翻译：本发明提供了基于在不同条件下具有改变的表达水平的特异性miRNA的测定来诊断健康状况的新方法，例如，疾病状态与健康对照相比。

8. 发明授权

US07790369B2 Method for producing polymers 有权
标题翻译：生产聚合物的方法
公开(公告)号：US07790369B2
公开(公告)日：2010-09-07
申请号：US10455369
申请日：2003-06-06
申请人： Peer F. Stähler , Cord F. Stähler , Manfred Müller
发明人： Peer F. Stähler , Cord F. Stähler , Manfred Müller
IPC分类号： C12Q1/68 , C12M1/00 , C12M1/34 , C07H21/02 , C07H21/04
CPC分类号： G06F19/22 , B01J19/0046 , B01J19/0093 , B01J2219/00317 , B01J2219/00432 , B01J2219/00436 , B01J2219/00439 , B01J2219/00441 , B01J2219/00448 , B01J2219/00479 , B01J2219/00497 , B01J2219/00511 , B01J2219/00529 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00603 , B01J2219/00605 , B01J2219/00608 , B01J2219/00621 , B01J2219/00626 , B01J2219/00648 , B01J2219/00659 , B01J2219/00675 , B01J2219/00689 , B01J2219/00702 , B01J2219/00704 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , B01L3/502707 , B01L3/5085 , B01L2300/0654 , B01L2300/069 , B01L2300/0864 , B82Y30/00 , C12N15/10 , C12N15/66 , C12P19/34 , C40B40/06 , C40B40/10 , C40B50/14 , G03F7/70216 , G06F19/28
摘要： The invention relates to a method for producing polymers, in particular synthetic nucleic acid double strands of optional sequence, comprising the steps: (a) providing a support having a surface area which contains a plurality of individual reaction areas, (b) location-resolved synthesizing nucleic acid fragments each having different base sequences in several of the individual reaction areas, and (c) detaching the nucleic acid fragments from individual reaction areas.
摘要翻译：本发明涉及用于制备聚合物的方法，特别是任选序列的合成核酸双链，包括以下步骤：（a）提供具有包含多个单个反应区域的表面积的载体，（b）位置分辨合成在几个单个反应区域中各自具有不同碱基序列的核酸片段，和（c）从各个反应区域分离核酸片段。

9. 发明申请

US20140024554A1 COMPLEX SETS OF MIRNAS AS NON-INVASIVE BIOMARKERS FOR GLIOBLASTOMA 审中-公开
标题翻译：复杂的MIRNAS集合作为GLIOBLASTOMA的非入侵生物标志物
公开(公告)号：US20140024554A1
公开(公告)日：2014-01-23
申请号：US13995956
申请日：2011-12-28
申请人： Andreas Keller , Markus Beier
发明人： Andreas Keller , Markus Beier
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/158 , C12Q2600/178
摘要： The present invention relates to non-invasive methods, kits and means for diagnosing and/or prognosing of glioblastoma in a body fluid sample from a subject. Further, the present invention relates to set of polynucleotides or sets of primer pairs for detecting sets of miRNAs for diagnosing and/or prognosing of glioblastoma in a body fluid sample from a subject. In addition, the present invention relates to sets of miRNAs for diagnosing and/or prognosing of glioblastoma in a body fluid sample from a subject.
摘要翻译：本发明涉及用于诊断和/或预测来自受试者的体液样品中胶质母细胞瘤的非侵入性方法，试剂盒和方法。此外，本发明涉及用于检测来自受试者的体液样品中用于诊断和/或预测胶质母细胞瘤的miRNA组的多核苷酸或引物对组。此外，本发明涉及用于诊断和/或预测来自受试者体液样品中胶质母细胞瘤的miRNA组。

10. 发明申请

US20130053264A1 MIRNA FINGERPRINT IN THE DIAGNOSIS OF PROSTATE CANCER 审中-公开
标题翻译： MIRNA指纹在前列腺癌诊断中的应用
公开(公告)号：US20130053264A1
公开(公告)日：2013-02-28
申请号：US13520014
申请日：2010-12-30
申请人： Andreas Keller , Eckart Meese , Anne Borries , Markus Beier
发明人： Andreas Keller , Eckart Meese , Anne Borries , Markus Beier
IPC分类号： C40B30/04 , C07H21/04 , C12Q1/68 , C40B40/06
CPC分类号： C12Q1/6883 , A61N5/10 , C12Q1/6886 , C12Q2600/112 , C12Q2600/158 , C12Q2600/178
摘要： MicroRNAs (miRNA) are a recently discovered class of small non-coding RNAs (17-14 nucleotides). Due to their function as regulators of gene expression they play a critical role both in physiological and in pathological processes, such as cancer. The present invention provides novel methods for diagnosing a state of health based on the determination of specific miRNAs that have altered expression levels in different conditions, e.g. disease states compared to healthy controls.
摘要翻译：微RNA（miRNA）是最近发现的一类小型非编码RNA（17-14个核苷酸）。由于它们作为基因表达调节因子的功能，它们在生理和病理过程如癌症中起关键作用。本发明提供了基于在不同条件下具有改变的表达水平的特异性miRNA的测定来诊断健康状况的新方法，例如，疾病状态与健康对照相比。

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