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1. 发明授权

US4549548A Pacemaker system with automatic event-programmed switching between unipolar and bipolar operation 失效
标题翻译：起搏器系统具有单极和双极操作之间的自动事件编程切换
公开(公告)号：US4549548A
公开(公告)日：1985-10-29
申请号：US532184
申请日：1983-09-14
申请人： Frederik H. M. Wittkampf , Willem Boute
发明人： Frederik H. M. Wittkampf , Willem Boute
IPC分类号： A61N1/368 , A61N1/372 , A61N1/36
CPC分类号： A61N1/368 , A61N1/36185 , A61N1/3686 , A61N1/3688 , A61N1/37211
摘要： A pacemaker system incorporates an implantable pacemaker and a plurality of electrodes, electrodes preferably being on a pacing lead for a single chamber pacemaker, or a pair of such leads for a dual chamber pacemaker. Programmable connection means are provided for connecting the pacemaker output to a selected combination of lead electrodes, the selection being changed during each pacer cycle to optimize the choice of unipolar and bipolar operation for given pacemaker events. In one mode, the system employs bipolar QRS sensing and unipolar pacing and T-wave sensing. In another mode, the system employs bipolar QRS sensing and pacing, and unipolar T-wave sensing.
摘要翻译：起搏器系统包括可植入起搏器和多个电极，电极优选地位于用于单室起搏器的起搏引线上，或者一对用于双室起搏器的这种引线。提供了可编程连接装置，用于将起搏器输出连接到所选择的引线电极组合，在每个起搏周期期间改变选择，以优化用于给定起搏器事件的单极和双极操作的选择。在一种模式中，系统采用双极QRS感测和单极起搏和T波感测。在另一种模式下，系统采用双极QRS感测和起搏，以及单极T波感测。

2. 发明授权

US4644954A Rate adaptive pacemaker apparatus and method 失效
标题翻译：率自适应起搏器装置及方法
公开(公告)号：US4644954A
公开(公告)日：1987-02-24
申请号：US745836
申请日：1985-06-18
申请人： Frederik H. M. Wittkampf , Anthony F. Rickards
发明人： Frederik H. M. Wittkampf , Anthony F. Rickards
IPC分类号： A61N1/365 , A61N1/36
CPC分类号： A61N1/365
摘要： A pacemaker and method of cardiac pacing employing the Tx mode of rate control, having means for automatically terminating the refractory period after sensing of an evoked T wave following a delivered stimulus. The pacemaker also is capable of overriding a natural rate and delivering one or more stimulus pulses so as to obtain a Tx rate determination during what would otherwise be inhibited pacer operation.
摘要翻译：采用速率控制的Tx模式的心脏起搏器和心脏起搏方法，具有在感测到传递的刺激之后的诱发T波的情况下自动终止不应期的装置。起搏器还能够覆盖自然率并递送一个或多个刺激脉冲，以便在否则会阻止起搏器操作时获得Tx速率确定。

3. 发明授权

US4532467A CMOS Circuits with parameter adapted voltage regulator 失效
标题翻译：具有参数适配电压调节器的CMOS电路
公开(公告)号：US4532467A
公开(公告)日：1985-07-30
申请号：US475025
申请日：1983-03-14
申请人： Kornelis A. Mensink , Hendrik L. Brouwer
发明人： Kornelis A. Mensink , Hendrik L. Brouwer
IPC分类号： G05F1/46 , G05F3/24 , G05F3/26 , G05F3/20
CPC分类号： G05F3/242 , G05F1/462 , G05F3/262
摘要： A self-adjusting voltage regulator circuit on a CMOS chip, for use with CMOS digital and/or analog circuit, providing a voltage which is selected in accordance with the characteristics of the chip to optimally current control operation of CMOS circuits on this chip. The voltage regulator circuit has a reference CMOS pair with a predetermined geometry, and current means are provided for driving a current through said reference pair which is adjusted to operate the pair at a desired point of current controlled operation. The voltage across the reference pair is utilized to provide the regulated voltage to other CMOS pairs, which pairs have respective geometries of predetermined relation to the reference pair geometry, whereby the regulated voltage and the relative geometry provide current controlled operation of each such CMOS pair.
摘要翻译：在CMOS芯片上的自调节电压调节器电路，用于CMOS数字和/或模拟电路，提供根据芯片特性选择的电压，以在该芯片上CMOS电路的最佳电流控制操作。电压调节器电路具有预定几何形状的参考CMOS对，并且提供电流装置用于驱动通过所述参考对的电流，该电流被调节以在电流控制操作的期望点操作该对。参考对两端的电压用于向其他CMOS对提供调节电压，这些对具有与参考对几何形状有预定关系的相应几何形状，由此调节电压和相对几何形状提供每个这样的CMOS对的电流受控操作。

4. 发明授权

US4527568A Dual chamber pacer with alternative rate adaptive means and method 失效
标题翻译：双室起搏器具有替代速率自适应装置和方法
公开(公告)号：US4527568A
公开(公告)日：1985-07-09
申请号：US566101
申请日：1983-12-27
申请人： Anthony F. Rickards
发明人： Anthony F. Rickards
IPC分类号： A61N1/368 , A61N1/36
CPC分类号： A61N1/368
摘要： A dual chamber pacemaker system is disclosed with means for operating in one or another of alternate rate adaptive modes. The pacemaker incorporates an atrial synchronous mode, wherein, pacing rate is determined as a function of sensed atrial signals. It also incorporates a T.sub.x mode, wherein pacing rate is controlled by a sensed QT interval, and an extra sensor mode, wherein pacing rate is controlled as a function of at least one sensed body parameter. The pacemaker comprises means for automatically testing the applicability or appropriateness of the mode currently in use, and for automatically selecting the appropriate rate control mode.
摘要翻译：公开了一种双室起搏器系统，其具有用于以一种或另一种替代速率自适应模式操作的装置。起搏器包括心房同步模式，其中起搏速率被确定为感测的心房信号的函数。其还包括Tx模式，其中起搏速率由感测的QT间隔控制，并且额外的传感器模式，其中起搏速率被控制为至少一个感测到的身体参数的函数。起搏器包括用于自动测试当前使用的模式的适用性或适当性以及用于自动选择适当的速率控制模式的装置。

5. 发明授权

US4539991A Dual chamber pacemaker 失效
标题翻译：双室起搏器
公开(公告)号：US4539991A
公开(公告)日：1985-09-10
申请号：US465890
申请日：1983-02-11
申请人： Wim Boute , Frederik H. M. Wittkampf , Gerrit W. van Arragon
发明人： Wim Boute , Frederik H. M. Wittkampf , Gerrit W. van Arragon
IPC分类号： A61N1/362 , A61N1/30
CPC分类号： A61N1/3622
摘要： An improved cardiac pacemaker adapted to be programmed into one of a plurality of given modes of operation, including dual chamber modes, and in particular synchronous operation for pacing the patient's ventricle following detection of natural atrial heartbeats. The pacemaker has means for monitoring the time relationship between delivered ventricular stimulus pulses and next succeeding atrial heartbeats, for determining the occurrence of pacemaker induced retrograde P waves, or pacemaker caused tachycardia. The timing, and thus the rate of sensed P signals is processed to determine the desirability of establishing a special P sense window for looking for the occurrence of P signals at rates above a normal maximum operating rate, in which event the stability of the V-A timing is monitored in accordance with predetermined criteria to determine the existence of pacemaker mediated tachycardia, which may be broken up by skipping a ventricular stimulus. During detection of atrial beats at a rate higher then the predetermined maximum operating rate, the synchronous ventricular stimulus rate is maintained at an average at or below the maximum rate, while maintaining a substantially constant A-V interval.
摘要翻译：改进的心脏起搏器适于被编程为多个给定操作模式中的一个，包括双室模式，并且特别是用于在检测到天然心房心跳之后起搏患者心室的同步操作。起搏器具有监测交付的心室刺激脉搏与下一次心房心跳之间的时间关系的手段，用于确定起搏器诱导的逆行P波的发生，或起搏器引起的心动过速。处理定时以及因此感测的P信号的速率被确定是否需要建立一个特殊的P检测窗口，用于以高于正常最大工作速率的速率寻找P信号的发生，在这种情况下，VA定时的稳定性根据预定标准监测以确定起搏器介导的心动过速的存在，其可以通过跳过心室刺激来分解。在以高于预定最大操作速率的速率检测心房搏动期间，同步心室刺激速率保持在最大速率或低于最大速率的平均值，同时保持基本恒定的A-V间隔。

6. 发明授权

US4425427A Simultaneous, kinetic, spectrophotometric analysis of blood serum for multiple components 失效
标题翻译：同时，动态，分光光度法分析多种成分的血清
公开(公告)号：US4425427A
公开(公告)日：1984-01-10
申请号：US198796
申请日：1980-10-20
申请人： Thomas K. J. Luderer
发明人： Thomas K. J. Luderer
IPC分类号： C12Q1/54 , C12Q1/60 , C12Q1/62 , G01N33/52 , G01N33/84 , G01N33/62 , G01N33/66 , G01N33/68
CPC分类号： C12Q1/60 , C12Q1/54 , C12Q1/62 , G01N33/52 , G01N33/84 , Y10S435/81 , Y10T436/144444 , Y10T436/171538
摘要： Method, kits and reagents for the simultaneous, kinetic spectrophotometric analysis of blood serum samples for multiple components. Pairs of components which may be simultaneously analyzed are: cholesterol and triglyceride; glucose and urea; uric acid and gamma glutamyl transferase; calcium and magnesium; albumins and total protein.
摘要翻译：用于多组分血样样品的同时动力学分光光度分析的方法，试剂盒和试剂。可以同时分析的成分对：胆固醇和甘油三酯; 葡萄糖和尿素; 尿酸和γ-谷氨酰转移酶; 钙和镁; 白蛋白和总蛋白。

7. 发明授权

US4373531A Apparatus for physiological stimulation and detection of evoked response 失效
标题翻译：用于生理刺激和诱发反应检测的装置
公开(公告)号：US4373531A
公开(公告)日：1983-02-15
申请号：US231882
申请日：1981-02-05
申请人： Frederik H. M. Wittkampf , Kornelis A. Mensink , Hendrik L. Brouwer
发明人： Frederik H. M. Wittkampf , Kornelis A. Mensink , Hendrik L. Brouwer
IPC分类号： A61N1/37 , A61N1/36
CPC分类号： A61N1/371 , A61N1/3712 , A61N1/3716
摘要： A physiological stimulating system includes improved means for minimizing the polarization that results at the stimulus site, thereby enabling enhanced detection of evoked responses. In the pacemaker embodiment, the stimulus signal comprises positive recharge pulses immediately before and immediately after the negative stimulus signal, the recharge pulses being adapted in a time duration and amplitude such that the total current delivered to the stimulus site, (e.g., a patient's heart) by the stimulus signal is substantially zero.
摘要翻译：生理刺激系统包括用于最小化在刺激部位产生的极化的改进方法，从而能够增强诱发反应的检测。在起搏器实施例中，刺激信号包括紧接在负刺激信号之前和之后的正再充电脉冲，补充脉冲在持续时间和幅度内适应，使得递送至刺激部位的总电流（例如患者心脏）基本为零。

8. 发明授权

US4352300A Combined linear and circular drive mechanism 失效
标题翻译：组合线性和圆形驱动机构
公开(公告)号：US4352300A
公开(公告)日：1982-10-05
申请号：US180004
申请日：1980-08-21
申请人： Johannes H. L. H. Esch
发明人： Johannes H. L. H. Esch
IPC分类号： F16H25/22 , F16H25/24 , F16H27/02 , F16H29/02
CPC分类号： F16H25/229 , Y10T74/18024
摘要： A combined linear and circular drive mechanism for driving a spindle in an up or down direction and also in a circular path about an axis parallel to the spindle. The mechanism has a dual or compound nut which is driven to rotate in a fixed plane so as to drive a spindle threaded therethrough in an up or down direction. The dual nut mechanism has a pair of nut components having respective eccentrically positioned threaded openings, the openings being displaced from each other such that one of the nut components engages the threaded spindle to drive it in a first direction while it is being carried in a circle, and a second nut component engages the spindle to drive it in the reverse direction, also while the shaft is being rotated in a circle. The threaded portion of the spindle is bounded by unthreaded portions, such that when it is driven to an upper or lower limit by one of the nut components such nut component ceases to engage the spindle threading, whereupon when the nut drive is reversed the other nut component engages the threaded portion and drives the spindle in the other direction.
摘要翻译：一种组合的线性和圆形驱动机构，用于在上下方向上驱动主轴，并且围绕平行于主轴的轴线以圆形路径驱动。该机构具有双固定螺母或复合螺母，该螺母被驱动以在固定平面中旋转，以便沿上下方向驱动穿过其的主轴。双螺母机构具有一对具有各自偏心定位的螺纹开口的螺母部件，这些开口彼此移位，使得螺母部件中的一个与螺纹主轴接合，以在第一方向上被驱动，同时将其以圆并且第二螺母部件接合主轴以沿着相反的方向驱动它，同时在轴旋转一圈时也是如此。主轴的螺纹部分由无螺纹部分限定，使得当螺母部件中的一个螺母部件停止接合主轴螺纹而被驱动到上限或下限时，因此当螺母驱动器反向时，另一个螺母部件接合螺纹部分并沿另一方向驱动主轴。

9. 发明授权

US4665919A Pacemaker with switchable circuits and method of operation of same 失效
标题翻译：起搏器具有可切换电路及其操作方法
公开(公告)号：US4665919A
公开(公告)日：1987-05-19
申请号：US778284
申请日：1985-09-19
申请人： Kornelis A. Mensink , Hendrik L. Brouwer
发明人： Kornelis A. Mensink , Hendrik L. Brouwer
IPC分类号： A61N1/365 , A61N1/36
CPC分类号： A61N1/365
摘要： A device such as a cardiac pacemaker or other implantable biomedical device, and method of operation thereof, containing one or more switchable circuits. A control system, preferably incorporating a microprocessor, controls predetermined changes of the operating characteristics of the switchable circuits. In a cardiac pacer embodiment, a circuit such as the input amplifier can be switched to have different characteristics, e.g. filter setting and sensitivity, during predetermined portions of the pacer cycle. Further, the operation of a circuit can be monitored over a plurality of operating cycles, with controlled switching of the circuit characteristics as a function of cumulative monitored circuit performance. A specific example of the invention is shown for changing characteristics of a filter circuit used in a pacer which adjusts the pacer rate as a function of determined stimulus-T wave time interval.
摘要翻译：诸如心脏起搏器或其他可植入生物医学装置的装置及其操作方法，其包含一个或多个可切换电路。优选地结合有微处理器的控制系统控制可切换电路的操作特性的预定变化。在心脏起搏器实施例中，诸如输入放大器的电路可以被切换成具有不同的特性，例如，过滤器设置和灵敏度，在起搏器循环的预定部分。此外，可以在多个操作周期中监视电路的操作，其中电路特性的受控切换作为累积监视的电路性能的函数。示出了本发明的具体示例，用于改变在起搏器中使用的滤波器电路的特性，其调整作为确定的刺激T波时间间隔的函数的起搏率。

10. 发明授权

US4627022A Pacemaker utilizing microprocessor DMA for generating output pulse sequences 失效
标题翻译：起搏器利用微处理器DMA产生输出脉冲序列
公开(公告)号：US4627022A
公开(公告)日：1986-12-02
申请号：US417167
申请日：1982-09-13
申请人： Kornelis A. Mensink , Henk L. Brouwer
发明人： Kornelis A. Mensink , Henk L. Brouwer
IPC分类号： A61N1/372 , G06F1/04 , A61N1/36
CPC分类号： A61N1/37211 , G06F1/04
摘要： Apparatus for producing programmable timing signals, having a microprocessor element with means for carrying out DMA operations when said microprocessor element is in a DMA mode, memory interconnected with said microprocessor element and containing a stored program and a plurality of data words stored at predetermined addresses for selection by said microprocessor when in said DMA mode, comprising controller means for transforming received data words into timing signals, connecting means for interconnecting said microprocessor element, said controller and said memory, said controller having means for setting said microprocessor in said DMA mode upon receipt of a predetermined signal generated by said program, means for receiving data words directly from said memory under control of said microprocessor when said microprocessor is in said DMA mode, and means for generating a two state timing signal corresponding to the data content of one or more such received data words. Hereby the operability of the pacer is improved whereas simultaneously low power requirements are maintained.
摘要翻译：用于产生可编程定时信号的装置，具有微处理器元件，该微处理器元件具有当所述微处理器元件处于DMA模式时进行DMA操作的装置，与所述微处理器元件相互连接的存储器，以及存储在预定地址处的多个数据字，所述微处理器在处于所述DMA模式时的选择，包括用于将接收的数据字变换为定时信号的控制器装置，用于互连所述微处理器元件，所述控制器和所述存储器的连接装置，所述控制器具有用于在接收到所述DMA模式时将所述微处理器设置由所述程序产生的预定信号的装置，用于当所述微处理器处于所述DMA模式时，在所述微处理器的控制下从所述存储器直接接收数据字的装置，以及用于产生与一个或多个数据的数据内容相对应的两个状态定时信号的装置这样收到的数据字。因此，提高了起搏器的可操作性，同时保持了低功率要求。

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