专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US11871900B2 Instrument comprising a contact force sensor device 有权
公开(公告)号：US11871900B2
公开(公告)日：2024-01-16
申请号：US17251167
申请日：2019-06-11
申请人： UNIVERSITÀ DEGLI STUDI DI SIENA
发明人： Domenico Prattichizzo , Chiara Gaudeni , Leonardo Meli
IPC分类号： A61B90/00 , A61B34/30 , A61B34/00 , A61B1/00 , A61B17/00 , B25J13/08 , G01L1/02 , B25J15/00
CPC分类号： A61B90/06 , A61B1/00082 , A61B17/00234 , A61B34/30 , A61B34/76 , A61B90/39 , B25J13/085 , B25J15/0009 , G01L1/02 , A61B2034/305 , A61B2090/065
摘要： A contact force sensor device (10) comprises a gas-inflatable balloon (20) 5 arranged to switch from a deflated state (D) to an inflated state (J) in which it protrudes out of a support member (11); a valve assembly (34) to inflate/deflate the gas-inflatable balloon (12) with a gas; a detector (41) of a force-related value related to a force acting on the inflated gas-inflatable balloon (20) including a membrane (22) due to a contact with a wall (90) 10 outside of support member (11); a processing unit (60) configured to receive a detection signal (45) and to consequently calculate a contact force signal (54) according to a predetermined function; and a notification device (70) configured to receive the contact force signal (54) and to notify it to a user. The value detected can be an excess pressure ΔP in gas-15 inflatable balloon 20, or a deformation parameter of gas-inflatable balloon 20 caused by the contact, or a strain or stress modification in membrane 22, all these effect being caused by the contact with wall 90. Due to its simple structure and small size, the contact force sensor device (10), can be advantageously used in an diagnostic or surgical instrument since, 20 deflated, it can be easily inserted into a patient's body through a very small entry site, possibly along with a surgical or diagnostic tool to perform a mini-invasive surgical or diagnostic operation.

2. 发明授权

US11778396B2 Electromechanical stimulation system for treating tinnitus 有权
公开(公告)号：US11778396B2
公开(公告)日：2023-10-03
申请号：US16641625
申请日：2018-08-27
申请人： UNIVERSITÀ DEGLI STUDI DI SIENA , AZIENDA OSPEDALIERA UNIVERSITARIA SENESE
发明人： Marco Mandala' , Domenico Prattichizzo , Simone Rossi
IPC分类号： H04R25/00
CPC分类号： H04R25/75 , H04R25/606 , H04R2460/13
摘要： An electromechanical stimulation system for treating tinnitus comprising a proximal unit (10), configured to be placed proximate to a user's ear (1), and an input interface (50) configured to be operated by the user. The proximal unit comprises an electromechanical device (30) configured to transmit mechanical vibrations (35) with predetermined frequency (f), intensity (A) and waveform, to tissues proximate to the user's ear; a control unit (20), configured to actuate the electromechanical device in such a way that the frequency, the intensity and the waveform of the mechanical vibrations can be modified; a transceiver element (40) adapted to receive control signals (45) for the control unit. The input interface comprises a transmitter element (60) configured to transmit control signals (45) to the transceiver element; a microcontroller (70) configured to emit the control signals to generate the mechanical vibrations of the electromechanical device at a first frequency between 20 Hz and 20 kHz, and to cause a repetition of the vibrations for all the plurality of frequencies of this range; an input element (80) configured to receive from the user an instruction to start generating said vibrations at a stationary frequency corresponding to a current frequency, to stand by, to receive from the user an instruction to stop modifying the frequency of said vibrations, such that said user can notify to said microcontroller (70) a frequency value at which he/she perceives a significant decrease of tinnitus symptoms; to continue generating mechanical vibrations at this stationary frequency.

3. 发明申请

US20210168545A1 ELECTROMECHANICAL STIMULATION SYSTEM FOR TREATING TINNITUS 有权
公开(公告)号：US20210168545A1
公开(公告)日：2021-06-03
申请号：US16641625
申请日：2018-08-27
申请人： UNIVERSITÀ DEGLI STUDI DI SIENA , AZIENDA OSPEDALIERA UNIVERSITARIA SENESE
发明人： Marco MANDALA' , Domenico PRATTICHIZZO , Simone ROSSI
IPC分类号： H04R25/00
摘要： An electromechanical stimulation system for treating tinnitus comprising a proximal unit (10), configured to be placed proximate to a user's ear (1), and an input interface (50) configured to be operated by the user. The proximal unit comprises an electromechanical device (30) configured to transmit mechanical vibrations (35) with predetermined frequency (f), intensity (A) and waveform, to tissues proximate to the user's ear; a control unit (20), configured to actuate the electromechanical device in such a way that the frequency, the intensity and the waveform of the mechanical vibrations can be modified; a transceiver element (40) adapted to receive control signals (45) for the control unit. The input interface comprises a transmitter element (60) configured to transmit control signals (45) to the transceiver element; a microcontroller (70) configured to emit the control signals to generate the mechanical vibrations of the electromechanical device at a first frequency between 20 Hz and 20 kHz, and to cause a repetition of the vibrations for all the plurality of frequencies of this range; an input element (80) configured to receive from the user an instruction to start generating said vibrations at a stationary frequency corresponding to a current frequency, to stand by, to receive from the user an instruction to stop modifying the frequency of said vibrations, such that said user can notify to said microcontroller (70) a frequency value at which he/she perceives a significant decrease of tinnitus symptoms; to continue generating mechanical vibrations at this stationary frequency.

4. 发明申请

US20130203831A1 NON PEPTIDIC 14-3-3 INHIBITORS AND THE USE THEREOF 有权
标题翻译：非特异性14-3-3抑制剂及其用途
公开(公告)号：US20130203831A1
公开(公告)日：2013-08-08
申请号：US13571065
申请日：2012-08-09
申请人： Maurizio BOTTA , Valentina CORRADI , Federico FALCHI , Manuela MANCINI , Maria Alessandra SANTUCCI
发明人： Maurizio BOTTA , Valentina CORRADI , Federico FALCHI , Manuela MANCINI , Maria Alessandra SANTUCCI
IPC分类号： A61K31/4152
CPC分类号： A61K31/4152 , A61K31/196 , A61K31/4035 , C12Q1/485 , G01N33/573 , G01N33/57426
摘要： The present invention refers to compounds with inhibitory activity against 14-3-3 proteins and their use in the treatment of tumors, in particular chronic myeloid leukemia. The invention also provides methods for the identification of 14-3-3 protein inhibitors.
摘要翻译：本发明涉及对14-3-3蛋白质具有抑制活性的化合物及其在治疗肿瘤，特别是慢性骨髓性白血病中的用途。本发明还提供了鉴定14-3-3蛋白抑制剂的方法。

5. 发明申请

US20120202814A1 COMPOUNDS WITH DDX3 INHIBITORY ACTIVITY AND USES THEREOF 审中-公开
标题翻译：具有DDX3抑制活性的化合物及其用途
公开(公告)号：US20120202814A1
公开(公告)日：2012-08-09
申请号：US13499547
申请日：2010-10-04
申请人： Marco Radi , Maurizio Botta , Federico Falchi , Giovanni Maga , Fausto Baldanti , Stefania Paolucci
发明人： Marco Radi , Maurizio Botta , Federico Falchi , Giovanni Maga , Fausto Baldanti , Stefania Paolucci
IPC分类号： C07D413/04 , A61K31/426 , A61K31/53 , C07D251/54 , A61P31/12 , A61K31/535 , A61K31/505 , C07D239/48 , C12N9/99 , C12N5/00 , C07D277/36 , C07D403/12
CPC分类号： C07D277/36 , A61K31/17 , A61K31/426 , A61K31/427 , A61K31/4725 , A61K31/53 , C07D207/452 , C07D239/48 , C07D251/66 , C07D403/12 , C07D405/12 , C07D417/12
摘要： The present invention relates to the medical use of the compound of formula 1, 2, 3 or 4:
摘要翻译：本发明涉及式1，化合物2,3或4的化合物的医疗用途：

6. 发明申请

US20110190198A1 PEPTIDE SEQUNCES, THEIR BRANCHED FORM AND USE THEREOF FOR ANTIMICROBIAL APPLICATIONS 有权
标题翻译：肽序列，其分布形式及其用于抗微生物应用
公开(公告)号：US20110190198A1
公开(公告)日：2011-08-04
申请号：US13122426
申请日：2009-10-05
申请人： Luisa Bracci , Chiara Falciani , Alessandro Pini
发明人： Luisa Bracci , Chiara Falciani , Alessandro Pini
IPC分类号： A61K38/08 , C07K7/06 , A61P31/04
CPC分类号： C07K7/06 , A61K38/00
摘要： The present invention relates to an antibacterial peptide having from the amino to the carboxylic terminal an amino acid sequences selected from the group of: KKIRVRLSA, SEQ ID NO. 1, RRIRVRLSA, SEQ ID NO. 2, KRIRVRLSA, SEQ ID NO. 3, RKIRVRLSA, SEQ ID NO. 4 or a derivative thereof and uses thereof.
摘要翻译：本发明涉及一种抗菌肽，其具有从氨基至羧基末端的氨基酸序列，所述氨基酸序列选自：KKIRVRLSA，SEQ ID NO： 1，RRIRVRLSA，SEQ ID NO： 2，KRIRVRLSA，SEQ ID NO： 3，RKIRVRLSA，SEQ ID NO： 4或其衍生物及其用途。

7. 发明授权

US08895600B2 Non peptidic 14-3-3 inhibitors and the use thereof 有权
标题翻译：非肽14-3-3抑制剂及其用途
公开(公告)号：US08895600B2
公开(公告)日：2014-11-25
申请号：US13571065
申请日：2012-08-09
申请人： Maurizio Botta , Valentina Corradi , Federico Falchi , Manuela Mancini , Maria Alessandra Santucci
发明人： Maurizio Botta , Valentina Corradi , Federico Falchi , Manuela Mancini , Maria Alessandra Santucci
IPC分类号： A01N43/56 , A61K31/415 , C07D401/00 , C12Q1/48 , G01N33/573 , A61K31/4152 , G01N33/574 , A61K31/4035 , A61K31/196
CPC分类号： A61K31/4152 , A61K31/196 , A61K31/4035 , C12Q1/485 , G01N33/573 , G01N33/57426
摘要： The present invention refers to compounds with inhibitory activity against 14-3-3 proteins and their use in the treatment of tumors, in particular chronic myeloid leukemia. The invention also provides methods for the identification of 14-3-3 protein inhibitors.
摘要翻译：本发明涉及对14-3-3蛋白质具有抑制活性的化合物及其在治疗肿瘤，特别是慢性骨髓性白血病中的用途。本发明还提供了鉴定14-3-3蛋白抑制剂的方法。

8. 发明授权

US08304410B2 Pyrrole compounds as inhibitors of mycobacteria, synthesis thereof and intermediates thereto 失效
标题翻译：吡咯化合物作为分枝杆菌的抑制剂，其合成及其中间体
公开(公告)号：US08304410B2
公开(公告)日：2012-11-06
申请号：US12679848
申请日：2008-09-25
申请人： Mariangela Biava , Giulio Cesare Porretta , Raffaello Pompei , Maurizio Botta , Fabrizio Manetti , Alessandro De Logu
发明人： Mariangela Biava , Giulio Cesare Porretta , Raffaello Pompei , Maurizio Botta , Fabrizio Manetti , Alessandro De Logu
IPC分类号： C07D207/33 , C07D417/06 , A61K31/402
CPC分类号： C07D207/335
摘要： The present invention relates to compounds having formula 3 as well as the synthesis, intermediates and methods of using the same.
摘要翻译：本发明涉及具有式3的化合物及其合成，中间体和使用方法。

9. 发明申请

US20210251714A1 INSTRUMENT COMPRISING A CONTACT FORCE SENSOR DEVICE 有权
公开(公告)号：US20210251714A1
公开(公告)日：2021-08-19
申请号：US17251167
申请日：2019-06-11
申请人： UNIVERSITÀ DEGLI STUDI DI SIENA
发明人： Domenico PRATTICHIZZO , Chiara GAUDENI , Leonardo MELI
IPC分类号： A61B90/00 , A61B34/30 , A61B34/00 , A61B17/00 , A61B1/00
摘要： A contact force sensor device (10) comprises a gas-inflatable balloon (20) 5 arranged to switch from a deflated state (D) to an inflated state (J) in which it protrudes out of a support member (11); a valve assembly (34) to inflate/deflate the gas-inflatable balloon (12) with a gas; a detector (41) of a force-related value related to a force acting on the inflated gas-inflatable balloon (20) including a membrane (22) due to a contact with a wall (90) 10 outside of support member (11); a processing unit (60) configured to receive a detection signal (45) and to consequently calculate a contact force signal (54) according to a predetermined function; and a notification device (70) configured to receive the contact force signal (54) and to notify it to a user. The value detected can be an excess pressure ΔP in gas-15 inflatable balloon 20, or a deformation parameter of gas-inflatable balloon 20 caused by the contact, or a strain or stress modification in membrane 22, all these effect being caused by the contact with wall 90. Due to its simple structure and small size, the contact force sensor device (10), can be advantageously used in an diagnostic or surgical instrument since, 20 deflated, it can be easily inserted into a patient's body through a very small entry site, possibly along with a surgical or diagnostic tool to perform a mini-invasive surgical or diagnostic operation.

10. 发明申请

US20110039854A1 LINEAR AND CYCLIC GUANIDINE DERIVATIVES, METHOD OF PREPARATION AND USES THEREOF 有权
标题翻译：线性和周期性胍基衍生物，其制备方法及其用途
公开(公告)号：US20110039854A1
公开(公告)日：2011-02-17
申请号：US12922232
申请日：2009-03-12
申请人： Maurizio Botta , Francesco Raffi , Paolo Visca
发明人： Maurizio Botta , Francesco Raffi , Paolo Visca
IPC分类号： A61K31/53 , C07D251/12 , C07D257/02 , A61K31/395 , A61P31/10
CPC分类号： C07D255/02 , C07C279/12 , C07C2601/02 , C07D259/00
摘要： The present invention relates to linear and cyclic guanidine derivatives, method of preparation and uses thereof, pharmaceutical compositions to be used as antifungal agents, in particular against Candida species.
摘要翻译：本发明涉及线性和环状胍衍生物，其制备方法及其用途，用作抗真菌剂的药物组合物，特别是针对假丝酵母属物种。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式