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1. 发明申请

US20190235036A1 B0 SHIMMING DEVICE FOR MRI 审中-公开
公开(公告)号：US20190235036A1
公开(公告)日：2019-08-01
申请号：US16083973
申请日：2017-01-17
申请人： ETH ZURICH , UNIVERSITAET ZUERICH
发明人： David Brunner , Simon Gross , Klaas Pruessmann
IPC分类号： G01R33/3873 , G01R33/38 , G01R33/54
CPC分类号： G01R33/3873 , G01R33/3804 , G01R33/543
摘要： A magnetic resonance (MR) apparatus comprises magnet means for generating a main magnetic field in a sample region, encoding means for generating encoding magnetic fields superimposed to the main magnetic field, RF transmitter means for generating MR radiofrequency fields, driver means for operating said encoding means and RF transmitter means to generate superimposed time dependent encoding fields and radiofrequency fields according to an MR sequence for forming images or spectra; and acquisition means for acquiring an MR signal from said object. The magnet means comprise a primary magnetic field source providing a static magnetic field B0 and at least one secondary magnetic field source providing an adjustable magnetic field B′. To provide improved shimming, the secondary magnetic field source comprises at least two spatially distinct portions of a first magnetic material and of a second magnetic material, respectively, said first magnetic material having a first magnetic moment density m1 and said second magnetic material having a second magnetic moment density m2, and means for independently adjusting said second magnetic moment density m2 by variation of an external control parameter.

2. 发明授权

US11215687B2 Magnetic resonance imaging method with hybrid filling of k-space 有权
公开(公告)号：US11215687B2
公开(公告)日：2022-01-04
申请号：US16754147
申请日：2018-10-08
申请人： ETH Zurich , UNIVERSITAET ZUERICH
发明人： Romain Froidevaux , Markus Weiger
IPC分类号： G01R33/48 , A61B5/055 , G01R33/561
摘要： A method for generating an image data set of an image area located in a measurement volume of a magnetic resonance system comprising a gradient system and an RF transmission/reception system, comprises the following method steps: —reading out k-space corresponding to the imaging area, by: (a) activating a frequency encoding gradient in a predetermined spatial direction and with a predetermined strength G0 by means of said gradient system, (b) after the activated frequency encoding gradient achieves its strength G0, radiating a non-slice-selective RF excitation pulse by means of said RF transmission/reception system, (c) after a transmit-receive switch time ΔtTR following the radiated excitation pulse, acquiring FID signals with said RF transmission/reception system and storing said FID signals as raw data points in k-space along a radial k-space trajectory that is predetermined by the direction and strength G0 of the frequency encoding gradient, (d) repeating (a) through (c) with respectively different frequency encoding gradient directions in each repetition until k-space corresponding to the image area is read out in an outer region of k-space along radial k-space trajectories, said radial k-space trajectories each having a radially innermost limit kgap which depends on said switch time ΔtTR, (e) reading out a remainder of k-space that corresponds to the imaging area, said remainder being an inner region of k-space not being filled by said first region and including at least a center of k-space, in a read out procedure that is different from (a) through (d), and storing all data points read out in (d) and (e); and —reconstructing image data from the read out data points in k-space by implementing a reconstruction algorithm; In order to constrain image fidelity and optimize scan duration under given circumstances, the inner k-space region is subdivided into a core region and at least one radially adjacent shell region.

3. 发明授权

US10977550B2 Method of converting neural network and recognition apparatus using the same 有权
公开(公告)号：US10977550B2
公开(公告)日：2021-04-13
申请号：US15631058
申请日：2017-06-23
申请人： SAMSUNG ELECTRONICS CO., LTD. , UNIVERSITAET ZUERICH
发明人： Bodo Ruckauer , Iulia-Alexandra Lungu , Yuhuang Hu , Michael Pfeiffer
IPC分类号： G06N3/08 , G06N3/04
摘要： A neural network conversion method and a recognition apparatus that implements the method are provided. A method of converting an analog neural network (ANN) to a spiking neural network (SNN) normalizes first parameters of a trained ANN based on a reference activation that is set to be proximate to a maximum activation of artificial neurons included in the ANN, and determines second parameters of an SNN based on the normalized first parameters.

4. 发明申请

US20210056394A1 INTERFACE NEURAL NETWORK 有权
公开(公告)号：US20210056394A1
公开(公告)日：2021-02-25
申请号：US17091837
申请日：2020-11-06
申请人： SAMSUNG ELECTRONICS CO., LTD. , UNIVERSITAET ZUERICH
发明人： Jun Haeng LEE , Tobi DELBRUCK , Eric Hyunsurk RYU
IPC分类号： G06N3/04
摘要： An operation method of a neural network, a training method, and a signal processing apparatus are provided. The operation method includes receiving an output signal from a first neural network, and converting a first feature included in the output signal to a second feature configured to be input to a second neural network, based on a conversion rule controlling conversion between a feature to be output from the first neural network and a feature to be input to the second neural network. The operation method further includes generating an input signal to be input to the second neural network, based on the second feature, and transmitting the input signal to the second neural network.

5. 发明授权

US10730912B2 Template-fixed peptidomimetics with antimicrobial activity 有权
公开(公告)号：US10730912B2
公开(公告)日：2020-08-04
申请号：US15392586
申请日：2016-12-28
申请人： POLYPHOR LTD. , UNIVERSITAET ZUERICH
发明人： Steven J. Demarco , Wim Vrijbloed , Ricardo Dias , John Anthony Robinson , Nityakalyani Srinivas , Frank Gombert , Daniel Obrecht
IPC分类号： C07K7/64 , C07K7/06 , C07K14/00 , C07K7/08 , A01N43/36 , C07K1/10 , A61K38/00
摘要： Template-fixed β-hairpin peptidomimetics of the general formula wherein Z is a template-fixed chain of 12 α-amino acid residues which, depending on their positions in the chain (counted starting from the N-terminal amino acid) are Gly, or Pro, or of certain types which, as the remaining symbols in the above formula, are defined in the description and the claims, and salts thereof, have the property to selectively inhibit the growth of or to kill microorganisms such as Pseudomonas aeruginosa. They can be used as disinfectants for foodstuffs, cosmetics, medicaments or other nutrient-containing materials, or as medicaments to treat or prevent infections. These β-hairpin peptidomimetics can be manufactured by processes which are based on a mixed solid- and solution phase synthetic strategy.

6. 发明授权

US10653819B2 Device for repair surgery of cylindrical organs, particularly ruptured tendons, comprising a therapeutic agent for stimulating regrowth, and method of producing such device 有权
公开(公告)号：US10653819B2
公开(公告)日：2020-05-19
申请号：US16077051
申请日：2017-02-10
申请人： UNIVERSITAET ZUERICH , ETH ZURICH
发明人： Johanna Buschmann , Olivera Evrova , Viola Vogel
IPC分类号： A61F2/08 , A61L27/58 , A61L27/18 , A61L27/36 , A61L27/54 , D01D5/00
摘要： A device for repair surgery of cylindrical organs, particularly of ruptured tendons, is configured as a tubular sheath (T) made of a mesh of elastic fibers formed by electrospinning a biocompatible and biodegradable polymer. The tubular sheath has a Young elasticity modulus of about 0.1 to about 4 MPa and a strain at break of about 50 to about 1,000%, and it has a first wall surface and a second wall surface substantially parallel thereto, with said first wall surface being comparatively smooth (WS) and said second wall surface being comparatively rough (WR). According to the invention, the elastic fibers comprise first fibers consist of polymer in neat form and second fibers consist of polymer with an admixture of a therapeutic agent for stimulating regrowth processes of a predetermined cylindrical organ. The tubular sheath comprises a first tubular region adjacent to the first wall and a second tubular region adjacent to the second wall, said first tubular region being formed of said first fibers and said second tubular region being formed of said second fibers.

7. 发明授权

US10296829B2 Convolution processing apparatus and method 有权
公开(公告)号：US10296829B2
公开(公告)日：2019-05-21
申请号：US15581872
申请日：2017-04-28
申请人： SAMSUNG ELECTRONICS CO., LTD. , UNIVERSITAET ZUERICH
发明人： Hesham Mostafa , Aimar Alessandro
IPC分类号： G06N3/08 , G06N3/04 , G06N3/063
摘要： A convolution processing apparatus and method are disclosed. The convolution processing apparatus may include a controller configured to load a pixel of an input image and skip a process associated with the pixel in response to a value of the loaded pixel being 0, a filter bank including at least one filter and configured to extract at least one kernel element corresponding to the pixel from the at least one filter based on an index of the pixel and an input channel of the pixel, and a multiplier-accumulator (MAC) configured to perform a convolution operation based on the value of the pixel and a value of the at least one kernel element and accumulatively store an operation result of the convolution operation, the operation result corresponding to an output image.

8. 发明申请

US20190070340A1 A DEVICE FOR REPAIR SURGERY OF CYLINDRICAL ORGANS, PARTICULARLY RUPTURED TENDONS, COMPRISING A THERAPEUTIC AGENT FOR STIMULATING REGROWTH, AND METHOD OF PRODUCING SUCH DEVICE 审中-公开
公开(公告)号：US20190070340A1
公开(公告)日：2019-03-07
申请号：US16077051
申请日：2017-02-10
申请人： UNIVERSITAET ZUERICH , ETH ZURICH
发明人： Johanna BUSCHMANN , Olivera EVROVA , Viola VOGEL
IPC分类号： A61L27/58 , D01D5/00 , A61L27/18 , A61L27/54 , A61L27/36 , A61F2/08
摘要： A device for repair surgery of cylindrical organs, particularly of ruptured tendons, is configured as a tubular sheath (T) made of a mesh of elastic fibers formed by electrospinning a biocompatible and biodegradable polymer. The tubular sheath has a Young elasticity modulus of about 0.1 to about 4 MPa and a strain at break of about 50 to about 1'000%, and it has a first wall surface and a second wall surface substantially parallel thereto, with said first wall surface being comparatively smooth (WS) and said second wall surface being comparatively rough (WR). According to the invention, the elastic fibers comprise first fibers consist of polymer in neat form and second fibers consist of polymer with an admixture of a therapeutic agent for stimulating regrowth processes of a predetermined cylindrical organ. The tubular sheath comprises a first tubular region adjacent to the first wall and a second tubular region adjacent to the second wall, said first tubular region being formed of said first fibers and said second tubular region being formed of said second fibers.

9. 发明授权

US10144765B2 Template-fixed peptidomimetics 有权
公开(公告)号：US10144765B2
公开(公告)日：2018-12-04
申请号：US15851270
申请日：2017-12-21
申请人： UNIVERSITAET ZUERICH , POLYPHOR LTD.
发明人： Daniel Obrecht , Frank Gombert , Steven J. Demarco , Christian Ludin , Jan Wim Vrijbloed , Kerstin Moehle , John-Anthony Robinson , Reshmi Mukherjee , Heiko Henze , Barbara Romagnoli
IPC分类号： C07K7/64 , A61K38/12 , C07K7/56 , A61K38/00
摘要： The template-fixed β-hairpin peptidomimetics Cyclo(-Tyr-His-Cys-Ser-Ala-DPro-Dab-Arg-Tyr-Cys-Tyr-Gln-Lys-D-Pro-Pro), disulfide bond between Cys4 and Gysl1, and pharmaceutically acceptable salts thereof, with X being Ala or Tyr, have CXCR4 antagonizing properties and can be used for where cancer is mediated or resulting from CXCR4 receptor activity.

10. 发明授权

US10032498B2 Memory cell unit and recurrent neural network including multiple memory cell units 有权
公开(公告)号：US10032498B2
公开(公告)日：2018-07-24
申请号：US15347501
申请日：2016-11-09
申请人： SAMSUNG ELECTRONICS CO., LTD. , UNIVERSITAET ZUERICH
发明人： Daniel Neil , Shih-Chii Liu , Michael Pfeiffer
IPC分类号： G11C7/00 , G11C7/22 , G06N3/08
摘要： A memory cell unit and a recurrent neural network including memory cell units are provided. The memory cell unit includes a first time gate configured to control a cell state value of the memory cell unit, based on a phase signal of an oscillatory frequency, and a second time gate configured to control an output value of the memory cell unit, based on the phase signal.

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