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1. 发明申请

US20220227872A1 ANTI-TEM1 ANTIBODIES AND ANTIGEN-BINDING PORTIONS THEREOF 有权
公开(公告)号：US20220227872A1
公开(公告)日：2022-07-21
申请号：US17613823
申请日：2020-05-29
申请人： Ludwig Institute for Cancer Research Ltd , Centre Hospitalier Universitaire Vaudois , Université de Lausanne
发明人： Steven M. Dunn , Julie K. Fierle , George Coukos
IPC分类号： C07K16/28 , C07K14/705 , C07K14/725 , A61P35/00
摘要： Provided herein are antibodies and antigen-binding portions thereof that bind to tumor endothelial marker 1 (TEM1), as well as methods of using the disclosed antibodies and antigen-binding portions thereof, including methods of treating cancer, reducing tumor growth, reducing tumor metastasis, and/or reducing tumor-associated fibrosis in a subject in need thereof.

2. 发明申请

US20110294873A1 Gene Transfer Vectors Comprising At Least One Isolated DNA Molecule Having Insulator Or Boundary Properties And Methods To Identify The Same 审中-公开
标题翻译：包含至少一个具有绝缘体或边界特性的分离的DNA分子的基因转移载体和鉴定其的方法
公开(公告)号：US20110294873A1
公开(公告)日：2011-12-01
申请号：US13125750
申请日：2009-10-23
申请人： Nicolas Mermod , Armelle Gaussin , Germain Esnault
发明人： Nicolas Mermod , Armelle Gaussin , Germain Esnault
IPC分类号： A61K48/00 , C07H21/04 , C12N5/10 , C12N15/63 , C12Q1/68
CPC分类号： C12N15/86 , C07K14/4702 , C07K14/7051 , C07K14/805 , C12N15/85 , C12N15/907 , C12N2740/13043 , C12N2830/40
摘要： The present invention relates to gene transfer vectors and in particular expression vectors which comprise at least one isolated DNA molecule having insulator and or boundary properties which limits the effects of a regulatory sequence upon another regulatory or coding sequence disposed upon the other side of said at least one isolated DNA molecule. The present invention also relates to methods of identifying isolated DNA molecule having insulator and or boundary properties and to the use of expression vector, in particular a retrovirus vector, in in vivo and ex vivo gene therapy methods as well as to cells and organisms transformed using vectors according to the present invention.
摘要翻译：本发明涉及基因转移载体，特别是包含至少一个具有绝缘体和/或边界特性的分离的DNA分子的表达载体，所述分离的DNA分子将调节序列的作用限制在所述至少另一方的另一侧上的另一个调节或编码序列一个分离的DNA分子。本发明还涉及在体内和离体基因治疗方法中鉴定具有绝缘体和/或边界特性的分离的DNA分子以及使用表达载体，特别是逆转录病毒载体的方法，以及使用根据本发明的载体。

3. 发明授权

US07033597B2 Intracellular delivery of biological effectors 失效
公开(公告)号：US07033597B2
公开(公告)日：2006-04-25
申请号：US10165015
申请日：2002-06-07
申请人： Christophe Bonny
发明人： Christophe Bonny
IPC分类号： A61K47/00 , C07K4/00 , C12P21/06
CPC分类号： C07K5/1016 , A61K38/00 , A61K47/60 , A61K47/62 , A61K47/65 , C07K1/047 , C07K5/1013 , C07K5/1019 , C07K5/1021 , C07K7/06 , C07K7/08 , C07K2319/00 , Y10S530/81
摘要： The invention relates to sequences of amino acids with the capacity to facilitate transport of an effector across a biological membrane. More specifically, the present invention relates to novel peptide transporters that specifically target certain cell types for the intracellular delivery of drugs and therapeutic agents.

4. 发明授权

US11738049B2 Kinase mutants and uses thereof 有权
公开(公告)号：US11738049B2
公开(公告)日：2023-08-29
申请号：US16615032
申请日：2018-05-24
申请人： SIB Swiss Institute of Bioinformatics , CHUV—Centre Hospitalier Universitaire Vaudois , Universite de Lausanne , Ludwig Institute for Cancer Research Ltd
发明人： Olivier Michielin , Vincent Zoete , George Coukos , Melita Irving , Nahzli Dilek , Patrick Reichenbach , Kelly Ascencao
IPC分类号： A61K38/00 , A61K35/17 , A61K31/517 , C07K14/55 , C12N9/12 , C12N15/10 , C12Q1/48 , G01N33/573
CPC分类号： A61K35/17 , A61K31/517 , C07K14/55 , C12N9/1205 , C12N15/1024 , C12Q1/485 , G01N33/573 , A61K38/00 , C12Y207/10
摘要： The present invention relates to methods of designing kinase mutants for reprogramming the sensitivity of a target kinase to some specific inhibitors, methods of reprogramming the sensitivity of a target kinase to some specific inhibitors, wherein those kinase inhibitors have little or no affinity for the wild-type target kinase, vectors or cells expressing said mutated kinases, composition and uses thereof for the prevention and/or treatment of a disease or disorder, in particular cancer.

5. 发明授权

US11193171B2 Diagnostic, prognostic and therapeutic uses of long noncoding RNAS for heart disease and regenerative medicine 有权
公开(公告)号：US11193171B2
公开(公告)日：2021-12-07
申请号：US15105319
申请日：2014-12-19
申请人： UNIVERSITÉ DE LAUSANNE
发明人： Samir Ounzain , Thierry Pedrazzini
IPC分类号： C12Q1/6883
摘要： This invention generally relates to lncRNAs and methods for diagnosing cardiac pathologies in a subject. The invention also provides methods for treating a cardiac pathology in a subject comprising administering to said subject an effective amount of a modulator of one or more lncRNAs of the invention.

6. 发明申请

US20210259251A1 FUNGICIDES TO PREVENT AND CONTROL FUNGAL PATHOGENS 有权
公开(公告)号：US20210259251A1
公开(公告)日：2021-08-26
申请号：US17259228
申请日：2019-07-09
申请人： UNIVERSITÉ DE LAUSANNE
发明人： Olga DUBEY , Edward FARMER , Christiane NAWRATH , Katia GINDRO , Sylvain SCHNEE , Sylvain DUBEY
IPC分类号： A01N47/46 , A61K8/46 , A61Q11/00 , A61P31/10 , A61K31/26 , A61K9/00
摘要： A field of biological fungicides with a broad range of antifungal activity coming from plant extracts from the order of Brassicales or molecules revealing similar chemical structure. In particular, Applicants surprisingly provided a new usage of a combination of sulfonyl and sulfinyl containing aliphatic glucosinolates, their by-products and synthetic analogues as efficient antifungal compounds with broad spectrum of activity.

7. 发明申请

US20210002265A1 PYRAZOLE DERIVATIVES AS INHIBITORS OF THE WNT SIGNALLING PATHWAY 有权
公开(公告)号：US20210002265A1
公开(公告)日：2021-01-07
申请号：US16976882
申请日：2019-03-01
申请人： Université de Lausanne
发明人： Vladimir L. Katanaev , Alexey Koval
IPC分类号： C07D405/14 , A61P35/00 , C07D405/10 , C07D401/04
摘要： The present invention relates to a novel class of compounds as inhibitors of the Wnt signalling pathway. The best compounds showed potencies in the low micromolar range and high efficacies (>80%) together with good microsomal stability. Furthermore, in vitro characterization of the compounds show promising effects in various anti-cancer assays. Finally, in vivo characterization showed high accumulation in breast tissue.

8. 发明授权

US08617180B2 Adjustable stereotactic device and method for frameless neurosurgical stereotaxy 失效
标题翻译：可调节的立体定向装置和无框神经外科立体定向的方法
公开(公告)号：US08617180B2
公开(公告)日：2013-12-31
申请号：US12741533
申请日：2008-11-05
申请人： Jean-Philippe Thiran , Claudio Pollo
发明人： Jean-Philippe Thiran , Claudio Pollo
IPC分类号： A61B19/00
CPC分类号： A61B17/1739 , A61B34/10 , A61B90/11 , A61B2017/00707 , A61B2017/00725 , A61B2017/3405 , A61B2090/363 , A61B2090/3916 , A61B2090/3983 , A61B2090/3987
摘要： The system comprises at least three anchors (2,2′,2″) intended to be attached to the patient and equipped with markers (5,5′,5″), an insertion guide device (6) with an insertion guide (7) intended to be attached to said anchors (2,2′,2″), an external calibration device (8) with at least three calibration markers (10,10′,10″) corresponding to said markers (5,5′,5″) and a planning and imaging software. The planning and imaging software is used to determine the position of a target point in the patient with respect to the markers (5,5′,5″), the calibration device is used to calibrate and orient the insertion guide (7) of the insertion guide device (6) mounted on said calibration markers (10,10′,10″) using the determination of the software before the insertion guide device is mounted on said markers (5,5′,5″) attached to the patient.
摘要翻译：该系统包括至少三个锚定件（2,2'，2“），用于附接到患者并配备有标记（5,5'，5”），插入引导装置（6），其具有插入导向件（7），旨在附接到所述锚定件（2,2'，2“），外部校准装置（8）具有对应于所述标记（5）的至少三个校准标记（10,10'，10”），5'，5“）和计划和成像软件。规划和成像软件用于确定患者相对于标记（5,5'，5“）的目标点的位置，校准装置用于校准和定向插入引导件（7）的插入引导件所述插入引导装置（6）在所述插入引导装置安装在所述标记（5,5'，5“）上之前，使用所述软件的确定来安装在所述校准标记（10,10'，10”）上，患者。

9. 发明授权

US10858626B2 Adoptive immunotherapy for treating cancer 有权
公开(公告)号：US10858626B2
公开(公告)日：2020-12-08
申请号：US15536258
申请日：2015-12-15
申请人： UNIVERSITÉ DE LAUSANNE
发明人： Marie-Agnes Doucey , Nicolas Guex , Isaac Crespo , Ioannis Xenarios
IPC分类号： A61K31/00 , C12N5/0783 , A61K39/00 , A61K31/444 , A61K31/4709 , A61K31/496 , A61K31/502 , A61K31/517 , A61K31/5377 , A61K45/06 , A61K31/404 , A61K31/44 , A61K31/5025 , A61K31/506 , A61K31/4439 , A61K31/47 , A61K31/4365
摘要： The present invention provides methods for producing and/or expanding tumor-infiltrating lymphocytes (TILs) that can be used in adoptive immunotherapy in cancer treatment.

10. 发明申请

US20190167814A1 Treatment And/Or Prevention Of DNA-Triplet Repeat Diseases Or Disorders 审中-公开
公开(公告)号：US20190167814A1
公开(公告)日：2019-06-06
申请号：US16093028
申请日：2017-04-13
申请人： UNIVERSITÉ DE LAUSANNE
发明人： Vincent DION , Lorene AESCHBACH , Cinzia CINESI
IPC分类号： A61K48/00 , C12N9/22 , A61P25/00 , A61P21/00
摘要： The present invention refers to the field of DNA repair and to compositions, kits and methods for the treatment and/or prevention of DNA-triplet repeat diseases or disorders.

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