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1. 发明公开

US20240373829A1 GENETIC RESISTANCE TO VIRAL DISEASE IN SALMONID FISH 审中-公开
公开(公告)号：US20240373829A1
公开(公告)日：2024-11-14
申请号：US18690014
申请日：2022-09-05
申请人： THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH
发明人： Ross HOUSTON , Jonathan PAVELIN , Diego Robledo SANCHEZ , Yehwa JIN
IPC分类号： A01K67/0275 , A61K31/708 , C07K14/46 , C12N15/90 , C12Q1/6876
CPC分类号： A01K67/0275 , A61K31/708 , C07K14/461 , C12N15/90 , C12Q1/6876 , A01K2227/40 , A01K2267/02 , C12Q2600/124 , C12Q2600/156 , C12Q2600/158
摘要： The present disclosure relates to methods of screening salmonids for increased resistance to viral infection, such as infectious pancreatic necrosis virus (IP-NV) infection. The present disclosure also relates to fish which have been genetic modified to have increased resistance to viral/IPNV infection. The present disclosure further relates to the use of these fish, which have been identified. or genetically modified to have increased genetic resistance. in aquaculture breeding programs and/or production. The present disclosure further relates to the use of small molecules which target NAE1 and their use in therapy or prevention of viral/IPNV infection.

2. 发明授权

US12012541B2 Defect mediated lyotropic nematic gel 有权
公开(公告)号：US12012541B2
公开(公告)日：2024-06-18
申请号：US17613858
申请日：2020-06-18
申请人： THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH
发明人： Tiffany Wood , Navneeta Katyan
IPC分类号： G02F1/1333 , C09K19/02 , C09K19/54
CPC分类号： C09K19/544 , C09K19/0208
摘要： This invention relates to a gel comprising a colloid dispersed in a lyotropic nematic liquid crystal, the lyotropic nematic liquid crystal comprising defect lines formed by the colloid. The invention also relates to a method for making the gel comprising the steps of: (a) mixing a nematogen with a liquid and the colloid to form a resulting dispersion, and (b) applying shear to the resulting dispersion at a temperature such that a lyotropic nematic liquid crystal phase is formed. In addition, the invention relates to an adhesive, lubricant, ceramic, film, spray, gel, lotion, foam, nanowire, yarn, medical implant, wearable, bone graft material, 3D printing material, ink, agrochemical formulation, topical formulation, paint, coating, composite, energy storage material, advanced material, responsive composite, cosmetic product, personal care product, pharmaceutical or foodstuff comprising the gel.

3. 发明公开

US20240158696A1 A SYSTEM COMPRISING A NEMATIC LIQUID CRYSTAL AND AN INTERFACE 审中-公开
公开(公告)号：US20240158696A1
公开(公告)日：2024-05-16
申请号：US18549164
申请日：2022-04-28
申请人： The University Court of the University of Edinburgh
发明人： Tiffany Wood
IPC分类号： C09K19/54 , B82Y40/00 , C09K19/52
CPC分类号： C09K19/544 , B82Y40/00 , C09K2019/526
摘要： A system comprising: a nematic liquid crystal, and at least one interface in contact with the nematic liquid crystal, wherein the interface comprises a first interface region on one side of the nematic liquid crystal and a second interface region on another side of the nematic liquid crystal, the interface comprising nucleation sites to form defect lines in the nematic liquid crystal extending across the nematic liquid crystal from the first interface region to the second interface region.

4. 发明授权

US11969479B2 MeCP2 expression cassettes 有权
公开(公告)号：US11969479B2
公开(公告)日：2024-04-30
申请号：US16497277
申请日：2018-03-23
申请人： THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH , THE UNIVERSITY COURT OF THE UNIVERSITY OF GLASGOW
发明人： Adrian Bird , Rebekah Tillotson , Stuart Robert Cobb , Ralph David Hector
IPC分类号： A61K48/00 , A61K9/00 , A61P25/00 , A61P25/14 , C07K14/00 , C07K14/47 , C12N5/12 , C12N7/00 , C12N15/113 , C12N15/86 , A61K38/00
CPC分类号： A61K48/0066 , A61K9/0019 , A61K9/0085 , A61P25/14 , C07K14/001 , C07K14/4703 , C12N7/00 , C12N15/86 , A61K38/00 , C12N2750/14143
摘要： The present invention provides nucleic acid molecules comprising a MeCP2 expression cassette, the expression cassette comprising, in operable linkage from 5′ to 3′: a 5′ transcriptional control region comprising a promoter capable of driving transcription in neural cells; an open reading frame encoding a MeCP2 protein; translation control signals; a 3′ untranslated region (3′UTR) comprising one or more of: (i) a binding site for mir-22; (ii) a binding site for mir-19; (iii) a binding site for miR-132; (iv) a binding site for miR124; and (v) an AU-rich element; and transcriptional termination signals; wherein the MeCP2 expression cassette is not more than about 5 kb in length. The invention further provides viral vectors, especially vectors derived from adeno-associated virus (AAV), for use in therapeutic delivery of such expression cassettes. The nucleic acid molecules and viral vectors disclosed herein provide novel tools for expressing MeCP2 and are of particular value in the treatment of disorders associated with reduced MeCP2 activity, including Rett syndrome.

5. 发明公开

US20240118422A1 SENSOR DEVICE FOR IMAGING 审中-公开
公开(公告)号：US20240118422A1
公开(公告)日：2024-04-11
申请号：US18275208
申请日：2022-02-01
申请人： The University Court of the University of Edinburgh
发明人： Michael DAVIES , Julian Andrés TACHELLA , Michael P. SHEEHAN
IPC分类号： G01S17/894 , G01S7/4865 , G01S7/487 , G01S17/10
CPC分类号： G01S17/894 , G01S7/4866 , G01S7/487 , G01S17/10
摘要： A sensor device (10) for photon-based imaging comprising one or more photon detectors configured to produce a plurality of photon detection signals in response to a plurality of photon detection events, wherein each photon detection event has a corresponding detection time and wherein the detection times of the plurality of photon detection events are distributed in accordance with a distribution over time; and processing circuitry configured to perform a sketching process using timing information of the plurality of photon detection events to obtain a compressed representation of the distribution over time, wherein the sketching process comprises: generating a plurality of feature values based on the timing information of the plurality of photon detection events using one or more feature functions; combining the generated plurality of feature values to obtain the compressed representation of the distribution over time, wherein the feature functions have one or more properties such that combining the plurality of feature values generated using the one or more feature functions preserves signal information and/or supresses background information and/or distinguishes signal information from background information in the compressed representation, wherein the compressed representation is such that at least one or more desired parameters of the distribution over time can be estimated by performing a parameter estimation process using the compressed representation, wherein the parameter estimation process is based on a model of the distribution over time.

6. 发明授权

US11768275B2 Strobe window dependent illumination for flash LIDAR 有权
公开(公告)号：US11768275B2
公开(公告)日：2023-09-26
申请号：US16778476
申请日：2020-01-31
申请人： The University Court of The University of Edinburgh , Sense Photonics, Inc.
发明人： Robert Henderson , Tarek Al Abbas , Neil Calder , Hod Finkelstein
IPC分类号： G01S7/48 , G01S7/484 , G01S17/931 , G01S7/481
CPC分类号： G01S7/484 , G01S7/4814 , G01S17/931
摘要： A Light Detection And Ranging (LIDAR) system includes one or more emitter elements configured to emit optical signals responsive to respective emitter control signals, one or more detector elements configured to detect incident photons for respective strobe windows of operation between pulses of the optical signals and at respective delays that differ with respect to the pulses, and at least one control circuit. The at least one control circuit is configured to generate the respective emitter control signals to differently operate the one or more emitter elements based on the respective strobe windows of operation of the one or more detector elements.

7. 发明公开

US20230227781A1 METHOD OF PRODUCING MACROPHAGES 审中-公开
公开(公告)号：US20230227781A1
公开(公告)日：2023-07-20
申请号：US17927786
申请日：2021-05-27
申请人： The University Court of The University of Edinburgh
发明人： Stuart Forbes , Lara Campana , Benjamin Dwyer , John Campbell , Alasdair Fraser
IPC分类号： C12N5/0786 , A61K35/15
CPC分类号： C12N5/0645 , A61K35/15 , C12N2506/115 , C12N2501/22 , C12N2501/2304 , C12N2501/231 , C12N2501/2313 , C12N2501/24
摘要： The improved 4-5 day, optionally 3-5 day GMP-compliant in-vitro method enables the production of macrophages from monocytes that benefits from a shorter cell culture time, fewer interventions whilst maintaining the desired characteristics of the human macrophages. The present invention describes a method wherein the monocytes are cultured in medium comprising one or more growth actors to stimulate macrophages with a pro-regenerative phenotype. The method described herein is xeno-free, serum-free and GMP compliant. In addition, further disclosed are macrophages produced according to the present invention and the use of said macrophages in the treatment of liver diseases, such as liver cirrhosis.

8. 发明授权

US11644549B2 Extended dynamic range and reduced power imaging for LIDAR detector arrays 有权
公开(公告)号：US11644549B2
公开(公告)日：2023-05-09
申请号：US16810299
申请日：2020-03-05
申请人： The University Court of The University of Edinburgh , Sense Photonics, Inc.
发明人： Robert Henderson , Tarek Al Abbas , Neil Calder , Hod Finkelstein
IPC分类号： G01S17/931 , G01S7/499 , G01S7/4863
CPC分类号： G01S7/4863 , G01S7/499 , G01S17/931
摘要： A Light Detection And Ranging (LIDAR) detector circuit includes a plurality of detector pixels, where each or a respective detector pixel of the detector pixels includes a plurality of detector elements. At least one control circuit is configured to provide one or more detector control signals that selectively activate one or more of the detector elements of the respective detector pixel to define a first active detection area including a first subset of the detector elements for a first image acquisition, and a second active detection area including a second subset of the detector elements for a second image acquisition. Related devices and methods of operation are also discussed.

9. 发明申请

US20220206158A1 EVENT DRIVEN SHARED MEMORY PIXEL 有权
公开(公告)号：US20220206158A1
公开(公告)日：2022-06-30
申请号：US17607056
申请日：2020-05-01
申请人： Sense Photonics, Inc. , The University Court of The University of Edinburgh
发明人： Robert Henderson , Hod Finkelstein
IPC分类号： G01S17/894 , G06F13/16 , G01S7/4914 , G01S7/4863 , G01S7/487 , G01S7/493
摘要： A Time of Flight (TOF) system includes an incrementing circuit and a plurality of pixels. Each pixel includes a plurality of detectors configured to output respective detection signals responsive to detection of a plurality of photons incident thereon and a shared memory configured to store a respective count of the photons incident on each of the plurality of detectors. The incrementing circuit is configured to update the respective count for each of the plurality of detectors in the shared memory based on the respective detection signals.

10. 发明授权

US11360103B2 Alpha-synuclein detection assay and method for diagnosing alpha- synucleinopathies 有权
公开(公告)号：US11360103B2
公开(公告)日：2022-06-14
申请号：US17409562
申请日：2021-08-23
申请人： The University Court of the University of Edinburgh
发明人： Alison Green , Graham Fairfoul
IPC分类号： G01N33/68 , G01N21/64 , G01N33/58
摘要： A method of detecting the presence of alpha-synuclein aggregation in a biological sample is provided whereby a biological sample is mixed with a reaction sample comprising a population of beads, a fluorophore adapted to bind to protein aggregates and to increase fluorescence when bound to protein aggregates, and alpha-synuclein or a fragment or variant thereof to form a reaction mixture, the reaction mixture is illuminated and at the same time incubated with intermittent agitation cycles, wherein a significant increase in the fluorescence of the reaction mixture during incubation is indicative of the presence of aggregates of alpha-synuclein in the biological sample. Method of diagnosing alpha-synucleinopathies such as Parkinson's disease or Dementia with Lewy Bodies.

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