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1. 发明申请

US20100204254A1 Use of statins in the prevention and treatment of radiation injury and other disorders associated with reduced endothelial thrombomodulin 审中-公开
标题翻译：在使用他汀类药物预防和治疗与减少内皮血栓调节素相关的放射性损伤和其他疾病
公开(公告)号：US20100204254A1
公开(公告)日：2010-08-12
申请号：US12657915
申请日：2010-01-29
申请人： Martin K. Hauer-Jensen , Louis M. Fink , Jawahar Lal Mehta , Junru Wang , Jacob Joseph
发明人： Martin K. Hauer-Jensen , Louis M. Fink , Jawahar Lal Mehta , Junru Wang , Jacob Joseph
IPC分类号： A61K31/505 , A61K31/225 , A61K31/366 , A61K31/40 , A61K31/404
CPC分类号： A61K31/22 , A61K31/366 , A61K31/40 , A61K31/404 , A61K31/505
摘要： The present invention discloses statins (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors) consistently and significantly increased endothelial cell thrombomodulin protein and functional activity. Statins also abrogated the downregulation of thrombomodulin that occurs in response to radiation injury. These results indicate that preserving or restoring endothelial thrombomodulin expression and function by statins may be useful in a variety of disorders associated with widespread endothelial dysfunction such as sepsis, adult respiratory distress syndrome, and normal tissue radiation injury.
摘要翻译：本发明公开了他汀类（3-羟基-3-甲基戊二酰辅酶A还原酶抑制剂）一致地显着增加内皮细胞血栓调节蛋白和功能活性。他汀类药物也消除了由于辐射损伤而发生的血栓调节素的下调。这些结果表明，通过他汀类药物保留或恢复内皮血栓调节蛋白的表达和功能可用于与广泛的内皮功能障碍如败血症，成人呼吸窘迫综合征和正常组织辐射损伤相关的各种疾病中。

2. 发明授权

US07638277B2 Transmembrane serine protease overexpressed in ovarian carcinoma and uses thereof 有权
标题翻译：卵巢癌中过表达的跨膜丝氨酸蛋白酶及其用途
公开(公告)号：US07638277B2
公开(公告)日：2009-12-29
申请号：US11400825
申请日：2006-04-07
申请人： Timothy J. O'Brien , Lowell J. Underwood
发明人： Timothy J. O'Brien , Lowell J. Underwood
IPC分类号： C12Q1/68
CPC分类号： C12N9/6424 , A61K38/00 , A61K39/00 , A61K48/00 , C07K14/4748 , C07K14/705 , C07K16/3069 , C07K2317/34 , C12N9/6472 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158 , C12Q2600/16 , G01N33/574
摘要： The present invention provides a TADG-12 protein and a DNA fragment encoding such protein. Also provided is a vector/host cell capable of expressing the DNA. The present invention further provides various methods of early detection of associated ovarian and other malignancies, and of interactive therapies for cancer treatment by utilizing the DNA and/or protein disclosed herein.
摘要翻译：本发明提供了TADG-12蛋白质和编码这种蛋白质的DNA片段。还提供能够表达DNA的载体/宿主细胞。本发明进一步提供各种早期检测相关卵巢癌和其他恶性肿瘤的方法，以及利用本文公开的DNA和/或蛋白质进行癌症治疗的相互作用治疗。

3. 发明授权

US07306927B2 Method of inducing immunity against stratum corneum chymotrytic enzyme 失效
标题翻译：诱导针对角质层糜蛋白酶的免疫力的方法
公开(公告)号：US07306927B2
公开(公告)日：2007-12-11
申请号：US09905083
申请日：2001-07-13
申请人： Timothy I. O'Brien
发明人： Timothy I. O'Brien
IPC分类号： G01N33/53 , C12Q1/70 , C12P21/06 , C12N5/08 , C12N15/63 , C07H21/02 , A01N63/00
CPC分类号： C12N9/6424 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2039/5154 , A61K2039/53 , C07K14/435 , C12N9/6472 , C12Q1/37 , C12Q1/686 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N33/573 , G01N33/574 , G01N33/57449 , G01N33/57492 , G01N2333/96486 , G01N2333/976
摘要： The disclosed nucleic acid primer sets, used in combination with quantitative amplification (PCR) of tissue cDNA, can indicate the presence of specific proteases in a tissue sample. The detected proteases are themselves specifically overexpressed in certain cancers, and their presence may serve for early detection of associated ovarian and other malignancies, and for the design of interactive therapies for cancer treatment.
摘要翻译：所公开的与组织cDNA的定量扩增（PCR）组合使用的核酸引物组可以指示组织样品中特异性蛋白酶的存在。检测到的蛋白酶本身在某些癌症中特异性地过表达，并且它们的存在可用于早期检测相关的卵巢癌和其他恶性肿瘤，并且用于设计用于癌症治疗的互动疗法。

4. 发明授权

US07202348B2 Monoclonal antibody antagonists for treating medical problems associated with d-amphetamine-like drugs 有权
标题翻译：用于治疗与苯丙胺类药物相关的医疗问题的单克隆抗体拮抗剂
公开(公告)号：US07202348B2
公开(公告)日：2007-04-10
申请号：US10255462
申请日：2002-09-26
申请人： Samuel M. Owens , Frank Ivy Carroll , Philip Abraham
发明人： Samuel M. Owens , Frank Ivy Carroll , Philip Abraham
IPC分类号： C07K16/44
CPC分类号： A61K31/13 , A61K2039/505 , C07B2200/07 , C07C217/60 , C07C233/18 , C07K16/44 , C07K2317/55
摘要： The present invention provides synthetic immunochemical haptens for the generation of antibodies that are designed to recognize the common molecular features of d-methamphetamine-like abused stimulants with insignificant cross-reactivity to endogenous substrates (e.g. dopamine) or over-the-counter medications (e.g. 1-methamphetamine, pseudoephedrine, phenylpropanolamine and ephedrine). These monoclonal antibodies and their antigen binding fragments are useful in treatment plans for recovering addicts, in emergency room settings for rapidly reversing a drug overdose, in protection of fetuses from drug-abusing pregnant mothers or in a psychiatric setting to reduce the exacerbation of psychotic disorders caused by stimulant drugs.
摘要翻译：本发明提供用于产生抗体的合成免疫化学半抗原，其被设计用于识别对内源底物（例如多巴胺）或非处方药物（例如，多巴胺）具有不显着交叉反应性的d-甲基苯丙胺样滥用兴奋剂的共同分子特征。 1-甲基苯丙胺，伪麻黄碱，苯丙醇胺和麻黄碱）。这些单克隆抗体及其抗原结合片段可用于恢复吸毒者的急救室设置，用于快速逆转药物过量的治疗计划，保护胎儿免受吸毒怀孕母亲或精神病治疗，以减少精神病的恶化由兴奋剂引起的。

5. 发明授权

US06875609B2 Methods for the early diagnosis of ovarian cancer 失效
标题翻译：卵巢癌早期诊断方法
公开(公告)号：US06875609B2
公开(公告)日：2005-04-05
申请号：US10102283
申请日：2002-03-20
申请人： Timothy J. O'Brien , Martin J. Cannon , Alessandro Santin
发明人： Timothy J. O'Brien , Martin J. Cannon , Alessandro Santin
IPC分类号： A61K39/00 , C07K14/435 , C12Q1/37 , C12Q1/68 , G01N33/573 , G01N33/574 , A01N61/00 , A01N37/18 , A61K31/00 , A61K38/00 , A61K38/16
CPC分类号： C07K14/435 , A61K39/00 , A61K2039/5154 , C12Q1/37 , C12Q1/686 , C12Q1/6886 , C12Q2600/158 , G01N33/573 , G01N33/57449 , G01N33/57492 , G01N2333/96433 , G01N2500/20
摘要： The disclosed nucleic acid primer sets, used in combination with quantitative amplification (PCR) of tissue cDNA, can indicate the presence of specific proteases in a tissue sample. Specifically, the present invention relates to expression of hepsin protease. The detected proteases are themselves specifically over-expressed in certain cancers, and the presence of their genetic precursors may serve for early detection of associated ovarian and other malignancies, and for the design of interactive therapies for cancer treatment.
摘要翻译：所公开的与组织cDNA的定量扩增（PCR）组合使用的核酸引物组可以指示组织样品中特异性蛋白酶的存在。具体而言，本发明涉及hepsin蛋白酶的表达。检测到的蛋白酶本身在某些癌症中特异性过度表达，并且其遗传前体的存在可用于早期检测相关的卵巢癌和其他恶性肿瘤，以及用于设计用于癌症治疗的互动疗法。

6. 发明授权

US07282198B2 Immunotherapeutic methods targeted towards stratum corneum chymotryptic enzyme 失效
标题翻译：靶向角质层糜蛋白酶的免疫治疗方法
公开(公告)号：US07282198B2
公开(公告)日：2007-10-16
申请号：US10372521
申请日：2003-02-21
申请人： Timothy J. O'Brien , Martin J. Cannon , Alessandro Santin
发明人： Timothy J. O'Brien , Martin J. Cannon , Alessandro Santin
IPC分类号： A01N63/00 , A61K38/48 , C12Q1/70 , C12P21/06 , C12N5/08 , C12N15/63 , C07H21/02
CPC分类号： A61K39/0011 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2039/5154 , A61K2039/5158 , A61K2039/53 , C07K14/435 , C07K16/3069 , C12N9/6424 , C12N9/6472 , C12N2799/022 , C12Q1/37 , C12Q1/686 , C12Q1/6886 , C12Q2600/112 , C12Q2600/136 , C12Q2600/142 , C12Q2600/158 , G01N33/573 , G01N33/574 , G01N33/57449 , G01N33/57492 , G01N2333/96486 , G01N2333/976
摘要： The present invention discloses the protease stratum corneum chymotrytic enzyme (SCCE) is specifically over-expressed in ovarian and other malignancies. A number of SCCE peptides can induce immune responses to SCCE, thereby demonstrating the potential of these peptides in monitoring and the development of immunotherapies for ovarian and other malignancies.
摘要翻译：本发明公开了卵巢癌和其他恶性肿瘤中特异性过度表达的蛋白酶角质层糜蛋白酶（SCCE）。许多SCCE肽可以诱导对SCCE的免疫应答，从而证明这些肽在监测和发展免疫治疗卵巢癌和其他恶性肿瘤方面的潜力。

7. 发明授权

US07183383B2 Uses of collagen IV 有权
标题翻译：使用胶原蛋白IV
公开(公告)号：US07183383B2
公开(公告)日：2007-02-27
申请号：US10393193
申请日：2003-03-20
申请人： Ricky Gene Schnellmann , Paul A. Nony
发明人： Ricky Gene Schnellmann , Paul A. Nony
IPC分类号： A61K38/17
CPC分类号： A61K38/39
摘要： The present invention provides a method of recovering cellular functions in cells following injury, comprising the step of contacting said cells with collagen IV or a natural or mutated fragment thereof. Further provided is a pharmaceutical composition, comprising a therapeutically effective amount of collagen IV or a natural or mutated fragment thereof and a topically acceptable carrier.
摘要翻译：本发明提供一种在损伤后的细胞中回收细胞功能的方法，包括使所述细胞与胶原IV或其天然或突变的片段接触的步骤。还提供了药物组合物，其包含治疗有效量的胶原IV或其天然或突变的片段和局部可接受的载体。

8. 发明申请

US20040127564A1 Derivatives of butyric acid and uses thereof 失效
标题翻译：丁酸的衍生物及其用途
公开(公告)号：US20040127564A1
公开(公告)日：2004-07-01
申请号：US10734919
申请日：2003-12-12
申请人： The University of Arkansas for Medical Sciences
发明人： Kathleen Gilbert , E. Kim Fifer
IPC分类号： A61K031/221 , A61K031/16
CPC分类号： C07D295/185 , C07C219/06 , C07D211/46 , C07D295/088 , C07D295/13
摘要： The present invention provides a series of compounds having structural formulas 1 wherein n1 is 1 to 5, n2 is 1 to 4 and m is 1 to 3; X is 0 or NH; Y is CH2, O, S, NH, NR; R is selected from the group consisting a straight-chain aliphatic group, a branched-chain aliphatic group and an alicyclic group; wherein Rnull is selected from the group consisting of hydrogen, methyl and ethyl; when Y is O, n1 is not 1; and wherein X and Rnull are independently optionally substituted at C2, C3 or C4 in compounds of Fomula IV or a pharmaceutically acceptable salt thereof. Also provided is a method of inactivating antigen-specific T cells in a n individual.
摘要翻译：本发明提供一系列具有结构式的化合物，其中n1为1至5，n2为1至4，m为1至3; X为0或NH; Y是CH 2，O，S，NH，NR; R选自直链脂族基团，支链脂族基团和脂环族基团; 其中R'选自氢，甲基和乙基; 当Y为O时，n1不为1; 并且其中X和R'独立地任选地被取代在C 3或C 4的化合物或其药学上可接受的盐的化合物中。还提供了灭活个体中的抗原特异性T细胞的方法。

9. 发明授权

US07335351B2 Immunotherapeutic methods targeted towards stratum corneum chymotryptic enzyme 失效
标题翻译：靶向角质层糜蛋白酶的免疫治疗方法
公开(公告)号：US07335351B2
公开(公告)日：2008-02-26
申请号：US10831075
申请日：2004-04-23
申请人： Timothy J. O'Brien , Martin J. Cannon , Alessandro Santin
发明人： Timothy J. O'Brien , Martin J. Cannon , Alessandro Santin
IPC分类号： A01N63/00 , A61K38/48 , C12Q1/70 , C12P21/06 , C12N5/08 , C12N15/63 , C07H21/02
CPC分类号： C12N9/6424 , A61K38/482 , A61K39/00 , A61K39/0011 , A61K48/00 , A61K2039/5154 , A61K2039/5156 , A61K2039/5158 , A61K2039/53 , C07K14/435 , C07K16/40 , C12N9/6472 , C12Q1/37 , C12Q1/686 , C12Q1/6886 , C12Q2600/112 , C12Q2600/142 , C12Q2600/158 , G01N33/573 , G01N33/574 , G01N33/57449 , G01N33/57492 , G01N2333/96486 , G01N2333/976
摘要： The present invention discloses the protease stratum corneum chymotrytic enzyme (SCCE) is specifically over-expressed in ovarian and other malignancies. A number of SCCE peptides can induce immune responses to SCCE, thereby demonstrating the potential of these peptides in monitoring and the development of immunotherapies for ovarian and other malignancies.
摘要翻译：本发明公开了卵巢癌和其他恶性肿瘤中特异性过度表达的蛋白酶角质层糜蛋白酶（SCCE）。许多SCCE肽可以诱导对SCCE的免疫应答，从而证明这些肽在监测和发展免疫治疗卵巢癌和其他恶性肿瘤方面的潜力。

10. 发明授权

US07308364B2 Diagnosis of multiple myeloma on gene expression profiling 有权
标题翻译：多发性骨髓瘤诊断基因表达谱
公开(公告)号：US07308364B2
公开(公告)日：2007-12-11
申请号：US10454263
申请日：2003-06-04
申请人： John D. Shaughnessy , Fenghuang Zhan , Bart Barlogie
发明人： John D. Shaughnessy , Fenghuang Zhan , Bart Barlogie
IPC分类号： G01N33/48 , C12Q1/68 , C12P19/34 , C07H21/04
CPC分类号： C12Q1/6886 , C12Q1/6837 , C12Q2600/112 , C12Q2600/158 , Y02A90/24
摘要： Gene expression profiling between normal B cells/plasma cells and multiple myeloma cells revealed four distinct subgroups of multiple myeloma plasma cells that have significant correlation with clinical characteristics known to be associated with poor prognosis. Diagnosis for multiple myeloma (and possibly monoclonal gammopathy of undetermined significance) based on differential expression of 14 genes, as well as prognostics for the four subgroups of multiple myeloma based on the expression of 24 genes were also established. Gene expression profiling also allows placing multiple myeloma into a developmental schema parallel to that of normal plasma cell differentiation. The development of a gene expression- or developmental stage-based classification system for multiple myeloma would lead to rational design of more accurate and sensitive diagnostics, prognostics and tumor-specific therapies for multiple myeloma.
摘要翻译：在正常B细胞/浆细胞和多发性骨髓瘤细胞之间的基因表达谱显示与已知与不良预后相关的临床特征具有显着相关性的多个骨髓瘤浆细胞的四个不同亚组。还建立了基于14个基因的差异表达的多发性骨髓瘤的诊断（以及可能的未确定意义的单克隆丙种球蛋白病），以及基于24个基因的表达的多发性骨髓瘤的四个亚组的预后。基因表达谱也允许将多发性骨髓瘤放置在与正常浆细胞分化平行的发育模式中。开发基因表达或发育阶段的多发性骨髓瘤分类系统将导致对多发性骨髓瘤的更准确和敏感的诊断，预后和肿瘤特异性治疗的合理设计。

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