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1. 发明授权

US08821409B2 Lung aerosol collection device 有权
标题翻译：肺气溶胶收集装置
公开(公告)号：US08821409B2
公开(公告)日：2014-09-02
申请号：US13141908
申请日：2009-12-21
申请人： David N. Ku , Larry J. Anderson , Prem A. Midha , Harris L. Bergman , Tamera Scholz
发明人： David N. Ku , Larry J. Anderson , Prem A. Midha , Harris L. Bergman , Tamera Scholz
IPC分类号： A61B5/08 , B65D81/00 , A61B10/00 , G01N33/497 , A61B5/097
CPC分类号： A61B5/097 , A61B5/082 , A61B2010/0087 , G01N33/497
摘要： A device for collecting material from lung aerosols. The device functions by collecting aerosols from the lower airway separated from material in the by collecting air from the upper airway in a chamber that when full causes the remaining exhaled aerosols from the lungs to be captured by a filter. The filter collects sample of material from the separated lung aerosols.
摘要翻译：用于从肺气溶胶收集材料的装置。该装置通过从下部气道中收集气溶胶而起作用，其通过在室中从上呼吸道收集空气而收集气体，当其完全导致剩余的来自肺部的呼出气溶胶被过滤器捕获时。过滤器从分离的肺气溶胶中收集材料样品。

2. 发明授权

US08420607B2 Anthrax carbohydrates, synthesis and uses thereof 有权
公开(公告)号：US08420607B2
公开(公告)日：2013-04-16
申请号：US12317693
申请日：2008-12-24
申请人： Russell W. Carlson , Geert-Jan Boons , Conrad Quinn , Mahalakshmi Vasan , Margreet A. Wolfert , Biswa Choudhury , Elmar Kannenberg , Christine Leoff , Alok Mehta , Elke Saile , Jana Rauvolfova , Patricia Wilkins , Alex J. Harvey
发明人： Russell W. Carlson , Geert-Jan Boons , Conrad Quinn , Mahalakshmi Vasan , Margreet A. Wolfert , Therese Buskas , Biswa Choudhury , Elmar Kannenberg , Christine Leoff , Alok Mehta , Elke Saile , Jana Rauvolfova , Patricia Wilkins
IPC分类号： A01N43/04 , A61K31/70 , A61K39/02 , A61K39/00 , A61K39/38 , C07G3/00 , C07G11/00 , C07H15/00 , C07H17/00
CPC分类号： G01N33/56911 , A61K39/07 , A61K2039/55583 , A61K2039/6068 , C07H3/04 , C07H3/06 , C07H5/04 , C07H9/04 , C07K16/1278 , G01N2333/32 , G01N2400/00 , G01N2469/00
摘要： The present invention presents the isolation, characterization and synthesis of oligosaccharides of Bacillus anthracis. Also presented are antibodies that bind to such saccharide moieties and various methods of use for such saccharide moieties and antibodies.

3. 发明授权

US08357525B2 Thermal inactivation of rotavirus 有权
标题翻译：轮状病毒的热灭活
公开(公告)号：US08357525B2
公开(公告)日：2013-01-22
申请号：US12676490
申请日：2008-09-04
申请人： Baoming Jiang , Roger I. Glass , Jean-Francois Saluzzo
发明人： Baoming Jiang , Roger I. Glass , Jean-Francois Saluzzo
IPC分类号： C12N7/04 , A61K39/15
CPC分类号： A61K39/15 , A61K39/12 , A61K2039/5252 , A61K2039/545 , A61K2039/55505 , A61K2039/575 , C12N2720/12334
摘要： Methods of thermally inactivating a rotavirus are provided according to the present invention which include exposing the rotavirus to a temperature in the range of about 50° C.-80° C., inclusive, for an incubation time sufficient to render the rotavirus incapable of replication or infection. The thermally inactivated rotavirus is antigenic and retains a substantially intact rotavirus particle structure. Vaccine compositions and methods of vaccinating a subject against rotavirus are provided which include generation and use of thermally inactivated rotavirus.
摘要翻译：提供了根据本发明的热灭活轮状病毒的方法，其包括将轮状病毒暴露于约50℃-80℃范围内的温度，其温育时间足以使轮状病毒不能复制或感染。热灭活的轮状病毒是抗原性的并且保留基本上完整的轮状病毒颗粒结构。提供疫苗组合物和接种患者抗轮状病毒的方法，其包括产生和使用热灭活的轮状病毒。

4. 发明授权

US07871779B2 Molecular identification of Aspergillus species 有权
标题翻译：曲霉菌的分子鉴定
公开(公告)号：US07871779B2
公开(公告)日：2011-01-18
申请号：US12115493
申请日：2008-05-05
申请人： Christine J. Morrison , Hans Peter Hinrikson
发明人： Christine J. Morrison , Hans Peter Hinrikson
IPC分类号： C12Q1/68 , C12P19/34 , C07H21/04
CPC分类号： C12Q1/6895
摘要： Novel techniques for the detection of Aspergillus in samples are disclosed. These techniques relate to PCR amplification and/or detection of Aspergillus ITS1 rDNA sequences, and the identification of particular species of Aspergillus by detecting differences in the ITS1-V1, ITS-V2, ITS-V3, ITS-V4, and ITS-V5 nucleic acid sequences of Aspergillus. The highly variable regions of the ITS1 rDNA sequences are particularly useful in distinguishing, for example, Aspergillus clavatus, Aspergillus granulosus, Aspergillus sydowii, Aspergillus flavipes, Aspergillus restrictus, Aspergillus versicolor, Aspergillus wentii, and Aspergillus chevalieri. In particular embodiments, the sequence differences are also able to distinguish among variants of particular species, such as Aspergillus granulosus CBS 119.5A, Aspergillus granulosus strain NRRL 1932, Aspergillus sydowii strain NRRL 250, Aspergillus sydowii strain NRRL 4768, Aspergillus sydowii strain CUHI, Aspergillus sydowii strain CUH2, Aspergillus sydowii strain CUH7, and Aspergillus sydowii strain CUH8.
摘要翻译：公开了用于检测样品中曲霉菌的新技术。这些技术涉及通过检测ITS1-V1，ITS-V2，ITS-V3，ITS-V4和ITS-V5核酸中的差异来鉴定曲霉ITS1 rDNA序列的PCR扩增和/或检测，并鉴定特定的曲霉种曲霉酸序列。 ITS1 rDNA序列的高度可变区特别可用于区分例如曲霉菌（Aspergillus clavatus），粒细菌（Aspergillus granulosus），曲霉（Aspergillus sydowii），曲霉（Aspergillus flavipes），限制曲霉（Aspergillus restrictionus），曲霉（Aspergillus versicolor），曲霉（Aspergillus goii）和曲霉（Aspergillus chevalieri）。在特定的实施方案中，序列差异也能够区分特定种类的变体，例如粒细菌芽孢杆菌CBS 119.5A，粒细菌菌株NRRL 1932，曲霉菌株NRRL 250，曲霉菌菌株NRRL 4768，曲霉菌菌株CUHI，曲霉属（Aspergillus sydowii） sydowii菌株CUH2，曲霉菌菌株CUH7和曲霉菌菌株CUH8。

5. 发明授权

US07407664B2 Peptide vaccines against group A streptococci 有权
标题翻译：针对A组链球菌的肽疫苗
公开(公告)号：US07407664B2
公开(公告)日：2008-08-05
申请号：US10477955
申请日：2002-05-20
申请人： Bernard W. Beall , George M. Carlone , Jacquelyn S. Sampson , Edwin W. Ades
发明人： Bernard W. Beall , George M. Carlone , Jacquelyn S. Sampson , Edwin W. Ades
IPC分类号： A61K39/09 , A61K39/00 , C07H21/04 , C12N15/00
CPC分类号： A61K39/092 , A61K39/00 , C07K14/001 , C07K14/315 , C07K2319/00
摘要： This invention, in one aspect, relates to synthetic immunoreactive peptides. These peptides are approximately 20-25 amino acids in length which are portions of the N termini of the M proteins of the most prevalent United States (U.S.) Group A Streptococcus (GAS) serotypes. At least some of the synthetic peptides can be recognized by M type-specific antibodies and are capable of eliciting functional opsonic antibodies and/or anti-attachment antibodies without eliciting tissue cross-reactive antibodies. In another aspect, it relates to compositions or vaccines comprising these synthetic serotype-specific peptides, including polypeptides and proteins. The invention may also be isolated antibodies which are raised in response to the peptides, compositions or vaccines. The invention further relates to kits for using the peptides, compositions, or antibodies. In still further aspects, the invention also relates to methods for using the peptides, compositions, vaccines, or antibodies and methods for tailoring vaccines.
摘要翻译：本发明在一个方面涉及合成免疫反应肽。这些肽的长度约为20-25个氨基酸，它们是最流行的美国（A）链球菌（GAS）血清型的M蛋白的N末端的部分。至少一些合成肽可被M型特异性抗体识别，并且能够引发功能性调理抗体和/或抗附着抗体而不引发组织交叉反应性抗体。另一方面，本发明涉及包含这些合成血清型特异性肽（包括多肽和蛋白质）的组合物或疫苗。本发明还可以是响应于肽，组合物或疫苗引起的分离的抗体。本发明还涉及使用肽，组合物或抗体的试剂盒。在另外的方面，本发明还涉及使用肽，组合物，疫苗或抗体的方法和用于定制疫苗的方法。

6. 发明授权

US07223836B2 Peptides for chlamydophila pneumoniae vaccine and diagnosis 有权
标题翻译：肺炎衣原体疫苗的多肽和诊断
公开(公告)号：US07223836B2
公开(公告)日：2007-05-29
申请号：US10479503
申请日：2002-05-31
申请人： Eric L. Marston , Jackie S. Sampson , George M. Carlone , Edwin W. Ades
发明人： Eric L. Marston , Jackie S. Sampson , George M. Carlone , Edwin W. Ades
IPC分类号： A61K38/00 , A61K39/118 , C07K1/00 , C12P21/04 , G01N33/53
CPC分类号： C07K14/295 , A61K39/00 , Y10S530/811 , Y10S530/814 , Y10S530/82 , Y10S530/825
摘要： Peptides are disclosed that include SEQ ID NO:1, SEQ ID NO: 2, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5, and SEQ ID NO:6, or a conservative variant or mimic thereof, wherein the conservative variant or mimic specifically binds an antibody that specifically binds SEQ ID NO:1, SEQ ID NO: 2, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5, SEQ ID or NO:6. These peptides are of use in generating an immune response against C. pneumoniae, or in preventing infection with against C. pneumoniae.
摘要翻译：公开了包括SEQ ID NO：1，SEQ ID NO：2，SEQ ID NO：3，SEQ ID NO：4，SEQ ID NO：5和SEQ ID NO：6的保守变体或其模拟物，其中所述保守变体或模拟物特异性结合特异性结合SEQ ID NO：1，SEQ ID NO：2，SEQ ID NO：3，SEQ ID NO：4，SEQ ID NO：5，SEQ ID或NO：6的抗体。这些肽可用于产生针对肺炎支原体的免疫应答，或用于预防感染肺炎克雷伯氏杆菌。

7. 发明申请

US20060160230A1 Wipes and methods for removal of metal contamination from surfaces 有权
公开(公告)号：US20060160230A1
公开(公告)日：2006-07-20
申请号：US11039178
申请日：2005-01-18
申请人： Eric Esswein , Mark Boeniger , Kevin Ashley
发明人： Eric Esswein , Mark Boeniger , Kevin Ashley
IPC分类号： G01N33/00
CPC分类号： C11D17/049 , C11D1/58 , C11D1/62 , C11D3/2075 , C11D3/2086
摘要： Wipes, methods and kits useful for testing and/or removal of metal from surfaces (such as, dermal surfaces) are disclosed. Exemplar wipes, including the combination of a three-dimensionally textured absorbent support, a cationic surfactant, and a weak acid, are disclosed. In some examples, the cationic surfactant is isostearamidopropyl morpholine lactate (ISML), and the weak acid is citric acid.

8. 发明授权

US11865172B2 Materials and methods for respiratory disease control in canines 有权
公开(公告)号：US11865172B2
公开(公告)日：2024-01-09
申请号：US17471370
申请日：2021-09-10
申请人： UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. , CORNELL RESEARCH FOUNDATION, INC. , The Government of The United States of America as represented by The Secretary of the Department of
发明人： Patti Cynthia Crawford , Paul J. Gibbs , Edward J. Dubovi , Ruben Omar Donis , Jacqueline Katz , Alexander I. Klimov , Nallakannu P. Lakshmanan , Melissa Anne Lum , Daniel Ghislena Emiel Goovaerts , Mark William Mellencamp , Nancy J. Cox , William L. Castleman
IPC分类号： A61K39/145 , A61K39/12 , C07K14/005 , C07K16/10 , C12N7/00 , C12Q1/70 , G01N33/569 , C12N15/86 , A61K39/00
CPC分类号： A61K39/145 , A61K39/12 , C07K14/005 , C07K16/1018 , C12N7/00 , C12N15/86 , C12Q1/701 , G01N33/56983 , A61K2039/5252 , A61K2039/53 , A61K2039/552 , A61K2039/55555 , A61K2039/55566 , C12N2710/24043 , C12N2760/16121 , C12N2760/16122 , C12N2760/16134 , C12N2760/16151 , C12N2760/16171 , G01N2333/11
摘要： The subject invention pertains to isolated influenza virus that is capable of infecting canids and causing respiratory disease in the canid. The subject invention also pertains to compositions and methods for inducing an immune response against an influenza virus of the present invention. The subject invention also pertains to compositions and methods for identifying a virus of the invention and diagnosing infection of an animal with a virus of the invention.

9. 发明授权

US09913892B2 Materials and methods for respiratory disease control in canines 有权
公开(公告)号：US09913892B2
公开(公告)日：2018-03-13
申请号：US14507332
申请日：2014-10-06
申请人： UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. , CORNELL RESEARCH FOUNDATION, INC. , The United States of America as Represented by the Secretary of the Department of Health and Human Services, Centers for Disease Control and Prevention
发明人： Patti Cynthia Crawford , Paul J. Gibbs , Edward J. Dubovi , Ruben Omar Donis , Jacqueline Katz , Alexander I. Klimov , Nallakannu P. Lakshmanan , Melissa Anne Lum , Daniel Ghislena Emiel Goovaerts , Mark William Mellencamp , Nancy J. Cox , William L. Castleman
IPC分类号： A61K39/145 , C07K14/005 , C12N7/00 , C12N15/86 , A61K39/12 , C07K16/10 , C12Q1/70 , G01N33/569 , A61K39/00
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/5252 , A61K2039/53 , A61K2039/552 , A61K2039/55555 , A61K2039/55566 , C07K14/005 , C07K16/1018 , C12N7/00 , C12N15/86 , C12N2710/24043 , C12N2760/16121 , C12N2760/16122 , C12N2760/16134 , C12N2760/16151 , C12N2760/16171 , C12Q1/701 , G01N33/56983 , G01N2333/11
摘要： The subject invention pertains to isolated influenza virus that is capable of infecting canids and causing respiratory disease in the canid. The subject invention also pertains to compositions and methods for inducing an immune response against an influenza virus of the present invention. The subject invention also pertains to compositions and methods for identifying a virus of the invention and diagnosing infection of an animal with a virus of the invention.

10. 发明授权

US09650422B2 Localization and characterization of flavivirus envelope glycoprotein cross-reactive epitopes and methods for their use 有权
公开(公告)号：US09650422B2
公开(公告)日：2017-05-16
申请号：US14659251
申请日：2015-03-16
申请人： The United States of America as represented by the Secretary of the Dept.of Health and Human Services
发明人： Gwong-Jen J. Chang , Wayne D. Crill
IPC分类号： A61K39/12 , C07K14/005 , C12N7/00 , G01N33/569 , A61K39/00
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K2039/5258 , A61K2039/53 , C12N7/00 , C12N2770/24122 , C12N2770/24123 , C12N2770/24134 , C12N2770/24171 , G01N33/56983 , G01N2333/185 , G01N2469/20 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394 , Y02A50/53 , Y02A50/60
摘要： Disclosed herein is a method for identifying flavivirus cross-reactive epitopes. Also provided are flavivirus E-glycoprotein cross-reactive epitopes and flavivirus E-glycoprotein cross-reactive epitopes having reduced or ablated cross-reactivity (and polypeptides comprising such epitopes), as well as methods of using these molecules to elicit an immune response against a flavivirus and to detect a flaviviral infection.

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