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    • 5. 发明授权
    • Chimeric isoprenoid synthases and uses thereof
    • 嵌合类异戊二烯合酶及其用途
    • US08354504B2
    • 2013-01-15
    • US12927805
    • 2010-11-23
    • Joseph ChappellKyoungwhan Back
    • Joseph ChappellKyoungwhan Back
    • C07K14/415
    • C12P5/007C07K2319/00C12N9/00C12N9/1003C12N9/88C12N15/8243
    • Provided is a chimeric isoprenoid synthase polypeptide including a first domain from a first isoprenoid synthase joined to a second domain from a second, heterologous, isoprenoid synthase, whereby the chimeric isoprenoid synthase is capable of catalyzing the production of isoprenoid reaction products that are not produced in the absence of the second domain of the second, heterologous, isoprenoid synthase. Also provided is a chimeric isoprenoid synthase polypeptide including an asymmetrically positioned heterologous domain, whereby the chimeric isoprenoid synthase is capable of catalyzing the production of isoprenoid reaction products that are not produced when the domain is positioned at its naturally-occurring site in the isoprenoid synthase polypeptide.
    • 本发明提供了一种嵌合型类异戊二烯合酶,​​其包含与第二种异戊二烯合成酶连接到第二结构域的第一种类型的类异戊二烯合酶的第一结构域,其中嵌合型类异戊二烯合酶能够催化不产生的类异戊二烯反应产物 不存在第二种异源的类异戊二烯合酶的第二结构域。 还提供了嵌合型类异戊二烯合酶多肽,其包括不对称定位的异源结构域,由此嵌合型类异戊二烯合酶能够催化当该结构域位于类固醇合成酶多肽的天然存在位点时不产生的类异戊二烯反应产物的产生 。
    • 6. 发明授权
    • Chimeric isoprenoid synthases and uses thereof
    • 嵌合类异戊二烯合酶及其用途
    • US08106260B2
    • 2012-01-31
    • US10717500
    • 2003-11-21
    • Joseph ChappellKyoungwhan Back
    • Joseph ChappellKyoungwhan Back
    • C12N15/29C12N15/52C12N15/82A01H5/00
    • C12P5/007C07K2319/00C12N9/00C12N9/1003C12N9/88C12N15/8243
    • Disclosed is a chimeric isoprenoid synthase polypeptide including a first domain from a first isoprenoid synthase joined to a second domain from a second, heterologous isoprenoid synthase, whereby the chimeric isoprenoid synthase is capable of catalyzing the production of isoprenoid reaction products that are not produced in the absence of the second domain of the second, heterologous isoprenoid synthase. Also disclosed is a chimeric isoprenoid synthase polypeptide including an asymmetrically positioned homologous domain, whereby the chimeric isoprenoid synthase is capable of catalyzing the production of isoprenoid reaction products that are not produced when the domain is positioned at its naturally-occurring site in the isoprenoid synthase polypeptide.
    • 本发明公开了一种嵌合型类异戊二烯合酶,​​其包括第一种类型的类异戊二烯合酶的第一结构域,其与第二异源类异戊二烯合酶连接到第二结构域,由此嵌合型类异戊二烯合酶能够催化不产生的类异戊二烯反应产物的产生 不存在第二种异源类异戊二烯合酶的第二结构域。 还公开了嵌合型类异戊二烯合酶多肽,其包括不对称定位的同源结构域,其中嵌合型类异戊二烯合酶能够催化产生类异戊二烯反应产物,当该结构域位于其在类异戊二烯合酶多肽的天然存在位点时不产生 。
    • 7. 发明授权
    • Inhibitors of bacterial collagenase
    • 细菌胶原酶抑制剂
    • US4558034A
    • 1985-12-10
    • US576005
    • 1984-01-31
    • Richard E. GalardyDamian Grobelny
    • Richard E. GalardyDamian Grobelny
    • C07K5/08A61K37/00
    • C07K5/0827
    • This invention relates to amino acid derivatives that are useful as inhibitors of bacterial collagenase. The compounds of this invention have a general formula: ##STR1## wherein R is alkyl, aralkyl, aryl, alkoxy, aryloxy, hydroxy or pharmaceutically acceptable salts thereof; R.sub.1 is hydrogen, alkali metal, lower alkyl, phenyl lower alkyl, or phenyl, or substituted phenyl wherein the substituent is halo, lower alkoxy or lower alkyl or nitro or carboxy or cyano, and pharmaceutically acceptable salts thereof; R.sub.2, R.sub.3 and R.sub.4 is hydrogen or alkyl; R.sub.2 and R.sub.4 may be the side groups found on the 20 common .alpha.-amino acids; R.sub.3 and R.sub.4 may be connected together to form an alkylene bridge of from 2 to 4 carbon atoms; Y is alkoxy, aryloxy, primary amide, amino acid derivative or ##STR2## where R.sub.5 and R.sub.6 is hydrogen or alkyl; R.sub.5 and R.sub.6 may be connected together to form an alkylene bridge of from 2 to 4 carbon atoms; X is hydroxyl or pharmaceutically acceptable salts thereof, or an amino acid derivative.
    • 本发明涉及可用作细菌胶原酶抑制剂的氨基酸衍生物。 本发明的化合物具有通式:其中R是烷基,芳烷基,芳基,烷氧基,芳氧基,羟基或其药学上可接受的盐; R1是氢,碱金属,低级烷基,苯基低级烷基或苯基,或取代的苯基,其中取代基是卤素,低级烷氧基或低级烷基或硝基或羧基或氰基,及其药学上可接受的盐; R2,R3和R4是氢或烷基; R2和R4可以是在20种常见的α-氨基酸上发现的侧基; R3和R4可以连接在一起形成2至4个碳原子的亚烷基桥; Y是烷氧基,芳氧基,伯酰胺,氨基酸衍生物或其中R 5和R 6是氢或烷基; R5和R6可以连接在一起形成2至4个碳原子的亚烷基桥; X是羟基或其药学上可接受的盐,或氨基酸衍生物。