专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20120202816A1 NOVEL COMPOUNDS 有权
标题翻译：新型化合物
公开(公告)号：US20120202816A1
公开(公告)日：2012-08-09
申请号：US13346968
申请日：2012-01-10
申请人： Laxmikant Chhipa , Shitalkumar Pukharaj Zambad , Ramesh Gupta , Davinder Tuli , Ashok Kasundra , Siralee Munshi , M. Amir Siddiqui , Subrat Kumar Bhattamisra , C. Dutt , Vijay Chauthaiwale
发明人： Laxmikant Chhipa , Shitalkumar Pukharaj Zambad , Ramesh Gupta , Davinder Tuli , Ashok Kasundra , Siralee Munshi , M. Amir Siddiqui , Subrat Kumar Bhattamisra , C. Dutt , Vijay Chauthaiwale
IPC分类号： A61K31/415 , C07D403/06 , A61K31/4155 , C07D409/04 , C07D413/06 , A61K31/4245 , C07D413/04 , A61K31/5377 , A61P3/04 , A61P5/48 , A61P3/10 , A61P3/06 , A61P3/00 , A61P5/14 , A61P3/08 , A61P25/24 , A61P9/00 , A61P17/00 , C07D231/18
CPC分类号： C07D403/06 , C07D231/12 , C07D231/14 , C07D231/18 , C07D403/10 , C07D403/12 , C07D409/04 , C07D413/06
摘要： The present invention discloses a novel thyroid like compounds of formula (I), wherein R1 R2, R3, R4 and Z are as defined in the specification, method for its preparation, composition containing such compounds and use of such compounds and composition as medicament. Further, compounds of formula (I) has significantly low binding affinity to thyroid receptors and thus considerably devoid of thyrotoxic effects. The invention also relates to the use of the compound of formula (I) for the preparation of a medicament for treating various disease conditions such as obesity, dyslipidemia, metabolic syndrome and co-morbidities associated with metabolic syndrome.
摘要翻译：本发明公开了一种新颖的甲状腺样化合物，其中R1 R2，R3，R4和Z如本说明书中所定义，其制备方法，含有这些化合物的组合物以及这些化合物的用途和作为药物的组合物。此外，式（I）化合物对甲状腺受体具有显着低的结合亲和力，因此显着缺乏甲状腺毒性作用。本发明还涉及式（I）化合物在制备用于治疗各种疾病状况如肥胖，血脂异常，代谢综合征和与代谢综合征相关的并发症的药物中的用途。

2. 发明授权

US6111101A Process for the preparation of 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine 失效
标题翻译：制备3,5-二氨基-6-（2,3-二氯苯基）-1,2,4-三嗪的方法
公开(公告)号：US6111101A
公开(公告)日：2000-08-29
申请号：US456501
申请日：1999-12-08
申请人： Sharad Kumar Vyas
发明人： Sharad Kumar Vyas
IPC分类号： C07D253/075
CPC分类号： C07D253/075
摘要： There is disclosed an improved process for the preparation of 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine which process comprises the step of reacting 2,3-dichlorobenzoylchloride with cuprous cyanide in presence of acetonitrile and a cosolvent to produce dichlorobenzoyl cyanide, said dichlorobenzoyl cyanide is reacted with aminoguanidine bicarbonate to produce an intermediate product, which is cyclized in presence of aqueous potassium hydroxide to produce 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine.
摘要翻译：公开了一种制备3,5-二氨基-6-（2,3-二氯苯基）-1,2,4-三嗪的改进方法，该方法包括在存在下使2,3-二氯苯甲酰氯与氰化亚铜反应的步骤的乙腈和共溶剂以产生二氯苯甲酰氰，所述二氯苯甲酰氰与氨基胍碳酸氢盐反应生成中间产物，其在氢氧化钾水溶液存在下环化，得到3,5-二氨基-6-（2,3-二氯苯基） -1,2,4-三嗪。

3. 发明授权

US11331334B2 Intranasal composition of methylcobalamin 有权
公开(公告)号：US11331334B2
公开(公告)日：2022-05-17
申请号：US16482491
申请日：2018-02-05
申请人： TORRENT PHARMACEUTICALS LTD.
发明人： Jaya Abraham , Vivek Mishra , Kiran Chaudhari , Vipul Mittal
IPC分类号： A61K31/714 , A61K9/00 , A61K47/10 , A61K47/36 , A61K47/44
摘要： The present invention relates to an intranasal composition, particularly once weekly intranasal composition comprising methylcobalamin and at least one gelling agent and a process for preparation thereof.

4. 发明申请

US20080226711A1 PHARMACEUTICAL COMPOSITIONS OF DULOXETINE 审中-公开
标题翻译： DULOXETINE的药物组合物
公开(公告)号：US20080226711A1
公开(公告)日：2008-09-18
申请号：US12045810
申请日：2008-03-11
申请人： Sheth Rakesh K. , Setty Umesh , Patel Hasmukh M.
发明人： Sheth Rakesh K. , Setty Umesh , Patel Hasmukh M.
IPC分类号： A61K31/381 , A61K9/14 , A61K9/58 , A61K9/62
CPC分类号： A61K31/381 , A61K9/5026 , A61K9/5042 , A61K9/5078
摘要： The present invention relates to solid oral pharmaceutical compositions of duloxetine, process for preparing such compositions and method of using such compositions. Preferably, the invention relates to a delayed release composition of duloxetine comprising a core comprising duloxetine, optional separating coat and an enteric coat.
摘要翻译：本发明涉及度洛西汀的固体口服药物组合物，该组合物的制备方法和使用该组合物的方法。优选地，本发明涉及度洛西汀的延迟释放组合物，其包含包含度洛西汀，任选分离包衣和肠溶衣的核心。

5. 发明申请

US20030045554A1 Novel compounds for the management of aging-related and diabetic vascular complications, process for their preparation, therapeutic and cosmetic uses thereof 失效
标题翻译：用于治疗老化和糖尿病性血管并发症的新型化合物，其制备方法，其治疗和美容用途
公开(公告)号：US20030045554A1
公开(公告)日：2003-03-06
申请号：US10116135
申请日：2002-04-05
申请人： TORRENT PHARMACEUTICALS LTD.
发明人： Alangudi Sankaranarayanan
IPC分类号： A61K031/4439 , C07D41/04
CPC分类号： C07D409/14 , C07D413/14
摘要： The invention discloses a new clause of a five membered heterocylic ring compounds of general formula 1 1 and its pharmaceutically or cosmetically acceptable salts, wherein R1, R2, R3, R4, R5, A, B, X and Y are as defined in the specification. The invention also discloses a process for preparation of these compound and their therapeutic and cosmetic applications particularly in the management of aging related and diabetic vascular complications. The compounds in question act by triple action of an AGE (Advanced Glycation Endproducts) breaker, AGE inhibitor and free radical scavenger which make them most suitable in different therapeutic and cosmetic applications. The invention also discloses pharmaceuticals and cosmetic compositions comprising these compounds and method of treatment of diseases caused by accumulation of AGE and/or free radicals in the body cells.
摘要翻译：本发明公开了通式1的五元杂环环化合物及其药学上或化妆品上可接受的盐的新条款，其中R1，R2，R3，R4，R5，A，B，X和Y如说明书中所定义。本发明还公开了一种制备这些化合物及其治疗和美容应用的方法，特别是用于治疗老化和糖尿病性血管并发症。所述化合物通过AGE（高级糖化终产物）破坏剂，AGE抑制剂和自由基清除剂的三重作用起作用，使其最适合于不同的治疗和美容应用。本发明还公开了包含这些化合物的药物和化妆品组合物以及治疗由身体细胞中AGE和/或自由基的积累引起的疾病的方法。

6. 发明申请

US20020103228A1 Composition and method for use of pyridinium derivatives in cosmetic and therapeutic applications 审中-公开
标题翻译：在化妆品和治疗应用中使用吡啶衍生物的组合物和方法
公开(公告)号：US20020103228A1
公开(公告)日：2002-08-01
申请号：US09995731
申请日：2001-11-29
申请人： TORRENT PHARMACEUTICALS LTD.
发明人： Alangudi Sankaranarayanan
IPC分类号： A61K031/44 , A61K007/00
CPC分类号： C07D213/77 , A61K31/4425 , A61K31/4436 , A61K31/444 , A61K45/06 , C07D213/82 , C07D213/87 , C07D409/06 , C07D409/14 , C07D417/12 , A61K2300/00
摘要： The invention discloses a new class of compounds particularly pyridinium derivatives which have been found to exhibit triple function of a free radical scavenger (antioxidant), AGE breaker and AGE inhibitor, and cosmetic composition comprising these compounds contained in a cosmetically acceptable carrier. The invention also discloses a method of cosmetic application by applying such composition. The invention further discloses a pharmaceutical composition comprising said compounds useful in scavenging free radicals from the body cells of a mammal, a method of scavenging free radicals from the body cells of a mammal and a method of treating of diseases caused by accumulation of free radicals in the body cells of a mammal by administering a composition made with the compounds of the invention. The invention also discloses composition and method for inhibiting AGE in a mammal by using the compounds of the invention.
摘要翻译：本发明公开了一类新的化合物，特别是已经发现自由基清除剂（抗氧化剂），AGE破坏剂和AGE抑制剂的三重功能的吡啶衍生物以及包含在化妆品可接受的载体中的这些化合物的化妆品组合物。本发明还公开了通过应用这种组合物的化妆品应用的方法。本发明还公开了一种药物组合物，其包含可用于清除哺乳动物的体细胞中的自由基的所述化合物，从哺乳动物的身体细胞中清除自由基的方法和治疗由自由基的积累引起的疾病的方法哺乳动物的体细胞通过施用本发明化合物制成的组合物。本发明还公开了通过使用本发明的化合物来抑制哺乳动物中的AGE的组合物和方法。

7. 发明授权

US09629818B2 Pharmaceutical composition of tapentadol for parenteral administration 有权
公开(公告)号：US09629818B2
公开(公告)日：2017-04-25
申请号：US14439840
申请日：2012-11-01
申请人： TORRENT PHARMACEUTICALS LTD
发明人： Sunil Sadanand Nadkarni , Jaya Abraham , Kapil Khatri
IPC分类号： A61K31/137 , A61K9/19 , A61K9/10 , A61K9/127 , A61K9/00 , A61K9/14 , A61K47/14 , A61K47/26 , A61K47/32 , A61K47/38 , A61K47/44 , A61K9/16 , A61K47/22 , A61K47/34
CPC分类号： A61K31/137 , A61K9/0019 , A61K9/0024 , A61K9/10 , A61K9/127 , A61K9/14 , A61K9/1647 , A61K9/19 , A61K47/14 , A61K47/22 , A61K47/26 , A61K47/32 , A61K47/34 , A61K47/38 , A61K47/44
摘要： The present invention relates to a pharmaceutical composition of tapentadol for parenteral administration which provides prolonged release of tapentadol. Present invention also relates to the process of preparation of pharmaceutical composition of tapentadol for parenteral administration and its use in the treatment of pain.

8. 发明申请

US20140170209A1 PHARMACEUTICAL INVENTION OF TAPENTADOL 审中-公开
标题翻译： TAPENTADOL的药物发明
公开(公告)号：US20140170209A1
公开(公告)日：2014-06-19
申请号：US14233265
申请日：2012-07-19
申请人： Sunil Sadanand Nadkarni , Jaya Abraham , Kapil Khatri , Vipul Mittal
发明人： Sunil Sadanand Nadkarni , Jaya Abraham , Kapil Khatri , Vipul Mittal
IPC分类号： A61K9/00 , A61K31/137
CPC分类号： A61K9/0043 , A61K9/08 , A61K31/137 , A61K47/10 , A61K47/18
摘要： The present invention relates to a pharmaceutical composition of tapentadol for nasal administration. Present invention also relates to the process of preparation of pharmaceutical composition of tapentadol for nasal administration and its use in the treatment of pain.
摘要翻译：本发明涉及用于鼻内给药的他喷他多的药物组合物。本发明还涉及用于鼻给药的他喷他多药物组合物的制备方法及其在治疗疼痛中的用途。

9. 发明授权

US08143424B2 Thyroid like compounds 有权
标题翻译：甲状腺样化合物
公开(公告)号：US08143424B2
公开(公告)日：2012-03-27
申请号：US12224168
申请日：2008-06-02
申请人： Laxmikant Chhipa , Shitalkumar Pukharaj Zambad , Ramesh Gupta , Davinder Tuli , Ashok Kasundra , Siralee Munshi , M. Amir Siddiqui , Subrat Kumar Bhattamisra , Chaitanya Dutt , Vijay Chauthaiwale
发明人： Laxmikant Chhipa , Shitalkumar Pukharaj Zambad , Ramesh Gupta , Davinder Tuli , Ashok Kasundra , Siralee Munshi , M. Amir Siddiqui , Subrat Kumar Bhattamisra , Chaitanya Dutt , Vijay Chauthaiwale
IPC分类号： A61K31/5377 , A61K31/415 , A61K31/4155 , A61K31/4245 , A61K31/506 , C07D231/20 , C07D403/06 , C07D403/04 , C07D413/04 , A61P3/04 , A61P3/06 , A61P3/10 , A61P3/00 , A61P5/14 , A61P17/00 , A61P9/00 , A61P25/24
CPC分类号： C07D403/06 , C07D231/12 , C07D231/14 , C07D231/18 , C07D403/10 , C07D403/12 , C07D409/04 , C07D413/06
摘要： A novel thyroid like compounds of formula (I), wherein R1, R2, R3, R4 and Z are as defined in the specification, method for its preparation, composition and use thereof. Further, compounds of formula (I) has significantly low binding affinity to thyroid receptors and thus considerably devoid of thyrotoxic effects. The invention also relates to the use of the compound of formula (I) for the preparation of a medicament for treating various disease conditions including obesity, dyslipidemia, metabolic syndrome and co-morbidities associated with metabolic syndrome.
摘要翻译：一种新型甲状腺类似式（I）的化合物，其中R1，R2，R3，R4和Z如说明书中所定义，其制备方法，组合物和用途。此外，式（I）化合物对甲状腺受体具有显着低的结合亲和力，因此显着缺乏甲状腺毒性作用。本发明还涉及式（I）化合物在制备用于治疗各种疾病状况，包括肥胖，血脂异常，代谢综合征和与代谢综合征相关的并发症的药物中的用途。

10. 发明申请

US20110027361A1 EXTENDED RELEASE DOSAGE FORM OF PALIPERIDONE 审中-公开
标题翻译：延长释放剂量的PALIPERIDONE
公开(公告)号：US20110027361A1
公开(公告)日：2011-02-03
申请号：US12865801
申请日：2009-02-03
申请人： Ganesan Murugesan , Jaya Abraham , Vinodkumar Gupta , Bhavesh Shah
发明人： Ganesan Murugesan , Jaya Abraham , Vinodkumar Gupta , Bhavesh Shah
IPC分类号： A61K9/28 , A61K9/00 , A61K31/519
CPC分类号： A61K9/2846 , A61K9/284 , A61K31/519
摘要： The present invention relates to an extended release solid oral pharmaceutical composition comprising Paliperidone or its pharmaceutically acceptable salts and process for preparing the same.
摘要翻译：本发明涉及包含哌啶酮或其药学上可接受的盐的延长释放固体口服药物组合物及其制备方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式