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1. 发明公开

US20240207456A1 PHOTOCURABLE COMPOSITIONS AND METHODS FOR DELIVERING RADIATION TO A SUBJECT 审中-公开
公开(公告)号：US20240207456A1
公开(公告)日：2024-06-27
申请号：US18335342
申请日：2023-06-15
申请人： THERAGENICS CORPORATION
发明人： Richard Brauckman , Jacob Freeman
IPC分类号： A61K51/06 , A61K45/06 , A61K51/12 , C08F2/50 , C08F222/10
CPC分类号： A61K51/06 , A61K45/06 , A61K51/1213 , C08F2/50 , C08F222/1065 , A61K2121/00
摘要： The disclosure is directed in part to polymerizable compositions that can incorporate a radioactive source and be used to treat subjects with certain conditions, and methods of producing and use thereof.

2. 发明授权

US09050458B2 Point of care radioactive material stranding systems 有权
标题翻译：放射性物质绞合系统
公开(公告)号：US09050458B2
公开(公告)日：2015-06-09
申请号：US13733272
申请日：2013-01-03
申请人： THERAGENICS CORPORATION
发明人： David Schreiber , Jack C. White , David Wesley Stephens , Henry C. Goode , Nathan Christopher Griffith , Ming K. Tai
IPC分类号： A61N5/10
CPC分类号： A61N5/1001 , A61N2005/1009 , A61N2005/1023
摘要： A point-of-care seed stranding device for automating assembly of brachytherapy seed strands for implantation in patients. The device includes a number of features to reduce the potential for mistakes by the user, as well as to reduce the potential for damaging the radioactive seeds during the stranding process. Tactile feedback may be provided to prevent exertion of too much force in the packing step of the stranding process, as well as to indicate that the seed and/or strand cartridges are empty and need to be replaced. The device may also include a mechanism for holding seeds or spacers in place to allow automated packing of seeds or spacers having corresponding geometries. The device may also be provided with a seed counter which can be employed to preset the number of seeds in a strand and which disables the device from dispensing or packing additional seeds once the preset number of seeds has been packed into the strand. Also, methods for automated assembly of seed strands including the steps of setting the number of seeds, dispensing seeds and spacers, packing seeds and spacers and transferring assembled strands to another device.
摘要翻译：一种用于自动装配近距离放射治疗种子股的护理种子绞合装置，用于植入患者。该装置包括许多特征，以减少使用者的错误的可能性，以及减少在绞合过程中损坏放射性种子的可能性。可以提供触觉反馈以防止在绞合过程的包装步骤中施加过大的力，并且指示种子和/或线束筒是空的并且需要更换。该装置还可以包括用于将种子或间隔物保持在适当位置以允许自动包装具有相应几何形状的种子或间隔物的机构。该装置还可以具有种子计数器，该种子计数器可用于预定股线中的种子数量，并且一旦预定数量的种子已经被包装到股线中，该种子计数器就禁止装置分配或包装额外的种子。此外，种子股线的自动装配的方法包括以下步骤：设定种子数量，分配种子和间隔物，包装种子和间隔物并将组装的股转移到另一装置。

3. 发明授权

US08398534B2 Expandable brachytherapy device 有权
标题翻译：可扩展近距离放射治疗装置
公开(公告)号：US08398534B2
公开(公告)日：2013-03-19
申请号：US12692289
申请日：2010-01-22
申请人： Jack C. White , David Wesley Stephens , Amit Prakash Govil , Joshua J. Bergman , Nathan Christopher Griffith , Kyle Kevin Millage
发明人： Jack C. White , David Wesley Stephens , Amit Prakash Govil , Joshua J. Bergman , Nathan Christopher Griffith , Kyle Kevin Millage
IPC分类号： A61N5/00
CPC分类号： A61N5/1015 , A61M29/02 , A61N5/1007 , A61N2005/1008 , A61N2005/1018 , A61N2005/1024
摘要： A brachytherapy device including an elongate member comprising a proximal portion and a distal portion. The device also includes a movable surface portion surrounding at least the distal portion of the elongate member and a plurality of source lumen tubes defining respective source lumens, the source lumen tubes being located around the elongate member, distal ends of the source lumen tubes coupled to the distal portion of the elongate member, the source lumen tubes extending a sufficient distance in a proximal direction such that the source lumen tubes extend outside a body when distal portions of the source lumen tubes are positioned in a body cavity for brachytherapy. The device also has structure coupled to the distal ends of the source lumen tubes for positioning the distal portions of the source lumen tubes at different distances from the elongate member for brachytherapy by exerting a force in a proximal direction on the distal ends of the source lumen tubes, the structure including an actuator for actuating the structure, at least a portion of the actuator being located outside the body when the distal portions of the source lumen tubes are positioned in a body cavity for brachytherapy. The device also includes a ring, tube or manifold securing a portion of the source lumen tubes proximal to the distal portion around the elongate member and a source of radiation suitable for insertion into the source lumens.
摘要翻译：一种近距离放射治疗装置，包括包括近端部分和远端部分的细长部件。该装置还包括围绕细长构件的至少远侧部分的可移动表面部分和限定相应源腔的多个源腔管，源腔管位于细长构件周围，源腔管的远端连接到细长构件的远端部分，源腔管在近端方向上延伸足够的距离，使得当源管腔的远端位于用于近距离放射治疗的体腔中时，源腔管延伸到身体外部。该装置还具有耦合到源腔管的远端的结构，用于通过在源腔的远端上沿近端方向施加力来将源腔管的远端部分定位在与细长构件不同的距离处，用于近距离放射治疗管，该结构包括用于致动结构的致动器，当源腔管的远端位于用于近距离放射治疗的体腔中时，致动器的至少一部分位于身体外部。该装置还包括环，管或歧管，其将源腔腔管的一部分靠近远端部分固定在细长构件周围，以及适于插入源腔的辐射源。

4. 发明申请

US20100222628A1 EXPANDABLE BRACHYTHERAPY DEVICE 有权
公开(公告)号：US20100222628A1
公开(公告)日：2010-09-02
申请号：US12775636
申请日：2010-05-07
申请人： JACK C. WHITE , DAVID WESLEY STEPHENS , AMIT PRAKASH GOVIL , JOSHUA J. BERGMAN , NATHAN CHRISTOPHER GRIFFITH , KYLE KEVIN MILLAGE
发明人： JACK C. WHITE , DAVID WESLEY STEPHENS , AMIT PRAKASH GOVIL , JOSHUA J. BERGMAN , NATHAN CHRISTOPHER GRIFFITH , KYLE KEVIN MILLAGE
IPC分类号： A61M36/04
CPC分类号： A61N5/1015 , A61M29/02 , A61N5/1007 , A61N2005/1008 , A61N2005/1018 , A61N2005/1024
摘要： A method for brachytherapy in a lumpectomy cavity of a breast including, positioning a distal end of a brachytherapy device within the cavity, expanding an expandable surface portion located between proximal and distal ends of the device within the cavity, the source lumen tubes defining a curved configuration within the cavity; and positioning a source of radiation sequentially within one or more source lumens of the source lumen tubes according to a brachytherapy treatment plan. The device includes an inner tube, and a plurality of source lumen tubes located around the inner tube and including distal ends secured together with the inner tube at the distal end disposed within the body cavity, the source lumen tubes comprising proximal portions sufficiently long to extend outside the breast.

5. 发明申请

US20160324508A1 METHODS AND APPARATUS FOR TISSUE REMOVAL 有权
标题翻译：用于组织去除的方法和装置
公开(公告)号：US20160324508A1
公开(公告)日：2016-11-10
申请号：US15186492
申请日：2016-06-19
申请人： tHERAGENICS cORPORATION
发明人： John Duggan , Hugh Tripp , Thomas Johnson
IPC分类号： A61B10/02 , A61B17/3205
CPC分类号： A61B10/0275 , A61B17/32053 , A61B2010/0208 , A61B2017/00862 , A61B2017/320064
摘要： A tissue removal apparatus and needle assembly for extracting a tissue portion from tissue or the like, the needle assembly comprising an inner tube having an interior cavity, an outer cannula having a proximal end, a distal end and an interior cavity, the interior cavity of the outer cannula having an interior diameter to slidably receive the inner tube and a collapsible section operably engaged with the inner tube and the outer cannula whereby a forward movement of a portion of the inner tube within the interior cavity of the outer cannula changes the collapsible section from a neutral position to a collapsed position to engage the tissue portion. In some embodiments, the outer cannula further comprises an aperture configured to allow a tissue portion from within the needle assembly to pass through or otherwise be expelled outside of the needle assembly.
摘要翻译：一种用于从组织或类似物提取组织部分的组织去除装置和针组件，所述针组件包括具有内腔的内管，具有近端，外端和内腔的外套管，所述外套管具有可滑动地容纳所述内管的内径和与所述内管和所述外套管可操作地接合的可折叠部分，由此所述内管的一部分在所述外套管的内腔内的向前运动改变所述可折叠部分从中立位置到折叠位置以接合组织部分。在一些实施例中，外套管还包括孔，其构造成允许来自针组件内的组织部分通过或以其它方式排出针组件外部。

6. 发明申请

US20150306421A1 EXPANDABLE BRACHYTHERAPY DEVICE 审中-公开
标题翻译：可扩展的BRACHYTHERAPY设备
公开(公告)号：US20150306421A1
公开(公告)日：2015-10-29
申请号：US14794551
申请日：2015-07-08
申请人： THERAGENICS CORPORATION
发明人： JACK C. WHITE , DAVID WESLEY STEPHENS , AMIT PRAKASH GOVIL , JOSHUA J. BERGMAN , NATHAN CHRISTOPHER GRIFFITH , KYLE KEVIN MILLAGE
IPC分类号： A61N5/10 , A61M29/02
CPC分类号： A61N5/1015 , A61M29/02 , A61N5/1007 , A61N2005/1008 , A61N2005/1018 , A61N2005/1024
摘要： A method for brachytherapy in a lumpectomy cavity of a breast including, positioning a distal end of a brachytherapy device within the cavity, expanding an expandable surface portion located between proximal and distal ends of the device within the cavity, the source lumen tubes defining a curved configuration within the cavity; and positioning a source of radiation sequentially within one or more source lumens of the source lumen tubes according to a brachytherapy treatment plan. The device includes an inner tube, and a plurality of source lumen tubes located around the inner tube and including distal ends secured together with the inner tube at the distal end disposed within the body cavity, the source lumen tubes comprising proximal portions sufficiently long to extend outside the breast.
摘要翻译：一种用于乳房肿瘤切除腔的近距离放射治疗方法，包括将近距离放射治疗装置的远端定位在腔内，使位于腔内的装置的近端和远端之间的可扩张表面部分膨胀，源腔管限定弯曲腔内配置; 以及根据近程放射疗法治疗计划将辐射源依次定位在源腔管的一个或多个源腔内。所述装置包括内管和位于所述内管周围的多个源管腔，并且包括远端，所述远端与设置在所述体腔内的远端处与所述内管固定在一起，所述源腔管包括足够长以延伸的近端部分在乳房外面

7. 发明申请

US20130190549A1 POINT OF CARE RADIOACTIVE MATERIAL STRANDING SYSTEMS 有权
标题翻译：护理放射性物质缠结系统的要点
公开(公告)号：US20130190549A1
公开(公告)日：2013-07-25
申请号：US13733272
申请日：2013-01-03
申请人： THERAGENICS CORPORATION
发明人： DAVID SCHREIBER , JACK C. WHITE , DAVID WESLEY STEPHENS , HENRY C. GOODE , NATHAN CHRISTOPHER GRIFFITH , MING K. TAI
IPC分类号： A61N5/10
CPC分类号： A61N5/1001 , A61N2005/1009 , A61N2005/1023
摘要： A point-of-care seed stranding device for automating assembly of brachytherapy seed strands for implantation in patients. The device includes a number of features to reduce the potential for mistakes by the user, as well as to reduce the potential for damaging the radioactive seeds during the stranding process. Tactile feedback may be provided to prevent exertion of too much force in the packing step of the stranding process, as well as to indicate that the seed and/or strand cartridges are empty and need to be replaced. The device may also include a mechanism for holding seeds or spacers in place to allow automated packing of seeds or spacers having corresponding geometries. The device may also be provided with a seed counter which can be employed to preset the number of seeds in a strand and which disables the device from dispensing or packing additional seeds once the preset number of seeds has been packed into the strand. Also, methods for automated assembly of seed strands including the steps of setting the number of seeds, dispensing seeds and spacers, packing seeds and spacers and transferring assembled strands to another device.
摘要翻译：一种用于自动装配近距离放射治疗种子股的护理种子绞合装置，用于植入患者。该装置包括许多特征，以减少使用者的错误的可能性，以及减少在绞合过程中损坏放射性种子的可能性。可以提供触觉反馈以防止在绞合过程的包装步骤中施加过大的力，并且指示种子和/或线束筒是空的并且需要更换。该装置还可以包括用于将种子或间隔物保持在适当位置以允许自动包装具有相应几何形状的种子或间隔物的机构。该装置还可以具有种子计数器，该种子计数器可用于预定股线中的种子数量，并且一旦预定数量的种子已经被包装到股线中，该种子计数器就禁止装置分配或包装额外的种子。此外，种子股线的自动装配的方法包括以下步骤：设定种子数量，分配种子和间隔物，包装种子和间隔物并将组装的股转移到另一装置。

8. 发明申请

US20110054447A1 LOCKABLE DRAINAGE CATHETER 审中-公开
标题翻译：可锁式排水导管
公开(公告)号：US20110054447A1
公开(公告)日：2011-03-03
申请号：US12548974
申请日：2009-08-27
申请人： Thomas R. Johnson , Andrew L. Cote, SR. , Yem Chin , Paul M. Scopton
发明人： Thomas R. Johnson , Andrew L. Cote, SR. , Yem Chin , Paul M. Scopton
IPC分类号： A61M25/00
CPC分类号： A61M27/00 , A61M1/008 , A61M25/007 , A61M25/0097 , A61M25/0147 , A61M25/04 , A61M2025/0078 , A61M2025/0163
摘要： A drainage catheter includes a shaft having a flexible distal portion to be anchored in a cavity of a patient and a proximal portion attached to a hub. The hub includes a side port with a deformable sealing insert having self-sealing passageways for tensioning members, such as nylon filaments, passing through the catheter shaft and exiting the side port. The tensioning members are pulled proximally to deform and thereby anchor the distal portion of the catheter. Excess filament length is wrapped around a resilient pinch washer and held inside a groove in the pinch washer, with the groove thereafter compressed by a C-clip to secure the excess filament length inside the groove.
摘要翻译：引流导管包括具有待固定在患者空腔中的柔性远端部分和附接到轮毂的近端部分的轴。毂包括具有可变形密封插入件的侧端口，其具有用于张紧构件（例如穿过导管轴并离开侧端口的尼龙细丝）的自密封通道。张紧构件被向近侧拉动以变形，从而锚定导管的远端部分。过多的细丝长度缠绕在弹性夹紧垫圈周围，并保持在夹紧垫圈中的凹槽内，随后槽被C形夹压缩，以将多余的长丝固定在凹槽内。

9. 发明授权

US07662082B2 Expandable brachytherapy device 有权
标题翻译：可扩展近距离放射治疗装置
公开(公告)号：US07662082B2
公开(公告)日：2010-02-16
申请号：US11266994
申请日：2005-11-04
申请人： Jack C. White , David Wesley Stephens , Amit Prakash Govil , Joshua J. Bergman , Nathan Christopher Griffith , Kyle Kevin Millage
发明人： Jack C. White , David Wesley Stephens , Amit Prakash Govil , Joshua J. Bergman , Nathan Christopher Griffith , Kyle Kevin Millage
IPC分类号： A61N5/00
CPC分类号： A61N5/1015 , A61M29/02 , A61N5/1007 , A61N2005/1008 , A61N2005/1018 , A61N2005/1024
摘要： A brachytherapy device for the provision of brachytherapy is disclosed. The brachytherapy device has at least one source lumen located outside a movable surface of the device. The source lumen may be secured to the movable outer surface in a manner whereby relative movement of the source lumen relative to the movable outer surface is permitted. The brachytherapy device is inserted into a body cavity. After insertion, the movable surface is moved to position the at least one source lumen closer to the tissue boundary of the cavity. One or more sources of radiation are then placed within the at least one source lumen to provide a customizable treatment. Also disclosed are methods for providing brachytherapy via body cavities.
摘要翻译：公开了一种用于提供近距离放射治疗的近距离放射治疗装置。近程放射治疗装置具有位于装置的可移动表面外部的至少一个源腔。源腔可以以允许源腔相对于可移动外表面的相对运动的方式固定到可移动外表面。近距离放射治疗装置插入体腔。在插入之后，可移动表面被移动以使至少一个源管腔更靠近腔的组织边界。然后将一个或多个辐射源放置在至少一个源腔内以提供可定制的治疗。还公开了通过体腔提供近距离放射治疗的方法。

10. 发明授权

US07497819B2 Expandable brachytherapy device 有权
公开(公告)号：US07497819B2
公开(公告)日：2009-03-03
申请号：US11682681
申请日：2007-03-06
申请人： Jack C. White , David Wesley Stephens , Amit Prakash Govil , Joshua J. Bergman , Nathan Christopher Griffith , Kyle Kevin Millage
发明人： Jack C. White , David Wesley Stephens , Amit Prakash Govil , Joshua J. Bergman , Nathan Christopher Griffith , Kyle Kevin Millage
IPC分类号： A61N5/00
CPC分类号： A61N5/1015 , A61M29/02 , A61N5/1007 , A61N2005/1008 , A61N2005/1018 , A61N2005/1024
摘要： A brachytherapy device for the provision of brachytherapy is disclosed. The brachytherapy device has at least one source lumen located outside a movable surface of the device. The source lumen may be secured to the movable outer surface in a manner whereby relative movement of the source lumen relative to the movable outer surface is permitted. The brachytherapy device is inserted into a body cavity. After insertion, the movable surface is moved to position the at least one source lumen closer to the tissue boundary of the cavity. One or more sources of radiation are then placed within the at least one source lumen to provide a customizable treatment. Also disclosed are methods for providing brachytherapy via body cavities.

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