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1. 发明授权

US09302013B2 Active principle for mitigating undesired medical conditions 有权
标题翻译：缓解不良医疗状况的主动原则
公开(公告)号：US09302013B2
公开(公告)日：2016-04-05
申请号：US13982492
申请日：2012-01-25
申请人： Tim Bowden , Kristoffer Bergman , Thomas Engstrand , Lennart Soderberg
发明人： Tim Bowden , Kristoffer Bergman , Thomas Engstrand , Lennart Soderberg
IPC分类号： A61K47/48 , A61K31/765 , A61K31/785
CPC分类号： A61K47/58 , A61K9/0014 , A61K31/765 , A61K31/785 , A61K31/787 , A61K47/32 , A61K47/61 , A61L26/00
摘要： A composition for treating or preventing inflammatory-related conditions includes as an active principle a carrier which exhibits a plurality of a scavenger structure capable of mitigating the activity of a mediator of inflammatory-related conditions. The scavenger structure includes a nucleophilic center complying with the formula X1(—R″—)(—R′)mHn where: a) X1 is a single-bonded heteroatom selected amongst N, O and S and exhibits a free electron pair; b) m is 0 or 1 and n is 1 or 2; c) —R″— is a bivalent organic group providing attachment to the carrier via one of its free valences and to X1 at the other free valence; and d) R′— is a monovalent organic group attached to the X1 via its free valence. A method for treating or preventing inflammatory-related conditions in an individual suffering from such conditions includes: providing the composition; and contacting the mediator within or separate from the individual.
摘要翻译：用于治疗或预防炎症相关病症的组合物包括作为活性成分的载体，其显示出能够减轻炎性相关病症介质活性的多种清道夫结构。清除结构包括符合式X1（-R“ - ）（ - R'）mHn的亲核中心，其中：a）X1是选自N，O和S中的单键合杂原子，并表现出自由电子对; b）m为0或1，n为1或2; c）-R“ - 是一种二价有机基团，其通过其自由价中的一种与另一种游离价的X 1连接至载体; 和d）R'是通过其自由价与X1连接的一价有机基团。用于治疗或预防患有这种病症的个体的炎症相关病症的方法包括：提供组合物; 并且在个体内或与个体分开时将介体接触。

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