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1. 发明申请

US20130096679A1 Mechanically Competent Scaffold for Ligament and Tendon Regeneration 有权
标题翻译：机械支架用于韧带和肌腱再生
公开(公告)号：US20130096679A1
公开(公告)日：2013-04-18
申请号：US13693878
申请日：2012-12-04
申请人： Soft Tissue Regeneration, Inc.
发明人： Cato T. Laurencin , Mark T. Aronson , Lakshmi Sreedharan Nair
IPC分类号： A61F2/08
CPC分类号： A61F2/08 , A61F2/0077 , A61F2250/0023 , A61F2250/003 , A61L27/14 , A61L27/58 , A61L2430/10
摘要： A multi-region device for repair, regeneration or reconstruction in articular tissue injury such as torn ligaments and tendons is provided. The device comprises at least one degradable material and biocompatible non-degradable polymeric fiber-based material, in a three-dimensional braided scaffold. The two end sections are designed for attachment of the device at the site of implantation and are designed to allow bone cell ingrowth, and one or more middle regions are designed to allow ligament or tendon cell ingrowth.
摘要翻译：提供了一种用于关节组织损伤如撕裂的韧带和腱的修复，再生或重建的多区域装置。该装置包括在三维编织支架中的至少一种可降解材料和生物相容性不可降解聚合纤维基材料。两个端部设计用于在植入部位处的装置的附接，并被设计成允许骨细胞向内生长，并且一个或多个中间区域被设计成允许韧带或肌腱细胞向内生长。

2. 发明申请

US20110238179A1 Mechanically Competent Scaffold for Rotator Cuff and Tendon Augmentation 有权
标题翻译：用于旋转器袖口和肌腱增强的机械能力支架
公开(公告)号：US20110238179A1
公开(公告)日：2011-09-29
申请号：US12730965
申请日：2010-03-24
申请人： Cato T. Laurencin , Mark T. Aronson , Lakshmi Sreedharan Nair , Joseph W. Reilly
发明人： Cato T. Laurencin , Mark T. Aronson , Lakshmi Sreedharan Nair , Joseph W. Reilly
IPC分类号： A61F2/08
CPC分类号： A61B17/1146 , A61F2/08 , D04C1/02 , D10B2509/00
摘要： A device has been developed to augment the rotator cuff tendon tissue as it proceeds in healing. The device has two purposes: to provide initial stability to the rotator cuff repair site to allow early mobilization of the upper extremity of the patient, and to allow for reinforcement of rotator cuff tendon repairs to increase the likelihood of successful rotator cuff tendon repairs. The device consists of an inter-connected, open pore structure that enables even and random distribution and in-growth of tendon cells. The braided structure allows for distribution of mechanical forces over a larger area of tissue at the fixation point(s).
摘要翻译：已经开发了一种装置，用于在愈合过程中增加肩袖肌腱组织。该装置具有两个目的：为肩袖修复部位提供初始稳定性，以允许患者上肢的早期动员，并且允许加强肩袖肌腱修复以增加成功的肩袖肌腱修复的可能性。该装置由相互连接的开放孔结构组成，能够均匀和随机分布和生长腱细胞。编织结构允许在固定点处的较大区域的组织上分布机械力。

3. 发明授权

US09433489B2 Absorbable synthetic braided matrix for breast reconstruction and hernia repair 有权
标题翻译：用于乳房重建和疝修补的可吸收合成编织基质
公开(公告)号：US09433489B2
公开(公告)日：2016-09-06
申请号：US13795294
申请日：2013-03-12
申请人： Soft Tissue Regeneration, Inc.
发明人： Joseph W. Reilly , Cato T. Laurencin
IPC分类号： A61F2/00 , D04C1/06 , A61F2/12
CPC分类号： A61F2/0063 , A61F2/12 , A61F2002/0068 , D04C1/06 , D10B2509/08
摘要： A braided, rather than woven, three-dimensional matrix has been developed to provide mechanical support in breast reconstruction or a mastopexy procedure. The braided three-dimensional matrix may be used to assist in hernia repair procedures. The matrix is a supple, strong, and flexible material, that can increase 50% to 100% in size when stretched along the vertical plane, but only extends by about 10% to 20% in length when stretched along the horizontal plane. Although the matrix is degradable, it provides sufficient mechanical and structural support for six to twelve months following implantation to allow for repair or growth of the breast tissue or the abdominal wall. The matrix is formed of three-dimensional braided multifilament polymeric fibers plied to create yarn bundles, and wherein the matrix comprises an inter-connected, open pore structure that enables even and random distribution and in-growth of cells.
摘要翻译：已经开发了编织而不是编织的三维矩阵，以在乳房重建或乳房解剖过程中提供机械支撑。编织三维矩阵可用于辅助疝修补程序。该基质是柔软，坚固且柔软的材料，当沿着垂直平面拉伸时，可以增加50％至100％的尺寸，但是当沿着水平面拉伸时，其仅延伸约10％至20％的长度。尽管基质是可降解的，但它在植入后六至十二个月可提供足够的机械和结构支持，以允许乳房组织或腹壁的修复或生长。基质由三维编织的复丝聚合物纤维形成，以生成纱线束，并且其中基质包括互连的开孔结构，其能够均匀和随机分布和生长细胞。

4. 发明授权

US08486143B2 Mechanically competent scaffold for ligament and tendon regeneration 有权
标题翻译：用于韧带和肌腱再生的机械性能支架
公开(公告)号：US08486143B2
公开(公告)日：2013-07-16
申请号：US12649913
申请日：2009-12-30
申请人： Cato T. Laurencin , Mark T. Aronson , Lakshimi Sreedharan Nair
发明人： Cato T. Laurencin , Mark T. Aronson , Lakshimi Sreedharan Nair
IPC分类号： A61F2/08
CPC分类号： A61F2/08 , A61F2/0077 , A61F2250/0023 , A61F2250/003 , A61L27/14 , A61L27/58 , A61L2430/10
摘要： A multi-region device for repair, regeneration or reconstruction in articular tissue injury such as torn ligaments and tendons is provided. The device comprises at least one degradable material and biocompatible non-degradable polymeric fiber-based material, in a three-dimensional braided scaffold. The two end sections are designed for attachment of the device at the site of implantation and are designed to allow bone cell ingrowth, and one or more middle regions are designed to allow ligament or tendon cell ingrowth.
摘要翻译：提供了一种用于关节组织损伤如撕裂的韧带和腱的修复，再生或重建的多区域装置。该装置包括在三维编织支架中的至少一种可降解材料和生物相容性不可降解聚合纤维基材料。两个端部设计用于在植入部位处的装置的附接，并被设计成允许骨细胞向内生长，并且一个或多个中间区域被设计成允许韧带或肌腱细胞向内生长。

5. 发明授权

US08758437B2 Mechanically competent scaffold for ligament and tendon regeneration 有权
标题翻译：用于韧带和肌腱再生的机械性能支架
公开(公告)号：US08758437B2
公开(公告)日：2014-06-24
申请号：US13693878
申请日：2012-12-04
申请人： Soft Tissue Regeneration, Inc.
发明人： Cato T. Laurencin , Mark T. Aronson , Lakshmi Sreedharan Nair
IPC分类号： A61F2/08
CPC分类号： A61F2/08 , A61F2/0077 , A61F2250/0023 , A61F2250/003 , A61L27/14 , A61L27/58 , A61L2430/10
摘要： A multi-region device for repair, regeneration or reconstruction in articular tissue injury such as torn ligaments and tendons is provided. The device comprises at least one degradable material and biocompatible non-degradable polymeric fiber-based material, in a three-dimensional braided scaffold. The two end sections are designed for attachment of the device at the site of implantation and are designed to allow bone cell ingrowth, and one or more middle regions are designed to allow ligament or tendon cell ingrowth.
摘要翻译：提供了一种用于关节组织损伤如撕裂的韧带和腱的修复，再生或重建的多区域装置。该装置包括在三维编织支架中的至少一种可降解材料和生物相容性不可降解聚合纤维基材料。两个端部设计用于在植入部位处的装置的附接，并被设计成允许骨细胞向内生长，并且一个或多个中间区域被设计成允许韧带或肌腱细胞向内生长。

6. 发明申请

US20100298937A1 MECHANICALLY COMPETENT SCAFFOLD FOR LIGAMENT AND TENDON REGENERATION 有权
标题翻译：机械和电力再生的机会性能
公开(公告)号：US20100298937A1
公开(公告)日：2010-11-25
申请号：US12649913
申请日：2009-12-30
申请人： Cato T. Laurencin , Mark T. Aronson , Lakshmi Sreedharan Nair
发明人： Cato T. Laurencin , Mark T. Aronson , Lakshmi Sreedharan Nair
IPC分类号： A61F2/08
CPC分类号： A61F2/08 , A61F2/0077 , A61F2250/0023 , A61F2250/003 , A61L27/14 , A61L27/58 , A61L2430/10
摘要： A multi-region device for repair, regeneration or reconstruction in articular tissue injury such as torn ligaments and tendons is provided. The device comprises at least one degradable material and biocompatible non-degradable polymeric fiber-based material, in a three-dimensional braided scaffold. The two end sections are designed for attachment of the device at the site of implantation and are designed to allow bone cell ingrowth, and one or more middle regions are designed to allow ligament or tendon cell ingrowth.
摘要翻译：提供了一种用于关节组织损伤如撕裂的韧带和腱的修复，再生或重建的多区域装置。该装置包括在三维编织支架中的至少一种可降解材料和生物相容性不可降解聚合纤维基材料。两个端部设计用于在植入部位处的装置的附接，并被设计成允许骨细胞向内生长，并且一个或多个中间区域被设计成允许韧带或肌腱细胞向内生长。

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