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1. 发明授权

US07235628B2 Analogues of GLP-1 失效
标题翻译： GLP-1的类似物
公开(公告)号：US07235628B2
公开(公告)日：2007-06-26
申请号：US11145782
申请日：2005-06-06
申请人： Zheng Xin Dong
发明人： Zheng Xin Dong
IPC分类号： C07K14/435 , C07K14/605
CPC分类号： C07K14/605 , A61K38/00
摘要： The present invention is directed to peptide analogues of glucagon-like peptide-1, the pharmaceutically-acceptable salts thereof, to methods of using such analogues to treat mammals and to pharmaceutical compositions useful thereof comprising said analogues.
摘要翻译：本发明涉及胰高血糖素样肽-1的肽类似物，其药学上可接受的盐，涉及使用这些类似物治疗哺乳动物的方法以及包含所述类似物的药物组合物。

2. 发明授权

US07078434B1 Use of Ginkgo extract 失效
标题翻译：使用银杏提取物
公开(公告)号：US07078434B1
公开(公告)日：2006-07-18
申请号：US10018448
申请日：2000-08-11
申请人： Katy Drieu , Vassilios Papadopoulos
发明人： Katy Drieu , Vassilios Papadopoulos
IPC分类号： A61K31/34 , A61K36/16
CPC分类号： A61K31/34 , A61K36/16
摘要： The present invention is directed to the use of the extract of Ginkgo biloba leaves or isolated Ginkgolide B (GKB), a component of the extract of Ginkgo biloba leaves in a method for decreasing the expression of peripheral-type benzodiazepine receptor (PBR) in cells of a patient in need thereof. Further, the present invention is directed to the use of the extract of Ginkgo biloba leaves or isolated GKB in a method for decreasing the proliferation of cancer cells in a patient. More particularly, the present invention is directed to the use of the extract of Ginkgo biloba leaves or isolated GKB in a method of decreasing cancer cell proliferation in a patient wherein the cancer cell is human breast cancer cell. Even more particularly, the present invention is directed to the use of the extract of Ginkgo biloba leaves or isolated GKB in method of decreasing cancer cell proliferation in a patient wherein the cancer cell is of the aggressive and invasive phenotype and expresses high levels of PBR in comparison to non-aggressive cancer cell.
摘要翻译：本发明涉及银杏提取物或银杏叶提取物的分离银杏内酯B（GKB）提取物在细胞中降低外周型苯二氮受体（PBR）表达的方法中的用途。的需要的患者。此外，本发明涉及银杏叶提取物或分离的GKB在减少患者癌细胞增殖的方法中的用途。更具体地，本发明涉及银杏叶提取物或分离的GKB在癌细胞是人乳腺癌细胞的患者中降低癌细胞增殖的方法中的用途。更具体地，本发明涉及银杏提取物或分离的GKB在降低癌细胞增殖的方法中的用途，其中癌细胞具有侵袭性和侵袭性表型，并且表达高水平的PBR 与非侵袭性癌细胞的比较。

3. 发明授权

US07632811B2 Analogs of parathyroid hormone 失效
标题翻译：甲状旁腺激素类似物
公开(公告)号：US07632811B2
公开(公告)日：2009-12-15
申请号：US11094662
申请日：2005-03-30
申请人： Zheng Xin Dong
发明人： Zheng Xin Dong
IPC分类号： A61K38/29 , C07K14/635
CPC分类号： A61K31/66 , A61K38/00 , A61K38/23 , A61K38/24 , C07K14/635 , A61K2300/00
摘要： The present invention is directed to peptide analogues of fragment of parathyroid hormone (PTH) or parathyroid hormone-related protein (PTHrP), a method of using said analogues alone or in combination with a bisphosphonate or calcitonin to treat osteoporosis and pharmaceutical compositions comprising said analogues alone or in combination with a bisphosphonate or calcitonin.
摘要翻译：本发明涉及甲状旁腺激素（PTH）或甲状旁腺激素相关蛋白（PTHrP）的片段的肽类似物，单独使用所述类似物或与二膦酸盐或降钙素联合治疗骨质疏松症的方法和包含所述类似物的药物组合物单独或与二膦酸盐或降钙素组合。

4. 发明授权

US07238695B2 Imidazolyl derivatives 失效
标题翻译：咪唑衍生物
公开(公告)号：US07238695B2
公开(公告)日：2007-07-03
申请号：US10771725
申请日：2004-02-04
申请人： Christophe Alain Thurieau , Lydie Francine Poitout , Marie-Odile Galcera , Christophe Philippe Moinet , Thomas D. Gordon , Barry A. Morgan
发明人： Christophe Alain Thurieau , Lydie Francine Poitout , Marie-Odile Galcera , Christophe Philippe Moinet , Thomas D. Gordon , Barry A. Morgan
IPC分类号： A01N43/50 , A61K31/415 , C07D233/00 , C07D413/00 , C07D403/00
CPC分类号： C07D233/64 , C07D401/14 , C07D403/06 , C07D403/14 , C07D405/14 , C07D409/14 , C07D471/04 , C07D471/10 , C07D487/04 , C07D491/14
摘要： The present invention is directed to imidazolyl derivatives or pharmaceutically acceptable salts thereof which are useful as agonists or antagonists of somatostatin receptors, having the following formula (I), wherein the substituents are defined in the specification.
摘要翻译：本发明涉及咪唑基衍生物或其药学上可接受的盐，其可用作生长抑素受体的激动剂或拮抗剂，具有下式（I），其中取代基在说明书中定义。

5. 发明授权

US07084135B1 Prenyl transferase inhibitors 失效
标题翻译：丙烯酰转移酶抑制剂
公开(公告)号：US07084135B1
公开(公告)日：2006-08-01
申请号：US09868356
申请日：1999-12-30
申请人： Thomas D. Gordon , Barry A. Morgan
发明人： Thomas D. Gordon , Barry A. Morgan
IPC分类号： A61P35/00 , A61K31/55 , C07D487/00
CPC分类号： C07D487/04 , C07D513/14
摘要： A family of imidazole compounds useful for inhibiting the activity of prenyl transferases. The compounds are covered by formula (I): wherein X is (CHR11)n3(CH2)n4Z(CH2)n5 where Z is O, N(R12), S, or a bond; Y is CO, CH2, CS, or a bond; R1 is A, B, C, D, E, F, G, H, I, J or N(R24R25); and the remaining substituents are as defined in the disclosure
摘要翻译：用于抑制异戊烯基转移酶活性的咪唑化合物家族。化合物被式（I）所覆盖：其中X是（CHR 11）n3（CH 2）n4

6. 发明申请

US20050026827A1 Octapeptide bombesin analogs 审中-公开
标题翻译：八肽铃蟾肽类似物
公开(公告)号：US20050026827A1
公开(公告)日：2005-02-03
申请号：US10788563
申请日：2004-02-27
申请人： David Coy , Jacques-Pierre Moreau , Sun Kim
发明人： David Coy , Jacques-Pierre Moreau , Sun Kim
IPC分类号： A61K38/00 , C07K7/02 , C07K7/08 , C07K7/18 , C07K14/575 , C07K14/685 , A61K38/17
CPC分类号： C07K7/086 , A61K38/00 , C07K7/02 , C07K7/18 , C07K14/57572 , C07K14/685
摘要： A linear (i.e., non-cyclic) analog of biologically active amphibian bombesin, mammalian gastrin-releasing peptide (GRP), or mammalian growth hormone releasing factor (GRF), having an active site and a binding site responsible for the binding of the peptide to a receptor on a target cell. Cleavage of a peptide bond in the active site of naturally occurring bombesin, GRP, or GRF is unnecessary for in vivo biological activity. The analog has one of the following modifications: (a) a deletion of an amino acid residue within the active site and a modification of an amino acid residue outside of the active site, (b) a replacement of two amino acid residues within the active site with a synthetic amino acid, a β-amino acid, or a γ-amino acid residue, or (c) a non-peptide bond. instead of a peptide bond between an amino acid residue of the active site and an adjacent amino acid residue.
摘要翻译：具有活性位点和负责肽结合的结合位点的生物活性水陆两栖铃蟾肽，哺乳动物胃泌素释放肽（GRP）或哺乳动物生长激素释放因子（GRF）的线性（即非循环）类似物到目标细胞上的受体。在天然存在的铃蟾肽，GRP或GRF的活性位点中肽键的切割对于体内生物活性是不必要的。类似物具有以下修饰之一：（a）活性位点内的氨基酸残基的缺失和活性位点之外的氨基酸残基的修饰，（b）在活性位点内置换两个氨基酸残基具有合成氨基酸，β-氨基酸或γ-氨基酸残基的位点，或（c）非肽键。而不是活性位点的氨基酸残基与相邻氨基酸残基之间的肽键。

7. 发明授权

US07410948B2 Analogs of parathyroid hormone 失效
标题翻译：甲状旁腺激素类似物
公开(公告)号：US07410948B2
公开(公告)日：2008-08-12
申请号：US11684383
申请日：2007-03-09
申请人： Zheng Xin Dong
发明人： Zheng Xin Dong
IPC分类号： A61K38/29 , C07K14/635
CPC分类号： A61K38/29 , A61K38/23 , C07K14/635 , A61K2300/00
摘要： The present invention is directed to peptide analogues of fragment of parathyroid hormone (PTH) or parathyroid hormone-related protein (PTHrP), a method of using said analogues alone or in combination with a bisphosphonate or calcitonin to treat osteoporosis and pharmaceutical compositions comprising said analogues alone or in combination with a bisphosphonate or calcitonin.
摘要翻译：本发明涉及甲状旁腺激素（PTH）或甲状旁腺激素相关蛋白（PTHrP）的片段的肽类似物，单独使用所述类似物或与二膦酸盐或降钙素联合治疗骨质疏松症的方法和包含所述类似物的药物组合物单独或与二膦酸盐或降钙素组合。

8. 发明授权

US07241737B2 Urotensin-II agonists and antagonists 失效
标题翻译：促肾上腺素Ⅱ激动剂和拮抗剂
公开(公告)号：US07241737B2
公开(公告)日：2007-07-10
申请号：US10399542
申请日：2001-10-19
申请人： David H. Coy , Wojciech J. Rossowski , John E. Taylor
发明人： David H. Coy , Wojciech J. Rossowski , John E. Taylor
IPC分类号： A61K38/08 , C07K7/06
CPC分类号： C07K7/52 , A61K38/00 , C07K14/57509
摘要： The present invention is directed to a novel class of cyclic polypeptides of the formula: (R1)a-AA1-cyclo[AA2-AA3-AA4-AA5-AA6-Cys]-AA7-R2, pharmaceutically acceptable salts thereof, wherein the variables are as defined in the specification, which inhibit the effects of urotensin-II and are useful for treating a variety of diseases and/or conditions characterized by an excess of urotensin-II including ischaemic heart disease, congestive heart failure, portal hypertension, variceal bleeding, hypotension, angina pectoris, myocardial infarction, ulcers, anxiety, schizophrenia, manic depression, delirium, dementia, mental retardation and/or dyskinesias.
摘要翻译：本发明涉及一类新型的下式的环状多肽：（R 1）a-A 1 - 环[AA] SUP→2→A→3→A→4→A→5→A→6→Cys〕其中所述变量如本说明书中所定义，其抑制泌尿生长素-2的作用，并且可用于治疗多种疾病和/或病症，其特征在于过量的泌尿生长素II，包括缺血性心脏病，充血性心力衰竭，门静脉高压，静脉曲张出血，低血压，心绞痛，心肌梗死，溃疡，焦虑，精神分裂症，躁狂抑郁，del妄，痴呆，精神发育迟滞和/或运动障碍。

9. 发明授权

US07205378B2 Lactone bearing absorbable polymers 失效
标题翻译：内酯可吸收聚合物
公开(公告)号：US07205378B2
公开(公告)日：2007-04-17
申请号：US11114452
申请日：2005-04-26
申请人： Francis X. Ignatious
发明人： Francis X. Ignatious
IPC分类号： C08G64/00
CPC分类号： A61K9/0019 , A61K9/0043 , A61K9/0073 , A61K9/5031 , A61K38/043 , A61K38/046 , A61K38/09 , A61K38/105 , A61K38/2235 , A61K38/23 , A61K38/24 , A61K38/25 , A61K38/26 , A61K38/29 , A61K38/31 , A61K38/34 , A61K47/593 , A61K47/60 , A61K47/62 , C08G63/08 , C08G63/199 , C08G63/672 , C08G64/00 , C08G64/0208 , C08G67/04 , Y10T428/1352
摘要： The present invention pertains to biodegradable polymers comprising a non-polymerizable lactone, biodegradable compositions comprising the polymer and a therapeutic agent, the use of the compositions for the sustained release of therapeutic agents, wherein the therapeutic agent is reversibly immobilized on the polymer matrix using ionic complexation between the latent carboxylic groups present on the lactone bearing polymer matrix and a cationic group on the therapeutic agent.
摘要翻译：本发明涉及包含不可聚合内酯的可生物降解的聚合物，包含聚合物和治疗剂的可生物降解的组合物，所述组合物用于治疗剂的持续释放的用途，其中所述治疗剂使用离子性可逆地固定在所述聚合物基质上存在于含有内酯的聚合物基质上的潜在羧基与治疗剂上的阳离子基团之间的络合。

10. 发明申请

US20070020294A1 Use of botulinum toxin for treatment of articular pathologies 审中-公开
标题翻译：使用肉毒杆菌毒素治疗关节病变
公开(公告)号：US20070020294A1
公开(公告)日：2007-01-25
申请号：US11527510
申请日：2006-09-27
申请人： Corrado Marchini , Fabiano Pinat , Fabio Pinat , Francesca Zecchini
发明人： Corrado Marchini , Fabiano Pinat , Fabio Pinat , Francesca Zecchini
IPC分类号： A61K39/08 , A61K38/38
CPC分类号： A61K38/4893 , Y10T436/10 , Y10T436/108331
摘要： Use of botulinum toxin to obtain a product intended to be administered intramuscular with lissive effect in treating articular pathologies, particularly coxarthrosis, or arthrosis of the hip, epicondylitis of the elbow and rotator muscle cap pathology of the shoulder.
摘要翻译：使用肉毒杆菌毒素来获得旨在肌肉内给药的产品，用于治疗关节病变，特别是关节炎，髋关节炎，肘部上髁炎和肩关节旋转肌肉盖病理学。

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