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1. 发明申请

US20120029030A1 METHOD FOR CUSTOMIZED DISPENSING OF VARIABLE DOSE DRUG COMBINATION PRODUCTS FOR INDIVIDUALIZING OF THERAPIES 有权
标题翻译：用于个体化治疗的可变剂量药物组合产品的定制分配方法
公开(公告)号：US20120029030A1
公开(公告)日：2012-02-02
申请号：US13197486
申请日：2011-08-03
申请人： Richard L. Kirsh , Steven D. Finkelmeier , Robert Glinecke , Luigi Martini
发明人： Richard L. Kirsh , Steven D. Finkelmeier , Robert Glinecke , Luigi Martini
IPC分类号： A61K31/4439 , A61K31/351 , A61P3/10 , A61K31/40
CPC分类号： A61K9/2095 , A23L33/30 , A61K9/2072 , A61K9/209 , A61K45/06 , Y02A90/26
摘要： Generally the method involves identifying the concentration of each of two or more active therapeutics tailored to treat a particular patient's unique metabolism and one or more diseases, communicating that information to a producer who has multiple fixed or variable concentrations of each active available, where the producer then combines the individual concentrations of each active into single units such as a tablets or pills, and distributes those indirectly or directly to the patient.
摘要翻译：通常，该方法包括确定为治疗特定患者的唯一代谢和一种或多种疾病而定制的两种或更多种活性治疗剂中的每一种的浓度，将该信息传达给具有多种固定或可变浓度的每种可用活性的生产者，其中生产者然后将每个活性物质的单个浓度合并成单个单位如片剂或丸剂，并间接地或直接地将其分配给患者。

2. 发明申请

US20110124559A1 NOVEL COMPOUNDS AS ANTAGONISTS OR INVERSE AGONISTS AT OPIOID RECEPTORS 有权
标题翻译：新化合物作为阿片受体的拮抗剂或逆转剂
公开(公告)号：US20110124559A1
公开(公告)日：2011-05-26
申请号：US12376580
申请日：2007-08-08
申请人： David John Cowan , Andrew Lamont Larkin , Cunyu Zhang , David Lee Musso , Gary Martin Green , Rodolfo Cadilla , Paul Kenneth Spearing , Michael Joseph Bishop , Jason Daniel Speake
发明人： David John Cowan , Andrew Lamont Larkin , Cunyu Zhang , David Lee Musso , Gary Martin Green , Rodolfo Cadilla , Paul Kenneth Spearing , Michael Joseph Bishop , Jason Daniel Speake
IPC分类号： A61K38/18 , C07D249/08 , A61K38/22 , A61K31/4196 , A61P3/04 , A61P3/10 , A61P9/12 , A61P25/24 , A61P25/22 , A61P25/30
CPC分类号： C07C237/48 , A61K31/166 , A61K31/381 , A61K31/4406 , A61K31/4468 , A61K31/472 , A61K31/495 , A61K31/5375 , A61K45/06 , C07C53/18 , C07C233/25 , C07C235/42 , C07C237/30 , C07C311/08 , C07C323/25 , C07C2601/14 , C07C2601/18 , C07C2602/08 , C07C2602/42 , C07C2603/74 , C07D209/08 , C07D211/60 , C07D213/38 , C07D213/56 , C07D213/81 , C07D217/02 , C07D217/04 , C07D231/12 , C07D233/64 , C07D233/70 , C07D233/72 , C07D249/06 , C07D249/08 , C07D249/10 , C07D271/06 , C07D275/02 , C07D277/32 , C07D285/10 , C07D307/52 , C07D333/20 , C07D333/24 , C07D333/38 , C07D401/10 , C07D417/12
摘要： Novel compounds which are antagonists or inverse agonists at one or more of the opioid receptors, pharmaceutical compositions containing them, to processes for their preparation.
摘要翻译：作为一种或多种阿片受体的拮抗剂或反向激动剂的新型化合物，含有它们的药物组合物，其制备方法。

3. 发明申请

US20100323329A1 Apparatus and Method for Manufacturing Customized Dentures 审中-公开
标题翻译：用于制造定制义齿的装置和方法
公开(公告)号：US20100323329A1
公开(公告)日：2010-12-23
申请号：US12918342
申请日：2009-02-20
申请人： Prasad Adusumilli , Stanley J. Lech , Zvi G. Loewy
发明人： Prasad Adusumilli , Stanley J. Lech , Zvi G. Loewy
IPC分类号： A61C13/00
CPC分类号： A61C19/00 , A61C9/0046 , A61C13/00
摘要： This disclosure relates to an apparatus and method for digitally utilizing and customizing dental features needed in the manufacture of dentures.
摘要翻译：本公开涉及用于数字利用和定制制造义齿所需的牙齿特征的装置和方法。

4. 发明申请

US20100311776A1 Novel sEH Inhibitors and their Use 审中-公开
标题翻译：新型sEH抑制剂及其用途
公开(公告)号：US20100311776A1
公开(公告)日：2010-12-09
申请号：US12864721
申请日：2009-01-30
申请人： Joseph Paul Marino, JR. , John Jeffrey McAtee
发明人： Joseph Paul Marino, JR. , John Jeffrey McAtee
IPC分类号： A61K31/506 , C07D401/04 , A61P9/12 , A61P9/10 , A61P11/06 , A61P11/00 , A61P3/10 , A61P3/04
CPC分类号： C07D401/04
摘要： The invention is directed to novel sEH inhibitors and their use in the treatment of diseases mediated by the sEH enzyme. Specifically, the invention is directed to compounds according to Formula I: wherein R1, R2, R3, R5a, R6a, A, B, K, L, M, Y, Z, l, and m are defined herein, and to pharmaceutically-acceptable salts thereof. The compounds of the invention are sEH inhibitors and can be used in the treatment of diseases mediated by the sEH enzyme, such as hypertension. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting sEH and treatment of conditions associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.
摘要翻译：本发明涉及新型sEH抑制剂及其在治疗由sEH酶介导的疾病中的用途。具体地，本发明涉及式I化合物：其中R1，R2，R3，R5a，R6a，A，B，K，L，M，Y，Z，l和m如本文所定义，其可接受的盐。本发明的化合物是sEH抑制剂，可用于治疗由sEH酶介导的疾病，例如高血压。因此，本发明进一步涉及包含本发明化合物的药物组合物。本发明还涉及使用本发明化合物或包含本发明化合物的药物组合物来抑制sEH和与之相关的病症的治疗方法。

5. 发明申请

US20100305133A1 Prolyl Hydroxylase Inhibitors 审中-公开
标题翻译：脯氨酰羟化酶抑制剂
公开(公告)号：US20100305133A1
公开(公告)日：2010-12-02
申请号：US12744704
申请日：2008-11-26
申请人： Mariela Colón , Duke M. Fitch
发明人： Mariela Colón , Duke M. Fitch
IPC分类号： A61K31/517 , C07D241/36 , C07D401/02 , C07D417/04 , C07D403/02 , A61P7/06
CPC分类号： C07D241/42 , C07D241/44 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04 , C07D409/14 , C07D413/04 , C07D417/04 , C07D417/14 , Y02A90/26
摘要： The invention described herein relates to certain quinoxaline-5-carboxamide derivatives of formula (I) which are antagonists of HIF prolyl hydroxylases and are useful for treating diseases benefiting from the inhibition of this enzyme, anemia being one example.
摘要翻译：本文描述的本发明涉及作为HIF脯氨酰羟化酶的拮抗剂的式（I）的某些喹喔啉-5-甲酰胺衍生物，可用于治疗受益于该酶的抑制的疾病，贫血是一个示例。

6. 发明申请

US20100267759A1 INHIBITORS OF Akt ACTIVITY 有权
公开(公告)号：US20100267759A1
公开(公告)日：2010-10-21
申请号：US12526111
申请日：2008-02-07
申请人： Mark A. Seefeld , Meagan B. Rouse , Dirk A. Heerding , Simon Peace , Dennis S. Yamashita , Kenneth C. McNulty
发明人： Mark A. Seefeld , Meagan B. Rouse , Dirk A. Heerding , Simon Peace , Dennis S. Yamashita , Kenneth C. McNulty
IPC分类号： A61K31/475 , C07D405/04 , A61K31/4155 , A61P35/00 , A61P19/02 , A61P35/02 , C07D403/04 , C07D409/04 , A61K31/4196 , A61K31/4178 , A61K31/4439 , A61K31/4192
CPC分类号： A61K31/4155 , A61K9/0019 , A61K9/0053 , A61K9/20 , A61K9/48 , A61K31/12 , A61K31/4178 , A61K31/4192 , A61K31/4196 , A61K31/4439 , A61K45/06 , C07D403/04 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/12 , C07D409/14
摘要： Invented are novel heterocyclic carboxamide compounds, the use of such compounds as inhibitors of protein kinase B activity and in the treatment of cancer and arthritis.

7. 发明申请

US20100249179A1 Farnesoid X Receptor Agonists 审中-公开
标题翻译：法呢型X受体激动剂
公开(公告)号：US20100249179A1
公开(公告)日：2010-09-30
申请号：US12663722
申请日：2008-06-13
申请人： David Norman Deaton , Frank Navas, III , Paul Kenneth Spearing
发明人： David Norman Deaton , Frank Navas, III , Paul Kenneth Spearing
IPC分类号： A61K31/4365 , C07D497/04 , A61P1/16 , C07D413/12 , A61K31/422 , C07D413/14 , A61K31/4439 , A61K31/423
CPC分类号： C07D413/12 , C07D261/08 , C07D413/14 , C07D495/04
摘要： The present invention provides novel isoxazole compounds, pharmaceutical compositions, therapeutic uses and processes for preparing the same.
摘要翻译：本发明提供新的异恶唑化合物，药物组合物，治疗用途及其制备方法。

8. 发明申请

US20100240642A1 1H-Indole-2-Carboxylic Acid Derivatives Useful As PPAR Modulators 审中-公开
标题翻译：可用作PPAR调制剂的1H-吲哚-2-羧酸衍生物
公开(公告)号：US20100240642A1
公开(公告)日：2010-09-23
申请号：US12438024
申请日：2007-08-31
申请人： Jeffrey Alan Oplinger , Paul Kenneth Spearing , Millard Hurst Lambert , John A. Ray , Christopher P. Laudeman , Jerzy R. Szewczyk , Pierette Banker
发明人： Jeffrey Alan Oplinger , Paul Kenneth Spearing , Millard Hurst Lambert , John A. Ray , Christopher P. Laudeman , Jerzy R. Szewczyk , Pierette Banker
IPC分类号： A61K31/404 , C07D209/42 , C07D401/04 , C07D413/10 , C07D409/12 , C07D403/10 , C07D417/10 , A61K31/4439 , A61K31/5377 , A61K31/496 , A61K31/541 , A61P3/10
CPC分类号： C07D209/42 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/04 , C07D409/12 , C07D413/10 , C07D413/12 , C07D417/10
摘要： The present invention relates to certain indole derivatives that are modulators of PPARγ, to processes for their preparation, to pharmaceutical compositions containing them and to their use in medicine.
摘要翻译：本发明涉及作为PPARγ调节剂的某些吲哚衍生物，其制备方法，含有它们的药物组合物及其在药物中的用途。

9. 发明申请

US20100179143A1 NAPHTHYRIDINE, DERIVATIVES AS P13 KINASE INHIBITORS 审中-公开
标题翻译：萘啶，衍生物作为P13激酶抑制剂
公开(公告)号：US20100179143A1
公开(公告)日：2010-07-15
申请号：US12602333
申请日：2008-05-29
申请人： Nicholas D. Adams , Joelle L. Burgess , Amita M. Chaudhari , David Knight , Cynthia A. Parrish
发明人： Nicholas D. Adams , Joelle L. Burgess , Amita M. Chaudhari , David Knight , Cynthia A. Parrish
IPC分类号： A61K31/4375 , C07D471/04 , A61K31/496 , A61K31/5377 , A61P37/06 , A61P29/00 , A61P37/08 , A61P9/00 , A61P11/06 , A61P1/18 , A61P13/12 , A61P17/06 , A61P25/00 , A61P25/28 , A61P9/10 , A61P35/00
CPC分类号： C07D471/04
摘要： Invented is a method of inhibiting the activity/function of PI3 kinases using naphthyridine derivatives. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of naphthyridine derivatives.
摘要翻译：本发明是使用萘啶衍生物抑制PI3激酶的活性/功能的方法。还发明了一种治疗选自以下的一种或多种疾病状态的方法：自身免疫性疾病，炎性疾病，心血管疾病，神经变性疾病，变态反应，哮喘，胰腺炎，多器官功能衰竭，肾脏疾病，血小板聚集，癌症，精子活力，移植排斥反应，通过施用萘啶衍生物的移植排斥和肺损伤。

10. 发明申请

US20100113444A1 PROLYL HYDROXYLASE INHIBITORS 有权
标题翻译：丙基羟基酶抑制剂
公开(公告)号：US20100113444A1
公开(公告)日：2010-05-06
申请号：US12305675
申请日：2007-06-22
申请人： Kevin J. Duffy , Duke M. Fitch , Jian Jin , Ronggang Liu , Antony N. Shaw , Kenneth Wiggall
发明人： Kevin J. Duffy , Duke M. Fitch , Jian Jin , Ronggang Liu , Antony N. Shaw , Kenneth Wiggall
IPC分类号： A61K31/506 , C07D239/60 , C07D401/04 , C07D405/04 , C07D413/06 , A61K31/505 , A61K31/5377 , A61P7/06 , A61P9/00
CPC分类号： C07D239/60 , A61K31/515 , C07D239/22 , C07D239/54 , C07D239/62 , C07D401/04 , C07D405/04 , C07D405/10 , C07D409/04 , C07D409/10 , C07D413/06 , C07D413/10 , C07D417/10
摘要： The invention described herein relates to certain pyrimidinetrione N-substituted glycine derivatives of formula (I), (I) which are antagonists of HIF prolyl hydroxylases and are useful for treating diseases benefiting from the inhibition of this enzyme, anemia being one example.
摘要翻译：本文描述的本发明涉及作为HIF脯氨酰羟化酶的拮抗剂的式（I），（I）的某些嘧啶四酮N-取代的甘氨酸衍生物，并且可用于治疗受益于该酶的抑制的疾病，贫血是一个示例。

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