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1. 发明授权

US09868757B2 5-β, 14-β-androstane derivatives useful for the treatment of proteinuria, glomerulosclerosis and renal failure 有权
公开(公告)号：US09868757B2
公开(公告)日：2018-01-16
申请号：US14931083
申请日：2015-11-03
申请人： SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.p.A.
发明人： Patrizia Ferrari , Giuseppe Bianchi , Mara Ferrandi
IPC分类号： A61K31/58 , C07J17/00 , C07J41/00 , C07J43/00
CPC分类号： C07J17/00 , C07J41/0038 , C07J43/003
摘要： Compound of formula (I), wherein the symbol have the meaning reported in the text; for preparing a medicament for the prevention and/or treatment of proteinuria, glomerulosclerosis or renal failure.

2. 发明授权

US09206133B2 Process for the synthesis of 7-chloro-4-(piperazin-1-yl)-quinoline 有权
标题翻译：合成7-氯-4-（哌嗪-1-基） - 喹啉的方法
公开(公告)号：US09206133B2
公开(公告)日：2015-12-08
申请号：US14123893
申请日：2012-06-05
申请人： Walter Cabri , Roberto Castagnani , Silvia Armaroli , Gianandrea Quattrociocchi , Vincenzo Colangeli
发明人： Walter Cabri , Roberto Castagnani , Silvia Armaroli , Gianandrea Quattrociocchi , Vincenzo Colangeli
IPC分类号： C07D401/04 , C07D215/46
CPC分类号： C07D215/46
摘要： The present invention provides a new process of synthesis of a polymorph of 7-chloro-4-(piperazin-1-yl)-quinoline of Formula I. Said quinoline compound is substantially pure of any impurities. The present invention further provides the use of the above-mentioned polymorph of 7-chloro-4-(piperazin-1-yl)-quinoline in the synthesis of piperaquine or one of its pharmaceutically acceptable salts.
摘要翻译：本发明提供了合成式I的7-氯-4-（哌嗪-1-基） - 喹啉的多晶型物的新方法。所述喹啉化合物基本上是任何杂质的纯的。本发明还提供上述7-氯-4-（哌嗪-1-基） - 喹啉的多晶型物在合成哌啶或其药学上可接受的盐之一中的用途。

3. 发明授权

US08853229B2 Composition containing statins and omega-3 fatty acids 有权
标题翻译：含有他汀类和ω-3脂肪酸的组合物
公开(公告)号：US08853229B2
公开(公告)日：2014-10-07
申请号：US11632953
申请日：2005-07-19
申请人： Claudio Cavazza
发明人： Claudio Cavazza
IPC分类号： A61K31/505 , A61K31/202 , A61K33/30 , A61K31/4433 , A61K31/366 , A61K33/04 , A61K31/175 , A61K31/045 , A61K45/06 , A61K31/122 , A61K31/05
CPC分类号： A61K45/06 , A61K31/045 , A61K31/05 , A61K31/122 , A61K31/175 , A61K31/202 , A61K31/366 , A61K31/4433 , A61K33/04 , A61K33/30 , A61K2300/00
摘要： A combination is described comprising at least one omega-3 fatty acid, optionally esterified or salified, at least one statin, Coenzyme Q10, resveratrol, at least one policosanol, pantethine, selenium, and zinc. This combination is endowed with a synergistic effect and is useful in the treatment of disease forms due to insulin resistance and in cardiovascular diseases.
摘要翻译：描述了包含至少一种ω-3脂肪酸，任选酯化或成盐，至少一种他汀类，辅酶Q10，白藜芦醇，至少一种二十烷醇，泛胺，硒和锌的组合。该组合具有协同作用，并且可用于治疗由于胰岛素抵抗和心血管疾病引起的疾病形式。

4. 发明授权

US08778389B2 Medicament for the treatment of fungal infections particularly aspergillosis 有权
标题翻译：药物用于治疗真菌感染，特别是曲霉病
公开(公告)号：US08778389B2
公开(公告)日：2014-07-15
申请号：US11579805
申请日：2005-04-28
申请人： Paolo Carminati , Giovanni Salvatori , Romani Luigina
发明人： Paolo Carminati , Giovanni Salvatori , Romani Luigina
IPC分类号： A61K9/127
CPC分类号： A61K38/1709 , A61K31/7048 , A61K2300/00
摘要： The combination of pentraxin PTX3 with antifungal agents is described for the treatment of fungal infections and particularly for infections caused by Aspergillus fumigatus. Thanks to the synergistic effect of the two drugs, the combination allows the administration of suboptimal doses of antifungal agent.
摘要翻译：描述了pentraxin PTX3与抗真菌剂的组合用于治疗真菌感染，特别是用于烟曲霉引起的感染。由于两种药物的协同效应，组合允许给予次优剂量的抗真菌剂。

5. 发明授权

US08536160B2 Azaheterocyclyl derivatives of androstanes and androstenes as medicaments for cardiovascular disorders 有权
标题翻译：雄激素和雄激素的氮杂环基衍生物作为心血管疾病的药物
公开(公告)号：US08536160B2
公开(公告)日：2013-09-17
申请号：US12296532
申请日：2007-04-11
申请人： Alberto Cerri , Giorgio Fedrizzi , Alessandra Benicchio , Giuseppe Bianchi , Patrizia Ferrari , Mauro Gobbini , Rosamaria Micheletti , Marco Pozzi , Piero Enrico Scotti
发明人： Alberto Cerri , Giorgio Fedrizzi , Alessandra Benicchio , Giuseppe Bianchi , Patrizia Ferrari , Mauro Gobbini , Rosamaria Micheletti , Marco Pozzi , Piero Enrico Scotti
IPC分类号： A61K31/58 , A61P9/12 , C07J43/00
CPC分类号： C07J43/003
摘要： Compounds of formula (I) wherein: the groups are as defined in the description, are useful for the preparation of medicaments for the treatment of cardiovascular disorders, in particular heart failure and hypertension. The compounds are inhibitors of the enzymatic activity of the Na+, K+-ATPase. They are useful for the preparation of a medicament for the treatment of a disease caused by the hypertensive effects of endogenous ouabain, such as renal failure progression in autosomal dominant polycystic renal disease (ADPKD), preeclamptic hypertension and proteinuria and renal failure progression in patients with adducin polymorphisms.
摘要翻译：式（I）化合物其中：所述基团如说明书中所定义，可用于制备用于治疗心血管疾病，特别是心力衰竭和高血压的药物。这些化合物是Na +，K + -ATP酶的酶活性的抑制剂。它们可用于制备用于治疗由内源性哇巴因的高血压作用引起的疾病的药物，例如常染色体显性多囊肾病（ADPKD）的肾衰竭进展，先兆子痫高血压和蛋白尿和肾衰竭进展 adducin多态性。

6. 发明授权

US08431617B2 Use of resveratrol for the preparation of a medicament useful for the treatment of influenza virus infections 有权
标题翻译：白藜芦醇用于制备可用于治疗流感病毒感染的药物
公开(公告)号：US08431617B2
公开(公告)日：2013-04-30
申请号：US10533942
申请日：2003-10-14
申请人： Enrico Garaci , Anna Teresa Palamara
发明人： Enrico Garaci , Anna Teresa Palamara
IPC分类号： A61K31/05
CPC分类号： A61K31/05
摘要： The use of resveratrol is described fir the preparation of a medicament for the treatment of influenza. Said medicament exerts itself in therapeutic activity through inhibition of viral replication.
摘要翻译：描述了使用白藜芦醇来制备用于治疗流感的药物。所述药物通过抑制病毒复制而发挥治疗活性。

7. 发明授权

US08394854B2 Use of L-carnitine for the treatment of cardiovascular diseases 有权
标题翻译：使用左旋肉碱治疗心血管疾病
公开(公告)号：US08394854B2
公开(公告)日：2013-03-12
申请号：US12972617
申请日：2010-12-20
申请人： Aleardo Koverech
发明人： Aleardo Koverech
IPC分类号： A61K31/205 , A61P9/10
CPC分类号： A61K45/06 , A61K31/205 , A61K31/221 , A61K31/7004 , A61K2300/00
摘要： The use of L-carnitine, or one of its pharmaceutically acceptable salts, is described in combination with glucose for the preparation of a medicament useful for diminishing the number of deaths caused by acute myocardial infarction, for reducing the number of days infarction patients spend in intensive care in hospital, and for reducing the number of episodes of post-infarction heart failure, in which the L-carnitine is administered intravenously within only a few hours of the onset of symptoms of acute myocardial infarction at an initial dose of 9 grams a day in combination with 1000-1500 mL of a 5% glucose solution for 5 days, after which the L-carnitine treatment is continued at a dose of 4 grams a day administered orally.
摘要翻译：联合使用左旋肉碱或其药学上可接受的盐之一与葡萄糖联合用于制备用于减少由急性心肌梗塞引起的死亡人数的药物，以减少患者花费的时间在医院进行重症监护，并减少梗死后心力衰竭的发作次数，其中在起始剂量为9克a的急性心肌梗死症状发作几小时内，左旋肉碱静脉注射天与1000-1500mL的5％葡萄糖溶液组合5天，之后以每天4克的剂量持续口服左旋肉碱治疗。

8. 发明授权

US08343979B2 Use of alkanoyl L-carnitine for the treatment of erectile dysfunction 有权
标题翻译：使用烷酰基L-肉毒碱治疗勃起功能障碍
公开(公告)号：US08343979B2
公开(公告)日：2013-01-01
申请号：US13280749
申请日：2011-10-25
申请人： Aleardo Koverech , Andrea Lenzi
发明人： Aleardo Koverech , Andrea Lenzi
IPC分类号： A01N43/90 , A61K31/519
CPC分类号： A61K31/485 , A61K31/205 , A61K31/415 , A61K31/519 , A61K31/557
摘要： Erectile dysfunction is treated with a combination of propionyl L-carnitine in combination with sildenafil, apomorphine prostaglandin El, pentolamine and papaverine.
摘要翻译：勃起功能障碍用丙酰肝素左旋肉碱与西地那非，阿扑吗啡前列腺素E1，五聚胺和罂粟碱组合治疗。

9. 发明申请

US20120252865A1 CARBAMATE DERIVATIVES IN PARTICULAR FOR THE TREATMENT OF NEUROLOGICAL DISORDERS 审中-公开
标题翻译：特别用于治疗神经疾病的碳酸盐衍生物
公开(公告)号：US20120252865A1
公开(公告)日：2012-10-04
申请号：US13202133
申请日：2010-03-08
申请人： Walter Cabri , Patrizia Minetti , Giuseppe Campiani , Stefania Butini
发明人： Walter Cabri , Patrizia Minetti , Giuseppe Campiani , Stefania Butini
IPC分类号： A61K31/40 , A61K31/341 , C07D207/34 , C07D333/22 , C07D307/68 , A61P25/00 , A61P3/00 , A61P9/00 , A61P11/00 , A61P1/16 , A61P1/00 , A61P35/00 , A61P21/00 , A61P25/22 , A61P25/16 , A61K31/38
CPC分类号： C07D207/34 , C07D307/56 , C07D333/26
摘要： The present invention relates to new carbamate derivatives of formula I, processes for their preparation, and to pharmaceutical compositions containing them for the treatment of neurological disorders, such as neuropathic pain and anxiety.
摘要翻译：本发明涉及式I的新型氨基甲酸酯衍生物，其制备方法，以及含有它们用于治疗神经性疾病如神经性疼痛和焦虑症的药物组合物。

10. 发明申请

US20120208883A1 TREATMENT OF ONCOLOGICAL DISEASES 审中-公开
标题翻译：治疗肿瘤疾病
公开(公告)号：US20120208883A1
公开(公告)日：2012-08-16
申请号：US13131948
申请日：2009-12-01
申请人： Claudio Cavazza , Anna Atti , Enrico Cavazza , Silvia Cavazza , Francesca Cavazza , Martina Cavazza , Paolo Carminati , Gabriella Singrossi , Silvia Carminati , Giuseppe Paolo Carminati , Claudio Pisano
发明人： Claudio Cavazza , Anna Atti , Enrico Cavazza , Silvia Cavazza , Francesca Cavazza , Martina Cavazza , Paolo Carminati , Gabriella Singrossi , Silvia Carminati , Giuseppe Paolo Carminati , Claudio Pisano
IPC分类号： A61K31/221 , A61P35/02 , A61P35/00
CPC分类号： A61K45/06 , A61K31/205 , A61K31/282 , A61K31/337 , A61K31/427 , A61K31/4745 , A61K31/475 , A61K31/513 , A61K31/555 , A61K38/14 , A61K2300/00
摘要： The present invention relates to the use of acetyl L-carnitine for the preparation of a medicament for the prevention and/or treatment of cancer. Methods of preventing and/or treatment of cancer by administering an effective amount of acetyl L-carnitine to subject in need thereof are also disclosed.
摘要翻译：本发明涉及乙酰左旋肉碱在制备用于预防和/或治疗癌症的药物中的应用。还公开了通过向有需要的受试者施用有效量的乙酰基左旋肉碱来预防和/或治疗癌症的方法。

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