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1. 发明授权

US07037323B2 Pledget-handling system and method for delivering hemostasis promoting material to a blood vessel puncture site by fluid pressure 有权
标题翻译：用于通过流体压力将止血促进材料输送到血管穿刺部位的药物处理系统和方法
公开(公告)号：US07037323B2
公开(公告)日：2006-05-02
申请号：US10732441
申请日：2003-12-09
申请人： Eduardo Chi Sing , Luis Urquidi , Mark Ashby , Andrew Cragg
发明人： Eduardo Chi Sing , Luis Urquidi , Mark Ashby , Andrew Cragg
IPC分类号： A61B17/08 , A61M31/00
CPC分类号： A61B17/0057 , A61B17/00491 , A61B2017/00637 , A61B2017/00654 , A61B2017/00672 , A61B2090/062 , A61M25/0606
摘要： A system for delivering hemostasis promoting material of the present invention allows the hemostasis promoting material to be delivered to a blood vessel puncture site by fluid pressure. The system allows the hemostasis promoting material to be delivered through an introducer sheath which is already in place within a tissue tract. This system includes a control tip which is insertable through the introducer sheath to locate and occlude the blood vessel puncture site and a hydration chamber for receiving and delivering the hemostasis promoting material to the blood vessel puncture site. The system accurately locates the blood vessel wall at a puncture site and for properly placing a hemostasis plug over the puncture site.
摘要翻译：用于输送本发明止血促进材料的系统允许止血促进材料通过流体压力输送到血管穿刺部位。该系统允许止血促进材料通过已经在组织管内已经就位的导引器鞘被递送。该系统包括能够通过引导器鞘插入以控制和闭塞血管穿刺部位的控制尖端，以及用于接收并输送止血促进材料到血管穿刺部位的水合室。系统准确地将穿刺部位的血管壁定位，并将止血塞适当地放置在穿刺部位上。

2. 发明授权

US07008440B2 System and method for delivering hemostasis promoting material to a blood vessel puncture site by fluid pressure 有权
标题翻译：通过流体压力将止血促进材料输送到血管穿刺部位的系统和方法
公开(公告)号：US07008440B2
公开(公告)日：2006-03-07
申请号：US10256493
申请日：2002-09-26
申请人： Eduardo Chi Sing , Mark Ashby , Luis Urquidi
发明人： Eduardo Chi Sing , Mark Ashby , Luis Urquidi
IPC分类号： A61B17/08
CPC分类号： A61B17/0057 , A61B17/00491 , A61B17/3498 , A61B2017/00637 , A61B2017/00654 , A61B2017/00672 , A61B2017/00898 , A61B2090/062
摘要： A system for delivering hemostasis promoting material of the present invention allows the hemostasis promoting material to be delivered to a blood vessel puncture site by fluid pressure. The system allows the hemostasis promoting material to be delivered through an producer sheath which is already in place within a tissue tract. The system includes a controlled tip which is insertable through the introducer sheath to locate and occlude the blood vessel puncture site and a hydration chamber for receiving and delivering the hemostasis promoting material to the blood vessel puncture site. The system accurately locates the blood vessel wall at a puncture site and for properly placing a hemostasis plug over the puncture site.
摘要翻译：用于输送本发明止血促进材料的系统允许止血促进材料通过流体压力输送到血管穿刺部位。该系统允许止血促进材料通过已经在组织道内就位的生产者护套递送。该系统包括可控制的尖端，其可插入穿过引导器鞘以定位和闭塞血管穿刺部位，以及用于接收并输送止血促进材料到血管穿刺部位的水合室。系统准确地将穿刺部位的血管壁定位，并将止血塞适当地放置在穿刺部位上。

3. 发明授权

US06863680B2 System and method for delivering hemostasis promoting material to a blood vessel puncture site by fluid pressure 失效
标题翻译：通过流体压力将止血促进材料输送到血管穿刺部位的系统和方法
公开(公告)号：US06863680B2
公开(公告)日：2005-03-08
申请号：US10007204
申请日：2001-11-08
申请人： Mark Ashby
发明人： Mark Ashby
IPC分类号： A61B17/00 , A61B19/00 , A61B17/08
CPC分类号： A61B17/0057 , A61B17/00491 , A61B2017/00637 , A61B2017/00654 , A61B2017/00672 , A61B2090/062
摘要： A system for delivering hemostasis promoting material of the present invention allows the hemostasis promoting material to be delivered to a blood vessel puncture site by fluid pressure. The system allows the hemostasis promoting material to be delivered through an introducer sheath which is already in place within a tissue tract. This system includes a controlled tip which is insertable through the introducer sheath to locate and occlude the blood vessel puncture site and a hydration chamber for receiving and delivering the hemostasis promoting material to the blood vessel puncture site. The system accurately locates the blood vessel wall at a puncture site and for properly placing a hemostasis plug over the puncture site.
摘要翻译：用于输送本发明止血促进材料的系统允许止血促进材料通过流体压力输送到血管穿刺部位。该系统允许止血促进材料通过已经在组织管内已经就位的导引器鞘被递送。该系统包括可控制的尖端，其可插入穿过引导器护套以定位和闭塞血管穿刺部位，以及用于接收和输送止血促进材料到血管穿刺部位的水合室。系统准确地将穿刺部位的血管壁定位，并将止血塞适当地放置在穿刺部位上。

4. 发明授权

US06846320B2 Device and method for facilitating hemostasis of a biopsy tract 有权
标题翻译：促进活检道止血的装置和方法
公开(公告)号：US06846320B2
公开(公告)日：2005-01-25
申请号：US09960389
申请日：2001-09-24
申请人： Mark Ashby , Vaughn P. Whalen , Eduardo Chi Sing
发明人： Mark Ashby , Vaughn P. Whalen , Eduardo Chi Sing
IPC分类号： A61B10/00 , A61B10/02 , A61B17/00 , A61B17/03 , A61B17/04 , A61B17/08 , A61B19/00 , A61F2/00 , A61M27/00
CPC分类号： A61B17/0057 , A61B10/02 , A61B10/0233 , A61B90/39 , A61B2017/00004 , A61B2017/00637 , A61B2017/00654
摘要： A biopsy cannula and a delivery catheter are configured to deliver one or more absorbable sponge pledgets to a biopsy site after removal of one or more tissue samples from the site. The delivery catheter allows a large amount of hydrated sponge material to be delivery to the biopsy site to facilitate hemostasis. One example of the delivery catheter includes a closed distal end, a side port, a tapered section, and an enlarged proximal portion for receiving the pledget. The side port of the delivery catheter is arranged to delivery the pledget through the side port of the biopsy cannula. In order to fill a relatively large biopsy site where multiple tissue samples have been taken in a radial pattern, the biopsy cannula is rotated and additional pledgets are delivered to the biopsy site at different radial locations. The absorbable sponge pledget may also be used as a marker for location of the biopsy site at a later time.
摘要翻译：活检插管和递送导管构造成在从该部位移除一个或多个组织样本之后将一个或多个可吸收海绵质量递送到活检部位。输送导管允许大量水合海绵材料输送到活检部位以促进止血。输送导管的一个实例包括封闭的远端，侧端口，锥形部分和用于接收毛细管的扩大的近端部分。输送导管的侧端口布置成通过活检插管的侧端口递送毛细管。为了填充已经以径向图案拍摄多个组织样本的相对较大的活检部位，旋转活检插管并且在不同的径向位置将额外的药物递送至活组织检查部位。吸收性海绵片也可以用作活检部位的位置的标记。

5. 发明申请

US20040019330A1 Sheath based blood vessel puncture locator and depth indicator 有权
标题翻译：基于护套的血管穿刺定位器和深度指示器
公开(公告)号：US20040019330A1
公开(公告)日：2004-01-29
申请号：US10302575
申请日：2002-11-22
申请人： SUB-Q, Inc., a California Corporation
发明人： Mark Ashby
IPC分类号： A61M005/178
CPC分类号： A61B17/0057 , A61B17/00491 , A61B2017/00637 , A61B2017/00654 , A61B2017/00672 , A61B2090/062
摘要： The present invention discloses a sheath based puncture locator and depth indicator. The present invention provides for locating a blood vessel puncture site and determining the depth of the puncture of the blood vessel extravascularly using the introducer sheath that is already in place within the tissue tract. The present invention also provide for positioning the introducer sheath extravascularly or outside the blood vessel, controlling the blood vessel puncture site, and delivering a hemostasis promoting material to a blood vessel puncture site.
摘要翻译：本发明公开了一种基于鞘的穿刺定位器和深度指示器。本发明提供了一种血管穿刺部位的定位，并且使用已经在组织管内已经就位的引导器套管来确定血管外血管穿刺的深度。本发明还提供了在血管外或血管外定位引导器护套，控制血管穿刺部位，并将止血促进材料输送到血管穿刺部位。

6. 发明授权

US6071300A Apparatus and method for percutaneous sealing of blood vessel punctures 失效
公开(公告)号：US6071300A
公开(公告)日：2000-06-06
申请号：US888851
申请日：1997-07-07
申请人： Rodney Brenneman , Andrew H. Cragg
发明人： Rodney Brenneman , Andrew H. Cragg
IPC分类号： A61B17/12 , A61B17/00 , A61B17/08 , A61B17/34 , A61B19/00 , A61M25/00 , A61M25/04
CPC分类号： A61M25/04 , A61B17/0057 , A61M25/0662 , A61M25/1011 , A61B17/085 , A61B2017/00557 , A61B2017/00672 , A61B90/39
摘要： A device for promoting hemostasis in a blood vessel puncture is employed with an introducer that accesses the puncture through an incision. The introducer has an open distal end positionable at the puncture, an external portion with an open proximal end, and an axial channel therebetween. The device includes a hollow catheter, dimensioned to pass through the introducer channel, having a distal end to which is attached an expansible compression element, which may be an inflatable balloon, a collapsible prong assembly, or a resilient foam pad. The compression element is collapsed when the distal end of the catheter is enclosed within the introducer. When the catheter and the introducer are located the desired distance from the puncture, the introducer is displaced axially relative to the catheter to expose the compression element to the subcutaneous tissue, whereupon the compression element is expanded. Pressure is applied to the compression element through the introducer to promote hemostasis by the compression of subcutaneous tissue adjacent the puncture. The device preferably includes a locator member passing into the blood vessel through the puncture. The locator member may be either a guide wire, or a hollow tube with a locating balloon, disposed near the portion of the tube insertable into the vessel. A dissolvable locating tip element, connected to the distal end of the catheter, may be used to maintain the position of the device while hemostasis takes place after the locator member is removed.

7. 发明授权

US5868762A Percutaneous hemostatic suturing device and method 失效
标题翻译：经皮止血缝合装置及方法
公开(公告)号：US5868762A
公开(公告)日：1999-02-09
申请号：US937939
申请日：1997-09-25
申请人： Andrew H. Cragg , Rodney Brenneman
发明人： Andrew H. Cragg , Rodney Brenneman
IPC分类号： A61B17/00 , A61B17/04
CPC分类号： A61B17/0469 , A61B17/0057 , A61B2017/00637 , A61B2017/00654 , A61B2017/00663 , A61B2017/047 , A61B2017/0472
摘要： A device for suturing a vascular puncture site includes a shaft having a distal end terminating in a pair of resilient prongs, each of which releasably carries a suture anchor attached to one end of a suture. The shaft is installed within a hollow tube for longitudinal translation therein between first and second positions. The tube has a distal end portion and an opening spaced proximally therefrom. When the shaft is in its first position, the prongs are radially closed in the distal end portion. When the shaft is in its second position, the prongs expand radially to an open position through the opening. The proximal end of the shaft is connected to an actuation member in a fitting that is removably connectable to the proximal end of a sheath. The distal end of the tube is introduced into the puncture site through the sheath, with the shaft in its first position. The sheath is partially withdrawn, leaving the distal end of the tube inside the vessel. The shaft is moved to its second position, whereupon the prongs expand to their open position, thus positioning the suture anchors for penetration of the vascular wall tissue by manipulation of the shaft and/or the tube. The shaft is moved back to its first position to retract the prongs back into the tube, leaving the suture anchors secured to the vascular wall tissue. The tube is withdrawn, leaving the sutures trailing from the anchors so as to be secured together.
摘要翻译：用于缝合血管穿刺部位的装置包括具有端部终止于一对弹性插脚的远端的轴，每个弹性插脚可释放地携带连接到缝合线的一端的缝合锚。轴安装在中空管内，用于在第一和第二位置之间纵向平移。管具有远端部分和与其近端间隔开的开口。当轴处于其第一位置时，尖端在远端部分中径向封闭。当轴处于其第二位置时，叉头径向扩张通过开口的打开位置。轴的近端连接到可拆卸地连接到护套的近端的配件中的致动构件。管的远端通过护套引入穿刺部位，轴处于第一位置。护套被部分拉出，使管的远端留在血管内。轴移动到其第二位置，于是叉头扩展到其打开位置，从而通过操纵轴和/或管来定位缝合锚固件以穿透血管壁组织。轴被移回到其第一位置以将叉头缩回到管中，留下缝合锚固件固定到血管壁组织。将管取出，留下缝合线从锚固件中脱落，以便固定在一起。

8. 发明授权

US5782861A Percutaneous hemostasis device 失效
标题翻译：经皮止血装置
公开(公告)号：US5782861A
公开(公告)日：1998-07-21
申请号：US778045
申请日：1996-12-23
申请人： Andrew H. Cragg , Rodney Brenneman
发明人： Andrew H. Cragg , Rodney Brenneman
IPC分类号： A61B17/00 , A61B17/08 , A61D1/00
CPC分类号： A61B17/0057 , A61B2017/00637
摘要： A vascular hemostasis device comprises a shaft coaxially received within a hollow tube, and having a distal end formed with an opposed pair of resilient grasping prongs. The tube has an open distal end that may be situated percutaneously adjacent a vascular puncture site. The shaft and the tube are axially movable with respect to one another, so that the distal end of the shaft may be selectively extended from and partially retracted into the distal end of the tube by means of an actuation member attached to the shaft. When the distal shaft end is in its extended position, the prongs are exposed from the distal end of the tube, and they resiliently expand to an open position. When the distal shaft end is moved to its retracted position, the prongs are partially retracted into the distal end of the tube, radially contracting them to a closed position. In contracting, the prongs grasp and gather tissue adjacent the puncture site to obstruct bleeding therefrom. In a first embodiment, the prongs are on a distal end portion, of resorbable material, that is detachable from the body of the shaft. The tube is a sleeve through which the shaft is slidably disposed, the sleeve being axially received within a trocar that is installed percutaneously to the puncture site. A second preferred embodiment includes a unitary shaft with the prongs at the distal end. The tube in which the shaft is axially disposed is the trocar itself.
摘要翻译：血管止血装置包括同轴地容纳在中空管内的轴，并且具有形成有相对的一对弹性抓握尖头的远端。管具有敞开的远端，其可以经皮位于血管穿刺部位附近。轴和管可以相对于彼此轴向移动，使得轴的远端可以通过附接到轴的致动构件选择性地延伸并且部分地缩回到管的远端中。当远端轴端处于其延伸位置时，尖头从管的远端露出，并且它们弹性地膨胀到打开位置。当远轴端移动到其缩回位置时，叉头部分地缩回到管的远端中，将其径向收缩到闭合位置。在收缩期间，尖头抓住并收集穿刺部位附近的组织以阻止其渗出。在第一实施例中，尖头在可再吸收材料的远端部分上，其可从轴的主体拆卸。管是套筒，轴可滑动地设置在其中，套筒轴向地容纳在经皮穿刺穿刺部位的套管针内。第二优选实施例包括在远端具有尖头的整体轴。轴在其中轴向设置的管是套管针本身。

9. 发明授权

US07611479B2 System and method for facilitating hemostasis of blood vessel punctures with absorbable sponge 失效
标题翻译：用吸收性海绵促进血管穿刺止血的系统和方法
公开(公告)号：US07611479B2
公开(公告)日：2009-11-03
申请号：US10319260
申请日：2002-12-13
申请人： Andrew M. Cragg , Rodney Brenneman , Mark Ashby , Eduardo Chi Sing
发明人： Andrew M. Cragg , Rodney Brenneman , Mark Ashby , Eduardo Chi Sing
IPC分类号： A61F13/20
CPC分类号： A61B17/0057 , A61B2017/00004 , A61B2017/00362 , A61B2017/00407 , A61B2017/00637 , A61B2017/00654 , A61B2017/00898 , A61F13/26 , A61F2013/00463
摘要： A system for facilitating hemostasis of a puncture site in a blood vessel injects an absorbable sponge pledget in a hydrated state to a position at an exterior of the blood vessel puncture to facilitate hemostasis. The system includes a tract dilator for locating the puncture, an introducer, and a pusher. The introducer includes a staging chamber for receiving the absorbent sponge pledget and a delivery chamber having a diameter smaller than a diameter of the staging chamber into which a hydrated pledget passes. The pledget is hydrated and compressed within the introducer and then ejected with the pusher to the delivery site to facilitate hemostasis of the blood vessel puncture. The system delivers the absorbable sponge pledget over a guidewire to ensure the proper positioning of the pledget over the puncture. The implanted absorbable sponge once delivered expands rapidly to fill the target site and is absorbed by the body over time.
摘要翻译：用于促进血管中穿刺部位止血的系统将水合状态的可吸收海绵状物质注入到血管穿刺外部的位置，以促进止血。该系统包括用于定位穿刺的管道扩张器，导引器和推动器。引导器包括用于接收吸收性海绵质量分数的分级室和具有比水合物渗透到的分级室直径小的直径的输送室。在导引器内水合并压缩毛细管，然后将推送器与推送器一起喷射到输送部位，以促进血管穿刺止血。系统通过导丝将可吸收的海绵填充物传送到导线上，以确保穿刺物在穿刺上的正确定位。植入的可吸收海绵一旦交付迅速膨胀，填补目标部位，随着时间的推移被身体吸收。

10. 发明授权

US07201725B1 Device and method for determining a depth of an incision 失效
标题翻译：用于确定切口深度的装置和方法
公开(公告)号：US07201725B1
公开(公告)日：2007-04-10
申请号：US10069107
申请日：2000-09-25
申请人： Andrew H. Cragg , Rodney Brenneman , Mark Ashby , Eduardo Chi Sing
发明人： Andrew H. Cragg , Rodney Brenneman , Mark Ashby , Eduardo Chi Sing
IPC分类号： A61B5/117 , A61B5/103
CPC分类号： A61B5/1076 , A61B5/489 , A61B17/0057 , A61B2017/00637 , A61B2017/00654 , A61B2017/00672 , A61B2090/036
摘要： A device for determining the depth of an incision from the epidermal layer to a puncture in a blood vessel in which the device includes an elongated member which has a lumen extending from a distal end to a proximal end. The distal end of the elongated member is configured to locate the blood vessel. After the device locates the blood vessel, a depth indicator is positioned to mark the depth of the blood vessel. In one embodiment, the elongated member includes a tapering interior surface which can receive a portion of the blood vessel. An extending control member may extend from the device at the distal end wherein the extending control member enters the blood vessel before the device locates the vessel. Fluid from the blood vessel enters the extending member through a vent hole and exits through an opening at the proximal end of the device, thereby providing a user with visual feedback that the device is moving in the desired direction toward the blood vessel.
摘要翻译：一种用于确定从表皮层切割到血管穿刺深度的装置，其中该装置包括具有从远端延伸到近端的内腔的细长构件。细长构件的远端构造成定位血管。在设备定位血管之后，定位深度指示器以标记血管的深度。在一个实施例中，细长构件包括可容纳血管的一部分的锥形内表面。扩展控制构件可以在远端处的装置延伸，其中延伸的控制构件在装置定位血管之前进入血管。来自血管的流体通过通气孔进入延伸构件，并通过设备近端的开口离开，从而为使用者提供视觉反馈，使得装置沿着期望的方向朝向血管运动。

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